Jakub Maksym, Piotr Scisło, Agnieszka Kapłon-Cieślicka, Zenon Huczek, Michał Marchel, Janusz Kochman, Karol Zbroński, Grzegorz Opolski, Marcin Grabowski, Tomasz Mazurek
{"title":"Incidence and predictors of device-related thrombus after left atrial appendage closure with Watchman device.","authors":"Jakub Maksym, Piotr Scisło, Agnieszka Kapłon-Cieślicka, Zenon Huczek, Michał Marchel, Janusz Kochman, Karol Zbroński, Grzegorz Opolski, Marcin Grabowski, Tomasz Mazurek","doi":"10.5114/aic.2024.140315","DOIUrl":"10.5114/aic.2024.140315","url":null,"abstract":"<p><strong>Introduction: </strong>Left atrial appendage closure (LAAC) with Watchman device prevents thromboembolism in patients with atrial fibrillation (AF). However, thrombus may develop on the atrial surface of the device.</p><p><strong>Aim: </strong>To investigate the incidence and predictors of device-related thrombus (DRT) in patients with AF who were treated with LAAC.</p><p><strong>Material and methods: </strong>Ninety-one consecutive patients with AF underwent LAAC procedure using first-generation Watchman 2.5 device followed by antiplatelet therapy. In our analysis we have included all patients (<i>n</i> = 78) who had clinical follow-up visits with transesophageal echocardiography (TEE) after the procedure.</p><p><strong>Results: </strong>The median (IQR) CHA<sub>2</sub>DS<sub>2</sub>-VASc score was 4 (4.0-6.0) and HAS-BLED score was 3 (3.0-4.0). DRTs were observed in 5 (6.4%) patients. When compared with patients without DRT, those with DRT presented more often with lower median ejection fraction (40% (23.5-45.5) versus 55% (48.0-60.0); <i>p</i> = 0.005), lower emptying velocity of LAA (25 cm/s (17.5-27.0) versus 53 cm/s (26.5-78.0); <i>p</i> = 0.009), and with greater depth of implantation (18 mm (14.0-20.5) versus 8 mm (5.0-11.0); <i>p</i> < 0.001). Furthermore, patients with DRT had greater depth of LAA (35 mm (29.5-41.0) versus 29 mm (25.5-31.0); <i>p</i> = 0.003), greater mean (SD) dimension in 90<sup>0</sup> (22.4 mm (3.2) versus 19 mm (2.7); <i>p</i> = 0.02). Patients with DRT were also younger than those without DRT (67.4 years (7) versus 75 years (8.3), <i>p</i> = 0.045).</p><p><strong>Conclusions: </strong>The DRT after Watchman device implantation remains a rare complication. Its formation was related to several patient and procedural characteristics, which need to be confirmed in larger studies.</p>","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Łukasz Czyż, Łukasz Tekieli, Adam Mazurek, Joan Rigla Cros, Piotr Musialek
{"title":"Neuro-tracking catheter technology for coronary thrombus extraction: Indigo CAT RX Continuous Aspiration System - first use in Poland.","authors":"Łukasz Czyż, Łukasz Tekieli, Adam Mazurek, Joan Rigla Cros, Piotr Musialek","doi":"10.5114/aic.2024.140850","DOIUrl":"10.5114/aic.2024.140850","url":null,"abstract":"","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmet Can Cakmak, İbrahim Kocayigit, Perihan Varım, Betül Sarıbıyık Çakmak, Yusuf Can, Mehmet Bülent Vatan
{"title":"The effect of the systemic immune-inflammatory index on the no-reflow phenomenon in patients undergoing saphenous vein intervention.","authors":"Ahmet Can Cakmak, İbrahim Kocayigit, Perihan Varım, Betül Sarıbıyık Çakmak, Yusuf Can, Mehmet Bülent Vatan","doi":"10.5114/aic.2024.140259","DOIUrl":"10.5114/aic.2024.140259","url":null,"abstract":"<p><strong>Introduction: </strong>The systemic immune inflammation index (SII), based on lymphocyte, neutrophil, and platelet counts, has been shown to be an independent indicator of no-reflow phenomenon during percutaneous intervention. However, the relationship between SII and no-reflow phenomenon (NRP) that develops after the procedure of saphenous vein grafts is unknown.</p><p><strong>Aim: </strong>In this study, we aimed to investigate the relationship between no-reflow phenomenon and SII during percutaneous intervention on saphenous vein grafts.