Quimica Nova最新文献_第5页

PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF THE ALKALOIDS OF MALVACEAE sensu lato SPECIES: A REVIEW 锦葵生物碱的植物化学和药理研究进展

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-06-26 DOI: 10.21577/0100-4042.20230028

A. Sobreira, Janderson B.L. de Albuquerque, Wallace de Queiroz, P. de Souza, D. Fernandes, M. de Souza

{"title":"PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF THE ALKALOIDS OF MALVACEAE sensu lato SPECIES: A REVIEW","authors":"A. Sobreira, Janderson B.L. de Albuquerque, Wallace de Queiroz, P. de Souza, D. Fernandes, M. de Souza","doi":"10.21577/0100-4042.20230028","DOIUrl":"https://doi.org/10.21577/0100-4042.20230028","url":null,"abstract":"Malvaceae sensu lato is a family containing about 245 genera and 4,465 species mainly distributed across tropical and subtropical regions worldwide. Species of this family usually contain alkaloids with anti-inflammatory, antinociceptive, antiparasitic, antimicrobial and anticancer properties due to its secondary metabolites. In this context, this review aims to checklist the alkaloids isolated from Malvaceae sensu lato species, evaluating their chemical profile and pharmacological potential, providing a broad and concise overview of these secondary metabolites. The results were collected from scientific databases such as Web of Science, Scifinder, Pubmed, ScienceDirect and Google Scholar, using the keywords “Alkaloids” and “Malvaceae”. Several pharmacological/ biological activities are reported in literature for the most varied alkaloid nuclei, such as: vasorelaxation of the mesentery of rats (cryptolepinone), antitrypanosomal activity (waltherione) and anti-inflammatory and bronchodilator activity (vasicine), which highlights a succession of activities related to this class of secondary metabolites. Presented data report the importance of the Malvaceae sensu lato family, demonstrating the biological relevance of its alkaloids, in order to contribute to scientific knowledge and the development of new drugs.","PeriodicalId":49641,"journal":{"name":"Quimica Nova","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68271172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MACHINE LEARNING-BASED VIRTUAL SCREENING, MOLECULAR DOCKING, DRUG-LIKENESS, PHARMACOKINETICS AND TOXICITY ANALYSES TO IDENTIFY NEW NATURAL INHIBITORS OF THE GLYCOPROTEIN SPIKE (S1) OF SARS-CoV-2 基于机器学习的虚拟筛选，分子对接，药物相似，药代动力学和毒性分析，以确定新的天然抑制SARS-CoV-2糖蛋白刺突(S1)

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-06-26 DOI: 10.21577/0100-4042.20230038

A. Cobre, B. Böger, M. Fachi, C. Ehrenfried, D. Stremel, E. D. de Melo, F. Tonin, R. Pontarolo

{"title":"MACHINE LEARNING-BASED VIRTUAL SCREENING, MOLECULAR DOCKING, DRUG-LIKENESS, PHARMACOKINETICS AND TOXICITY ANALYSES TO IDENTIFY NEW NATURAL INHIBITORS OF THE GLYCOPROTEIN SPIKE (S1) OF SARS-CoV-2","authors":"A. Cobre, B. Böger, M. Fachi, C. Ehrenfried, D. Stremel, E. D. de Melo, F. Tonin, R. Pontarolo","doi":"10.21577/0100-4042.20230038","DOIUrl":"https://doi.org/10.21577/0100-4042.20230038","url":null,"abstract":"To identify natural bioactive compounds (NBCs) as potential inhibitors of spike (S1) by means of in silico assays. NBCs with previously proven biological in vitro activity were obtained from the ZINC database and analyzed through virtual screening and molecular docking to identify those with higher affinity to the spike protein. Eight machine learning models were used to validate the results: Principal Component Analysis (PCA), Artificial Neural Network (ANN), Support Vector Machine (SVM), k-Nearest Neighbors (KNN), Partial Least Squares-Discriminant Analysis (PLS-DA), Gradient Boosted Tree Discriminant Analysis (XGBoostDA), Soft Independent Modelling of Class Analogies (SIMCA) and Logistic Regression Discriminate Analysis (LREG). Selected NBCs were submitted to drug-likeness prediction using Lipinski’s and Veber’s rule of five. A prediction of pharmacokinetic parameters and toxicity was also performed (ADMET). Antivirals currently used for COVID-19 (remdesivir and molnupiravir) were used as a comparator. A total of 170,906 compounds were analyzed. Of these, 34 showed greater affinity with the S1 (affinity energy < -7 kcal mol-1). Most of these compounds belonged to the class of coumarins (benzopyrones), presenting a benzene ring fused to a lactone (group of heterosides). The PLS-DA model was able to reproduce the results of the virtual screening and molecular docking (accuracy of 97.0%). Of the 34 compounds, only NBC5 (feselol), NBC14, NBC15 and NBC27 had better results in ADMET predictions. These had similar binding affinity to S1 when compared to remdesivir and molnupirvir. Feselol and three other NBCs were the most promising candidates for treating COVID-19. In vitro and in vivo studies are needed to confirm these findings.","PeriodicalId":49641,"journal":{"name":"Quimica Nova","volume":"48 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68271552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

