Seizure-European Journal of Epilepsy最新文献

{"title":"Before the variant c.541A>G in UGT1A6 can be held responsible for valproate-induced tremor, alternative causes must be ruled out","authors":"Josef Finsterer","doi":"10.1016/j.seizure.2024.07.021","DOIUrl":"10.1016/j.seizure.2024.07.021","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"122 ","pages":"Pages 179-180"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rituximab-responsive late-onset Rasmussen's encephalitis","authors":"Seyda Erdoğan , Gamar Aliyeva , Tuğba Erguvan Özel Kızıl , Özden Şener","doi":"10.1016/j.seizure.2024.10.009","DOIUrl":"10.1016/j.seizure.2024.10.009","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"123 ","pages":"Pages 57-59"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation with Transcranial Magnetic Stimulation in Epilepsia Partialis Continua: Scoping review and clinical experience","authors":"Matilde Velasco-Mérida ,&nbsp;Marian Lázaro ,&nbsp;John S Duncan ,&nbsp;Gonzalo Alarcon ,&nbsp;Ioannis Stavropoulos ,&nbsp;Antonio Valentín","doi":"10.1016/j.seizure.2024.10.018","DOIUrl":"10.1016/j.seizure.2024.10.018","url":null,"abstract":"<div><h3>Introduction</h3><div>Epilepsia Partialis Continua (EPC) is a challenging condition in which repetitive transcranial magnetic stimulation (rTMS) can induce a neuromodulation effect of potential diagnostic and therapeutic value.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted using Pubmed and Web of Science databases to identify cases of EPC who underwent rTMS, including children and adults. Additionally, we present two patients from our centre who underwent rTMS at a low frequency (0.5 Hz) with simultaneous EEG recording with the aim of assessing potential improvement in seizure frequency and severity.</div></div><div><h3>Results</h3><div>Eight articles were selected comprising 16 patients (15 with EPC and one with continuous myoclonia). In three of these patients, no clinical or EEG changes were noted; the remaining cases showed transitory clinical improvements. We report two patients with EPC, in whom low frequency rTMS was associated with transient reduction in frequency and severity of seizures and improvements in hand function and dexterity. In one of these cases, rTMS suggested a potential target for intracranial recordings, subacute cortical stimulation and localised resection.</div></div><div><h3>Conclusion</h3><div>In selected patients with EPC, rTMS can be used as a potential diagnostic and therapeutic tool.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"123 ","pages":"Pages 74-81"},"PeriodicalIF":2.7,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert opinion on use of vagus nerve stimulation therapy in the management of pediatric epilepsy: A Delphi consensus study","authors":"James W. Wheless ,&nbsp;Jeffrey S. Raskin ,&nbsp;Anthony L. Fine ,&nbsp;Kelly G. Knupp ,&nbsp;John Schreiber ,&nbsp;Adam P. Ostendorf ,&nbsp;Gregory W. Albert ,&nbsp;Eric H. Kossoff ,&nbsp;Joseph R. Madsen ,&nbsp;Prakash Kotagal ,&nbsp;Adam L. Numis ,&nbsp;Nisha Gadgil ,&nbsp;Deborah L. Holder ,&nbsp;Elizabeth A. Thiele ,&nbsp;George M. Ibrahim","doi":"10.1016/j.seizure.2024.10.013","DOIUrl":"10.1016/j.seizure.2024.10.013","url":null,"abstract":"<div><h3>Purpose</h3><div>To provide consensus-based recommendations for use of vagus nerve stimulation (VNS) therapy in the management of pediatric epilepsy.</div></div><div><h3>Methods</h3><div>Delphi methodology with two rounds of online survey was used to build consensus. A steering committee developed 43 statements related to pediatric epilepsy and the use of VNS therapy, which were evaluated by a panel of 12 neurologists/neurosurgeons with expertise in pediatric epilepsy, who graded their agreement with each statement on a scale of 1 (“I do not agree at all”) to 5 (“I strongly agree”). For each statement, consensus was established if ≥70% of the agreement scores were 4 or 5 and &lt;30% were 1 or 2 in the final survey.