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Review of Current Policy Strategies to Reduce US Cancer Drug Costs. 降低美国癌症药物成本的现行政策策略综述。
IF 45.3
Mathematical and Computer Modelling Pub Date : 2020-02-01 Epub Date: 2019-12-05 DOI: 10.1200/JCO.19.01628
Angela K Green, Jennifer A Ohn, Peter B Bach
{"title":"Review of Current Policy Strategies to Reduce US Cancer Drug Costs.","authors":"Angela K Green, Jennifer A Ohn, Peter B Bach","doi":"10.1200/JCO.19.01628","DOIUrl":"10.1200/JCO.19.01628","url":null,"abstract":"Recent breakthroughs in cancer drugs have led to practice-changing paradigms in cancer care and new treatment options, yet patients, insurers, and policymakers struggle with determining how to afford them. Although cancer is currently among the fastest growing therapeutic areas for drug sales and the primary focus for industry research and development, rising cancer drug costs are unsustainable for the US health care system. Furthermore, financial toxicity compromises access to recommended therapies, reduces quality of life, and potentially shortens survival among patients with cancer. Averaging 12% to 15% growth each year, US health care spending on cancer drugs is projected to grow to $100 billion by 2022. In 2017, the chimeric antigen receptor (CAR) T-cell therapies, tisagenlecleucel (Kymriah; Novartis, Basel, Switzerland), and axicabtagene ciloleucel (Yescarta; Kite Pharma, Santa Monica, CA) broke the price record with one-time price tags of $475,000 and $373,000, respectively, far exceeding the estimated $150,000 average cost of cancer care and treatment.","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"12 1","pages":"372-379"},"PeriodicalIF":45.3,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1200/JCO.19.01628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75959592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Analytical mathematical feedback guidance scheme for low-thrust orbital plane change maneuvers 低推力轨道变平面机动的解析数学反馈制导方案
Mathematical and Computer Modelling Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.06.014
I. Shafieenejad , A.B. Novinzade , R. Shisheie
{"title":"Analytical mathematical feedback guidance scheme for low-thrust orbital plane change maneuvers","authors":"I. Shafieenejad ,&nbsp;A.B. Novinzade ,&nbsp;R. Shisheie","doi":"10.1016/j.mcm.2013.06.014","DOIUrl":"10.1016/j.mcm.2013.06.014","url":null,"abstract":"<div><p>This paper which is based on neighboring optimal control investigates the application of an analytical feedback guidance scheme for the problems of low-thrust orbital transfer. Neighboring optimal control is one of the methods that has been proposed for the closed-loop optimal guidance. This method focuses on expanding the cost function to second order and examining the robustness of the system by the feedback law gains. At first, the open-loop analytical guidance policy is considered as the optimal thrust steering program that will transfer the vehicle from the inclined low earth orbits to the high earth orbits. Secondly, proper feedback optimal guidance laws are analytically obtained to maintain the trajectories around their optimum with assessed disturbances. The proposed guidance scheme is distinguished for two desired performance indices as minimum-time and minimum-effort. Finally performance indices are compared and the best policy is obtained regarding the robustness of the two performance indices against disturbances.</p></div>","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"58 11","pages":"Pages 1714-1726"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mcm.2013.06.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77724137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A multiresolution and smooth fictitious domain method for one-dimensional elliptical and Stefan problems 一维椭圆和Stefan问题的多分辨率光滑虚域方法
Mathematical and Computer Modelling Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.06.013
Ping Yin , Jacques Liandrat , Wanqiang Shen , Zhe Chen
{"title":"A multiresolution and smooth fictitious domain method for one-dimensional elliptical and Stefan problems","authors":"Ping Yin ,&nbsp;Jacques Liandrat ,&nbsp;Wanqiang Shen ,&nbsp;Zhe Chen","doi":"10.1016/j.mcm.2013.06.013","DOIUrl":"10.1016/j.mcm.2013.06.013","url":null,"abstract":"<div><p>We present a wavelet based multiresolution method coupled with smooth fictitious domain and wavelet–vaguelette method to solve the one-dimensional elliptic problem equipped with Dirichlet boundary condition. Its advantages over the classical fictitious domain method are analyzed by interior error estimate and numerical examples. The efficiency of our method is pointed out by considering a Stefan problem with exact solution in one dimension.</p></div>","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"58 11","pages":"Pages 1727-1737"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mcm.2013.06.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88261182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
WITHDRAWN: A study on the influences of R&D investment on IT for the machine and material industry and the electronics industry 撤回:机械材料工业和电子工业研发投入对IT的影响研究
Mathematical and Computer Modelling Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2012.06.008
Seung-Ryung Oh, Kun Woo Kim
{"title":"WITHDRAWN: A study on the influences of R&D investment on IT for the machine and material industry and the electronics industry","authors":"Seung-Ryung Oh,&nbsp;Kun Woo Kim","doi":"10.1016/j.mcm.2012.06.008","DOIUrl":"10.1016/j.mcm.2012.06.008","url":null,"abstract":"<div><p>This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at <span>http://www.elsevier.com/locate/withdrawalpolicy</span><svg><path></path></svg>.</p></div>","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"58 11","pages":"Page 1846"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mcm.2012.06.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84497777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valedictory Editorial 告别编辑
Mathematical and Computer Modelling Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.09.001
Philip Broadbridge
{"title":"Valedictory Editorial","authors":"Philip Broadbridge","doi":"10.1016/j.mcm.2013.09.001","DOIUrl":"10.1016/j.mcm.2013.09.001","url":null,"abstract":"","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"58 11","pages":"Pages 1677-1678"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mcm.2013.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75958469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WITHDRAWN: A robust control strategy for a direct drive valve based on a voice coil motor 基于音圈电机的直接驱动阀的鲁棒控制策略
