Mutation Research-Reviews in Mutation Research最新文献_第4页

International Workshops on Genotoxicity Testing (IWGT): Origins, achievements and ambitions 基因毒性试验国际研讨会：起源、成就和雄心。

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2023-07-01 DOI: 10.1016/j.mrrev.2023.108469

Hans-Joerg Martus , Andreas Zeller , David Kirkland

{"title":"International Workshops on Genotoxicity Testing (IWGT): Origins, achievements and ambitions","authors":"Hans-Joerg Martus , Andreas Zeller , David Kirkland","doi":"10.1016/j.mrrev.2023.108469","DOIUrl":"10.1016/j.mrrev.2023.108469","url":null,"abstract":"<div><p><span>Over the past thirty years, the International Workshops on Genotoxicity Testing (IWGT) became one of the leading groups in the field of regulatory genotoxicology, not only due to the diversity of participants with respect to </span>geography and professional affiliation, but also due to the unique setup of recurring IWGT meetings every four years. The hallmarks of the IWGT process have been diligent initial planning approaches of the working groups, collection of data so as to stimulate data-driven discussions and debate, and striving to reach consensus recommendations. The scientific quality of the Working Groups (WGs) has been exceptional due to the selection of highly regarded experts on each topic. As a result, the IWGT working group reports have become important documents. The deliberations and publications have provided guidance on test systems and testing protocols that have influenced the development or revision of test guidelines of the Organisation for Economic Co-operation and Development (OECD), guidance by the International Council for Harmonisation (ICH), and strategic testing or data analysis approaches in general. This article summarizes the history of the IWGT, identifies some of its major achievements, and provides an outlook for the future.</p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"792 ","pages":"Article 108469"},"PeriodicalIF":5.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to nanoplastic particles and DNA damage in mammalian cells 哺乳动物细胞暴露于纳米塑料颗粒和DNA损伤

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2023-07-01 DOI: 10.1016/j.mrrev.2023.108468

Peter Møller, Martin Roursgaard

{"title":"Exposure to nanoplastic particles and DNA damage in mammalian cells","authors":"Peter Møller, Martin Roursgaard","doi":"10.1016/j.mrrev.2023.108468","DOIUrl":"10.1016/j.mrrev.2023.108468","url":null,"abstract":"<div><p>There is concern about human exposure to nanoplastics from intentional use or degradation of plastics in the environment. This review assesses genotoxic effects of nanoplastics, defined as particles with a primary size of less than 1000 nm. The majority of results on genotoxicity come from studies on polystyrene (PS) particles in mammalian cell cultures. Most studies have measured DNA strand breaks (standard comet assay), oxidatively damaged DNA (Fpg-modified comet assay) and micronuclei. Twenty-nine out of 60 results have shown statistically significant genotoxic effects by PS exposure in cell cultures. A statistical analysis indicates that especially modified PS particles are genotoxic (odds ratio = 8.6, 95 % CI: 1.6, 46) and immune cells seems to be more sensitive to genotoxicity than other cell types such as epithelial cells (odds ratio = 8.0, 95 % CI: 1.6, 39). On the contrary, there is not a clear association between statistically significant effects in genotoxicity tests and the primary size of PS particles, (i.e. smaller versus larger than 100 nm) or between the type of genotoxic endpoint (i.e. repairable versus permanent DNA lesions). Three studies of PS particle exposure in animals have shown increased level of DNA strand breaks in leukocytes and prefrontal cortex cells. Nanoplastics from polyethylene, propylene, polyvinyl chloride and polyethylene terephthalate have been investigated in very few studies and it is currently not possible to draw conclusion about their genotoxic hazard. In summary, there is some evidence suggesting that PS particles may be genotoxic in mammalian cells.</p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"792 ","pages":"Article 108468"},"PeriodicalIF":5.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10541222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of the single cell gel electrophoresis assay for the detection of DNA-protective dietary factors: Results of human intervention studies 使用单细胞凝胶电泳法检测dna保护饮食因素:人为干预研究的结果

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2023-01-01 DOI: 10.1016/j.mrrev.2023.108458

Miroslav Mišík , Marlen Staudinger , Michael Kundi , Nadine Worel , Armen Nersesyan , Franziska Ferk , Maria Dusinska , Amaya Azqueta , Peter Møller , Siegfried Knasmueller

