Neurology Psychiatry and Brain Research最新文献

{"title":"Neurological manifestations of COVID-19 and other coronaviruses: A systematic review","authors":"Alyne Oliveira Correia ,&nbsp;Pedro Walisson Gomes Feitosa ,&nbsp;Jorge Lucas de Sousa Moreira ,&nbsp;Samuel Átila Rodrigues Nogueira ,&nbsp;Ricardo Brandão Fonseca ,&nbsp;Maria Elizabeth Pereira Nobre","doi":"10.1016/j.npbr.2020.05.008","DOIUrl":"10.1016/j.npbr.2020.05.008","url":null,"abstract":"<div><h3>Objective</h3><p>To describe the main neurological manifestations related to coronavirus infection in humans.</p></div><div><h3>Methodology</h3><p>A systematic review was conducted regarding clinical studies on cases that had neurological manifestations associated with COVID-19 and other coronaviruses. The search was carried out in the electronic databases PubMed, Scopus, Embase, and LILACS with the following keywords: “coronavirus” or “Sars-CoV-2” or “COVID-19” and “neurologic manifestations” or “neurological symptoms” or “meningitis” or “encephalitis” or “encephalopathy,” following the Systematic Reviews and Meta-Analyses (PRISMA) guidelines.</p></div><div><h3>Results</h3><p>Seven studies were included. Neurological alterations after CoV infection may vary from 17.3% to 36.4% and, in the pediatric age range, encephalitis may be as frequent as respiratory disorders, affecting 11 % and 12 % of patients, respectively. The Investigation included 409 patients diagnosed with CoV infection who presented neurological symptoms, with median age range varying from 3 to 62 years. The main neurological alterations were headache (69; 16.8 %), dizziness (57, 13.9 %), altered consciousness (46; 11.2 %), vomiting (26; 6.3 %), epileptic crises (7; 1.7 %), neuralgia (5; 1.2 %), and ataxia (3; 0.7 %). The main presumed diagnoses were acute viral meningitis/encephalitis in 25 (6.1 %) patients, hypoxic encephalopathy in 23 (5.6 %) patients, acute cerebrovascular disease in 6 (1.4 %) patients, 1 (0.2 %) patient with possible acute disseminated encephalomyelitis, 1 (0.2 %) patient with acute necrotizing hemorrhagic encephalopathy, and 2 (1.4 %) patients with CoV related to Guillain-Barré syndrome.</p></div><div><h3>Conclusion</h3><p>Coronaviruses have important neurotropic potential and they cause neurological alterations that range from mild to severe. The main neurological manifestations found were headache, dizziness and altered consciousness.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"37 ","pages":"Pages 27-32"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.05.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38295032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet mass index as an indicator of platelet activation in manic episode","authors":"Aysu Kara ,&nbsp;Nesrin Karamustafalioglu ,&nbsp;Tevfik Kalelioglu ,&nbsp;Abdullah Genc ,&nbsp;Murat Emul","doi":"10.1016/j.npbr.2020.04.004","DOIUrl":"10.1016/j.npbr.2020.04.004","url":null,"abstract":"<div><h3>Background</h3><p>Discovering the biological basis of bipolar disorder has been the focus of studies in recent years. Alterations in platelet parameters were found to be associated with episodes of bipolar disorder. This study aimed to compare the differences in platelet parameters especially the platelet mass index as an inflammation marker between the patients with bipolar mania and healthy controls.</p></div><div><h3>Methods</h3><p>68 male inpatients with manic episodes and 60 age-gender matched healthy controls were included in the study. Platelet mass index, mean platelet volume and platelet counts were compared between controls and manic patients.</p></div><div><h3>Results</h3><p>Platelet mass index of manic group was significantly higher than the controls (p = 0.002). Statistically significant difference was also observed between groups in terms of mean platelet volume (p = 0.012). For platelet counts; there was no statistically significant difference between manic and control groups (p = 0.171).</p></div><div><h3>Limitation</h3><p>The limitations of this study is that, platelet mass index was not measured in manic patients after manic episodes subsided. Other limitations are relatively small sample size, cross-sectional nature and lacking the data about other inflammation and cardiovascular marker, and lack of the longitudinal outcomes of multiple drugs and effects of lifestyle factors.</p></div><div><h3>Conclusion</h3><p>Platelet mass index reflects platelet functionality and is thought to be a useful parameter for plaque formation capacity of platelets. In our study, we have shown an increment in platelet activation in manic episode compared to healthy controls; which may reflect the inflammation process and cardiovascular status in bipolar disorder.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"37 ","pages":"Pages 1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87221767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Globalization, internet and psychiatric disorders: Call for research and action in global mental health","authors":"Jude Mary Cénat","doi":"10.1016/j.npbr.2020.02.007","DOIUrl":"10.1016/j.npbr.2020.02.007","url":null,"abstract":"<div><h3>Background</h3><p>Studies have largely analyzed the association between globalization and mental health. However, the main focus has been on the challenges of migration trauma and living together into multicultural societies. Yet, Internet-related mental disorders are poorly studied, while Internet, as the main tool of 21st century globalization, is reconceptualizing psychiatric illnesses.