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Seminars in Pediatric Surgery最新文献

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Lymphatic failure and lymphatic interventions: Knowledge gaps and future directions for a new frontier in congenital heart disease 淋巴衰竭和淋巴干预：先天性心脏病新领域的知识差距和未来方向
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-06-01 DOI: 10.1016/j.sempedsurg.2024.151426
Benjamin Smood , Christopher Smith , Yoav Dori , Constantine D. Mavroudis , Stephanie Fuller , J. William Gaynor , Katsuhide Maeda
{"title":"Lymphatic failure and lymphatic interventions: Knowledge gaps and future directions for a new frontier in congenital heart disease","authors":"Benjamin Smood ,&nbsp;Christopher Smith ,&nbsp;Yoav Dori ,&nbsp;Constantine D. Mavroudis ,&nbsp;Stephanie Fuller ,&nbsp;J. William Gaynor ,&nbsp;Katsuhide Maeda","doi":"10.1016/j.sempedsurg.2024.151426","DOIUrl":"10.1016/j.sempedsurg.2024.151426","url":null,"abstract":"<div><p>Lymphatic failure is a broad term that describes the lymphatic circulation's inability to adequately transport fluid and solutes out of the interstitium and into the systemic venous circulation, which can result in dysfunction and dysregulation of immune responses, dietary fat absorption, and fluid balance maintenance. Several investigations have recently elucidated the nexus between lymphatic failure and congenital heart disease, and the associated morbidity and mortality is now well-recognized. However, the precise pathophysiology and pathogenesis of lymphatic failure remains poorly understood and relatively understudied, and there are no targeted therapeutics or interventions to reliably prevent its development and progression. Thus, there is growing enthusiasm towards the development and application of novel percutaneous and surgical lymphatic interventions. Moreover, there is consensus that further investigations are needed to delineate the underlying mechanisms of lymphatic failure, which could help identify novel therapeutic targets and develop innovative procedures to improve the overall quality of life and survival of these patients. With these considerations, this review aims to provide an overview of the lymphatic circulation and its vasculature as it relates to current understandings into the pathophysiology and pathogenesis of lymphatic failure in patients with congenital heart disease, while also summarizing strategies for evaluating and managing lymphatic complications, as well as specific areas of interest for future translational and clinical research efforts.</p></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 3","pages":"Article 151426"},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
State-of-the-art imaging for children with central lymphatic disorders 儿童中枢淋巴系统疾病的最新成像技术
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-06-01 DOI: 10.1016/j.sempedsurg.2024.151417
Karen I. Ramirez-Suarez , Sean Schoeman , Hansel J. Otero , Christopher L. Smith , David M. Biko
{"title":"State-of-the-art imaging for children with central lymphatic disorders","authors":"Karen I. Ramirez-Suarez ,&nbsp;Sean Schoeman ,&nbsp;Hansel J. Otero ,&nbsp;Christopher L. Smith ,&nbsp;David M. Biko","doi":"10.1016/j.sempedsurg.2024.151417","DOIUrl":"10.1016/j.sempedsurg.2024.151417","url":null,"abstract":"<div><p>Lymphatic imaging plays a crucial role in novel lymphatic interventions, offering valuable insights into central lymphatic drainage. Lymphatic system abnormalities may appear in various pediatric disorders, and accurate imaging is crucial for effective diagnosis and tailored therapeutic interventions. Traditional imaging modalities have offered valuable insights, but the demand for non-invasive, high-resolution techniques has fueled the development of innovative lymphatic imaging methods. In this review, we explore the state of the art in lymphatic imaging specifically within the context of pediatric surgery.</p></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 3","pages":"Article 151417"},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex lymphatic anomalies: Molecular landscape and medical management 复杂淋巴异常：分子结构和医疗管理
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-06-01 DOI: 10.1016/j.sempedsurg.2024.151422
Alexandra J. Borst , Allison Britt , Denise M. Adams
{"title":"Complex lymphatic anomalies: Molecular landscape and medical management","authors":"Alexandra J. Borst ,&nbsp;Allison Britt ,&nbsp;Denise M. Adams","doi":"10.1016/j.sempedsurg.2024.151422","DOIUrl":"10.1016/j.sempedsurg.2024.151422","url":null,"abstract":"<div><p>The lymphatic system is one of the most essential and complex systems in the human body. Disorders that affect the development or function of the lymphatic system can lead to multi-system complications and life-long morbidity. The past two decades have seen remarkable progress in our knowledge of the basic biology and function of the lymphatic system, the molecular regulators of lymphatic development, and description of disorders associated with disrupted lymphangiogensis. In this chapter we will touch on the clinical features of complex lymphatic anomalies, new molecular knowledge of the drivers of these disorders, and novel developmental therapeutics for lymphatic disease.</p></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 3","pages":"Article 151422"},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141132520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphatic interventions in congenital heart disease 先天性心脏病的淋巴管介入治疗
