Giovanni Salzano XXX, Simona Barone XXX, Pietro De Luca XXX, Gerardo Borriello XXX, Luigi Angelo Vaira XXX, Stefania Troise XXX, Vincenza Granata XXX, Umberto Committeri XXX, Francesco Perri XXX, Maria Esposito XXX, Fabio di Blasi XXX, Marzia Petrocelli XXX, Franco Ionna XXX, Luigi Califano XXX, Giovanni Dell'Aversana Orabona XXX, Arianna Di Stadio XXX
{"title":"Predictive value of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and systemic inflammatory index for detection of recurrence of pleomorphic adenoma of the major salivary glands: a multicenter study","authors":"Giovanni Salzano XXX, Simona Barone XXX, Pietro De Luca XXX, Gerardo Borriello XXX, Luigi Angelo Vaira XXX, Stefania Troise XXX, Vincenza Granata XXX, Umberto Committeri XXX, Francesco Perri XXX, Maria Esposito XXX, Fabio di Blasi XXX, Marzia Petrocelli XXX, Franco Ionna XXX, Luigi Califano XXX, Giovanni Dell'Aversana Orabona XXX, Arianna Di Stadio XXX","doi":"10.1016/j.oooo.2024.08.014","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.014","url":null,"abstract":"The aim of this study was to investigate the correlation among inflammatory biomarkers, such as the systemic immune-inflammation index (SII), the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), and the recurrence of pleomorphic adenomas (PAs).","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriella C. Speakman DDS, Kristin K. McNamara XXX, John R. Kalmar XXX, Prokopios P. Argyris XXX
{"title":"SATB2 expression in oral sarcomatoid (spindle cell) squamous cell carcinoma: clinicopathologic and immunophenotypic characterization of 10 cases","authors":"Gabriella C. Speakman DDS, Kristin K. McNamara XXX, John R. Kalmar XXX, Prokopios P. Argyris XXX","doi":"10.1016/j.oooo.2024.08.016","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.016","url":null,"abstract":"Sarcomatoid squamous cell carcinoma (sSCC) represents an uncommon histopathologic variant of squamous cell carcinoma (SCC). We examined the clinicopathologic and immunophenotypic characteristics, including SATB2 expression, of 10 cases of oral sSCCs.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Petra Pandurevic, Ian Furst DDS MSc, Mark Roger Darling BChD MSc (Dent) MSc (Med) MChD
{"title":"Ulcerated mass and radiolucency of the left mandible","authors":"Petra Pandurevic, Ian Furst DDS MSc, Mark Roger Darling BChD MSc (Dent) MSc (Med) MChD","doi":"10.1016/j.oooo.2024.08.023","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.023","url":null,"abstract":"","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A retrospective comparative study of extensive sinus membrane perforations repairing using collagen membranes with pouch and nonpouch techniques","authors":"Liang Xia DDS MD, Zonghe Xu DDS MD, Duohong Zou DDS PhD","doi":"10.1016/j.oooo.2024.08.019","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.019","url":null,"abstract":"To evaluate the clinical and radiological outcomes of employing collagen membranes with pouch and nonpouch techniques to repair extensive maxillary sinus membrane perforation.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical significance and biological role of claudin-1 in oral squamous cell carcinoma cells","authors":"Tadayoshi Nobumoto DDS PhD, Sachiko Yamasaki DDS PhD, Atsuko Hamada DDS PhD, Mirai Higaki DDS PhD, Nanako Ito DDS PhD, Fumitaka Obayashi DDS PhD, Yasutaka Ishida DDS PhD, Tomoaki Hamana DDS PhD, Tomoaki Shintani DDS PhD, Ryouji Tani DDS PhD, Koichi Koizumi DDS PhD, Souichi Yanamoto DDS PhD, Yasutaka Hayashido DDS PhD","doi":"10.1016/j.oooo.2024.08.020","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.020","url":null,"abstract":"Claudin (CLD), a major component of tight junctions, is a four-transmembrane protein, and 24 subtypes have been reported in humans. CLD expression is highly tissue-specific; CLD1 has been reported to be expressed in the skin and mucosa. There have been few reports on CLD1 expression and its function in oral cancer.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathaly de Oliveira Ciaramicolo DDS MS, Gabriela Barbosa Bisson DDS MS, Osny Ferreira Jr. DDS MSc
