arXiv - QuanBio - Cell Behavior最新文献_第6页

Contractility-driven cell motility against a viscoelastic resistance 收缩力驱动的细胞运动对抗粘弹性阻力

arXiv - QuanBio - Cell Behavior Pub Date : 2024-02-27 DOI: arxiv-2402.17669

Tapas Singha, Pierre Sens

引用次数: 0

Rebuildable biochronometer: inferences and hypothesis on eukaryotic timing system 可重建的生物计时器：真核生物计时系统的推论和假设

arXiv - QuanBio - Cell Behavior Pub Date : 2024-02-26 DOI: arxiv-2402.16271

Ming-Jia Fu

{"title":"Rebuildable biochronometer: inferences and hypothesis on eukaryotic timing system","authors":"Ming-Jia Fu","doi":"arxiv-2402.16271","DOIUrl":"https://doi.org/arxiv-2402.16271","url":null,"abstract":"The biochronometers used to keep time in eukaryotes include short-period\u0000biochronometer (SPB) and long-period biochronometer (LPB). Because the\u0000circadian clock reflects the biological time rhythm of a day, it is considered\u0000as SPB. Telomere shortening, which reflects the decreasing of telomere DNA\u0000length of chromosomes with the increase of cell division times, can be used to\u0000time the lifespan of organisms, so it is regarded as LPB. It is confirmed that\u0000SPB and LPB exist in most eukaryotes, and it is speculated that SPB and LPB are\u0000closely related. In this paper, based on existing studies, it is speculated\u0000that SPB and LPB of most eukaryotes can be co-attenuated with cell division in\u0000the process of aging. Due to the attenuated phenomenon of key components in the\u0000biochronometers during the growth and development of organisms, the\u0000biochronometers attenuate with the aging. Based on existing research results,\u0000it is preliminarily determined that the biochronometers can be rebuilt in the\u0000co-attenuated process. When the key components of biochronometers are reversed\u0000and increased in the organism, it can lead to the reversal of biochronometers,\u0000which further leads to the phenomenon of biological rejuvenation and makes the\u0000organism younger. In addition, the rebuilding of biochronometers can also lead\u0000to the acceleration of biochronometers and the shortening of the original\u0000timing time of biochronometers, thus shortening the life span of organisms. The\u0000rebuilding of biochronometers includes the reversal of biochronometers, the\u0000truncation of biochronometers timing and Uncoordinated co-attenuation of\u0000biochronometer and so on. The reversal of the biochronometers, which leads to\u0000rejuvenation, can give us a whole new understanding of life expectancy to be\u0000different from anti-aging.","PeriodicalId":501321,"journal":{"name":"arXiv - QuanBio - Cell Behavior","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139977419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism and Prevention of Hyperbaric Oxygen Convulsions 高压氧惊厥的机理与预防

