Korean Journal of Parasitology最新文献_第7页

Endemicity of Zoonotic Trematode Metacercariae in Fish from Deokcheon-gang (River) in Sancheong-gun, Gyeongsangnam-do, Republic of Korea. 韩国庆尚南道三清郡德川江鱼中人畜共患吸虫囊蚴的地方性研究

4区医学

Korean Journal of Parasitology Pub Date : 2021-10-01 Epub Date: 2021-10-22 DOI: 10.3347/kjp.2021.59.5.523

Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Jung-Won Ju, Myoung-Ro Lee, Jeong-Gil Park, Jihee Ahn

{"title":"Endemicity of Zoonotic Trematode Metacercariae in Fish from Deokcheon-gang (River) in Sancheong-gun, Gyeongsangnam-do, Republic of Korea.","authors":"Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Jung-Won Ju, Myoung-Ro Lee, Jeong-Gil Park, Jihee Ahn","doi":"10.3347/kjp.2021.59.5.523","DOIUrl":"https://doi.org/10.3347/kjp.2021.59.5.523","url":null,"abstract":"The endemicity of zoonotic trematode metacercariae (ZTM) was investigated with total 871 freshwater fishes (19 species) from Deokcheon-gang (a branch stream of Gyeongho-gang) in Sancheong-gun, Gyeongsangnam-do, Korea for 3 years (2018–2020). All fishes were examined with the artificial digestion method. The metacercariae of Clonorchis sinensis (CsMc) were detected in 233 (36.3%) out of 642 fish in 11 positive fish species (PFS), and their infection intensity was 27 per fish infected (PFI). Especially, in index fish, Puntungia herzi, of CsMc infection, prevalence was 64.2% and infection intensity was 37 PFI. Metagonimus spp. metacercariae (MsMc) were found in 760 (87.5%) out of 869 fish in 18 PFS and their infection intensity was 228 PFI. In sweet smelt, Plecoglossus altivelis, the prevalence of MsMc was 97.6% and their infection intensity was 3,570 PFI. Centrocestus armatus metacercariae were detected in 209 (29.4%) out of 710 fish in 8 PFS and their infection intensity was 1,361 PFI. Echinostoma spp. metacercariae were found in 293 (42.6%) out of 688 fish in 15 PFS and their infection intensity was 5 PFI. Metacercariae of Clinostomum complanatum and Metorchis orientalis were also detected in 2.7% and 21.2% fish in 4 PFS and their infection intensities were 3.1 and 3.4 PFI respectively. By the present study, it was confirmed that some species of ZTM including CsMc and MsMc are more or less prevalent in fishes from Deokcheon-gang in Sancheong-gun, Gyeongsangnam-do, Korea.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/35/kjp-59-5-523.PMC8561055.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39581900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Microbiome of Haemaphysalis longicornis Tick in Korea. 韩国长角血蜱微生物组。

4区医学

Korean Journal of Parasitology Pub Date : 2021-10-01 Epub Date: 2021-10-22 DOI: 10.3347/kjp.2021.59.5.489

Myungjun Kim, Ju Yeong Kim, Myung-Hee Yi, In-Yong Lee, Dongeun Yong, Bo-Young Jeon, Tai-Soon Yong

引用次数: 4

Geographical Distribution and Epidemiologic Factors of Chigger Mites on Apodemus agrarius during Autumn in Korea. 韩国秋黑线姬鼠恙螨地理分布及流行因素分析。

4区医学

Korean Journal of Parasitology Pub Date : 2021-10-01 Epub Date: 2021-10-22 DOI: 10.3347/kjp.2021.59.5.473

In Yong Lee, Jae-Won Lim, Jang Hoon Seo, Heung Chul Kim, Ku Jae Lee, Tai-Soon Yong, Won-Ja Lee, Jae-Ran Yu, Seobo Sim

