Radiation Oncology最新文献

{"title":"Radionecrosis risk and local control after CyberKnife^® fractionated stereotactic radiotherapy for brain metastases: an eight-year single-centre cohort.","authors":"Aurélia Alati, Philippe Giraud, Jean-Emmanuel Bibault, Emmanuelle Fabiano, Sarah Kreps, Catherine Durdux","doi":"10.1186/s13014-026-02824-x","DOIUrl":"10.1186/s13014-026-02824-x","url":null,"abstract":"","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient clinical workflow for intraoperative electron radiation therapy with a mobile electron accelerator.","authors":"Deepak K Shrestha, Amanda M Jackson, Steven M Herchko, Michael Lowe, Christopher Serago, Jingjing M Dougherty, Deanna Hasenauer, Mi Huang, Ralph Young, Chris J Beltran, Robert Miller, Amit Merchea, John Stauffer, Michael Rutenberg, Byron May","doi":"10.1186/s13014-026-02831-y","DOIUrl":"10.1186/s13014-026-02831-y","url":null,"abstract":"","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensity-modulated radiotherapy/Volumetric modulated Arc therapy including four Brachytherapy fractions versus 3D conformal radiotherapy containing five Brachytherapy fractions in the treatment of cervical cancer.","authors":"Barin Feroz, Christoph Ebner, Sergej Skvortsov, Ricarda Purtscheller, Katharina Steger, Magdalena Steinlechner, Miriam Emmelheinz, Jana Rieker, Katharina Leitner, Ute Ganswindt, Sarah Maier, Christian Marth, Alain Gustave Zeimet","doi":"10.1186/s13014-026-02834-9","DOIUrl":"10.1186/s13014-026-02834-9","url":null,"abstract":"","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging radiotherapy before anti-CD19 CAR T-cell therapy for Large B-cell lymphoma - results from a single-center study.","authors":"Sebastian M Stolz, Camilla von Wachter, Jonas Willmann, Max J Rieger, Stefanie Kreutmair, Weeda Mamozai, Wiebke Rösler, Philipp Hockl, Maiwand Ahmadsei, Sebastian M Christ, Laura Motisi, Matthias Guckenberger, Dominik Schneidawind, Michael Mayinger","doi":"10.1186/s13014-026-02822-z","DOIUrl":"10.1186/s13014-026-02822-z","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy (RT) with immunochemotherapy (ICT) followed by CAR T-cell therapy may have synergistic effects due to cytoreduction and enhancing antigen spread, thereby inducing anti-cancer immune responses. The aim of this study was to analyze retrospective comparative data on the use of RT prior to anti-CD19 directed CAR T-cell therapy with a special focus on cytoreduction and RT related side effects.</p><p><strong>Methods: </strong>All patients aged ≥ 18 years with relapsed/ refractory Large B-Cell-lymphoma (r/r LBCL) treated with anti-CD19 CAR T-cell therapy in our institution from 05/ 2019-08/2023 were analyzed retrospectively, with the RT therapy group comprising all patients receiving RT with or without concomitant systemic therapy. The control (CO) group was manually matched on age, prior therapy lines and remission state at lymphodepletion. Post-RT tumor volumes (TV) were calculated for 6 out of 7 patients pre-CAR T and for 1 patient post-CAR T. Primary endpoints were reduction of TV and CAR T as well as RT related side effects. Secondary endpoints included overall survival (OS) and progression free survival (PFS).</p><p><strong>Results: </strong>8 patients receiving RT within 60 days prior to CAR T-cell infusion and 8 controls were included in the final analysis. 6 out of 8 patients received concomitant bridging therapy. RT alone or in combination with concomitant systemic therapy led to a significant reduction of TV (average reduction of 68%) within the radiated field from baseline to post RT (p = 0.028). The combination of RT and CAR T-cell therapy was not associated with an increased rate of CAR T related side effects or complications (cytokine release syndrome p = 0.6, immune effector cell-associated neurotoxicity p = 0.2, corticosteroid use p > 0.9, Tocilizumab use p > 0.9, transfer to intensive care unit p = 0.6). OS and PFS did not differ between the RT- and CO-group (OS p = 0.64, PFS p = 0.35).</p><p><strong>Conclusions: </strong>Our data indicate that RT is a feasible and effective way of cytoreduction before CAR T-cell therapy, also in combination with systemic chemotherapy.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Re-irradiation in oligorecurrence and oligometastatic cervical cancer in modern radiotherapy era.","authors":"Wiwatchai Sittiwong, Tissana Prasartseree, Pongpop Tuntapakul, Wajana Thaweerat, Nantakan Apiwarodom, Yaowalak Chansilpa, Pittaya Dankulchai","doi":"10.1186/s13014-026-02832-x","DOIUrl":"10.1186/s13014-026-02832-x","url":null,"abstract":"","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":"21 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13032539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147534142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of novel cardiovascular and immune system dosimetric parameters in stage III NSCLC patients treated with radiotherapy.","authors":"Francesco Dionisi, Giulia Mascari, Isabella Sperduti, Lucia Goanta, Alessia Nardangeli, Pedro Ordonez, Marco D'Andrea, Antonella Soriani, Giuseppe Sanguineti","doi":"10.1186/s13014-026-02835-8","DOIUrl":"10.1186/s13014-026-02835-8","url":null,"abstract":"","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of survival for locally advanced rectal cancer patients with poor response to neoadjuvant chemoradiotherapy.","authors":"Kasra Kolahdouzan, Romina Abyaneh, Erfan Barootchi, Pardis Zamani, Sara Naseri, Setayesh Mostakhdemin Hoseini, Ali Nouranifar, Hamidreza Javid, Ehsan Saraee, Reza Ghalehtaki","doi":"10.1186/s13014-026-02820-1","DOIUrl":"10.1186/s13014-026-02820-1","url":null,"abstract":"","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between radiation volume and breast density for skin toxicity and breast edema after radiotherapy in breast conserving therapy of breast cancer.","authors":"Mathias Sonnhoff, Oyur Rojin Oyur, Becker Jan-Nicklas, Hermann Robert Michael, Carl Cedric Oliver, Nitsche Mirko, Christiansen Hans, Blach Robert Maximilian","doi":"10.1186/s13014-026-02833-w","DOIUrl":"10.1186/s13014-026-02833-w","url":null,"abstract":"","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of quantitative goal exercise combined with whole process refined nutrition management on the nutritional status and quality of life of head and neck cancer patients undergoing radiotherapy: an open-label, randomized, controlled trial.","authors":"Juanli Shi, Xiaoli Long, Mai Zhang, Xiao Zhang, Meiling Cheng, YangYang Yin, Geng Xiang, Lina Zhao","doi":"10.1186/s13014-026-02823-y","DOIUrl":"10.1186/s13014-026-02823-y","url":null,"abstract":"","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147534070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A time-adapted risk stratification framework guided by longitudinal post-radiotherapy EBV DNA clearance for high-risk nasopharyngeal carcinoma patients.","authors":"Ying Li, Zongwei Huang, Zihan Chen, Mingzhu Liu, Jue Wang, Jiajia Zheng, Qisi Zhang, Xiaoke Wang, Yuhui Pan, Sufang Qiu","doi":"10.1186/s13014-026-02830-z","DOIUrl":"10.1186/s13014-026-02830-z","url":null,"abstract":"","PeriodicalId":49639,"journal":{"name":"Radiation Oncology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}