Journal of Medical and Biological Engineering最新文献

{"title":"Multiscale Mechanical Modeling of Skeletal Muscle: A Systemic Review of the Literature","authors":"Aude Loumeaud, Philippe Pouletaut, Sabine F. Bensamoun, Daniel George, Simon Chatelin","doi":"10.1007/s40846-024-00879-3","DOIUrl":"https://doi.org/10.1007/s40846-024-00879-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>From the myofibrils to the whole muscle scale, muscle micro-constituents exhibit passive and active mechanical properties, potentially coupled to electrical, chemical, and thermal properties. Experimental characterization of some of these properties is currently not available for all muscle constituents. Multiscale multiphysics models have recently gained interest as a numerical alternative to investigate the healthy and diseased physiological behavior of the skeletal muscle.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This paper refers to the multiscale mechanical models proposed in the literature to investigate the mechanical properties and behavior of skeletal muscles. More specifically, we focus on the scale transition methods, constitutive laws and experimental data implemented in these models.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Using scale transition methods such as homogenization, coupled to appropriate constitutive behavior of the constituents, these models explore the mechanisms of ageing, myopathies, sportive injuries, and muscle contraction.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Emerging trends include the development of multiphysics simulations and the coupling of modeling with the acquisition of experimental data at different scales, with increasing focus to little known constituents such as the extracellular matrix and the protein titin.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"33 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141506556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Thread Design Parameters on Central Screw Loosening: A 3D Finite Element Analysis","authors":"Liang-wei Xu, Kang-jie Cheng","doi":"10.1007/s40846-024-00880-w","DOIUrl":"https://doi.org/10.1007/s40846-024-00880-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The objective of this study was to evaluate the effect of thread shape outline, thread pitch and preload on the central screw loosening or fracturing by using 3D finite element (FE) method.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>By using a commercial implant system as prototypes, nine central screw models and matching implant components were created by combinations of two parameters with different values: three screw shapes (triangle, buttress and reverse buttress) and three screw pitches (0.2 mm, 0.3 mm and 0.4 mm). These models were inserted into a bone block. After applying pre-tightening torque to each central screw, a 100 N load tilted at 45 degrees was applied to the abutment to simulate an occlusal load. The stability performance of the central screws was evaluated through FE software.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>For the central screw shape, the highest stress was always located at the level of the first thread, while the highest stress of the reverse buttress group was always located at the level of the second thread. Triangle (average 650 MPa) and reverse buttress (average 729 MPa) threads were more conducive to reducing central screw stress than buttress thread (average 920 MPa). Moreover, it is necessary to avoid thread parameters design with buttress shape/0.3 mm pitch and buttress shape/0.4 mm pitch.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Thread shape outline and thread pitch significantly influenced central screw stability performance. The central screw with a triangle thread shape and a pitch of 0.2 mm presented the best mechanical properties.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"23 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141506557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning for Epilepsy: A Comprehensive Exploration of Novel EEG and MRI Techniques for Seizure Diagnosis","authors":"Naily Rehab, Yahia Siwar, Zaied Mourad","doi":"10.1007/s40846-024-00874-8","DOIUrl":"https://doi.org/10.1007/s40846-024-00874-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This work focuses on automated epileptic seizure diagnosis (ESD) and prediction (ESP) to clarify the expanding role of machine learning (ML) in epileptic analysis. It outlines the current approaches and challenges in the diagnosis and prognosis of epilepsy and examines the convergence of magnetic resonance imaging (MRI), electroencephalogram (EEG), and ML.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This paper lists current methods for segmentation, localization, feature extraction, diagnosis, and prognosis after providing a brief medical review to distinguish between different forms of epilepsy. A particular focus is on using ML to EEG and MRI data, describing classification techniques to differentiate normal and epileptic activity.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>We highlight the potential of ML-driven methods for computer-aided epilepsy diagnosis and prognosis. We discuss achievements, challenges, and future directions, including devising novel techniques for automated alerts and seizure frequency estimation with minimal computational burden.