{"title":"Geographical Distribution and Epidemiologic Factors of Chigger Mites on Apodemus agrarius during Autumn in Korea.","authors":"In Yong Lee, Jae-Won Lim, Jang Hoon Seo, Heung Chul Kim, Ku Jae Lee, Tai-Soon Yong, Won-Ja Lee, Jae-Ran Yu, Seobo Sim","doi":"10.3347/kjp.2021.59.5.473","DOIUrl":"https://doi.org/10.3347/kjp.2021.59.5.473","url":null,"abstract":"A nationwide survey of chigger mites causing scrub typhus and an investigation of epidemiologic factors for chigger mites was conducted at 16 localities in 8 provinces in Korea during autumn 2009, 2012, and 2013. A total of 233 Apodemus agrarius were captured, and all were infested with chigger mites. The chigger index was highest in Chungcheongbuk-do in 2009 (358.3) and 2012 (290.1) and Chungcheongnam-do in 2013 (294.4). The predominant chigger mite species was Leptotrombidium pallidum in the northern and central parts and L. scutellare in the southern and western parts, Korea. L. pallidum was not found in Jellanam-do and Gyeongsangnam-do and the distribution of L. scutellare had been expanded in the northern parts of Korea. The chigger index of L. pallidum was positively correlated with temperature and negatively correlated with humidity. The incidence of scrub typhus is dependent on L. scutellare index. These findings could be helpful to monitor the distribution of chigger mites and to develop a preventive measures for scrub typhus in Korea.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/f1/kjp-59-5-473.PMC8561048.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39581937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Trichinosis Imitating an Inflammatory Systematic Disease. 旋毛虫病是一种炎性全身性疾病。

4区医学

Korean Journal of Parasitology Pub Date : 2021-10-01 Epub Date: 2021-10-22 DOI: 10.3347/kjp.2021.59.5.497

Maria Kosmidou, Georgios Papamichail, Eleftherios Klouras, Konstantinos Tsamis, Ioannis Sarmas, Iro Rapti, Haralampos Milionis

{"title":"Trichinosis Imitating an Inflammatory Systematic Disease.","authors":"Maria Kosmidou, Georgios Papamichail, Eleftherios Klouras, Konstantinos Tsamis, Ioannis Sarmas, Iro Rapti, Haralampos Milionis","doi":"10.3347/kjp.2021.59.5.497","DOIUrl":"https://doi.org/10.3347/kjp.2021.59.5.497","url":null,"abstract":"Trichinellosis (trichinosis) is a parasitic infection caused by nematodes of the genus Trichinella. Pigs are the most common source of human infection. We describe a case of a 47-year-old woman presented with a wide range of intermittent symptoms including prolonged fever, dry cough, diarrhea, rash, myalgias and arthralgias. The patient was attended by physicians with various medical specialties such as dermatologists, rheumatologists and allergiologists, but they did not establish a certain diagnosis because of the gradual onset of symptoms, raising the suspicion of a systematic disease. After extensive work up, the diagnosis of trichinosis was established with femoral muscle biopsy compatible with inflammatory myopathy of parasitic etiology with trichinosis to be the predominant diagnosis. Despite the significant delay of diagnosis for almost three months, patient was treated successfully with no further complications. Trichinellosis is a food-borne treatable infection. Preventive measures include community education especially in zones where parasite prevalence is increased, improvement of farming and cooking techniques.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/f4/kjp-59-5-497.PMC8561047.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39581940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naegleria fowleri Induces Jurkat T Cell Death via O-deGlcNAcylation. 福氏奈格氏菌通过o -去glcn酰化诱导Jurkat T细胞死亡。

4区医学

Korean Journal of Parasitology Pub Date : 2021-10-01 Epub Date: 2021-10-22 DOI: 10.3347/kjp.2021.59.5.501

