{"title":"Echo intensity of the superficial part of the medial infrapatellar fat pad and medial meniscal extrusion are associated with knee symptoms in community-dwelling older adults.","authors":"Shohei Nakayama, Yoshihiro Fukumoto, Masashi Taniguchi, Tsuyoshi Asai, Masanori Wakida, Emi Miki, Sayaka Nakao, Takuya Fukushima, Katsuyasu Kouda, Tome Ikezoe","doi":"10.1007/s10396-024-01512-1","DOIUrl":"10.1007/s10396-024-01512-1","url":null,"abstract":"<p><strong>Purpose: </strong>Knee pain is a characteristic symptom of early-stage knee osteoarthritis. Recently, the association between knee symptoms and infrapatellar fat pad (IFP) degeneration has garnered attention. This study aimed to clarify the association between ultrasound-derived size and echo intensity (EI) in the IFP and knee symptoms.</p><p><strong>Methods: </strong>A total of 163 community-dwelling older individuals (women, n = 106; age, 75.1 ± 7.0 years) participated. An ultrasound imaging device was used to assess the area and EI of the superficial and deep parts of the central, medial, and lateral IFP and presence of medial meniscal extrusion (MME) and medial tibial osteophytes. Based on the 2011 version of the Knee Society Knee Scoring System (KSS) symptoms category, the participants were classified into a symptomatic (KSS symptom score < 23, n = 74) or asymptomatic (KSS symptom score ≧23, n = 89) group. Logistic regression analyses were performed with groups as dependent variables and EI and area of the IFP as independent variables.</p><p><strong>Results: </strong>EI of the superficial part of the medial IFP was significantly associated with knee symptoms, adjusting for age, sex, body mass index, MME, and medial osteophytes (p < 0.05). MME was also significantly associated with knee symptoms (p < 0.05). EI of the other parts, area of any parts, and medial osteophytes were not associated with knee symptoms.</p><p><strong>Conclusion: </strong>These findings suggested the utility of evaluating EI on the superficial part of the medial IFP and MME as the articular structures associated with knee symptoms.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"179-185"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Segmentation approach.","authors":"Manatomo Toyono","doi":"10.1007/s10396-025-01527-2","DOIUrl":"https://doi.org/10.1007/s10396-025-01527-2","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":"52 2","pages":"175-178"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three-dimensional and spatiotemporal image correlation high-definition flow images of a true knot of the umbilical cord with the nuchal cord.","authors":"Takashi Suzuki, Soya Ide, Saori Kondo, Osamu Oguchi","doi":"10.1007/s10396-025-01525-4","DOIUrl":"10.1007/s10396-025-01525-4","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"267-268"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomofumi Nakatsukasa, Tomoko Ishizu, Ruriko Hayakawa, Masumi Ouchi, Naoto Kawamatsu, Kimi Sato, Masayoshi Yamamoto, Tomoko Machino-Ohtsuka, Kunio Kawanishi, Yoshihiro Seo
{"title":"Correction: Assessment of renal congestion in a rat model with congestive heart failure using superb microvascular imaging.","authors":"Tomofumi Nakatsukasa, Tomoko Ishizu, Ruriko Hayakawa, Masumi Ouchi, Naoto Kawamatsu, Kimi Sato, Masayoshi Yamamoto, Tomoko Machino-Ohtsuka, Kunio Kawanishi, Yoshihiro Seo","doi":"10.1007/s10396-025-01533-4","DOIUrl":"https://doi.org/10.1007/s10396-025-01533-4","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: The roles of exercise stress echocardiography for the evaluation of heart failure with preserved ejection fraction in the heart failure pandemic era.","authors":"Naoki Yuasa, Tomonari Harada, Kazuki Kagami, Hideki Ishii, Masaru Obokata","doi":"10.1007/s10396-025-01529-0","DOIUrl":"https://doi.org/10.1007/s10396-025-01529-0","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Usefulness of color Doppler and strain elastography adjunctive to B-mode ultrasonography in the diagnosis of non-mass abnormalities of the breast: results of the BC-07 multicenter study of 385 cases.","authors":"Toshitaka Okuno, Takanori Watanabe, Takuhiro Yamaguchi, Sachiyo Konno, Rie Takaki, Ryoji Watanabe, Kanako Ban, Koichi Hirokaga, Masahiko Tsuruoka, Takako Morita","doi":"10.1007/s10396-024-01485-1","DOIUrl":"10.1007/s10396-024-01485-1","url":null,"abstract":"<p><strong>Purpose: </strong>The concept of non-mass abnormalities of the breast has been employed in Japan for approximately 20 years. Although B-mode findings are classified as non-mass abnormalities, the usefulness of adding color Doppler ultrasonography (US) and strain elastography to B-mode US is unclear. Therefore, we conducted a multicenter study (JABTS BC-07) to establish the diagnostic criteria for breast US, including color Doppler and elastography, for non-mass abnormalities of the breast and verify their diagnostic usefulness.</p><p><strong>Methods: </strong>We registered US images of non-mass abnormalities of the breast and their clinical and histopathological data from 13 institutions (202 malignant and 183 benign non-mass lesions). Furthermore, we evaluated the centralized image interpretation usefulness of the diagnostic criteria for B-mode and color Doppler US, as well as the sensitivity and specificity when color Doppler US and elastography were added to B-mode US.