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>ML interfaces offer new possibilities for real-time seizure diagnosis in refractory epilepsy patients through wearables and implants. This discovery opens the door for improved diagnostic precision and individualized treatment plans in this field by using ML’s capabilities.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3><p>The graphical abstract presents the machine Learning (ML) workflow for epileptic seizure diagnosis (ES) in detail. It begins with collecting data, such as magnetic resonance imaging (MRI) and electroencephalogram (EEG) data. Subsequently, features were extracted from the MRI and EEG data and used to train and evaluate machine learning models. The trained models were then applied to ES classification. Finally, ML algorithms proved to have the potential to revolutionize the diagnosis and treatment of epilepsy. By enabling early detection and personalized treatment, ML algorithms can help improve patient outcomes and quality of life.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"173 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141506559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Segment Foot Kinematics during Gait in Adults with Asymptomatic and Symptomatic Flatfoot","authors":"Wei-Chi Tsai, Zong-Rong Chen, Jui-Tse Hsu, Chen-Yi Song","doi":"10.1007/s40846-024-00877-5","DOIUrl":"https://doi.org/10.1007/s40846-024-00877-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To investigate the differences in foot kinematics during gait between adults with asymptomatic and symptomatic flatfoot.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The study included 10 participants (six males and four females, aged 25.7 ± 6.5 years) with symptomatic flatfoot and 10 participants (eight males and two females, aged 21.2 ± 1.0 years) with asymptomatic flatfoot. Multi-segment foot kinematics were captured during barefoot gait analysis using a 3D software. Angles were calculated for the calcaneus with respect to the shank (Sha-Cal), the midfoot with respect to the calcaneus (Cal-Mid), and the metatarsus with respect to the midfoot (Mid-Met) during the stance phase.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Some differences were noted between medium-to-large effect sizes. The symptomatic group had a decreased Mid-Met dorsiflexion angle at the initial contact to 50% of the stance phase compared with the asymptomatic group. The symptomatic group also showed decreased Mid-Met abduction at initial contact, larger Sha-Cal eversion angles at 10% of the stance phase, and larger Cal-Mid eversion angles at 50% and 70% of the stance phase compared to the asymptomatic group. The symptomatic group also had a larger peak Sha-Cal eversion angle than the asymptomatic group.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Adults with symptomatic flatfoot exhibit significant differences in foot kinematics towards decreased forefoot dorsiflexion at initial contact to mid-stance, decreased forefoot abduction at initial contact, and increased rearfoot eversion during the stance phase compared with those with asymptomatic flatfoot during gait. Pain may impair intersegmental motion.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"29 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141506558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1D Convolutional Neural Network Impact on Heart Rate Metrics for ECG and BCG Signals","authors":"Juan Pablo Moreno, Miguel A. Sepúlveda, Esteban J. Pino","doi":"10.1007/s40846-024-00872-w","DOIUrl":"https://doi.org/10.1007/s40846-024-00872-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The presence of motion artifacts (MA) in cardiac signals negatively impacts the reliability of higher-level information such as the Heart Rate (HR), and therefore the correct diagnosis of pathologies. This paper proposes an MA detection method, based on One-Dimensional Convolutional Neural Networks (1D CNN), to label noisy zones of signals as unreliable, and subsequently avoid them for metric calculations.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>To validate the concept, we first design a CNN to detect MAs in electrocardiogram (ECG) recordings from MIT–BIH Arrhythmia and Noise Stress Test Databases. This network extracts features from 1 s data segments, and then classifies them as clean or noisy. Also, we then train a tuned version of the model with semi-synthetic ballistocardiogram (BCG) signals.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The classification in ECG achieves an accuracy of 95.9% and the BCG classification obtains an accuracy of 91.1%. Both classifiers are incorporated into beat detection systems, which produce an increase in the sensitivity of the detection algorithms from 75 to 98.5% in the ECG case, and from 72.1 to 94.5% in the case of BCG, for signals contaminated at 0 dB of SNR.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>We propose that this method will improve accuracy of any processing algorithm on BCG signals by identifying useful segments where a high accuracy can be achieved.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"19 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141257976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Practical Computer Aided Diagnosis System for Breast Ultrasound Classifying Lesions into the ACR BI-RADS Assessment","authors":"Hsin-Ya Su, Chung-Yueh Lien, Pai-Jung Huang, Woei-Chyn Chu","doi":"10.1007/s40846-024-00869-5","DOIUrl":"https://doi.org/10.1007/s40846-024-00869-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>In this paper, we propose an open-source deep learning-based computer-aided diagnosis system for breast ultrasound images based on the Breast Imaging Reporting and Data System (BI-RADS).