</p><p><strong>Material and methods: </strong>A total of 133 patients who underwent percutaneous intervention for saphenous vein grafts due to acute coronary syndrome between 2019 and 2022 were included in this study. The receiver-operating characteristics (ROC) curve was used to determine the cut-off value of SII to predict the no-reflow. The multivariate regression was used to analyse the correlation between no-reflow and SII.</p><p><strong>Results: </strong>The median value of SII was significantly higher in patients with no-reflow in comparison with normal reperfusion (543 (447, 717) vs. 861 (642, 1272), <i>p</i> < 0.001). The optimal threshold for SII in predicting the no-reflow phenomenon was 613, with sensitivity and specificity of 84% and 66%, respectively. The area under the ROC curve (AUC) was 0.80 (95% CI: 0.73-0.89, <i>p</i> < 0.001). In multivariate analysis, SII ≥ 613 showed an independent predictive value for the no-reflow (OR = 4.02, 95% CI: 1.40-11.57, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Our results showed that high SII levels were independently associated with the development of no-reflow phenomenon in patients presenting with acute coronary syndrome and undergoing percutaneous intervention to the SVG.</p>","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Barbara Zdzierak, Agata Krawczyk-Ożóg, Artur Dziewierz
{"title":"The gender gap in interventional cardiology research: insights from <i>Advances in Interventional Cardiology</i> journal (2015-2023).","authors":"Barbara Zdzierak, Agata Krawczyk-Ożóg, Artur Dziewierz","doi":"10.5114/aic.2024.140904","DOIUrl":"10.5114/aic.2024.140904","url":null,"abstract":"","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lukasz Tekieli, Andrej Afanasjev, Maciej Mazgaj, Vladimir Borodetsky, Kolja Sievert, Zoltan Ruzsa, Magdalena Knapik, Audrius Širvinskas, Adam Mazurek, Karolina Dzierwa, Thomas Sanczuk, Valerija Mosenko, Malgorzata Urbanczyk-Zawadzka, Mariusz Trystula, Piotr Paluszek, Lukasz Wiewiorka, Justyna Stefaniak, Piotr Pieniazek, Inga Slautaitė, Tomasz Kwiatkowski, Artūras Mackevičius, Michael Teitcher, Horst Sievert, Iris Q Grunwald, Piotr Musialek
{"title":"A multi-center study of the MicroNET-covered stent in consecutive patients with acute carotid-related stroke: SAFEGUARD-STROKE.","authors":"Lukasz Tekieli, Andrej Afanasjev, Maciej Mazgaj, Vladimir Borodetsky, Kolja Sievert, Zoltan Ruzsa, Magdalena Knapik, Audrius Širvinskas, Adam Mazurek, Karolina Dzierwa, Thomas Sanczuk, Valerija Mosenko, Malgorzata Urbanczyk-Zawadzka, Mariusz Trystula, Piotr Paluszek, Lukasz Wiewiorka, Justyna Stefaniak, Piotr Pieniazek, Inga Slautaitė, Tomasz Kwiatkowski, Artūras Mackevičius, Michael Teitcher, Horst Sievert, Iris Q Grunwald, Piotr Musialek","doi":"10.5114/aic.2024.140963","DOIUrl":"10.5114/aic.2024.140963","url":null,"abstract":"<p><strong>Introduction: </strong>Acute carotid-related stroke (CRS), with its large thrombo-embolic load and large volume of affected brain tissue, poses significant management challenges. First generation (single-layer) carotid stents fail to insulate the athero-thrombotic material; thus they are often non-optimized (increasing thrombosis risk), yet their use is associated with a significant (20-30%) risk of new cerebral embolism.</p><p><strong>Aim: </strong>To evaluate, in a multi-center multi-specialty investigator-initiated study, outcomes of the MicroNET-covered (cell area ≈ 0.02-0.03 mm<sup>2</sup>) carotid stent (CGuard, InspireMD) in consecutive CRS patients eligible for emergency recanalization. Treatment, other than study device use, was according to center/operator routine.</p><p><strong>Material and methods: </strong>Seventy-five patients (age 40-89 years, 26.7% women) were enrolled in 7 interventional stroke centers.