</div></div><div><h3>Results</h3><div>Twenty-four statements regarding the need for seizure reduction in pediatric epilepsy, the recommended treatment algorithm, the benefits and safety of VNS therapy, management of side effects of VNS therapy, patient selection for VNS therapy, and the use, dosing, and titration of VNS therapy achieved consensus. VNS and other neuromodulation therapies should be considered for pediatric patients with drug-resistant epilepsy who are not candidates for resective surgery, or who do not remain seizure free after resective surgery. When VNS therapy is initiated, the target dose range should be achieved via the fastest and safest titration schedule for each patient. Scheduled programming can be helpful in dose titration.</div></div><div><h3>Conclusion</h3><div>The expert consensus statements represent the panelists’ collective opinion on the best practice use of VNS therapy to optimize outcomes in the management of pediatric epilepsy.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"123 ","pages":"Pages 97-103"},"PeriodicalIF":2.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global survey of telemedicine use in epilepsy care – practices before, during and after the COVID-19 pandemic","authors":"Hsiang-Yu Yu ,&nbsp;Mamta Bhushan Singh ,&nbsp;Josephine Chan ,&nbsp;Pauline Samia ,&nbsp;Amza Ali ,&nbsp;Ji Yeoun Yoo ,&nbsp;Yanin Rivera ,&nbsp;Jitendra Kumar Sahu ,&nbsp;Patricia Osborne Shafer ,&nbsp;Bosanka Jocic-Jakubi ,&nbsp;Johan Zelano ,&nbsp;Ana Carolina Coan ,&nbsp;Roberto Horacio Caraballo ,&nbsp;Pablo Sebastián Fortini ,&nbsp;Najib Kissani ,&nbsp;J Helen Cross","doi":"10.1016/j.seizure.2024.10.012","DOIUrl":"10.1016/j.seizure.2024.10.012","url":null,"abstract":"<div><h3>Purpose</h3><div>Telemedicine was widely adopted for epilepsy care during the COVID-19 pandemic. Its role extends beyond preventing disease transmission, offering an efficient and high-quality care alternative. To understand the global scenario, an international group conducted a survey comparing telemedicine practices in epilepsy care before, during, and after the pandemic.</div></div><div><h3>Methods</h3><div>The survey included 26 questions on demographics, telemedicine use for epilepsy care, regulations, reimbursement mechanisms, and tools used. Responses were collected via an online survey platform from June to October 2023.</div></div><div><h3>Results</h3><div>Two hundred eighty-five respondents from 60 countries participated. The average telemedicine use in daily practice was 0 %, 0–10 % (median, IQR) before the pandemic, 65 %, 30–90 % during the pandemic, and 20 %,10–50 % after the COVID pandemic. Female respondents reported higher telemedicine use than males after the pandemic (25 %, 10–50 % vs 15 %, 5 %-30 %, <em>p</em> = 0.002). According to respondents' perceptions, post-pandemic telemedicine regulations flexibilities were reported as expanded by 36.8 %, restricted by 17.2 %, and unchanged by 46 %. Reimbursement for telemedicine increased during the pandemic but decreased afterward (Cochran's Q test, <em>p</em> &lt; 0.001). Voice calls were the most used telemedicine platform (46.6 %). Privacy issues were reported by 49 respondents (18.3 %).</div></div><div><h3>Conclusion</h3><div>Telemedicine use for epilepsy care increased during the pandemic and remained higher than pre-pandemic levels. However, improvements are needed in telemedicine applications, regulations, reimbursement, and patient privacy. International collaboration and experience sharing can enhance telemedicine's acceptance and practice globally.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"123 ","pages":"Pages 82-87"},"PeriodicalIF":2.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of association of first and second-line medication dosing and progression to refractory status epilepticus in children","authors":"Cristina Barcia Aguilar ,&nbsp;Marta Amengual-Gual ,&nbsp;J. Nicholas Brenton ,&nbsp;Kevin E. Chapman ,&nbsp;Justice Clark ,&nbsp;William D. Gaillard ,&nbsp;Joshua L. Goldstein ,&nbsp;Howard P. Goodkin ,&nbsp;Robert Kahoud ,&nbsp;Yi-Chen Lai ,&nbsp;Mohamad A. Mikati ,&nbsp;Lindsey A. Morgan ,&nbsp;Eric T. Payne ,&nbsp;Craig A. Press ,&nbsp;Latania Reece ,&nbsp;Tristan T. Sands ,&nbsp;Kumar Sannagowdara ,&nbsp;Theodore Sheehan ,&nbsp;Renée A. Shellhaas ,&nbsp;Robert C. Tasker ,&nbsp;Tobias Loddenkemper","doi":"10.1016/j.seizure.2024.10.017","DOIUrl":"10.1016/j.seizure.2024.10.017","url":null,"abstract":"<div><h3>Purpose</h3><div>Evaluate the relationship between first and second-line medication dosing and progression to refractory status epilepticus (RSE) in children.