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Our dataset with 8,026 region-of-interest images preprocessed with ten times data augmentation. We compared the classification performance of VGG-16, ResNet-50, and DenseNet-121 and two ensemble methods integrated the single models.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The ensemble model achieved the best performance, with 81.8% accuracy. Our results show that our model is performant enough to classify Category 2 and Category 4/5 lesions, and data augmentation can improve the classification performance of Category 3.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Our main contribution is to classify breast ultrasound lesions into BI-RADS assessment classes that place more emphasis on adhering to the BI-RADS medical suggestions including recommending routine follow-up tracing (Category 2), short-term follow-up tracing (Category 3) and biopsies (Category 4/5).</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"19 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141193805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Approach to Segment Nuclei and Cytoplasm in Lung Cancer Brightfield Images Using Hybrid Swin-Unet Transformer","authors":"Sreelekshmi Palliyil Sreekumar, Rohini Palanisamy, Ramakrishnan Swaminathan","doi":"10.1007/s40846-024-00873-9","DOIUrl":"https://doi.org/10.1007/s40846-024-00873-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Segmentation of nuclei and cytoplasm in cellular images is essential for estimating the prognosis of lung cancer disease. The detection of these organelles in the unstained brightfield microscopic images is challenging due to poor contrast and lack of separation of structures with irregular morphology. This work aims to carry out semantic segmentation of nuclei and cytoplasm in lung cancer brightfield images using the Swin-Unet Transformer.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>For this study, publicly available brightfield images of lung cancer cells are pre-processed and fed to the Swin-Unet for semantic segmentation. Model specific hyperparameters are identified after detailed analysis and the segmentation performance is validated using standard evaluation metrics.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The hyperparameter analysis provides the selection of optimum parameters as focal loss, learning rate of 0.0001, Adam optimizer, and Swin Transformer patch size of 4. The obtained results show that with these parameters, the Swin-Unet Transformer accurately segmented the nuclei and cytoplasm in the brightfield images with pixel-F1 scores of 90.71% and 79.29% respectively.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>It is observed that the model could identify nuclei and cytoplasm with varied morphologies. The detection of cytoplasm with weak and subtle edge details indicates the effectiveness of shifted window based self attention mechanism of Swin-Unet in capturing the global and long distance pixel interactions in the brightfield images. Thus, the adopted methodology in this study can be employed for the precise segmentation of nuclei and cytoplasm for assessing the malignancy of lung cancer disease.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"23 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141166996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Finite Element Analysis of Bone Tissues with Different Scales in the Bone Regeneration Area after Scoliosis Surgery","authors":"Xiaozheng Yang, Rongchang Fu, Pengju Li, Kun Wang, Huiran Chen, Fu","doi":"10.1007/s40846-024-00870-y","DOIUrl":"https://doi.org/10.1007/s40846-024-00870-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This paper aims to analyze the influence of mechanical force on bone regeneration from macro and micro perspectives, to investigate the mechanical response of bone tissues at various scales after operation and provide a theoretical basis for further research and clinical practice.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>An effective postoperative lumbar model was constructed, and the bone regeneration area was established at the osteotomy. The area was divided into five stages, from 10 MPa to 100 MPa. Then, the osteon and bone lacuna-osteocyte models were constructed, and their biomechanical characteristics under different working conditions were studied.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>From the first stage to the fifth stage, the macroscopic bone tissue larger than 3000 µε decreased by about 40%, the maximum stress ratio n approximates k (E_O/E_T) of macro- and micro-bone tissues, and the area of osteocytes less than 3000 µε increased by about 45%. In the second stage, 41.7% of the bone cells have a strain of 1000 µε ∼ 3000 µε, and this percentage increases to 66.7%∼72.2% after the fourth stage.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The macro-meso stress ratio is related to the tissue strength around the osteon. In the first stage, the patient should lie flat and rest, instead of standing upright. At the beginning of the fourth stage, the rate of bone regeneration is much faster than the rate of lesions, making it suitable for upright recovery, and the recovery speed increases.