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The preventive effect of omega-3 fish oil on the formation of peritoneal adhesions. ω-3鱼油对腹膜粘连形成的预防作用。

Polski przeglad chirurgiczny Pub Date : 2023-02-17 DOI: 10.5604/01.3001.0016.2730

Kerem Karaman, Hüseyin Çakıroğlu, Fatıma Betül Tuncer, Mehmet Ramazan Şekeroğlu, Fahri Yılmaz

{"title":"The preventive effect of omega-3 fish oil on the formation of peritoneal adhesions.","authors":"Kerem Karaman, Hüseyin Çakıroğlu, Fatıma Betül Tuncer, Mehmet Ramazan Şekeroğlu, Fahri Yılmaz","doi":"10.5604/01.3001.0016.2730","DOIUrl":"10.5604/01.3001.0016.2730","url":null,"abstract":" Introduction: Postoperative peritoneal adhesions that form after abdominal surgery still continue to exist as an unresolved health problem. Aim: The aim of the study is to examine whether omega-3 fish oil has a preventive effect on postoperative peritoneal adhesions. Material and methods: Twenty-one female Wistar albino rats were separated into 3 groups (sham, control and experimental), each consisting of 7 rats. In the sham group, only laparotomy was performed. In both the control and experimental group rats, the right parietal peritoneum and cecum were traumatised to form petechiae. Following this procedure, the abdomen was irrigated with omega-3 fish oil in the experimental group. The rats were re-explored on the 14th postoperative day and any adhesions were scored. Tissue samples and blood samples were taken for histopathological and biochemical analysis. Results: None of the rats that were administered omega-3 fish oil developed macroscopic postoperative peritoneal adhesions (P = 0.005). The omega-3 fish oil formed an anti-adhesive lipid barrier on the injured tissue surfaces. Microscopic evaluation revealed diffuse inflammation with excessive connective tissue and fibroblastic activity in the control group rats, while foreign body reactions were common in the omega-3 rats. The mean amount of hydroxyproline in samples from injured tissues was significantly lower in the omega-3 rats than in the control rats (P = 0.004). Conclusion: Intraperitoneal application of omega-3 fish oil prevents postoperative peritoneal adhesions by forming an anti-adhesive lipid barrier on injured tissue surfaces. However, further studies are needed to determine whether this adipose layer is permanent or will be resorbed over time.</br&gt.","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"96 1","pages":"8-14"},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anastomotic Leak in Colorectal Surgery: Predictive Factors and Survival. 结直肠手术中的吻合口漏：预测因素与存活率。

Polski przeglad chirurgiczny Pub Date : 2022-12-20 DOI: 10.5604/01.3001.0016.1602

Swetha Prabhakaran, Sowmya Prabhakaran, Wei Mou Lim, Glen Guerra, Alexander G Heriot, Joseph C Kong

{"title":"Anastomotic Leak in Colorectal Surgery: Predictive Factors and Survival.","authors":"Swetha Prabhakaran, Sowmya Prabhakaran, Wei Mou Lim, Glen Guerra, Alexander G Heriot, Joseph C Kong","doi":"10.5604/01.3001.0016.1602","DOIUrl":"https://doi.org/10.5604/01.3001.0016.1602","url":null,"abstract":" Introduction: Anastomotic leak (AL) is a serious complication following colorectal surgery. Aim: The aim of this study was to identify factors associated with the development of AL and to analyze its impact on survival. Materials and methods: All consecutive adult colorectal cancer resections performed between 2007 and 2020 with curative intent and anastomosis formation were included from a prospectively maintained database. The primary outcome measure was the rate of AL. The secondary outcome measure was 5-year overall survival (OS). Results: There were 6837 eligible patients. The rate of AL was 2.2% and 4.0% in patients with colon and rectal cancer, respectively. AL was a significant independent predictor of reduced 5-year OS in patients who underwent curative surgery for rectal cancer (odds ratio 2.293, p = 0.009). Emergency surgery (p = 0.015), surgery at a public hospital (p = 0.002), and an open surgical approach (p = 0.021) were all associated with a significantly higher risk of AL in patients with colon cancer, with higher rates of AL noted in left colectomies as compared to right hemicolectomies (4.4% vs. 1.3%, p < 0.001). In rectal cancer patients, AL was associated with neoadjuvant chemoradiotherapy (p = 0.038) and male gender (p = 0.002). The anastomosis formation technique (hand-sewn vs. stapled) did not impact the rate of AL (p = 0.116 and p = 0.198 with colon and rectal cancer, respectively). Discussion: Clinicians should be cognizant of the predictive factors for AL and should consider early intervention for at-risk patients.</br&gt.","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"95 5","pages":"56-64"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138816215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dupuytren's disease - what's new: a review. Dupuytren氏病——最新进展:综述。

Polski przeglad chirurgiczny Pub Date : 2022-10-24 DOI: 10.5604/01.3001.0016.0058

Andrzej Żyluk

{"title":"Dupuytren's disease - what's new: a review.","authors":"Andrzej Żyluk","doi":"10.5604/01.3001.0016.0058","DOIUrl":"10.5604/01.3001.0016.0058","url":null,"abstract":" Introduction: Dupuytren's disease is a common fibrotic disorder of the palmar aponeurosis characterized by the formation of nodules and cords, as well as development of progressive flexion deformities in the digits, leading to functional impairment. Surgical excision of the affected aponeurosis remains the most common treatment. Quite a few new information appeared about epidemiology, pathogenesis and particularly treatment of the disorder. Aim: The aim of this study is an updated review of scientific data in this topic. Results: Results of epidemiologic studies showed that Dupuytren's disease is not so uncommon in Asian and African population as it was earlier believed. An important role of genetic factors on development of the disease in a proportion of patients was demonstrated, however, it did not translate neither to the treatment nor to the prognosis. The most changes concerned the management of Dupuytren's disease. A positive effect of steroids injections into the nodules and cords for inhibition of the disease in early stages was shown. In the advanced stages, a standard technique of partial fasciectomy was partly replaced by mini-invasive methods such as needle fasciotomy and collagenase Clostirdium hystolyticum injections. Unexpected withdrawal of collagenase from the market in 2020 resulted in considerable limitation of the availability of this treatment. Conclusion: It seems that updated knowledge on Dupuytren's disease may be interested and useful for surgeons involved in management of the disorder.</br&gt.","PeriodicalId":501107,"journal":{"name":"Polski przeglad chirurgiczny","volume":"95 6","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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