medRxiv - Surgery最新文献_第4页

EndoGPT: A Proof-of-concept Large Language Model Based Assistant for the Management of Thyroid Nodules EndoGPT：基于大语言模型的甲状腺结节管理助手的概念验证

medRxiv - Surgery Pub Date : 2024-05-31 DOI: 10.1101/2024.05.29.24308002

Meghal Shah, Eric J. Kuo, Jennifer H. Kuo, Shawn Hsu, Catherine McManus, Rachel Liou, James A. Lee, Tejas S. Sathe

引用次数: 0

Protocol for the Development of Artificial Intelligence Models for the Reduction of Surgical Complications Based on Intraoperative Video - Surg_Cloud project 基于术中视频减少手术并发症的人工智能模型开发协议 - Surg_Cloud 项目

medRxiv - Surgery Pub Date : 2024-05-27 DOI: 10.1101/2024.05.26.24307908

Antonio Sampaio Soares, Sophia Bano, Laura T Castro, Ricardo Rocha, Paulo Alves, Paulo Mira, João Costa, Manish Chand, Danail Stoyanov

引用次数: 0

Efficacy and safety of ethanolamine oleate in sclerotherapy in patients with difficult-to-resect venous malformations: A multicenter, open-label, single-arm study 油酸乙醇胺对难以切除的静脉畸形患者进行硬化疗法的有效性和安全性：一项多中心、开放标签、单臂研究

medRxiv - Surgery Pub Date : 2024-05-09 DOI: 10.1101/2024.05.06.24306216

Mine Ozaki, Tadashi Nomura, Keigo Osuga, Masakazu Kurita, Ayato Hayashi, Shunsuke Yuzuriha, Noriko Aramaki-Hattori, Makoto Hikosaka, Taiki Nozaki, Michio Ozeki, Junko Ochi, Shimpei Akiyama, Yasumasa Kakei, Keiko Miyakoda, Naoko Kashiwagi, Takahiro Yasuda, Yuki Iwashina, Tsuyoshi Kaneko, Kiyoko Kamibeppu, Takafumi Soejima, Kiyonori Harii

引用次数: 0

Protocol for assessing the impact of the 6th National Audit Project recommendations on practice 第六次国家审计项目建议对实践影响的评估规程

medRxiv - Surgery Pub Date : 2024-05-04 DOI: 10.1101/2024.05.03.24306350

Sigrún Eyrúnardóttir Clark, Iain Moppett, S. Ramani Moonesinghe, Cecilia Vindrola-Padros

{"title":"Protocol for assessing the impact of the 6th National Audit Project recommendations on practice","authors":"Sigrún Eyrúnardóttir Clark, Iain Moppett, S. Ramani Moonesinghe, Cecilia Vindrola-Padros","doi":"10.1101/2024.05.03.24306350","DOIUrl":"https://doi.org/10.1101/2024.05.03.24306350","url":null,"abstract":"Patient safety has been a growing area of concern, especially within perioperative care where risks of major complications during surgery exist. Anaphylaxis in the operating theatre is a life-threatening drug reaction that happens suddenly, without warning and can affect anyone. The 6th National Audit Project (NAP6) of the Royal College of Anaesthetists (RCoA): Perioperative Anaphylaxis was the largest ever prospective study of anaphylaxis related to anaesthesia and surgery. The findings from the audit were collated into a report and included recommendations for improved patient care. The purpose of this study is to understand the perceptions of the NAP6 recommendations and their impact on practice. This study will use ethnographic qualitative methods in the form of observations, interviews and a documentary analysis. The sessions targeted for observations will include departmental or hospital meetings, and educational or training sessions, related to perioperative anaphylaxis. The target sample size of 78 healthcare professionals across six hospitals within England, will include individuals with roles specific to anaesthesia, surgery, immunology, allergy and governance. Additionally, six stakeholders will be interviewed who can provide insights into the NAP6 recommendations at the national level. Across the six sites, local collaborators will share any relevant documents related to perioperative anaphylaxis or the NAP-6 recommendations. The study has received regulatory approvals from the Health Research Authority and has been funded by the National Institute for Health and Care Research.","PeriodicalId":501051,"journal":{"name":"medRxiv - Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140930392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA methylation in pituitary adenomas: scoping review protocol 垂体腺瘤中的 DNA 甲基化：范围审查协议

medRxiv - Surgery Pub Date : 2024-04-29 DOI: 10.1101/2024.04.29.24306412

Morten Winkler Møller, Mathias Just Nortvig, Mikkel Schou Andersen, Frantz Rom Poulsen