</p></div><div><h3>Aims</h3><p>This current debate paper discusses the association between globalization, Internet and mental disorders. It aims to stimulate a current, important, urgent and necessary debate to integrate this important characteristic of globalization in the genesis, etiology, and treatment of mental disorders.</p></div><div><h3>Observations</h3><p>Although studies have been conducted on the relation between mental health and Internet (cyberbullying, online gambling addiction, cyberdependence, etc.), none has integrated globalization in their analysis. Similarly, Internet-related traumas are less explored, while traumatic images from the Internet are increasingly present in the children, adolescents and adults’ lives. Also, globalization is based primarily on the interconnectedness of institutions, populations and individuals and plays an increasingly key role in the individuals’ life. The resulted hyperconnectivity is bringing new mental disorders, reconceptualizing others and, above all, can obsolete mental disorder classification manuals if the various factors associated with it are not integrated.</p></div><div><h3>Conclusions</h3><p>This study shows that it is important to adapt our tools for assessing, classifying and describing mental disorders in the light of this new reality of globalization. With a perspective both as a researcher and a clinician, it shows research and action options needed before the train is too far away and difficult to catch.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"36 ","pages":"Pages 27-29"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.02.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45279268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine changes in different types of depression: Specific or general?","authors":"Haoyin Wang ,&nbsp;Peng Li ,&nbsp;Yongping Zhang ,&nbsp;Cai Zhang ,&nbsp;Kangwei Li ,&nbsp;Cai Song","doi":"10.1016/j.npbr.2020.02.009","DOIUrl":"10.1016/j.npbr.2020.02.009","url":null,"abstract":"<div><h3>Background</h3><p>Various cytokine changes have been reported in patients with different types of depression. However, it is unclear whether depression is a consequence of brain general response to chronic or severe immune inflammation, or specific cytokine changes contribute to a different subtype of depression.</p></div><div><h3>Methods</h3><p>Two terms (cytokine OR inflammation) AND (subtype of depression) from Pubmed were used to select the patients with first-episode or drug-free. A total of 39 articles in 7 subtypes of depression were selected and included in the review.</p></div><div><h3>Results</h3><p>M1 and T helper (Th) 1 pattern dominates in major depression, such as increased interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and interferon (IFN)-γ, but reduced IL-10. Similarly, M1 cytokines IL-1β, IL-6 and TNF-α are increased except for transforming growth factor in bipolar disorder, and IL-1β, IL-6, TNF-α and IFN-γ increased in seasonal affective disorder. However, a certain cytokine change is correlated to a subtype of depression. For example, pro-inflammatory cytokines are altered during different period of prenatal and postpartum depression. Th phenotypes difference between atypical depression and melancholic depression is related to IL-2 and IL-4. As well, higher levels of IL-6 and lower IL-2 in suicide attempters compared to non-suicidal, etc.</p></div><div><h3>Limitations</h3><p><em>S</em>tudies in specific depression were not enough. Inconsistent investigation designs and results were reported in different subtypes of depression.</p></div><div><h3>Conclusions</h3><p>A certain immune/cytokine pattern may be related to a subtype of depression. However, Big Data Analysis and Precision Medicine should be utilized to figure out the real connection between cytokine changes and depression.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"36 ","pages":"Pages 39-51"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.02.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41898520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iloperidone-induced urinary incontinence in a female patient with schizophrenia: A case report","authors":"S.M. Yasir Arafat","doi":"10.1016/j.npbr.2020.04.001","DOIUrl":"10.1016/j.npbr.2020.04.001","url":null,"abstract":"<div><h3>Background</h3><p>Iloperidone, a second-generation antipsychotic has been approved for the management of schizophrenia. Although it has been found well-tolerated multiple side effects have been reported.</p></div><div><h3>Objectives</h3><p>I report a case of iloperidone-induced urinary incontinence in a Bangladeshi female.</p></div><div><h3>Method</h3><p>This patient has been taking psychiatric consultations for the last five years. After developing the side effect, informed consent was taken, details of history were obtained, and routine physical examination and mental status of the patient was performed.</p></div><div><h3>Results</h3><p>I report a case of 20 years old female who developed urinary incontinence due to iloperidone. Her symptoms improved after discontinuing the drug.