</div></div><div><h3>Methods</h3><div>This is a retrospective analysis of prospectively collected data from September 2014 to February 2020 of children with status epilepticus (SE) who received at least two antiseizure medications (ASMs). We evaluated the risk of developing RSE after receiving a low total benzodiazepine dose (lower than 100 % of the minimum recommended dose for each benzodiazepine dose administered within 10 min) and a low first non-benzodiazepine ASM dose (lower than 100 % of the minimum recommended dose of non-benzodiazepine ASM given as the first single-dose) using a logistic regression model, adjusting for confounders such as time to ASMs. The proportion of patients receiving low first non-benzodiazepine ASM doses was calculated and a logistic regression model was used to evaluate risk factors for low dosing of the first non-benzodiazepine ASM.</div></div><div><h3>Results</h3><div>Among 320 children, 170 (53.1 %) developed RSE, and 150 (46.9 %) responded to the first non-benzodiazepine ASM dose (non-RSE). One hundred thirty-seven (42.8 %) received a low total benzodiazepine dose, and 128 (40 %) received a low first non-benzodiazepine ASM dose. The odds of developing RSE were not higher after a low total benzodiazepine dose (OR=0.76, 95 %CI 0.47–1.23, <em>p</em> = 0.27) or low first non-benzodiazepine ASM dose (OR=0.85, 95 %CI 0.42–1.71, <em>p</em> = 0.65). Receiving a low first non-benzodiazepine ASM dose was independently associated with having received a low total benzodiazepine dose (OR=1.65, 95 %CI 1.01–2.70, <em>p</em> = 0.04).</div></div><div><h3>Conclusion</h3><div>For most patients, dosing variability in first and second-line medications for SE was not the sole clinical feature predicting progression to RSE in this cohort of benzodiazepine-resistant patients. Identification of additional modifiable clinical biomarkers that predict progression to RSE is needed. Though lower ASM doses did not predict RSE in this model, the administration of ASMs at doses likely to prevent RSE remains crucial in SE treatment.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"123 ","pages":"Pages 133-141"},"PeriodicalIF":2.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epileptic seizure as the prominent symptom in Fahr syndrome, case report and literature review","authors":"Mengyao Zhang ,&nbsp;Yu Jia ,&nbsp;Huifang Wang ,&nbsp;Aihua Liu ,&nbsp;Lehong Gao ,&nbsp;Yuping Wang","doi":"10.1016/j.seizure.2024.09.023","DOIUrl":"10.1016/j.seizure.2024.09.023","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"123 ","pages":"Pages 88-91"},"PeriodicalIF":2.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehospital seizure management protocols need standardized guidelines. A descriptive study from Norway","authors":"Ingrid Anette Hustad ,&nbsp;Morten Horn ,&nbsp;Marius Rehn ,&nbsp;Erik Taubøll ,&nbsp;Maren Ranhoff Hov","doi":"10.1016/j.seizure.2024.10.002","DOIUrl":"10.1016/j.seizure.2024.10.002","url":null,"abstract":"<div><h3>Background</h3><div>Patients with convulsive seizures constitute a significant group in acute neurology. No common European clinical practice guidelines on prehospital seizure management exist, and today most patients are brought to hospital for seizure treatment, with great variation in which prehospital treatment is provided. Only 33 % of status epilepticus patients receive a benzodiazepine as first anti-seizure medication (ASM). The aim of this study is to assess the prehospital seizure control protocols in the Emergency Medical Services (EMS) in Norway, and compare these with current evidence for acute management.