{"title":"Use of the single cell gel electrophoresis assay for the detection of DNA-protective dietary factors: Results of human intervention studies","authors":"Miroslav Mišík , Marlen Staudinger , Michael Kundi , Nadine Worel , Armen Nersesyan , Franziska Ferk , Maria Dusinska , Amaya Azqueta , Peter Møller , Siegfried Knasmueller","doi":"10.1016/j.mrrev.2023.108458","DOIUrl":"10.1016/j.mrrev.2023.108458","url":null,"abstract":"<div><p><span><span>The single cell gel electrophoresis<span> technique is based on the measurement of DNA migration in an electric field and enables to investigate via determination of DNA-damage the impact of foods and their constituents on the genetic stability. DNA-damage leads to adverse effects including cancer, neurodegenerative disorders and infertility. In the last 25 years approximately 90 human intervention trials have been published in which DNA-damage, formation of oxidized bases, alterations of the sensitivity towards </span></span>reactive oxygen species<span> and chemicals and of repair functions were investigated with this technique. In approximately 50% of the studies protective effects were observed. Pronounced protection was found with certain plant foods (spinach, kiwi fruits<span>, onions), coffee, green tea, honey and olive oil. Also diets with increased contents of vegetables caused positive effects. Small amounts of certain phenolics (gallic acid, xanthohumol) prevented oxidative damage of DNA; with antioxidant vitamins and cholecalciferol protective effects were only detected after intake of doses that exceed the recommended daily uptake values. The evaluation of the quality of the studies showed that many have methodological shortcomings (lack of controls, no calibration of </span></span></span>repair enzymes, inadequate control of the compliance and statistical analyses) which should be avoided in future investigations.</p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"791 ","pages":"Article 108458"},"PeriodicalIF":5.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9576291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Empirical relationship between chromosomal damage and airborne particulate matter: A systematic review and meta-analysis of studies in exposed populations 染色体损伤与空气中颗粒物之间的经验关系:对暴露人群研究的系统回顾和荟萃分析

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2023-01-01 DOI: 10.1016/j.mrrev.2023.108454

Francisco Carlos da Silva Junior , Leticya Pinto de Araújo , João Paulo de Mendonça Freitas , Nilmara de Oliveira Alves , Stefano Bonassi , Silvia Regina Batistuzzo de Medeiros

{"title":"Empirical relationship between chromosomal damage and airborne particulate matter: A systematic review and meta-analysis of studies in exposed populations","authors":"Francisco Carlos da Silva Junior , Leticya Pinto de Araújo , João Paulo de Mendonça Freitas , Nilmara de Oliveira Alves , Stefano Bonassi , Silvia Regina Batistuzzo de Medeiros","doi":"10.1016/j.mrrev.2023.108454","DOIUrl":"10.1016/j.mrrev.2023.108454","url":null,"abstract":"<div><p>Ambient particulate matter<span> (PM) has gained significant attention as an environmental risk factor for human health. Although the association between ambient PM and micronucleus (MN) induction has been investigated, the quantitative association of PM and genomic instability<span> is inconclusive. We conducted a systematic review and meta-analysis to study the association between PM exposure and MN endpoint. Four databases were systematically searched for studies published up to November 2022, to find papers investigating the relationship between ambient PM and MN induction. Random effect models were conducted to estimate the overall effect based on the Ratio of Means (RoM) with 95% confidence intervals (95% CIs). Subgroup analysis, funnel plot, and Egger and Begg tests, were also performed. Twenty-three studies across nine countries, including 4450 participants, were included. A meta-RoM of 2.13 for MN (95% CI 1.63–2.79) was observed for individuals exposed to ambient PM compared to non-exposed. A significant difference in the subgroup test was found for buccal cells (3.16, 95% CI 2.20–4.52) and low economy level (3.61, 95% CI 1.44–9.01). Our meta-analysis suggests the presence of an association between PM exposure and the frequency of MN and identified the kind of cells and economic status as possible effect modifiers. The use of effective methods, such as the MN assay, enables identification of early genetic damage in humans, which in turn may anticipate the risk of developing respiratory diseases, including lung cancer.</span></span></p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"791 ","pages":"Article 108454"},"PeriodicalIF":5.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9931201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The cell transformation assay to assess potential carcinogenic properties of nanoparticles 细胞转化试验评估纳米颗粒潜在的致癌特性

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2023-01-01 DOI: 10.1016/j.mrrev.2023.108455

Ruzanna Hayrapetyan , Théo Lacour , Annette Luce , Francis Finot , Marie-Christine Chagnon , Isabelle Séverin