</p></div><div><h3>Conclusion</h3><p>This is the first case, reporting urinary incontinence caused by iloperidone in a patient with schizophrenia which could be an effect of bladder neck dysfunction due to the high alpha 1 receptor blockade.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"36 ","pages":"Pages 86-87"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45723148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity changes in patients with brain tumours—A systematic review on resting state-fMRI","authors":"Hanani Abdul Manan ,&nbsp;Elizabeth A. Franz ,&nbsp;Noorazrul Yahya","doi":"10.1016/j.npbr.2020.03.003","DOIUrl":"10.1016/j.npbr.2020.03.003","url":null,"abstract":"<div><h3>Aim</h3><p>Resting-state functional magnetic resonance imaging (rs-fMRI) has been utilised to explore the brain's functional changes in patients with brain tumours. However, it remains unclear how such alterations affect functional connectivity (FC) and thus lead to changes in behaviour. To better understand the present state of knowledge, we conducted a systematic review.</p></div><div><h3>Material and methods</h3><p>A systematic literature search of patients with brain tumours with rs-fMRI methods was conducted using the PubMed/MEDLINE and Cochrane Library electronic databases following PRISMA guidelines. References and citations were checked in Scopus database.</p></div><div><h3>Results</h3><p>Ten independent studies were identified, comprising of 361 adult participants (218 had brain tumours; and the remainder were healthy controls). In comparison to healthy controls, patients with brain tumours demonstrated network distortions, alterations, and associated changes in the resting state networks (RSNs). Location and types of tumour affected RSNs integrity, particularly in the Default Mode Network (DMN). The left hemisphere was reported to have the largest effect on RSNs regardless of size or type of tumour. Result also demonstrate significant alterations to the local networks (decreases in the intra-hemispheric and inter-hemispheric FC). Studies also demonstrated that alterations in rs-fMRI were related to poorer neuropsychological task performance.</p></div><div><h3>Conclusion</h3><p>However, more studies utilising rs-fMRI to investigate effects of brain tumours on different types of RSNs are needed to draw clear conclusions about effects of tumour growth on properties of brain functional networks. Notably, not all studies have used the same nodes or regions for the networks, even though tumour locations often overlap.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"36 ","pages":"Pages 73-82"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49303015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics, methods and precipitating events of suicidal behaviors in Bangladesh: A year-round content analysis of six national newspapers","authors":"S.M. Yasir Arafat ,&nbsp;Bithika Mali ,&nbsp;Hasina Akter","doi":"10.1016/j.npbr.2020.02.005","DOIUrl":"10.1016/j.npbr.2020.02.005","url":null,"abstract":"<div><h3>Background</h3><p>Epidemiological aspect of suicidal behaviors is an under-researched matter in Bangladesh.</p></div><div><h3>Objectives</h3><p>It was aimed to see the characteristics, methods and precipitating events of suicidal behaviors by analyzing the contents of national daily newspapers of Bangladesh.</p></div><div><h3>Methods</h3><p>We analyzed the published contents of six daily newspapers that were collected and hand-searched between 01 November 2018 and 31 October 2019. A total of 403 articles were collected and subsequently analyzed.</p></div><div><h3>Results</h3><p>The mean age of suicide victims reported in these newspapers was 25.81 ± 11.62 years (Range: 8–80 years). More than fifty percent of the reported cases were less than 30 years of age, 55.6 % were female, 33.25 % were students, and 48.4 % were married. Hanging was found as the commonest method (76 %) and marital discords (14.89 %), familial discords (9.68 %), sexual issues (9.18 %), affair related issues (5.71 %), were found as the mentionable precipitating events. Year-round tracing of suicides based on the reports revealed peaks in April and November.</p></div><div><h3>Conclusion</h3><p>The study showed adults less than thirty years, females, and students are exhibiting more suicidal behaviors. Hanging was the most commonly used method and the majority of the precipitating events were within the family.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"36 ","pages":"Pages 14-17"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.02.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44151491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress, antioxidant defense and depressive disorders: A systematic review of biochemical and molecular markers","authors":"Maiza Lacerda Barbosa ,&nbsp;Ag-Anne Pereira Melo de Meneses ,&nbsp;Rai Pablo Sousa de Aguiar ,&nbsp;João Marcelo de Castro e Sousa ,&nbsp;Ana Amélia de Carvalho Melo Cavalcante ,&nbsp;Sharbel Weidner Maluf","doi":"10.1016/j.npbr.2020.02.006","DOIUrl":"10.1016/j.npbr.2020.02.006","url":null,"abstract":"<div><h3>Background</h3><p>Oxidative stress (OS) can contribute to the development of several diseases, including depressive disorders (DD). Antioxidant therapy been an important tool to depressive disorders or to side effects of the current therapy. This systematic review aimed to correlate the biochemical and molecular biomarkers of oxidative stress and antioxidant defenses with depressive disorders, through the evaluation of clinical studies.