</p><p><strong>Results: </strong>The median Alberta Stroke Program Early CT Score (ASPECTS) was 9 (6-10). Study stent use was 100% (no other stent types implanted); retrograde strategy predominated (69.2%) in tandem lesions. Technical success was 100%. Post-dilatation balloon diameter was 4.0 to 8.0 mm. 89% of patients achieved final modified Thrombolysis in Cerebral Infarction (mTICI) 2b-c/3. Glycoprotein IIb/IIIa inhibitor use as intraarterial (IA) bolus + intravenous (IV) infusion was an independent predictor of symptomatic intracranial hemorrhage (OR = 13.9, 95% CI: 5.1-84.5, <i>p</i> < 0.001). The mortality rate was 9.4% in-hospital and 12.2% at 90 days. Ninety-day mRS0-2 was 74.3%, mRS3-5 13.5%; stent patency was 93.2%. Heparin-limited-to-flush predicted patency loss on univariate (OR = 14.3, 95% CI: 1.5-53.1, <i>p</i> < 0.007) but not on multivariate analysis. Small-diameter balloon/absent post-dilatation was an independent predictor of stent patency loss (OR = 15.2, 95% CI: 5.7-73.2, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>This largest to-date study of the MicroNET-covered stent in consecutive CRS patients demonstrated a high acute angiographic success rate, high 90-day patency and favorable clinical outcomes despite variability in procedural strategies and pharmacotherapy (SAFEGUARD-STROKE NCT05195658).</p>","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michał Jarocki, Mikołaj Błaziak, Kamila Florek, Weronika Wietrzyk, Katarzyna Modrzejewska, Wiktor Kuliczkowski
{"title":"Eisenmenger syndrome complicated by the presence of an aneurysm of the pulmonary trunk and compression of the left main coronary artery.","authors":"Michał Jarocki, Mikołaj Błaziak, Kamila Florek, Weronika Wietrzyk, Katarzyna Modrzejewska, Wiktor Kuliczkowski","doi":"10.5114/aic.2024.139688","DOIUrl":"10.5114/aic.2024.139688","url":null,"abstract":"","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yahya Kemal İçen, Fatih Sivri, Mustafa Lütfullah Ardıç, Hazar Harbalıoğlu, Emre Sezici, Mevlüt Koç
{"title":"Secret signal delayed mapping in patients with premature ventricular contractions.","authors":"Yahya Kemal İçen, Fatih Sivri, Mustafa Lütfullah Ardıç, Hazar Harbalıoğlu, Emre Sezici, Mevlüt Koç","doi":"10.5114/aic.2024.140265","DOIUrl":"10.5114/aic.2024.140265","url":null,"abstract":"<p><strong>Introduction: </strong>Mapping and radiofrequency ablation (RFA) of premature ventricular contractions (PVC) that show diurnal changes during the day, and which are rare during 3-D mapping has become very difficult. The most delayed signal mapping in the right ventricular outflow tract (RVOT) with RV apical pacing might be useful in these situations and we called this method Secret Signal Delayed Mapping (SSDM).</p><p><strong>Aim: </strong>To compare the classical RFA and SSDM in patients with PVC.</p><p><strong>Material and methods: </strong>A total of 60 patients with > 10% PVCs detected in 24-hour rhythm Holter recordings and admitted to the laboratory for RFA, 30 of whom underwent classical ablation according to the local activation time (LAT) and 30 of whom were included in the SSDM group, were included in our study. In patients who did not have enough PVCs during 3-D mapping, a catheter was placed in the right ventricle, and delayed signals after the ventricular electrogram (EGM) were collected by fixed pacing and such patients were included in the SSDM group.</p><p><strong>Results: </strong>In all patients, PVC originated from the RVOT. The mean follow-up time of the patients was 10.2 ±1.6 months. Recurrence was detected in 11 (36.6%) patients in the LAT group and 4 (13.3%) patients in the SSDM group. Signal earlyness in LAT mapping was significantly higher in the LAT group (<i>p</i> < 0.001). In the SSDM group, an average of 128 ±24 delayed signals were collected, the mean delayed signal time was 77.6 ±17.7 ms. In the SSDM group, the average distance between the earliest signal on the LAT and the most delayed signal on the SSDM was 4.8 ±1.2 mm.</p><p><strong>Conclusions: </strong>In the treatment of PVCs with RFA, the SSDM method can be used in addition to classical ablation.</p>","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Crush technique for percutaneous management of bifurcation of renal artery aneurysms.","authors":"Paweł Latacz, Dorota Studzinska, Marian Simka","doi":"10.5114/aic.2024.140183","DOIUrl":"10.5114/aic.2024.140183","url":null,"abstract":"","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haşim Tuner, Yüksel Kaya, Gülsüm Bingol, Özge Özden, Serkan Ünlü, Emre Özmen, Medeni Karaduman, Rabia Çoldur, Enes Alıç, Fatih Öztürk