{"title":"The cell transformation assay to assess potential carcinogenic properties of nanoparticles","authors":"Ruzanna Hayrapetyan , Théo Lacour , Annette Luce , Francis Finot , Marie-Christine Chagnon , Isabelle Séverin","doi":"10.1016/j.mrrev.2023.108455","DOIUrl":"10.1016/j.mrrev.2023.108455","url":null,"abstract":"<div><p><span><span>Nanoparticles (NPs) are present in many daily life products with particular physical-chemical properties (size, density, porosity, geometry …) giving very interesting technological properties. Their use is continuously growing and NPs represent a new challenge in terms of risk assessment, consumers being multi-exposed. Toxic effects have already been identified such as </span>oxidative stress<span>, genotoxicity, inflammatory effects, and immune reactions, some of which are leading to carcinogenesis. Cancer is a complex phenomenon implying multiple modes of action and key events, and prevention strategies in cancer include a proper assessment of the properties of NPs. Therefore, introduction of new agents like NPs into the market creates fresh regulatory challenges for an adequate safety evaluation and requires new tools. The Cell Transformation Assay (CTA) is an </span></span><em>in vitro</em> test able of highlighting key events of characteristic phases in the cancer process, initiation and promotion. This review presents the development of this test and its use with NPs. The article underlines also the critical issues to address for assessing NPs carcinogenic properties and approaches for improving its relevance.</p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"791 ","pages":"Article 108455"},"PeriodicalIF":5.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9931716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the potential carcinogenicity of micro- and nano-plastics 深入了解微塑料和纳米塑料的潜在致癌性

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2023-01-01 DOI: 10.1016/j.mrrev.2023.108453

Josefa Domenech , Balasubramanyam Annangi , Ricard Marcos , Alba Hernández , Julia Catalán

{"title":"Insights into the potential carcinogenicity of micro- and nano-plastics","authors":"Josefa Domenech , Balasubramanyam Annangi , Ricard Marcos , Alba Hernández , Julia Catalán","doi":"10.1016/j.mrrev.2023.108453","DOIUrl":"10.1016/j.mrrev.2023.108453","url":null,"abstract":"<div><p>There is a growing concern regarding the potential health effects that continuous exposure to environmental micro- and nano-plastics (MNPLs) may cause on humans. Due to their persistent nature, MNPLs may accumulate in different organs and tissues and may induce in the long term the development of cancer. The present study aimed to review the existing literature on the carcinogenic potential of MNPLs. As studies directly assessing carcinogenicity were expected to be scarce, studies dealing with indirect outcomes associated with the carcinogenic process were considered in the literature search. Of the 126 studies screened, 19 satisfied the inclusion criteria. Besides, 7 additional cross-referenced articles, identified through a careful reading of the previously selected papers, also met the inclusion criteria and, consequently, were included in the review. Most of the selected studies were performed using <em>in vitro</em> models whereas about 40% of the studies were done in rodents, although none of them included a 2-year carcinogenicity assay. Most of the reviewed studies pointed out the potential of MNPLs to induce inflammation and genotoxicity, the latter being recognized as a strong predictor of carcinogenicity. These, along with other important findings such as the MNPLs’ ability to accumulate into cells and tissues, or their capacity to induce fibrosis, may suggest an association between MNPLs exposures and the carcinogenic potential. Nevertheless, the limited number of available studies precludes reaching clear conclusions. Therefore, this review also provides several recommendations to cover the current knowledge gaps and address the future evaluation of the MNPLs’ carcinogenic risk.</p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"791 ","pages":"Article 108453"},"PeriodicalIF":5.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9931198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Variations in genomic regions encoding long non-coding RNA genes associated with increased prostate cancer risk 编码长链非编码RNA基因的基因组区域变异与前列腺癌风险增加有关

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2023-01-01 DOI: 10.1016/j.mrrev.2023.108456

Esra Bozgeyik

引用次数: 1

Predicting mutational function using machine learning 使用机器学习预测突变函数

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2023-01-01 DOI: 10.1016/j.mrrev.2023.108457

Anthony Shea , Josh Bartz , Lei Zhang , Xiao Dong

{"title":"Predicting mutational function using machine learning","authors":"Anthony Shea , Josh Bartz , Lei Zhang , Xiao Dong","doi":"10.1016/j.mrrev.2023.108457","DOIUrl":"10.1016/j.mrrev.2023.108457","url":null,"abstract":"<div><p><span>Genetic variations are one of the major causes of phenotypic variations between human individuals. Although beneficial as being the substrate of evolution, </span>germline<span><span><span><span> mutations may cause diseases, including Mendelian diseases and complex diseases such as diabetes and heart diseases. Mutations occurring in somatic cells are a main cause of cancer and likely cause age-related phenotypes and other age-related diseases. Because of the high abundance of genetic variations in the </span>human genome, i.e., millions of germline variations per human subject and thousands of additional </span>somatic mutations per cell, it is technically challenging to experimentally verify the function of every possible mutation and their interactions. Significant progress has been made to solve this problem using computational approaches, especially machine learning (ML). Here, we review the progress and achievements made in recent years in this field of research. We classify the </span>computational models<span> in two ways: one according to their prediction goals including protein structural alterations, gene expression changes, and disease risks, and the other according to their methodologies, including non-machine learning methods, classical machine learning methods, and deep neural network methods. For models in each category, we discuss their architecture, prediction accuracy, and potential limitations. This review provides new insights into the applications and future directions of computational approaches in understanding the role of mutations in aging and disease.</span></span></p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"791 ","pages":"Article 108457"},"PeriodicalIF":5.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9574389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay of cGAS with micronuclei: Regulation and diseases cGAS与微核的相互作用:调控与疾病