Young Ah Lee, Kyeong Ah Kim, Myeong Heon Shin

{"title":"Naegleria fowleri Induces Jurkat T Cell Death via O-deGlcNAcylation.","authors":"Young Ah Lee, Kyeong Ah Kim, Myeong Heon Shin","doi":"10.3347/kjp.2021.59.5.501","DOIUrl":"https://doi.org/10.3347/kjp.2021.59.5.501","url":null,"abstract":"The pathogenic free-living amoeba Naegleria fowleri causes primary amoebic meningoencephalitis, a fatal infection, by penetrating the nasal mucosa and migrating to the brain via the olfactory nerves. N. fowleri can induce host cell death via lytic necrosis. Similar to phosphorylation, O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation) is involved in various cell-signaling processes, including apoptosis and proliferation, with O-GlcNAc addition and removal regulated by O-GlcNAc transferase and O-GlcNAcase (OGA), respectively. However, the detailed mechanism of host cell death induced by N. fowleri is unknown. In this study, we investigated whether N. fowleri can induce the modulation of O-GlcNAcylated proteins during cell death in Jurkat T cells. Co-incubation with live N. fowleri trophozoites increased DNA fragmentation. In addition, incubation with N. fowleri induced a dramatic reduction in O-GlcNAcylated protein levels in 30 min. Moreover, pretreatment of Jurkat T cells with the OGA inhibitor PUGNAc prevented N. fowleri-induced O-deGlcNAcylation and DNA fragmentation. These results suggest that O-deGlcNAcylation is an important signaling process that occurs during Jurkat T cell death induced by N. fowleri.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/e7/kjp-59-5-501.PMC8561043.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39581941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroprevalence of Plasmodium vivax Circumsporozoite Protein Antibody in High-Risk Malaria Areas in Korea. 韩国疟疾高发地区间日疟原虫环孢子子蛋白抗体血清阳性率分析。

4区医学

Korean Journal of Parasitology Pub Date : 2021-08-01 Epub Date: 2021-08-18 DOI: 10.3347/kjp.2021.59.4.415

Jinyoung Lee, Kyoung Jin, Seong Kyu Ahn, Sung-Keun Lee, Hyung Wook Kwon, Byoung-Kuk Na, Tong-Soo Kim

{"title":"Seroprevalence of Plasmodium vivax Circumsporozoite Protein Antibody in High-Risk Malaria Areas in Korea.","authors":"Jinyoung Lee, Kyoung Jin, Seong Kyu Ahn, Sung-Keun Lee, Hyung Wook Kwon, Byoung-Kuk Na, Tong-Soo Kim","doi":"10.3347/kjp.2021.59.4.415","DOIUrl":"https://doi.org/10.3347/kjp.2021.59.4.415","url":null,"abstract":"The circumsporozoite protein (CSP) of Plasmodium spp. is a diagnostic antigen and useful biomarker for monitoring short-term/seasonal changes to malaria transmission. Using P. vivax CSP antibody ELISA, epidemiological characteristics were analyzed in the residents of Ganghwa, Cheorwon, Paju, and Goseong from 2017 to 2018. In Ganghwa and Cheorwon, 1.6% and 1.2% of residents, respectively, were PvCSP-antibody-positive in 2018, which indicates a decrease of 0.4% in the positive rate compared to 2017. The annual parasite incidence (API) in Ganghwa and Cheorwon was 24.9 and 10.5 in 2017 and 20.3 and 10.7 in 2018, respectively. Although the changes were not significant, the API in Ganghwa decreased slightly by 4.5 in 2018 compared to the previous year. In Paju and Goseong, 3.9% and 2.0% of residents were positive for the PvCSP antibody. The API in Paju was 13.1 in 2017 and 16.0 in 2018, although no malaria patients were reported for the 2 years. Therefore, the results suggest that PvCSP is a useful antigen for confirming initial malaria infection. Additionally, considering that the antibody is relatively transient, it can be employed for sero-epidemiological studies to determine the extent of malaria transmission in the current year.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/dd/kjp-59-4-415.PMC8413862.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39374465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Helminth Eggs Detected in Soil Samples of a Possible Toilet Structure Found at the Capital Area of Ancient Baekje Kingdom of Korea. 在古百济首都地区发现的疑似厕所结构的土壤样本中发现了蠕虫卵。

4区医学

Korean Journal of Parasitology Pub Date : 2021-08-01 Epub Date: 2021-08-18 DOI: 10.3347/kjp.2021.59.4.393

Chang Seok Oh, Sang-Yuck Shim, Yongjun Kim, Jong Ha Hong, Jong-Yil Chai, Hisashi Fujita, Min Seo, Dong Hoon Shin