{"title":"Flow-mediated dilatation facilitates transradial coronary angiography: a comparative study.","authors":"Haşim Tuner, Yüksel Kaya, Gülsüm Bingol, Özge Özden, Serkan Ünlü, Emre Özmen, Medeni Karaduman, Rabia Çoldur, Enes Alıç, Fatih Öztürk","doi":"10.5114/aic.2024.139716","DOIUrl":"10.5114/aic.2024.139716","url":null,"abstract":"<p><strong>Introduction: </strong>Radial artery (RA) spasm is demonstrated to be one of the most common complications of transradial approach (TRA).</p><p><strong>Aim: </strong>We hypothesised that radial flow-mediated dilation (FMD) can be used as a preprocedural method to assess the likelihood of arterial spasm.</p><p><strong>Material and methods: </strong>The patients were divided into 2 groups: those with and without flow-mediated RA dilatation. A blood pressure cuff was placed on the upper part of the antecubital region of the patients in the FMD group and inflated for 10 min, allowing the pressure to rise to 30 mm Hg above the systolic blood pressure. RA diameters of the patients in both groups were measured via quantitive coronary angiography method before transradial coronary angiography.</p><p><strong>Results: </strong>A total of 165 patients were included in the study, of whom 64 (38.8%) were women. The median age of the patients was 56 years (48-63). The mean RA diameter was significantly larger in the FMD group (3.44 ±0.48 vs. 2.96 ±0.46 mm, <i>p</i> < 0.001), and the number of punctures required for successful transradial cannulation was found to be significantly higher in the group without FMD (1.55 ±0.7 vs. 1.20 ±0.64; <i>p</i> < 0.001). Linear regression analysis revealed diabetes and FMD as independent predictors of RA diameter. In the diabetic subgroup, RA diameter remained larger in the FMD group (3.00 ±0.35 vs. 2.78 ±0.26, <i>p</i> = 0.036). Radial puncture attempts were significantly higher in the control group compared to the FMD group (1.55 ±0.7 vs. 1.20 ±0.64; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>In our study, we demonstrated that FMD created by pressure application significantly increased RA diameter and reduced puncture attempt during TRA.</p>","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Łukasz Szymański, Natalia Gołąbek, Jakub Piórek, Witold Gerber, Piotr P Buszman, Krzysztof Sanetra
{"title":"Need for repeat revascularisation in hybrid coronary revascularisation vs. percutaneous coronary intervention.","authors":"Łukasz Szymański, Natalia Gołąbek, Jakub Piórek, Witold Gerber, Piotr P Buszman, Krzysztof Sanetra","doi":"10.5114/aic.2024.140903","DOIUrl":"10.5114/aic.2024.140903","url":null,"abstract":"<p><p>Hybrid coronary revascularisation (HCR), being a treatment path combining both coronary artery bypass grafting and percutaneous coronary intervention (PCI) approaches, offers the advantages of both methods in patients with multi-vessel coronary artery disease. Since available literature provides few studies comparing the need for repeat revascularisation (RR) after HCR in comparison to PCI, our review aimed at summarising the latest data on this topic from the last 5 years (2018-2023). The search was conducted within the PubMed and Embase databases, followed by application of inclusion and exclusion criteria and providing a summary of data and characteristics of eligible studies. On the basis of 7 records included in the final analysis, RR and/or follow-up target vessel revascularisation (TVR) were significantly less frequently required in the case of HCR than in PCI in 3 out of 7 records, whereas the remaining four provided no significant differences in analysed rates between the 2 therapeutic pathways. When it comes to lowering the necessity for follow-up TVR and/or RR in a fraction of instances, HCR demonstrates a significant advantage over PCI. The complexity of outcomes associated with these therapies is emphasised by the fact that no statistically significant differences were observed between the 2 methods in the remaining 4 records.</p>","PeriodicalId":49678,"journal":{"name":"Postepy W Kardiologii Interwencyjnej","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}