arXiv - QuanBio - Cell Behavior Pub Date : 2024-02-22 DOI: arxiv-2402.14669

Ondrej Groborz, Ludek Sefc, Petr Marsalek

{"title":"Mechanism and Prevention of Hyperbaric Oxygen Convulsions","authors":"Ondrej Groborz, Ludek Sefc, Petr Marsalek","doi":"arxiv-2402.14669","DOIUrl":"https://doi.org/arxiv-2402.14669","url":null,"abstract":"Hyperbaric oxygen therapy (HBOT) proves vital in saving lives by elevating\u0000the partial pressure of oxygen (pO2). However, HBOT may also have toxic\u0000effects, including lung and retinal damage (peripheral HBOT toxicity), muscle\u0000spasms and violent myoclonic convulsions (CNS HBOT toxicity), which may even\u0000lead to death if left untreated. Despite the severity of the toxic effects of\u0000HBOT, their mechanism is only poorly understood to date. This lack of\u0000understanding the underlying mechanism hinders the development of new,\u0000effective therapies and preventive strategies to supress HBOT toxicity. Herein,\u0000we provide evidence that (1) increased pO2 increases the content of reactive\u0000oxygen species (ROS) in tissues, which causes peripheral HBOT toxicity and\u0000contributes to CNS toxicity by irreversibly altering cell receptors. Moreover,\u0000(2) increased ROS concentration in brain lowers activity of glutamic\u0000decarboxylase (GD), which lowers concentrations of inhibitory neurotransmitter\u0000gamma-aminobutyric acid (GABA), thereby contributing to the onset of\u0000HBOT-derived convulsions. At last, we provide long overlooked evidence that (3)\u0000elevated ambient pressure directly inhibits GABA(A) and glycine receptors,\u0000thereby leading to the rapid onset of HBOT-derived convulsions. We show that\u0000only a combination of these three mechanisms (1 + 2 + 3) are needed to explain\u0000most phenomena seen in HBOT toxicity (especially in CNS toxicity). Based on\u0000these proposed intertwined mechanisms, we propose administering antioxidants\u0000(lowering ROS concentrations), pyridoxine (restoring GD activity), and low\u0000doses of sedatives/ anaesthetics (reversing inhibitory effects of pressure on\u0000GABA(A) and glycine receptors) before routine hyperbaric oxygen therapies and\u0000deep-sea diving to prevent the HBOT toxicity.","PeriodicalId":501321,"journal":{"name":"arXiv - QuanBio - Cell Behavior","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139946258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination Therapy for Chronic Hepatitis B Using Capsid Recycling Inhibitor 利用囊壳再循环抑制剂联合治疗慢性乙型肝炎

arXiv - QuanBio - Cell Behavior Pub Date : 2024-02-12 DOI: arxiv-2402.07701

Rupchand Sutradhar, D C Dalal

引用次数: 0

Transduction of an immortalized olfactory ensheathing glia cell line with the green fluorescent protein (GFP) gene: evaluation of its neuroregenerative capacity as a proof of concept 用绿色荧光蛋白（GFP）基因转导永生化嗅觉鞘神经胶质细胞系：作为概念验证评估其神经再生能力

arXiv - QuanBio - Cell Behavior Pub Date : 2024-01-26 DOI: arxiv-2401.15133

N Plaza, D Simón, J Sierra, MT Moreno-Flores

引用次数: 0

Sensory adaptation in a continuum model of bacterial chemotaxis -- working range, cost-accuracy relation, and coupled systems 细菌趋化连续模型中的感官适应--工作范围、成本-精度关系和耦合系统

arXiv - QuanBio - Cell Behavior Pub Date : 2024-01-20 DOI: arxiv-2401.11341

Vansh Kharbanda, Benedikt Sabass

{"title":"Sensory adaptation in a continuum model of bacterial chemotaxis -- working range, cost-accuracy relation, and coupled systems","authors":"Vansh Kharbanda, Benedikt Sabass","doi":"arxiv-2401.11341","DOIUrl":"https://doi.org/arxiv-2401.11341","url":null,"abstract":"Sensory adaptation enables organisms to adjust their perception in a changing\u0000environment. A paradigm is bacterial chemotaxis, where the output activity of\u0000chemoreceptors is adapted to different baseline concentrations via receptor\u0000methylation. The range of internal receptor states limits the stimulus\u0000magnitude to which these systems can adapt. Here, we employ a highly idealized,\u0000Langevin-equation based model to study how the finite range of state variables\u0000affects the adaptation accuracy and the energy dissipation in individual and\u0000coupled systems. Maintaining an adaptive state requires constant energy\u0000dissipation. We show that the steady-state dissipation rate increases\u0000approximately linearly with the adaptation accuracy for varying stimulus\u0000magnitudes in the so-called perfect adaptation limit. This result complements\u0000the well-known logarithmic cost-accuracy relationship for varying chemical\u0000driving. Next, we study linearly coupled pairs of sensory units. We find that\u0000the interaction reduces the dissipation rate per unit and affects the overall\u0000cost-accuracy relationship. A coupling of the slow methylation variables\u0000results in a better accuracy than a coupling of activities. Overall, the\u0000findings highlight the significance of both the working range and collective\u0000operation mode as crucial design factors that impact the accuracy and energy\u0000expenditure of molecular adaptation networks.","PeriodicalId":501321,"journal":{"name":"arXiv - QuanBio - Cell Behavior","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139557105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How cytoskeletal crosstalk makes cells move: bridging cell-free and cell studies 细胞骨架串联如何使细胞运动：无细胞研究与细胞研究的桥梁

