Biomechanical Finite Element Analysis of Bone Tissues with Different Scales in the Bone Regeneration Area after Scoliosis Surgery

IF 1.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Xiaozheng Yang, Rongchang Fu, Pengju Li, Kun Wang, Huiran Chen, Fu
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Abstract

Purpose

This paper aims to analyze the influence of mechanical force on bone regeneration from macro and micro perspectives, to investigate the mechanical response of bone tissues at various scales after operation and provide a theoretical basis for further research and clinical practice.

Methods

An effective postoperative lumbar model was constructed, and the bone regeneration area was established at the osteotomy. The area was divided into five stages, from 10 MPa to 100 MPa. Then, the osteon and bone lacuna-osteocyte models were constructed, and their biomechanical characteristics under different working conditions were studied.

Results

From the first stage to the fifth stage, the macroscopic bone tissue larger than 3000 µε decreased by about 40%, the maximum stress ratio n approximates k (EO/ET) of macro- and micro-bone tissues, and the area of osteocytes less than 3000 µε increased by about 45%. In the second stage, 41.7% of the bone cells have a strain of 1000 µε ∼ 3000 µε, and this percentage increases to 66.7%∼72.2% after the fourth stage.

Conclusion

The macro-meso stress ratio is related to the tissue strength around the osteon. In the first stage, the patient should lie flat and rest, instead of standing upright. At the beginning of the fourth stage, the rate of bone regeneration is much faster than the rate of lesions, making it suitable for upright recovery, and the recovery speed increases.

Abstract Image

脊柱侧弯手术后骨再生区不同尺度骨组织的生物力学有限元分析
目的 本文旨在从宏观和微观角度分析机械力对骨再生的影响,探讨术后骨组织在不同尺度上的机械反应,为进一步的研究和临床实践提供理论依据。方法 构建有效的术后腰椎模型,在截骨处建立骨再生区。该区域被分为五个阶段,从 10 兆帕到 100 兆帕。结果从第一阶段到第五阶段,大于 3000 µε 的宏观骨组织减少了约 40%,宏观和微观骨组织的最大应力比 n 接近 k(EO/ET),小于 3000 µε 的骨细胞面积增加了约 45%。在第二阶段,41.7% 的骨细胞应变为 1000 µε ∼ 3000 µε,第四阶段后这一比例增至 66.7% ∼ 72.2%。在第一阶段,患者应平躺休息,而不是直立。第四阶段开始时,骨再生速度远快于病变速度,适合直立恢复,恢复速度加快。
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来源期刊
CiteScore
4.30
自引率
5.00%
发文量
81
审稿时长
3 months
期刊介绍: The purpose of Journal of Medical and Biological Engineering, JMBE, is committed to encouraging and providing the standard of biomedical engineering. The journal is devoted to publishing papers related to clinical engineering, biomedical signals, medical imaging, bio-informatics, tissue engineering, and so on. Other than the above articles, any contributions regarding hot issues and technological developments that help reach the purpose are also included.
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