Mathematical and Computer Modelling Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2011.10.032
Baifen Liu , Ying Gao
{"title":"WITHDRAWN: A robust control strategy for a direct drive valve based on a voice coil motor","authors":"Baifen Liu ,&nbsp;Ying Gao","doi":"10.1016/j.mcm.2011.10.032","DOIUrl":"10.1016/j.mcm.2011.10.032","url":null,"abstract":"<div><p>This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at <span>http://www.elsevier.com/locate/withdrawalpolicy</span><svg><path></path></svg>.</p></div>","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"58 11","pages":"Page 1844"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mcm.2011.10.032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82670764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
WITHDRAWN: Risk analysis and damage assessment of financial institutions in cyber attacks between nations 撤回:金融机构在国家间网络攻击中的风险分析和损害评估
Mathematical and Computer Modelling Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2012.06.007
Won Hyung Park
{"title":"WITHDRAWN: Risk analysis and damage assessment of financial institutions in cyber attacks between nations","authors":"Won Hyung Park","doi":"10.1016/j.mcm.2012.06.007","DOIUrl":"10.1016/j.mcm.2012.06.007","url":null,"abstract":"<div><p>This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at <span>http://www.elsevier.com/locate/withdrawalpolicy</span><svg><path></path></svg>.</p></div>","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"58 11","pages":"Page 1845"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mcm.2012.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72724200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A fuzzy logic based decision support system for evaluation of suppliers in supply chain management practices 供应链管理实践中基于模糊逻辑的供应商评价决策支持系统
Mathematical and Computer Modelling Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.07.003
Darshan Kumar , Jagdev Singh , Om Pal Singh , Seema
{"title":"A fuzzy logic based decision support system for evaluation of suppliers in supply chain management practices","authors":"Darshan Kumar ,&nbsp;Jagdev Singh ,&nbsp;Om Pal Singh ,&nbsp;Seema","doi":"10.1016/j.mcm.2013.07.003","DOIUrl":"https://doi.org/10.1016/j.mcm.2013.07.003","url":null,"abstract":"<div><p>Supply chain management is an increasingly important organizational concern, and proper evaluation of suppliers constitutes one essential element of supply chain success. Continuous evaluation of a particular supplier becomes more important considering the fact that in most industries the cost of raw materials and component parts constitutes the main cost of a product, such that in some cases it can account for up to 70%. However, there is little research that has helped the organizations in continuous evaluation of their suppliers. We propose a new model, based on fuzzy logic to handle the various attributes, associated with supplier evaluation problems. Four multi-input single output (MISO) mamdani fuzzy inference systems have been proposed for supplier evaluation. The proposed model has also been illustrated through a case study.</p></div>","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"58 11","pages":"Pages 1679-1695"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mcm.2013.07.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136819493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Airline network design and adjustment in response to fluctuation in jet fuel prices 航空公司网络设计及调整以因应航油价格波动
Mathematical and Computer Modelling Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.04.005
Chaug-Ing Hsu, Wei-Yin Eie
{"title":"Airline network design and adjustment in response to fluctuation in jet fuel prices","authors":"Chaug-Ing Hsu,&nbsp;Wei-Yin Eie","doi":"10.1016/j.mcm.2013.04.005","DOIUrl":"10.1016/j.mcm.2013.04.005","url":null,"abstract":"<div><p>This study develops a series of models to determine aircraft types and flight frequencies on individual routes, and evaluate the reliability of proposed network planning during fluctuations in jet fuel prices. The reliability of individual routes is evaluated as to whether revenues from flights with initially proposed flight frequencies and aircraft types can accommodate variations in jet fuel expenditures. We define reliability as the probability that the proposed flight frequencies will operate in at least a break-even condition under future fuel price fluctuations. A case study is provided using an international airline in Taiwan to evaluate its network reliability in response to jet fuel price fluctuations in 2008. The results indicate that not only do routes with low load factors show low reliability, but long distance routes with high load factors also show low reliability during periods with high fuel prices. The results of the study provide effective ways to enhance commercial airline network designs in response to the uncertainty of jet fuel prices.</p></div>","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"58 11","pages":"Pages 1791-1803"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mcm.2013.04.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74575178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Numerical solution of a nonlinear singular Volterra integral system by the Newton product integration method 用牛顿积积分法求解非线性奇异Volterra积分系统
Mathematical and Computer Modelling Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.06.016
B. Babayar-Razlighi , B. Soltanalizadeh
{"title":"Numerical solution of a nonlinear singular Volterra integral system by the Newton product integration method","authors":"B. Babayar-Razlighi ,&nbsp;B. Soltanalizadeh","doi":"10.1016/j.mcm.2013.06.016","DOIUrl":"10.1016/j.mcm.2013.06.016","url":null,"abstract":"<div><p>In this paper, we consider a nonlinear system of Volterra integral equations, and apply Newton’s method to linearize it. We solve each step of Newton’s system by the product integration technique. Also, we provide the sufficient conditions for convergence of the numerical method. Finally, we give a test problem to illustrate the applicability and accuracy of the presented method.</p></div>","PeriodicalId":49872,"journal":{"name":"Mathematical and Computer Modelling","volume":"58 11","pages":"Pages 1696-1703"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mcm.2013.06.016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80074877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
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