O VIDRO E SUA IMPORTÂNCIA NA VIDA E NA QUÍMICA 玻璃及其在生命和化学中的重要性

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-06-26 DOI: 10.21577/0100-4042.20230033

Wladmir da Silva, Carlos Filgueiras

引用次数: 0

UM NOVO COMPOSTO DE COORDENAÇÃO DINUCLEAR PROJETADO PARA NÃO APRESENTAR DANOS OXIDATIVOS E EFEITOS TOXICOLÓGICOS 一种新型双核配位化合物，设计无氧化损伤和毒理学作用

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-06-26 DOI: 10.21577/0100-4042.20230032

Jamerson da Silva, André Galembeck, Mônica Belian, Wagner Silva, Jandyson Santos, Jacinto Silva Neto, J. Aguiar, T. Gonçalves

{"title":"UM NOVO COMPOSTO DE COORDENAÇÃO DINUCLEAR PROJETADO PARA NÃO APRESENTAR DANOS OXIDATIVOS E EFEITOS TOXICOLÓGICOS","authors":"Jamerson da Silva, André Galembeck, Mônica Belian, Wagner Silva, Jandyson Santos, Jacinto Silva Neto, J. Aguiar, T. Gonçalves","doi":"10.21577/0100-4042.20230032","DOIUrl":"https://doi.org/10.21577/0100-4042.20230032","url":null,"abstract":"A NEW DINUCLEAR COORDINATION COMPOUND DESIGNED TO HAVE NO OXIDATIVE DAMAGE AND TOXICOLOGICAL EFFECTS. The synthesis, characterization, acute toxicity, antitumor activity, and histopathological analysis of a novel dinuclear platinum(2+) complex − [Pt(DACH-κ2N)µ-(C4H2O6-κ4O)Pt(DACH-κ2N)] − is reported. Through acute toxicity tests, it was possible to place the platinum complexes into categories according to the OECD protocol. The dinuclear complex was classified in category 2 (cisplatin - category 1; and oxaliplatin - category 2). Analyzing the interaction between dsDNA and dinuclear complex was observed an Tm increase, suggesting that the dinuclear complex-dsDNA interact probably through of the interstrand form. Evaluations of tumor masses extracted from mice inoculated with Ehrlich carcinoma demonstrated a percent of tumor inhibition similar for cisplatin and oxaliplatin, but statistically different and superior for the case of the dinuclear complex. Cisplatin and oxaliplatin showed 41.4 and 40.8% inhibition, respectively, while the dinuclear complex presented 66.3%. The histopathological analysis demonstrated that the group treated with cisplatin showed more significant tissue damage, moderate hepatic steatosis, and nephritis. The livers, spleens, and kidneys of the animals treated with the dinuclear complex were within the normality range with no tissue lesions, and absence of metastasis.","PeriodicalId":49641,"journal":{"name":"Quimica Nova","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68271666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DESENVOLVIMENTO DE UM EQUIPAMENTO DE SPIN COATING COM SISTEMA DE FIXAÇÃO DE SUBSTRATO A VÁCUO EMPREGANDO MATERIAIS REUTILIZADOS 利用回收材料研制真空基板固定系统的旋涂设备