</p><p><strong>Results: </strong>Echogenic foci in the mammary gland (odds ratio 3.45, 95% confidence interval [CI] 1.92-6.19, p < 0.0001) and the configuration of internal solid components of the ducts (odds ratio 0.056, 95% CI 0.005-0.591, p < 0.0165) significantly differentiated benign and malignant non-mass abnormalities. The sensitivity of B-mode alone (83.7%) was significantly improved by adding color Doppler US (93.1%) (p = 0.0004); however, adding color Doppler US and elastography to B-mode US made no significant difference in either sensitivity or specificity.</p><p><strong>Conclusion: </strong>Although adding color Doppler US and elastography to B-mode US improved sensitivity, the diagnostic significance was limited. Therefore, a comprehensive diagnostic method comprising mammography and magnetic resonance imaging is warranted.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"157-168"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between ultrasonographic findings and subscales of the Knee Injury and Osteoarthritis Outcome Score in patients with early knee osteoarthritis: a multicenter study.","authors":"Yushin Mizuno, Yasushi Takata, Yosuke Shima, Kenichi Goshima, Kazunari Kuroda, Tomoyuki Kanayama, Yoshihiro Ishida, Naoki Takemoto, Manase Nishimura, Takuya Sengoku, Satoru Demura, Junsuke Nakase","doi":"10.1007/s10396-024-01498-w","DOIUrl":"10.1007/s10396-024-01498-w","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the ultrasonographic findings of patients with early knee osteoarthritis (KOA) and determine which findings were associated with the Knee Injury and Osteoarthritis Outcome Score (KOOS) subscale.</p><p><strong>Methods: </strong>The study included 98 knees (35 men, 63 women, 60.3 ± 11.5 years) diagnosed with early KOA with no major deformity radiographically, but with pain during activity and tenderness in the medial knee. Synovial hyperplasia in the suprapatellar bursa, knee joint effusion, horizontal tear of the medial meniscus (MM), osteophytes of the medial condyle of the femur and tibia, blood flow signals in the synovium of the suprapatellar bursa, medial collateral ligament bursa, infrapatellar fat pad, MM extrusion (MME) in the supine and upright positions, and the amount of change in MME were observed using ultrasonography.</p><p><strong>Results: </strong>Correlations (p < 0.05) were found between the presence of synovial hyperplasia of the suprapatellar bursa (r<-0.20) and amount of MME in the upright position (r< - 0.24) and all KOOS subscales. Presence of joint effusion and the four KOOS subscales except quality of life (QOL) were correlated (p < 0.05). Partial correlation coefficients showed correlations (p < 0.05) between knee joint effusion and symptoms (r = 0.299) and activities of daily living (ADL) (r = 0.254) of the KOOS subscales, and between MME in the upright position and symptoms (r= - 0.263), pain (r= - 0.256), and ADL (r= - 0.212).</p><p><strong>Conclusion: </strong>Quality and difficulty of life of patients with early KOA may be influenced by synovial hyperplasia in the suprapatellar bursa, joint effusion, and MME values in the upright position. Among them, synovial hyperplasia of the suprapatellar bursa and amount of MME in the upright position were independently associated with the KOOS subscales.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"139-148"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperechogenicity and histopathological features of focal liver lesions.","authors":"Kumiko Okino, Satoshi Wakasugi, Shin Ichihara","doi":"10.1007/s10396-024-01475-3","DOIUrl":"10.1007/s10396-024-01475-3","url":null,"abstract":"<p><p>The identification and accurate diagnosis of focal liver lesions are important in modern medicine, where diagnostic radiology plays an essential role. This review aimed to examine the hyperechogenicity and histopathological features of focal liver lesions. Hyperechogenic liver lesions can be either benign or malignant. Evidence shows that hyperechogenicity is caused by factors such as fat deposition, sinusoidal dilation, peliotic changes, and pseudoglandular patterns. Fat deposition is a common cause of increased echogenicity in hepatocellular carcinoma (HCC). Meanwhile, sinusoidal dilation and peliotic changes are more frequently observed in larger HCC nodules. Pseudoglandular patterns, characterized by the reflection of ultrasound waves at the walls of numerous acini, are associated with hyperechogenicity in well-to-moderately differentiated HCCs. Moreover, this review comprehensively examined the histological features that may cause hyperechogenic internal echoes in not only HCCs but also localized liver lesions (metastases of adenocarcinoma and neuroendocrine neoplasm, intrahepatic cholangiocarcinoma, cavernous hemangioma, focal nodular hyperplasia, and angiomyolipoma). To make an accurate diagnosis and provide appropriate management, it is important to understand the histopathological basis for hyperechogenicity in focal liver lesions. By maximizing the accuracy of imaging studies and enhancing the radiology-pathology correlation, unnecessary biopsies can be avoided, thereby reducing potential complications and mortality. This review can help facilitate the effective management of patients with focal liver lesions, thereby resulting in timely and appropriate treatment decision-making.