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"58 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141166997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Results: Comparison of Convolutional Neural Network Architectures as an Auxiliary Clinical Tool Applied to Screening Mammography in Mexican Women","authors":"Samara Acosta-Jiménez, Susana Aideé González-Chávez, Javier Camarillo-Cisneros, César Pacheco-Tena, Mirelle Barcenas-López, Laura Esther González-Lozada, Claudia Hernández-Orozco, Jesús Humberto Burboa-Delgado, Rosa Elena Ochoa-Albíztegui","doi":"10.1007/s40846-024-00868-6","DOIUrl":"https://doi.org/10.1007/s40846-024-00868-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Mammography is the modality of choice for the early detection of breast cancer. Deep learning, using convolutional neural networks (CNNs) specifically, have achieved extraordinary results in the classification of diseases, including breast cancer, on imaging. The images used to train a CNN varies based on several factors, such as imaging technique, imaging equipment, and study population; these factors significantly affect the accuracy of the CNN models. The aim of this study was to develop a novel CNN for the classification of mammograms as benign or malignant and to compare its utility to that of popular pre-trained CNNs in the literature using transfer learning. All CNNs were trained to detect breast cancer on mammograms using mammograms from a created database of Mexican women (MAMMOMX-PABIOM) and from a public database of UK women (MIAS).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A database (MAMMOMX-PABIOM) was built comprising 1,070 mammography images of 235 Mexican patients from 4 hospitals in Mexico. The study also used mammographic images from the Mammographic Image Analysis Society (MIAS) public database, which comprises mammography images from the UK National Breast Screening Programme. A novel CNN was developed and trained based on different configurations of training data; the accuracy of the models resulting from the novel CNN were compared with models resulting from more advanced pre-trained CNNs (DenseNet121, MobileNetV2, ResNet 50, VGG16) which were built using transfer learning.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Of the models resulting from pre-trained CNNs using transfer learning, the model based on MobileNetV2 and training data from the MAMMOMX-PABIOM database achieved the highest validation accuracy of 70.10%. In comparison, the novel CNN, when trained with the data configuration A6, which comprises data from both the MAMMOMX-PABIOM database and the MIAS database, produced a much higher accuracy of 99.14%.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Although transfer learning is a widely used technique when training, data is scarce. The novel CNN produced much higher accuracy values across all configurations of training data compared to the accuracy values of pre-trained CNNs using transfer learning. In addition, this study addresses the gap in that neither a national database of mammograms of Mexican women exists, nor a deep learning tool for the classification of mammograms as benign or malignant that is focused on this population.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"37 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of Three Gene Prognostic Markers in Pancreatic Ductal Adenocarcinoma Using Machine Learning Approach","authors":"Pragya Pragya, Praveen Kumar Govarthan, Malay Nayak, Sudip Mukherjee, Jac Fredo Agastinose Ronickom","doi":"10.1007/s40846-024-00859-7","DOIUrl":"https://doi.org/10.1007/s40846-024-00859-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent form of pancreatic cancer, accounting for about 85% of all occurrences. It is highly challenging to treat PDAC because of its extreme aggressiveness and lack of therapeutic options. Identifying new gene markers can help in the design of novel targeted therapeutics.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>In this study, we identified three different gene prognostic markers in PDAC using a machine learning approach. Initially, the differential expression genes (DEGs) profile of accession number GSE183795 was downloaded from the gene expression omnibus database of the National Center for Biotechnology Information (NCBI), which consists of the expression profile of the 244 patients with PDAC (139 pancreatic tumors, 102 adjacent non-tumors and 3 normal). Then, the expression dataset was preprocessed using different packages of R programming, such as GEOquery, Affy, and Limma. Further, DEGs were identified by the machine learning algorithms, including random forest (RF) and extreme gradient boost (XGboost). Finally, survival analysis was performed to identify DEGs using GEPIA software (TCGA database).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Our results revealed that 6 out of 25 DEGs (ERCC3, ACY3, ATP2A3, MW-TW1879, MW-TW3829, and ZBTB7A) identified by RF and XGBoost algorithm were the same, indicating their feature importance. Moreover, three genes, including ATP2A3 (<i>p</i> = 0.029), NRL (<i>p</i> = 0.012), and FBXO45 (<i>p</i> = 0.013), were statistically significant when tested for survival analysis and may be utilized as the prognostic marker genes for PDAC.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>These findings provide valuable insights into the molecular characteristics of PDAC and can potentially guide future research on cancer theranostics interventions for this devastating disease.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"77 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140940984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}