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2022-07-01 DOI: 10.1016/j.mrrev.2022.108440

Xihan Guo , Henning Hintzsche , Weijiang Xu , Juan Ni , Jinglun Xue , Xu Wang

{"title":"Interplay of cGAS with micronuclei: Regulation and diseases","authors":"Xihan Guo , Henning Hintzsche , Weijiang Xu , Juan Ni , Jinglun Xue , Xu Wang","doi":"10.1016/j.mrrev.2022.108440","DOIUrl":"10.1016/j.mrrev.2022.108440","url":null,"abstract":"<div><p><span><span><span>In higher eukaryotes, sophisticate regulation of genome function requires all chromosomes to be packed into a single nucleus. Micronucleus (MN), the dissociative nucleus-like structure frequently observed in aging and multiple disease settings, has critical, yet under-recognized, pathophysiological functions. Micronuclei (MNi) have recently emerged as major sources of cytosolic DNA that can activate the cGAS-STING axis in a cell-intrinsic manner. However, MNi induced from different genotoxic stressors display great heterogeneity in binding or activating </span>cGAS<span> and the signaling responses downstream of the MN-induced cGAS-STING axis have divergent outcomes including autoimmunity, autoinflammation, metastasis, or cell death. Thus, full characterization of molecular network underpinning the interplay of cGAS and MN is important to elucidate the pathophysiological roles of immunogenic MN and design improved drugs that selectively target cancer via boosting the MN-derived cGAS-STING axis. Here, we summarize our current understanding of the mechanisms for self-DNA discrimination by cGAS. We focus on discussing how MN immunogencity is dictated by multiple mechanisms including integrity of micronuclear envelope, state of nucleosome and DNA, competitive factors, damaged mitochondrial DNA and micronucleophagy. We also describe emerging links between immunogenic MN and human diseases including cancer, neurodegenerative diseases and COVID-19. Particularly, we explore the exciting concept of inducing immunogenic MN as a therapeutic approach in treating cancer. We propose a new theoretical framework to describe immunogenic MN as a biological sensor to modulate </span></span>cellular processes in response to genotoxic stress and provide perspectives on developing novel experimental approaches to unravel the complexity of MN </span>immunogenicity<span> regulation and immunogenic MN pathophysiology.</span></p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"790 ","pages":"Article 108440"},"PeriodicalIF":5.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10801738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Histone–lysine N-methyltransferase 2 (KMT2) complexes – a new perspective 组蛋白-赖氨酸n -甲基转移酶2 (KMT2)复合物-一个新的视角

IF 5.3 2区医学

Mutation Research-Reviews in Mutation Research Pub Date : 2022-07-01 DOI: 10.1016/j.mrrev.2022.108443

Elzbieta Poreba , Krzysztof Lesniewicz , Julia Durzynska

{"title":"Histone–lysine N-methyltransferase 2 (KMT2) complexes – a new perspective","authors":"Elzbieta Poreba , Krzysztof Lesniewicz , Julia Durzynska","doi":"10.1016/j.mrrev.2022.108443","DOIUrl":"10.1016/j.mrrev.2022.108443","url":null,"abstract":"<div><p>Histone H3 Lys4 (H3K4) methylation is catalyzed by the Histone–Lysine N-Methyltransferase 2 (KMT2) protein family, and its members are required for gene expression control. In vertebrates, the KMT2s function in large multisubunit complexes known as COMPASS or COMPASS-like complexes (COMplex of Proteins ASsociated with Set1). The activity of these complexes is critical for proper development, and mutation-induced defects in their functioning have frequently been found in human cancers. Moreover, inherited or <em>de novo</em> mutations in KMT2 genes are among the etiological factors in neurodevelopmental disorders such as Kabuki and Kleefstra syndromes. The canonical role of KMT2s is to catalyze H3K4 methylation, which results in a permissive chromatin environment that drives gene expression. However, current findings described in this review demonstrate that these enzymes can regulate processes that are not dependent on methylation: noncatalytic functions of KMT2s include DNA damage response, cell division, and metabolic activities. Moreover, these enzymes may also methylate non-histone substrates and play a methylation-dependent function in the DNA damage response. In this review, we present an overview of the new, noncanonical activities of KMT2 complexes in a variety of cellular processes. These discoveries may have crucial implications for understanding the functions of these methyltransferases in developmental processes, disease, and epigenome-targeting therapeutic strategies in the future.</p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"790 ","pages":"Article 108443"},"PeriodicalIF":5.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1383574222000333/pdfft?md5=011323914a0349da2e62257de103063a&pid=1-s2.0-S1383574222000333-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10511422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3