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"55-67"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic performance of two-dimensional shear wave elastography and attenuation imaging for fibrosis and steatosis assessment in chronic liver disease.","authors":"Tamaki Kobayashi, Takuma Nakatsuka, Masaya Sato, Yoko Soroida, Hiromi Hikita, Hiroaki Gotoh, Tomomi Iwai, Ryosuke Tateishi, Makoto Kurano, Mitsuhiro Fujishiro","doi":"10.1007/s10396-024-01473-5","DOIUrl":"10.1007/s10396-024-01473-5","url":null,"abstract":"<p><strong>Purpose: </strong>We investigated the diagnostic performance of two-dimensional shear wave elastography (2D-SWE) and attenuation imaging (ATI) in detecting fibrosis and steatosis in patients with chronic liver disease (CLD), comparing them with established methods.</p><p><strong>Methods: </strong>In 190 patients with CLD, 2D-SWE and vibration-controlled transient elastography (VCTE) were used for liver stiffness measurement (LSM), and ATI and controlled attenuation parameter (CAP) were used for steatosis quantification. The correlations between these new and established methods were analyzed.</p><p><strong>Results: </strong>Significant correlations were found between 2D-SWE and VCTE (r = 0.78, P < 0.001), and between ATI and CAP (r = 0.70, P < 0.001). Liver stiffness tended to be lower with 2D-SWE compared with that with VCTE, especially in cases with higher LSM, and ATI was less influenced by skin-capsular distance than CAP. Area under the receiver-operating characteristics curves (AUCs) and optimal cut-offs of 2D-SWE for diagnosing liver fibrosis stages F2, F3, and F4 were 0.73 (8.7 kPa), 0.79 (9.1 kPa), and 0.88 (11.6 kPa), respectively. The AUCs and optimal cut-offs of ATI for diagnosing hepatic steatosis grades S1, S2, and S3 were 0.91 (0.66 dB/cm/MHz), 0.80 (0.79 dB/cm/MHz), and 0.88 (0.86 dB/cm/MHz), respectively. A subgroup analysis of 86 patients with metabolic dysfunction-associated steatotic liver disease also demonstrated good performance for 2D-SWE and ATI.</p><p><strong>Conclusion: </strong>2D-SWE and ATI performed comparably with conventional VCTE and CAP in evaluating CLD, offering reliable alternatives for diagnosing liver fibrosis and steatosis.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"95-103"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing deep-seated hepatocellular carcinoma detection: assessing the added value of high mechanical index setting in sonazoid-based contrast-enhanced ultrasound during post-vascular phase.","authors":"Ying Zhang, Kazushi Numata, Hiromi Nihonmatsu, Akihiro Funaoka, Haruo Miwa, Ritsuko Oishi, Akito Nozaki, Shin Maeda","doi":"10.1007/s10396-024-01507-y","DOIUrl":"10.1007/s10396-024-01507-y","url":null,"abstract":"<p><strong>Purpose: </strong>This retrospective study aimed to investigate the role of an additional high mechanical index (MI) setting scan during the post-vascular phase (PVP) in detecting deep-seated hepatocellular carcinoma (HCC) lesions.</p><p><strong>Methods: </strong>A total of 805 confirmed HCCs, which underwent Sonazoid-based contrast-enhanced ultrasound (CEUS) between January 2014 and October 2021, were included. Low MI scan was initially employed for lesion detection during the PVP, followed by high MI scan. Propensity score matching (PSM) was utilized to address confounding variables.</p><p><strong>Results: </strong>Of the 805 study lesions, 668 were detected as perfusion defects at the initial low MI setting, while 137 remained undetected. Among these 137 undetected lesions, 77 were identified at the subsequent high MI setting, whereas 60 remained undetected. Lesions that were larger (18.69 ± 11.27 mm vs. 16.55 ± 7.42 mm, p = 0.006), more superficial (6.06 ± 2.41 cm vs. 7.40 ± 2.74 cm, p < 0.001), and hypoechoic (482/668 vs. 62/137, p < 0.001) were detectable at the initial low MI setting. Male patients benefited more from the additional high MI scan (63/97 vs. 14/40, p < 0.001). Lesions identified with additional high MI were larger (18.30 ± 8.76 mm vs. 14.30 ± 4.34 mm, p < 0.001) and deeper than undetected ones (8.48 ± 2.48 cm vs. 6.02 ± 2.43 cm, p < 0.001). After PSM, depth was shown to be an independent predictor in multivariate analysis (odds ratio: 1.557, 95% confidence interval: 1.249-1.941). The depth cutoff was 7.75 cm, with a sensitivity of 0.681, specificity of 0.851, and area under the curve of 0.774.</p><p><strong>Conclusions: </strong>The additional high MI setting scan during the PVP of Sonazoid-based CEUS leads to enhanced detection of deep-seated HCCs.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"105-117"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}