</p></div><div><h3>Methods</h3><p>The literature were obtained from the PubMed, Scielo, VHL, Medline and Scopus databases with the descriptors [depressive disorders], [vitamin antioxidants], [vitamin C], [retinol palmitate], [vitamin A] and [depression], combined.</p></div><div><h3>Results</h3><p>Several biomarkers of oxidative damage that affect biomolecules such as DNA, RNA, proteins and lipids and antioxidant defense biomarkers were analyzed in 28 articles selected by the the inclusion criteria. The biomarkers found were 8-OHdG, 3-NT, PCC, F2-Iso, 4-HNE, 8-Iso, MDA, SOD, CAT, GPx and vitamins A and C.</p></div><div><h3>Conclusions</h3><p>Most of the studies found significant associations between these biomarkers, depressive disorders. Thus, there are many perspectives for further studies that can clarify the relation of these biomarkers with depressive disorders.</p></div><div><h3>Limitations</h3><p>The scarce literature that fit the inclusion criteria may have limited this review.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"36 ","pages":"Pages 65-72"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.02.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89496356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of clinical features and biomarkers with treatment-resistant depression","authors":"Ana Carolina Congio MD ,&nbsp;Maisa Norcia MD ,&nbsp;Mariana Ragassi Urbano PhD ,&nbsp;Waldiceu A. Verri Jr PhD ,&nbsp;Sandra Odebrecht Vargas Nunes PhD","doi":"10.1016/j.npbr.2020.02.004","DOIUrl":"https://doi.org/10.1016/j.npbr.2020.02.004","url":null,"abstract":"<div><h3>Background</h3><p>Treatment-resistant depression (TRD) is associated with inflammatory biomarkers, childhood maltreatment, suicidal behaviour and functional impairment.</p></div><div><h3>Methods</h3><p>Our sample was divided in 3 groups. TRD group was considered with a 17-item Hamilton Depression Rating Scale (HDRS₁₇) for depression score remaining greater to 16 after 2 consecutive adequate treatment for bipolar disorder (BD) or major depressive disorder (MDD) (n = 24), non-TRD (n = 120) group and controls (n = 82). Socio-demographic and clinical data were assessed by structured questionnaire. Other assessments used were body mass index (BMI), Sheehan Disability Scale and Childhood Trauma Questionnaire. Laboratory biomarkers were leptin and high-sensitivity C-reactive protein (hs-CRP).</p></div><div><h3>Results</h3><p>The clinical features associated with TDR group were earlier at onset of first episode, increased number of depressive episodes, higher lifetime suicide attempts and comorbidities with panic disorder and PTSD. TRD group was more likely to have disability for work (OR = 8.20) and underproductive days (OR = 1.09) than non-TRD and control groups. Higher levels of leptin, hs-CRP &gt; 3 mg/L and higher BMI were also found to be associated with TRD. The TRD patients with hs-CRP &gt; 3 mg/L presented on average higher levels of leptin for the same BMI, compared to non-TRD.</p></div><div><h3>Limitation</h3><p>Retrospective assessment to investigate child abuse could be based on recall bias.</p></div><div><h3>Conclusions</h3><p>These findings suggest TRD is associated with earlier onset age, more depressive episodes and suicide attempts, comorbidities and functional impairment. TRD patients also should be assessed to comorbidities, childhood sexual abuse and increased levels of CRP and leptin.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"36 ","pages":"Pages 32-38"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.02.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91712198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urophilia associated with obsessive-compulsive disorder in a Bangladeshi male: A rare case report","authors":"S.M. Yasir Arafat ,&nbsp;Sujita Kumar Kar ,&nbsp;Sanjida Tanjin Khan","doi":"10.1016/j.npbr.2020.04.003","DOIUrl":"10.1016/j.npbr.2020.04.003","url":null,"abstract":"<div><h3>Background</h3><p>Urophilia has been conceptualized by sexual arousal caused by urine which is an under-researched area, globally. There is a paucity of data regarding its prevalence and association with other psychiatric conditions. Individuals with urophilia derive sexual gratification from smell, sight and even consumption of urine of the sexual partner.</p></div><div><h3>Objectives</h3><p>We report a case of urophilia with obsessive-compulsive disorder in an adult male, which the first reported case of urophilia in Bangladesh.</p></div><div><h3>Method</h3><p>After getting the informed consent, details of history were obtained, routine physical examination and mental status of the patient was performed.</p></div><div><h3>Results</h3><p>We report a case of 35 years old Bangladeshi male presented with urophilia and obsessive-compulsive disorder.</p></div><div><h3>Conclusion</h3><p>This is the first reported case of urophilia in a sexually conservative country, Bangladesh.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":"36 ","pages":"Pages 96-97"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2020.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48974435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}