</div></div><div><h3>Method</h3><div>We performed a descriptive analysis of the 18 regional EMS protocols in Norway and compared the findings with recent evidence on prehospital treatment. We analysed recommended drug and dosage, route of medication administration, number of additional rescue doses permitted, requirements for registration of type of seizures and seizure duration.</div></div><div><h3>Results</h3><div>The protocols vary in terms of preferred medication, administration method, dosage and recommendations regarding first- and second-line therapies. 33 % of protocols explicitly define status epilepticus according to contemporary guidelines, and 16.7 % have an operational definition of <em>when</em> to administer benzodiazepines. All protocols showed variations in dosing and administration instructions and only 28 % had a clearly stated first line treatment.</div></div><div><h3>Conclusion</h3><div>There are disparities in the prehospital seizure management protocols within the Norwegian healthcare system, a system comparable to other European countries. To improve seizure management there is a need for standardised guidelines for prehospital treatment.</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"123 ","pages":"Pages 92-96"},"PeriodicalIF":2.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of Mozart K.448 on interictal epileptiform discharges in adult patients with drug-resistant focal epilepsy: A crossover randomized controlled trial","authors":"Somjet Tosamran ,&nbsp;Thanaporn Pakotiprapha ,&nbsp;Thtiwat Asavalertpalakorn ,&nbsp;Thanakorn Kiatprungvech ,&nbsp;Totsapol Surawattanawong ,&nbsp;Chusak Limotai","doi":"10.1016/j.seizure.2024.10.016","DOIUrl":"10.1016/j.seizure.2024.10.016","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to validly assess the efficacy of Mozart K.448 on reducing interictal epileptiform discharges (IEDs) in adult patients with drug-resistant focal epilepsy (DRE).</div></div><div><h3>Methods</h3><div>This is a crossover RCT study. Adults with DRE were included. Stratified 1:1 randomization by epileptic foci i.e., temporal versus extratemporal foci, was performed. Intervention consisted of two study arms i.e., “Mozart arm” and “Control arm”. Study period encompassed 2 consecutive nights, each night consisted of baseline and intervention period. Outcomes were IED number and proportion of patients with significant IED reduction i.e., reduction ≥ 25 %. Within-group, within-subject and between-group analyses were used to test differences of IED number when listened to the Mozart piece as compared with baseline or with Control.</div></div><div><h3>Results</h3><div>Twenty-six patients were randomized; 13 in Mozart and 13 in Control arm. Overall, 16 (61.54 %) out of 26 patients had significant IED reduction when listening to the Mozart piece, as compared with only 7 (26.92 %) when continuing sleep (silence). Between-group analysis showed that IED number during intervention period i.e., listening to the Mozart piece in Mozart arm and silence in Control arm was significantly different, with a lower number in Mozart arm, 39.5 (IQR 89) vs 56.5 (IQR 114); <em>p</em> = 0.007.</div></div><div><h3>Conclusions</h3><div>Our study demonstrates an acute effect of the Mozart K.448 on reducing IEDs in adult patients with DRE. Patients with temporal rather than extratemporal lobe epilepsy better responded to the Mozart piece. Mozart K.448 is safe and feasible in real practice. Further RCT study assessing its long-term effect is warranted.</div></div><div><h3>Trial registration</h3><div>Thai Clinical Trials Registry, TCTR20231019005, 19 October 2023, “retrospectively registered”</div></div>","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"123 ","pages":"Pages 66-73"},"PeriodicalIF":2.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the connection: Insights into SARS-CoV-2 vaccines and status epilepticus","authors":"Fedele Dono ,&nbsp;Michelangelo Dasara ,&nbsp;Giacomo Evangelista ,&nbsp;Stefano Sensi","doi":"10.1016/j.seizure.2024.10.015","DOIUrl":"10.1016/j.seizure.2024.10.015","url":null,"abstract":"","PeriodicalId":49552,"journal":{"name":"Seizure-European Journal of Epilepsy","volume":"123 ","pages":"Pages 49-50"},"PeriodicalIF":2.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}