引用次数: 0

A roadmap for implanting microelectrode arrays to evoke tactile sensations through intracortical microstimulation 通过皮层内微刺激唤起触觉的微电极阵列植入路线图

medRxiv - Surgery Pub Date : 2024-04-28 DOI: 10.1101/2024.04.26.24306239

John E Downey, Hunter R Schone, Stephen T Foldes, Charles Greenspon, Fang Liu, Ceci Verbaarschot, Daniel Biro, David Satzer, Chan Hong Moon, Brian A Coffman, Vahab Youssofzadeh, Daryl Fields, Taylor G Hobbs, Elizaveta Okorokova, Elizabeth C Tyler-Kabara, Peter C Warnke, Jorge Gonzalez-Martinez, Nicholas G Hatsopoulos, Sliman J Bensmaia, Michael L Boninger, Robert A Gaunt, Jennifer L Collinger

{"title":"A roadmap for implanting microelectrode arrays to evoke tactile sensations through intracortical microstimulation","authors":"John E Downey, Hunter R Schone, Stephen T Foldes, Charles Greenspon, Fang Liu, Ceci Verbaarschot, Daniel Biro, David Satzer, Chan Hong Moon, Brian A Coffman, Vahab Youssofzadeh, Daryl Fields, Taylor G Hobbs, Elizaveta Okorokova, Elizabeth C Tyler-Kabara, Peter C Warnke, Jorge Gonzalez-Martinez, Nicholas G Hatsopoulos, Sliman J Bensmaia, Michael L Boninger, Robert A Gaunt, Jennifer L Collinger","doi":"10.1101/2024.04.26.24306239","DOIUrl":"https://doi.org/10.1101/2024.04.26.24306239","url":null,"abstract":"Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of a bidirectional brain-computer interface to restore upper limb function. Evoking tactile sensations of the hand through ICMS requires precise targeting of implanted electrodes. Here we describe the presurgical imaging procedures used to generate functional maps of the hand area of the somatosensory cortex and subsequent planning that guided the implantation of intracortical microelectrode arrays. In five participants with cervical spinal cord injury, across two study locations, this procedure successfully enabled ICMS-evoked sensations localized to at least the first four digits of the hand. The imaging and planning procedures developed through this clinical trial provide a roadmap for other brain-computer interface studies to ensure successful placement of stimulation electrodes.","PeriodicalId":501051,"journal":{"name":"medRxiv - Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140830375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ALLIANCE A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer Alliance A022104/NRG-GI010：Janus直肠癌试验：一项随机II/III期试验，测试三联化疗与二联化疗对局部晚期直肠癌患者临床完全反应和无病生存期的疗效

medRxiv - Surgery Pub Date : 2024-04-27 DOI: 10.1101/2024.04.25.24306396

J Alvarez, Q Shi, A Dasari, J Garcia-Aguilar, H Sanoff, TJ George, TS Hong, G Yothers, PA Philip, GD Nelson, T Al Baghdadi, O Alese, W Zambare, DM Omer, FS Verheij, J Buckley, H Williams, M George, R Garcia, EM O’Reilly, JA Meyerhardt, A Shergill, N Horvat, PB Romesser, WA Hall, JJ Smith