{"title":"Helminth Eggs Detected in Soil Samples of a Possible Toilet Structure Found at the Capital Area of Ancient Baekje Kingdom of Korea.","authors":"Chang Seok Oh, Sang-Yuck Shim, Yongjun Kim, Jong Ha Hong, Jong-Yil Chai, Hisashi Fujita, Min Seo, Dong Hoon Shin","doi":"10.3347/kjp.2021.59.4.393","DOIUrl":"https://doi.org/10.3347/kjp.2021.59.4.393","url":null,"abstract":"Although research conducted in East Asia has uncovered parasite eggs from ancient toilets or cesspits, data accumulated to date needs to be supplemented by more archaeoparasitological studies. We examined a total of 21 soil samples from a toilet-like structure at the Hwajisan site, a Baekje-period royal villa, in present-day Korea. At least 4 species of helminth eggs, i.e., Trichuris trichiura, Ascaris lumbricoides, Clonorchis sinensis, and Trichuris sp. (or Trichuris vulpis) were detected in 3 sediment samples of the structure that was likely a toilet used by Baekje nobles. The eggs of T. trichiura were found in all 3 samples (no. 1, 4, and 5); and A. lumbricoides eggs were detected in 2 samples (no. 4 and 5). C. sinensis and T. vulpis-like eggs were found in no. 5 sample. From the findings of this study, we can suppose that the soil-transmitted helminths were prevalent in ancient Korean people, including the nobles of Baekje Kingdom during the 5th to 7th century.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/51/62/kjp-59-4-393.PMC8413860.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39376091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Infestation and Related Ecology of Chigger Mites on the Asian House Rat (Rattus tanezumi) in Yunnan Province, Southwest China. 中国西南部云南省亚洲家鼠（Rattus tanezumi）上的恙螨侵扰及相关生态学研究。

IF 1.4 4区医学

Korean Journal of Parasitology Pub Date : 2021-08-01 Epub Date: 2021-08-18 DOI: 10.3347/kjp.2021.59.4.377

Fan Ding, Wen-Li Jiang, Xian-Guo Guo, Rong Fan, Cheng-Fu Zhao, Zhi-Wei Zhang, Ke-Yu Mao, Rong Xiang

{"title":"Infestation and Related Ecology of Chigger Mites on the Asian House Rat (Rattus tanezumi) in Yunnan Province, Southwest China.","authors":"Fan Ding, Wen-Li Jiang, Xian-Guo Guo, Rong Fan, Cheng-Fu Zhao, Zhi-Wei Zhang, Ke-Yu Mao, Rong Xiang","doi":"10.3347/kjp.2021.59.4.377","DOIUrl":"10.3347/kjp.2021.59.4.377","url":null,"abstract":"This paper is to illustrate the infestation and related ecological characteristics of chigger mites on the Asian house rat (Rattus tanezumi). A total of 17,221 chigger mites were collected from 2,761 R. tanezumi rats, and then identified as 131 species and 19 genera in 2 families. Leptotrombidium deliense, the most powerful vector of scrub typhus in China, was the first major dominant species on R. tanezumi. All the dominant mite species were of an aggregated distribution among different individuals of R. tanezumi. The species composition and infestations of chiggers on R. tanezumi varied along different geographical regions, habitats and altitudes. The species-abundance distribution of the chigger mite community was successfully fitted and the theoretical curve equation was Ŝ (R)=37e-(0.28R)2. The total chigger species on R. tanezumi were estimated to be 199 species or 234 species, and this further suggested that R. tanezumi has a great potential to harbor abundant species of chigger mites. The results of the species-plot relationship indicated that the chigger mite community on R. tanezumi in Yunnan was an uneven community with very high heterogeneity. Wide geographical regions with large host samples are recommended in the investigations of chigger mites.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/e4/kjp-59-4-377.PMC8413864.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39376090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acanthoparyphium shinanense n. sp. (Digenea: Echinostomatidae) from Experimental Chicks Infected with Metacercariae Encysted in Brackish Water Clams in the Republic of Korea. 实验雏鸡感染韩国咸淡水蛤蜊包膜囊蚴感染的棘球绦虫(迪亚那亚纲:棘孔虫科)

4区医学

Korean Journal of Parasitology Pub Date : 2021-08-01 Epub Date: 2021-08-18 DOI: 10.3347/kjp.2021.59.4.341

Seungwan Ryoo, Bong-Kwang Jung, Taehee Chang, Sooji Hong, Hyejoo Shin, Jong-Yil Chai