{"title":"Adverse effects associated with the irresponsible use of phenol peeling - literature review","authors":"Nathaly de Oliveira Ciaramicolo DDS MS, Gabriela Barbosa Bisson DDS MS, Osny Ferreira Jr. DDS MSc","doi":"10.1016/j.oooo.2024.08.018","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.018","url":null,"abstract":"Carbolic acid or phenol is considered a chemical agent that produces intense facial rejuvenation when used correctly, however, solutions containing this substance are dangerous and their action must be controlled. The aim of this study was to collect information on the adverse effects of the use of phenolic compounds for facial esthetic purposes. Phenol promotes the denaturation and coagulation of epidermal keratin proteins, deep chemical peels carried out with phenol, when well indicated and properly conducted, produce incomparable results, however, the ignorant use of these solutions can produce ectropion, keloids, and unsightly scars on the face and neck, in addition, systemic absorption is related to hepatorenal and cardiac toxicity. Although the cardiotoxicity of phenol is well described in the literature, its carcinogenic potential is still unknown and further studies are needed. It is known that the substance induces unscheduled DNA synthesis, inducing genetic mutation. Successful results depend on a balance among art and technique and safety standards. Future research investigating the carcinogenic potential of phenol peels is desirable to ensure patient safety and adequate information for professionals. We believe that the indiscriminate use of phenol peels can cause serious problems for patients and their general health. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel D. Raffaelli DDS, Timothy W. Neal DDS MD, Jonathan J. Jelmini DDS MD, Roderick Y. Kim DDS MD MBA FACS, Fayette C. Williams DDS MD FACS
{"title":"Evaluation of postoperative peri-implant reactive tissues following implant supported prosthetic rehabilitation in fibula free flaps","authors":"Samuel D. Raffaelli DDS, Timothy W. Neal DDS MD, Jonathan J. Jelmini DDS MD, Roderick Y. Kim DDS MD MBA FACS, Fayette C. Williams DDS MD FACS","doi":"10.1016/j.oooo.2024.08.017","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.017","url":null,"abstract":"The purpose of this study was to measure the frequency of peri-implant reactive tissue development in a cohort of patients following immediate implant supported prosthetic rehabilitation in fibula free flaps at our institution and to document 2 cases of management based on our institution's experience. To address this question of study design, a case series was performed from October 2014 to May 2022. We included patients that underwent a fibula free flap reconstruction of the mandible or maxilla with immediate implant placement and dental prostheses fabrication. Forty-four patients met the inclusion criteria, and, among the participants, a total of 26 male patients (59%) and 18 female patients (41%) were evaluated, with 185 implants placed all together. Twenty patients (45%) were treated for benign pathology, 12 with malignant pathology (27%), 5 with trauma (11%), and 7 with osteoradionecrosis (16%). Postoperative peri-implant reactive tissues were seen to develop at 39 of the implant sites (21%). Reactive tissues were found to be a common complication in patients treated with fibular free flap reconstructions involving implant rehabilitation. Our institution noted that local excision of such reactive tissues, in addition to silver nitrate cauterization and topical steroid application, may provide reasonable success in dealing with these occurrences. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Vitor Mota Lemos, Joyce Ohana de Lima Martins, Larissa Carvalho Machado, Lara Rabelo Aragão, Maria Elisa Quezado Lima Verde, Cláudia do Ó. Pessoa, Maria Júlia Barbosa Bezerra, Ana Paula Negreiros Nunes Alves, Paulo Goberlânio de Barros Silva