{"title":"ALLIANCE A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer","authors":"J Alvarez, Q Shi, A Dasari, J Garcia-Aguilar, H Sanoff, TJ George, TS Hong, G Yothers, PA Philip, GD Nelson, T Al Baghdadi, O Alese, W Zambare, DM Omer, FS Verheij, J Buckley, H Williams, M George, R Garcia, EM O’Reilly, JA Meyerhardt, A Shergill, N Horvat, PB Romesser, WA Hall, JJ Smith","doi":"10.1101/2024.04.25.24306396","DOIUrl":"https://doi.org/10.1101/2024.04.25.24306396","url":null,"abstract":"<strong>Background</strong> Recent data have demonstrated that in locally advanced rectal cancer (LARC), a total neoadjuvant therapy (TNT) approach improves compliance with chemotherapy and increases rates of tumor response compared to neoadjuvant chemoradiation (CRT) alone. They further indicate that the optimal sequencing of TNT involves consolidation (rather than induction) chemotherapy to optimize complete response rates. Data, largely from retrospective studies, have also shown that patients with clinical complete response (cCR) after neoadjuvant therapy may be managed safely with the watch and wait approach (WW) instead of preemptive total mesorectal resection (TME). However, the optimal consolidation chemotherapy regimen to achieve cCR has not been established, and a randomized clinical trial has not robustly evaluated cCR as a primary endpoint. Collaborating with a multidisciplinary oncology team and patient groups, we designed this NCI-sponsored study of chemotherapy intensification to address these issues and to drive up cCR rates, to provide opportunity for organ preservation, improve quality of life for patients and improve survival outcomes.","PeriodicalId":501051,"journal":{"name":"medRxiv - Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140830374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing 90-day mortality and anastomotic leakage predictions after oesophagectomy for cancer using explainable AI (XAI) 利用可解释人工智能（XAI）推进癌症食管切除术后 90 天死亡率和吻合口漏的预测工作

medRxiv - Surgery Pub Date : 2024-04-10 DOI: 10.1101/2024.04.09.24305451

Sebastian Djerf, Oscar Åkesson, Magnus Nilsson, Mats Lindblad, Jakob Hedberg, Jan Johansson, Attila Frigyesi

{"title":"Advancing 90-day mortality and anastomotic leakage predictions after oesophagectomy for cancer using explainable AI (XAI)","authors":"Sebastian Djerf, Oscar Åkesson, Magnus Nilsson, Mats Lindblad, Jakob Hedberg, Jan Johansson, Attila Frigyesi","doi":"10.1101/2024.04.09.24305451","DOIUrl":"https://doi.org/10.1101/2024.04.09.24305451","url":null,"abstract":"Oesophagectomy for cancer of the oesophagus carries significant morbidity and mortality. Ninety-day mortality and anastomosis leakage are critical early postoperative problems traditionally analysed through logistic regression. In this study, we challenge traditional logistic regression models to predict results with new explainable AI (XAI) models. We used the Swedish National Quality Register for Oesophageal and Gastric Cancer (NREV) to perform traditional multivariable logistic regression and XAI. The 90-day mortality was 6.0%, while anastomosis leakage was present in 12.4%. The XAI models yielded an area under the curve (AUC) of 0.91 for 90-day mortality (as compared with 0.84 for logistic regression). For anastomosis leakage, the AUC was 0.84 using XAI (0.74 using logistic regression). We show that age (mortality increases sharply after 55 years) and body mass index (BMI) (lowest mortality for BMI 30 kg/m<sup>2</sup>) are important survival factors. Additionally, we show that surgery time (minimum anastomosis leakage for a surgery time of 200 min to sharply increase to a maximum at 375 min) and BMI (the lower the BMI, the less anastomosis leakage) are important factors for anastomosis leakage. The surgical understanding of anastomosis leakage and mortality after oesophagectomy is advanced by judiciously applying XAI to structured data. Our nationwide oesophagectomy data contains significant nonlinear relationships. With the help of XAI, we extract personalised knowledge, bringing oesophagus surgery one step closer to personalised medicine.","PeriodicalId":501051,"journal":{"name":"medRxiv - Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal Variations and the Associated Factors of Acute Appendicitis at a Tertiary Hospital: A Case of SPHMMC, Addis Ababa, Ethiopia 一家三级医院急性阑尾炎的季节变化及相关因素：埃塞俄比亚亚的斯亚贝巴 SPHMMC 病例

medRxiv - Surgery Pub Date : 2024-04-09 DOI: 10.1101/2024.04.06.24305309

Lohide Daniel, Fekadu Negash

引用次数: 0

Teaching Uncommon Diseases in Surgery: Conceptual Framework for the Development of a Peritoneal Surface Malignancy Curriculum 外科常见病教学：腹膜表面恶性肿瘤课程开发的概念框架

medRxiv - Surgery Pub Date : 2024-04-08 DOI: 10.1101/2024.04.06.24305431

Frederick A Godley, Varun V Bansal, David G. Su, Vadim Gushchin, Mecker G Moller, Rupen Shah, Alexandra Gangi, Deepa Magge, Dan G Blazer, Oliver S Eng, Laura Lambert, Sean Dineen, Sherif Abdel-Misih, John Encandela, Kiran K Turaga

引用次数: 0