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-06-26 DOI: 10.21577/0100-4042.20230022

Antonio Chepluki, T. Frizon, Igor Villares De Carvalho

引用次数: 0

OCORRÊNCIA DE AGROTÓXICOS EM SOLOS ARGILOSOS E ARENOSOS APÓS APLICAÇÃO EM PASTAGENS E CANA-DE-AÇÚCAR 牧场和甘蔗施用后粘土和沙质土壤中农药的发生情况

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-06-26 DOI: 10.21577/0100-4042.20230025

I. Feitosa, N. Munin, B. Goulart, Cassiana Montagner

{"title":"OCORRÊNCIA DE AGROTÓXICOS EM SOLOS ARGILOSOS E ARENOSOS APÓS APLICAÇÃO EM PASTAGENS E CANA-DE-AÇÚCAR","authors":"I. Feitosa, N. Munin, B. Goulart, Cassiana Montagner","doi":"10.21577/0100-4042.20230025","DOIUrl":"https://doi.org/10.21577/0100-4042.20230025","url":null,"abstract":"OCCURRENCE OF PESTICIDES IN CLAY AND SANDY SOILS AFTER APPLICATION IN PASTURE AND SUGARCANE CROPS. Sugarcane is considered one of the greatest alternatives for the biofuels sector due to the high potential in the production of ethanol and its respective by-products. Processes of converting degraded pastures into sugarcane crops have been increasingly common in Brazil, as well as the use of pesticides to control plant diseases and pests in several crops. The objective of this work was to evaluate the occurrence of 2,4-D, ametryn, tebuthiuron, fipronil and its degradation products (fipronil sulfide and fipronil sulfone) in clay and sandy soils when applied to pasture and sugarcane management. Solid-liquid extraction and liquid chromatography coupled to mass spectrometry were used to quantify the compounds. The optimized method was validated with the following parameters: linear range from 0.5 to 300 μg L-1; linearity (r) > 0.99; precision with CV from 1.0 to 15.0%; accuracy of 60 to 117%, instrumental limit of detection (LOD) from 0.1 to 1.0 μg L-1 and instrumental limit of quantification (LOQ) of 0.5 μg L-1 for all pesticides, except 2,4-D (5.0 μg L-1). Pesticides concentrations of the experimental farms ranged from 0.1 to 266 μg kg-1, with the highest concentrations found in the months of pesticide’s application. The results showed the persistence of some pesticides in the soils even after months of use.","PeriodicalId":49641,"journal":{"name":"Quimica Nova","volume":"13 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68271119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PESTICIDES IN PROCESSED FOOD - MULTIRESIDUE PESTICIDES IN NATURAL GRAPE JUICES BY HIGHRESOLUTION MASS SPECTROMETRY 加工食品中的农药——天然葡萄汁中多重残留农药的高分辨质谱分析

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-06-26 DOI: 10.21577/0100-4042.20230024

M. Chiarello, Luana C. Crocoli, Vinícius B. Molon, S. Moura

{"title":"PESTICIDES IN PROCESSED FOOD - MULTIRESIDUE PESTICIDES IN NATURAL GRAPE JUICES BY HIGHRESOLUTION MASS SPECTROMETRY","authors":"M. Chiarello, Luana C. Crocoli, Vinícius B. Molon, S. Moura","doi":"10.21577/0100-4042.20230024","DOIUrl":"https://doi.org/10.21577/0100-4042.20230024","url":null,"abstract":"Grapes are among the most widely cultivated fruits in the world, with the majority of Brazilian production focusing on natural grape juice. In this work, a total of 40 samples of 2 types of natural grape juice were analyzed for the presence of 86 pesticide residues, with multiresidue extraction based on modified QuEChERS, by liquid chromatography with high-resolution mass spectrometry (LC-HRMS). Limits of detection and quantification were below 6 μg L-1 and 20 μg L-1, RSD < 20%, R2 > 0.99 and recovery ranged from 80 and 120%. Thus, the developed method was validated and good performance characteristics such as linearity, trueness, repeatability and inter-day precision were obtained. As results, 7 pesticides were detected in real samples (azoxystrobin, benalaxyl, carbendazim, tebuconazol, thiophanate-methyl, pyriproxiphen and pyrimethanil). The method was successfully validated for simultaneous evaluation of 86 multiclass pesticides residues levels, which was applied in 40 natural white and red grape juice market samples. The limits of quantification (LOQs) were low enough and the method was tested on samples showing its applicability, and therefore, this method can be used in routine analysis. Also, this work therefore also serves as an alert regarding the contamination of processed products.","PeriodicalId":49641,"journal":{"name":"Quimica Nova","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68271062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LOW-COST AND EASY ACCESS MATERIALS FOR A LABORATORY CLASS: A PROPOSAL OF LIQUID CHROMATOGRAPHY FOR FOOD COLORING SEPARATION AS AN EXPERIENCE OF MEANINGFUL LEARNING 低成本和易于获取的实验材料:液相色谱法分离食用色素的建议，作为一个有意义的学习经验