arXiv - QuanBio - Cell Behavior Pub Date : 2024-01-16 DOI: arxiv-2401.08368

James P. Conboy, Irene Istúriz Petitjean, Anouk van der Net, Gijsje H. Koenderink

引用次数: 0

Phenotypic switching mechanisms determine the structure of cell migration into extracellular matrix under the `go-or-grow' hypothesis 表型转换机制决定了 "要么走要么长 "假说下细胞向细胞外基质迁移的结构

arXiv - QuanBio - Cell Behavior Pub Date : 2024-01-14 DOI: arxiv-2401.07279

Rebecca M. Crossley, Kevin J. Painter, Tommaso Lorenzi, Philip K. Maini, Ruth E. Baker

{"title":"Phenotypic switching mechanisms determine the structure of cell migration into extracellular matrix under the `go-or-grow' hypothesis","authors":"Rebecca M. Crossley, Kevin J. Painter, Tommaso Lorenzi, Philip K. Maini, Ruth E. Baker","doi":"arxiv-2401.07279","DOIUrl":"https://doi.org/arxiv-2401.07279","url":null,"abstract":"A fundamental feature of collective cell migration is phenotypic\u0000heterogeneity which, for example, influences tumour progression and relapse.\u0000While current mathematical models often consider discrete phenotypic\u0000structuring of the cell population, in-line with the `go-or-grow' hypothesis\u0000cite{hatzikirou2012go, stepien2018traveling}, they regularly overlook the role\u0000that the environment may play in determining the cells' phenotype during\u0000migration. Comparing a previously studied volume-filling model for a\u0000homogeneous population of generalist cells that can proliferate, move and\u0000degrade extracellular matrix (ECM) cite{crossley2023travelling} to a novel\u0000model for a heterogeneous population comprising two distinct sub-populations of\u0000specialist cells that can either move and degrade ECM or proliferate, this\u0000study explores how different hypothetical phenotypic switching mechanisms\u0000affect the speed and structure of the invading cell populations. Through a\u0000continuum model derived from its individual-based counterpart, insights into\u0000the influence of the ECM and the impact of phenotypic switching on migrating\u0000cell populations emerge. Notably, specialist cell populations that cannot\u0000switch phenotype show reduced invasiveness compared to generalist cell\u0000populations, while implementing different forms of switching significantly\u0000alters the structure of migrating cell fronts. This key result suggests that\u0000the structure of an invading cell population could be used to infer the\u0000underlying mechanisms governing phenotypic switching.","PeriodicalId":501321,"journal":{"name":"arXiv - QuanBio - Cell Behavior","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139481323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofilm growth on rugose surfaces 生物膜在凹凸不平的表面上生长

arXiv - QuanBio - Cell Behavior Pub Date : 2024-01-13 DOI: arxiv-2401.07135

David Rodriguez, Baldvin Einarsson, Ana Carpio

引用次数: 0

Incorporating Cellular Stochasticity in Solid--Fluid Mixture Biofilm Models 将细胞随机性纳入固液混合物生物膜模型

arXiv - QuanBio - Cell Behavior Pub Date : 2024-01-13 DOI: arxiv-2401.07088

Ana Carpio, Elena Cebrian

引用次数: 0