{"title":"Acanthoparyphium shinanense n. sp. (Digenea: Echinostomatidae) from Experimental Chicks Infected with Metacercariae Encysted in Brackish Water Clams in the Republic of Korea.","authors":"Seungwan Ryoo, Bong-Kwang Jung, Taehee Chang, Sooji Hong, Hyejoo Shin, Jong-Yil Chai","doi":"10.3347/kjp.2021.59.4.341","DOIUrl":"https://doi.org/10.3347/kjp.2021.59.4.341","url":null,"abstract":"Acanthoparyphium shinanense n. sp. (Digenea: Echinostomatidae) is described from chicks experimentally infected with the metacercariae encysted in 2 brackish water clam species, Ruditapes philippinarum and Coecella chinensis, in the Republic of Korea. The metacercariae were round to oval, armed with 23 collar spines, and 0.216 (0.203-0.226) mm in diameter. From 5 chicks experimentally infected each with 200 metacercariae, 34 juvenile (5-day-old worms) and 104 adult flukes (7-day-old worms) were harvested from their small intestines, with the average worm recovery rate of 13.8%. The adult flukes were 3.18 (2.89-3.55) mm long and 0.68 (0.61-0.85) mm wide, with an elongated, posteriorly tapering body, and a prominent head collar armed with 23 collar spines arranged in a single uninterrupted row. The posterior testis of A. shinanense was longitudinally elongated, which is similar to Acanthoparyphium spinulosum Johnston, 1917 but unique from the other closely related species, including Acanthoparyphium tyosenense Yamaguti, 1939, Acanthoparyphium kurogamo Yamaguti, 1939, and Acanthoparyphium marilae Yamaguti, 1934. The eggs of A. shinanense were larger than those of A. spinulosum, and the anterior extent of 2 lateral groups of vitellaria was slightly more limited in A. shinanense than in A. spinulosum. Molecular analysis of nuclear and mitochondrial genes revealed low homology with A. spinulosum from USA (96.1% in 5.8S rRNA) and Ukraine (97.9% in 28S rRNA), Acanthoparyphium n. sp. from USA (98.0% in 28S rRNA), and Acanthoparyphium sp. from Australia, Kuwait, and New Zealand. Biological characteristics, including its first intermediate host and natural definitive hosts, as well as its zoonotic capability, should be elucidated.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/04/93/kjp-59-4-341.PMC8413851.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39376086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helicobacter pylori GroEL Seropositivity Is Associated with an Increased Risk of Opisthorchis viverrini-Associated Hepatobiliary Abnormalities and Cholangiocarcinoma. 幽门螺杆菌GroEL血清学阳性与猪腹毒相关的肝胆异常和胆管癌风险增加相关

4区医学

Korean Journal of Parasitology Pub Date : 2021-08-01 Epub Date: 2021-08-18 DOI: 10.3347/kjp.2021.59.4.363

Isabelle Jala, Muhammad Luthfi Almanfaluthi, Thewarach Laha, Sakawrat Kanthawong, Sirikachorn Tangkawattana, Prasert Saichua, Sutas Suttiprapa, Banchob Sripa

{"title":"Helicobacter pylori GroEL Seropositivity Is Associated with an Increased Risk of Opisthorchis viverrini-Associated Hepatobiliary Abnormalities and Cholangiocarcinoma.","authors":"Isabelle Jala, Muhammad Luthfi Almanfaluthi, Thewarach Laha, Sakawrat Kanthawong, Sirikachorn Tangkawattana, Prasert Saichua, Sutas Suttiprapa, Banchob Sripa","doi":"10.3347/kjp.2021.59.4.363","DOIUrl":"https://doi.org/10.3347/kjp.2021.59.4.363","url":null,"abstract":"Despite the synergistic effect of Opisthorchis viverrini and Helicobacter pylori co-infection on pathogenesis of severe hepatobiliary abnormalities (HBA) including advanced periductal fibrosis and replace with cholangiocarcinoma (CCA) have been established, the immune response to H. pylori in O. viverrini infected population has never been explored. Hence, this study aimed to investigate the antibody responses to 2 immunogenic H. pylori proteins in O. viverrini-infected patients with HBA and CCA. The risk analysis by multinomial logistic regression revealed that GroEL seropositivity was associated with higher risks of hepatobiliary abnormalities and CCA with adjusted odds ratios (95% confidence intervals) of 2.11 (95% CI=1.20-3.71, P=0.008) and 2.13 (95% CI=1.21-3.75, P=0.009), respectively. These findings indicate that GroEL seropositivity might be a biomarker for early detection of O. viverrini associated HBA and CCA.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/44/kjp-59-4-363.PMC8413853.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39376088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6