{"title":"Digoxin attenuates bisphosphonate related osteonecrosis of the jaws by RORγt-dependent Th17 response in male rats","authors":"José Vitor Mota Lemos, Joyce Ohana de Lima Martins, Larissa Carvalho Machado, Lara Rabelo Aragão, Maria Elisa Quezado Lima Verde, Cláudia do Ó. Pessoa, Maria Júlia Barbosa Bezerra, Ana Paula Negreiros Nunes Alves, Paulo Goberlânio de Barros Silva","doi":"10.1016/j.oooo.2024.08.013","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.013","url":null,"abstract":"The study aimed to evaluate digoxin, an RORγt inhibitor, in Medication-Related Osteonecrosis of the Jaws (MRONJ) in male rats treated with zoledronic acid (ZA). Forty male Wistar rats were divided into a negative control group (0.1 mL/kg saline), a positive control group (ZA, 0.20 mg/kg), and three test groups treated with ZA and digoxin at 1 (DG1), 2 (DG2), or 4 (DG4) mg/kg. These groups received treatment three times weekly. ZA was administered intravenously on days 0, 7, and 14, followed by extraction of the left lower first molar on day 42, a final ZA dose on day 49, and euthanasia on day 70. Analyses included radiographic, histomorphometric, and immunohistochemical evaluation of the mandibles, western blotting of gingiva, and mechanical tests on femurs. Statistical analysis was performed using ANOVA/Bonferroni tests ( < .05). Digoxin reduced radiolucency of MRONJ ( < .001), inflammatory cells, empty osteocyte lacunae ( < .001), apoptotic osteoclasts ( < .001), and Caspase-3-positive osteocytes ( = .021). ZA increased immunoreactivity for most markers except c-Fos, while digoxin reduced interleukin 17, TNF-α, IL-6, IL-2, FOXP3, c-Jun, NFκB ( < .001), TGF-β ( = .009), RANKL ( = .035), and OPG ( = .034). Digoxin also reversed RORγt expression ( < .001), increased diarrhea scores ( = .028), renal and cardiac indexes ( < .001), and enhanced femur mechanical properties ( < .013). Digoxin attenuated MRONJ by inhibiting RORγt and reducing the Th17 response.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Firdevs Aşantoğrol MDS DDS, Ayşe Nur Koruyucu MDS DDS
{"title":"Evaluation of antihypertensive drug-induced changes in mandibular bone using fractal analysis","authors":"Firdevs Aşantoğrol MDS DDS, Ayşe Nur Koruyucu MDS DDS","doi":"10.1016/j.oooo.2024.08.015","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.015","url":null,"abstract":"The aim was to evaluate changes in trabecular and cortical mandibular bone caused by antihypertensive (AHT) drugs through fractal analysis. This retrospective study included 230 patients who were taking AHT medication and had no conditions affecting bone metabolism other than hypertension. A control group of 230 healthy, sex-matched individuals was also included. Patients were divided into subgroups according to AHT drugs: thiazide diuretics (TDs), beta-blockers (BBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), and a combination of drugs. The fractal dimension (FD) was calculated bilaterally in 5 regions of interest (ROI 1 – ROI 5) including 4 trabecular regions and 1 cortical region using Image J software. Mean FD values were significantly higher in all ROIs for the study group compared to the control group ( < .001). FDs were significantlty higher for BB, ACEI, ARB, CCB, and combined subgroups compared to controls in ROIs 1, 2, and 4; for ACEI and CCB subgroups compared to controls in ROI 3; and for TD, BB, ACEI, ARB, CCB, and combined subgroups compared to controls in ROI 5 ( < .001). AHTs may increase FD values of the trabecular and cortical structures. Assessment of the effects of AHT drugs is essential for predicting the prognosis for bone healing after tooth extraction, osseointegration after implant surgery or other surgical procedures.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}