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-06-26 DOI: 10.21577/0100-4042.20230027

B. Cerqueira, G. Lima, A. Mascarenhas, H. Andrade, Rodrigo De Paula

{"title":"LOW-COST AND EASY ACCESS MATERIALS FOR A LABORATORY CLASS: A PROPOSAL OF LIQUID CHROMATOGRAPHY FOR FOOD COLORING SEPARATION AS AN EXPERIENCE OF MEANINGFUL LEARNING","authors":"B. Cerqueira, G. Lima, A. Mascarenhas, H. Andrade, Rodrigo De Paula","doi":"10.21577/0100-4042.20230027","DOIUrl":"https://doi.org/10.21577/0100-4042.20230027","url":null,"abstract":"The experimental activities for undergraduate chemistry students play an important role to develop skills and expertise in that science thus, the practice-experimental classes are so important to achieve this purpose. This work deals with a demonstrative experience for dye separation from food coloring sample using liquid column chromatography. Beyond the experimental practice and the facility in visualizing the separation, this demonstration shows how a simple experiment involving alternative and easy access materials can promote a meaningful learning once it is possible to handle the acquired data, trace and analyze the results themselves, thus developing skills rather than the operational procedure. This proposal could be implemented in initial chemistry classes in Brazilian universities. Sea and river sands were used as stationary phases and aqueous ethanolic solutions were used as mobile phases. A food coloring (a mixture of 3 dyes) was chosen as sample to be studied. Chromatographic separation was followed by spectrophotometric measurements. A set of analyses were carried out to discuss the solubility of the food coloring, granulometric studies of the stationary phases used and electronic microscopy images of the sands studied here. As alternative materials were used in this work, a chromatographic column was also constructed with low-cost materials.","PeriodicalId":49641,"journal":{"name":"Quimica Nova","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68271164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COMPARANDO A EFICIÊNCIA ANALÍTICA DAS TÉCNICAS FTIR, UV-VIS, CLAE-DAD E ESI(+)MS NO ESTUDO DE CORANTES ALIMENTARES 比较了FTIR、UV-VIS、hplc -DAD和ESI(+)MS对食用色素的分析效率

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-06-26 DOI: 10.21577/0100-4042.20230037

Marco Lyrio, D. Debona, N. Conceição, Francisco Gomes, A. Pereira, Henrique Frizzera, Jéssica Reis, Taila Grecco, Bruna Pires, Valdemar Lacerda Jr., E. Castro, Marsele Isidoro, P. Filgueiras, W. Romão

{"title":"COMPARANDO A EFICIÊNCIA ANALÍTICA DAS TÉCNICAS FTIR, UV-VIS, CLAE-DAD E ESI(+)MS NO ESTUDO DE CORANTES ALIMENTARES","authors":"Marco Lyrio, D. Debona, N. Conceição, Francisco Gomes, A. Pereira, Henrique Frizzera, Jéssica Reis, Taila Grecco, Bruna Pires, Valdemar Lacerda Jr., E. Castro, Marsele Isidoro, P. Filgueiras, W. Romão","doi":"10.21577/0100-4042.20230037","DOIUrl":"https://doi.org/10.21577/0100-4042.20230037","url":null,"abstract":"COMPARING THE ANALYTICAL EFFICIENCY OF FTIR, UV-VIS, CLAE-DAD AND ESI(+)MS TECHNIQUES IN THE STUDY OF FOOD DYES. Food additives are chemical substances added to improve organoleptic characteristics, in this context, there are several synthetic dyes, such as sunset yellow, tartrazine, erioglaucine, allura red, indigo carmine, and new coccine, that can also be identified through different analytical techniques such as infrared spectroscopy, UV-Vis spectrophotometry, high performance liquid chromatography with diode array detector and mass spectrometry. Therefore, the objective of this work was to compare methods developed for different analytical techniques, in order to identify the one that presents greater efficiency in certain applications. For this, the patterns of the dyes were analyzed, as well as their mixtures and foods that had them. As a result, the CLAE-DAD presents excellent selectivity and linearity of the calibration curves, but it presents higher LD and LQ values when compared to the UV-Vis, in turn the infrared provides information regarding functional groups and bonds. Mass spectrometry showed great capabilities in identifying the molecular formula and better selectivity in the absence of the erioglaucine dye. It is not feasible to indicate the best or worst analytical approach, but it is possible to point out which one is more suitable for each application. Regarding the quantification capacity, chromatography and UV-Vis are good alternatives, but in mixtures containing more than one dye, CLAE-DAD is more suitable due to the better selectivity. Regarding the identification capacity, mass spectrometry, especially FT-ICR MS, is the most appropriate technique to propose molecular formulas due to its high resolution and mass accuracy. The advantage of FTIR was the easier sample preparation, being able to analyze the dyes in the solid state.","PeriodicalId":49641,"journal":{"name":"Quimica Nova","volume":"35 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68271511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NANOPARTÍCULAS DE SÍLICA (NPSiO2) UTILIZADAS PARA O TRATAMENTO DE DISTÚRBIOS ASSOCIADOS AO SISTEMA NERVOSO CENTRAL (SNC) 二氧化硅纳米颗粒（NPSiO2）用于治疗与中枢神经系统（CNS）相关的紊乱

IF 0.8 4区化学

Quimica Nova Pub Date : 2023-05-29 DOI: 10.21577/0100-4042.20230015

João Guilherme Pallin De Oliveira, Jussânia Gnoatto, Tanira Aguirre

{"title":"NANOPARTÍCULAS DE SÍLICA (NPSiO2) UTILIZADAS PARA O TRATAMENTO DE DISTÚRBIOS ASSOCIADOS AO SISTEMA NERVOSO CENTRAL (SNC)","authors":"João Guilherme Pallin De Oliveira, Jussânia Gnoatto, Tanira Aguirre","doi":"10.21577/0100-4042.20230015","DOIUrl":"https://doi.org/10.21577/0100-4042.20230015","url":null,"abstract":"SILICA NANOPARTICLES (SiO2NP) USED FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH THE CENTRAL NERVOUS SYSTEM (CNS). In the last decade, nanomedicine has investigated the potential use of silica nanoparticles for drug delivery due to the favorable physicochemical properties of these systems as carriers. Specifically, a few studies have focused on applying silica-based nanosystems to deliver drugs into the central nervous system to treat neurological disorders. The present review aimed to evaluate the properties of silica nanoparticles, such as size, zeta potential, surface area, entrapment efficiency, drug loading, and release profile, exclusively applied for the treatment of central nervous system disorders as well as to describe the correlation between biological outcomes and physicochemical properties. Furthermore, the main processes related to the development of silica nanoparticles, such as preparation and characterization methods, were covered in this review to aid the systematic development of silica-based nanoparticles. In the articles reviewed, silica nanocarriers used in neurological disorders did not exhibit physicochemical similarities. Thus, attempts to prospect relations between physicochemical properties and biological effects are still inefficient when silica nanoparticles are used as drug delivery systems in neurological disorders. Therefore, each silica-based nanocarrier must be fully physicochemical and biologically characterized to comprehend how the structural features of silica nanoparticles affect biological systems.","PeriodicalId":49641,"journal":{"name":"Quimica Nova","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68270733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0