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-06-01 DOI: 10.1016/j.sempedsurg.2024.151419
Christopher L. Smith , Ganesh Krishnamurthy , Abhay Srinivasan , Yoav Dori
{"title":"Lymphatic interventions in congenital heart disease","authors":"Christopher L. Smith ,&nbsp;Ganesh Krishnamurthy ,&nbsp;Abhay Srinivasan ,&nbsp;Yoav Dori","doi":"10.1016/j.sempedsurg.2024.151419","DOIUrl":"10.1016/j.sempedsurg.2024.151419","url":null,"abstract":"<div><p>Congenital heart disease affects 1/100 live births and is one of the most common congenital abnormalities. The relationship between congenital heart disease and lymphatic abnormalities and/or dysfunction is well documented and can be grossly divided into syndromic and non-syndromic etiologies. In patients with genetic syndromes (as examples listed above), there are known primary abnormal lymphatic development leading to a large pleiotropic manifestation of lymphatic dysfunction. Non-syndromic patients, or those without clear genetic etiologies for their lymphatic dysfunction, are often thought to be secondary to physiologic abnormalities as sequelae of congenital heart disease and palliative surgeries. Patients with congenital heart disease and lymphatic dysfunction have a wide variety of clinical manifestations for which there were not many therapeutic interventions available. The development of new imaging techniques allows us to understand better the pathophysiology of these problems and to develop different percutaneous interventions aiming to restore normal lymphatic function.</p></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 3","pages":"Article 151419"},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical management of chronic lymphatic pleural effusions and chronic lymphatic ascites 慢性淋巴性胸腔积液和慢性淋巴性腹水的手术治疗
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-05-23 DOI: 10.1016/j.sempedsurg.2024.151420
Pablo Laje, Yoav Dori, Christopher Smith, Katsuhide Maeda
{"title":"Surgical management of chronic lymphatic pleural effusions and chronic lymphatic ascites","authors":"Pablo Laje,&nbsp;Yoav Dori,&nbsp;Christopher Smith,&nbsp;Katsuhide Maeda","doi":"10.1016/j.sempedsurg.2024.151420","DOIUrl":"https://doi.org/10.1016/j.sempedsurg.2024.151420","url":null,"abstract":"<div><p>Patients with central lymphatic conduction disorders commonly have recalcitrant pleural effusions and or ascites. These conditions cause a profound deterioration in the patient's quality of life. Support measures such as low-fat diet and diuretics alone hardly ever provide meaningful improvement. New understanding of the pathophysiology of these disorders has opened the door in recent years to the development of several surgical procedures that have remarkable success rates. However, these patients must be managed by expert multidisciplinary teams.</p></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 3","pages":"Article 151420"},"PeriodicalIF":1.7,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141095220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical care management of patients with lymphatic conduction disorders 淋巴传导障碍患者的重症监护管理
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-05-23 DOI: 10.1016/j.sempedsurg.2024.151423
Aaron DeWitt, Erin Pinto, Lauren Biroc, Meghan Scott, Felina Mille, Emmanuelle Favilla, Danish Vaiyani, Samuel Rosenblatt
{"title":"Critical care management of patients with lymphatic conduction disorders","authors":"Aaron DeWitt,&nbsp;Erin Pinto,&nbsp;Lauren Biroc,&nbsp;Meghan Scott,&nbsp;Felina Mille,&nbsp;Emmanuelle Favilla,&nbsp;Danish Vaiyani,&nbsp;Samuel Rosenblatt","doi":"10.1016/j.sempedsurg.2024.151423","DOIUrl":"https://doi.org/10.1016/j.sempedsurg.2024.151423","url":null,"abstract":"<div><p>Lymphatic dysfunction in critical illness is complex. Primary complex lymphatic anomalies can lead to profound organ dysfunction, particularly respiratory failure and shock. Critical illness, the complications of critical illness, and the procedures and therapies used to treat critical illness, can lead to secondary lymphatic dysfunction. This is most often seen with congenital and acquired cardiovascular disease and respiratory disease. The critical care management of these patients requires an expert multidisciplinary team.</p></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 3","pages":"Article 151423"},"PeriodicalIF":1.7,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141095222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical management of thoracic duct anomalies 胸导管异常的手术治疗
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-05-23 DOI: 10.1016/j.sempedsurg.2024.151421
Pablo Laje, Yoav Dori, Christopher Smith, Katsuhide Maeda
{"title":"Surgical management of thoracic duct anomalies","authors":"Pablo Laje,&nbsp;Yoav Dori,&nbsp;Christopher Smith,&nbsp;Katsuhide Maeda","doi":"10.1016/j.sempedsurg.2024.151421","DOIUrl":"https://doi.org/10.1016/j.sempedsurg.2024.151421","url":null,"abstract":"<div><p>The development of new imaging techniques for the study of the central lymphatic system allows us to understand the anatomy and pathophysiology of all the disorders of the thoracic duct. With the help of catheters placed percutaneously in the thoracic duct, we can do now complex operations on the thoracic duct to restore its functionality. Advance imaging, expert percutaneous skills, and expert microsurgical skills are critical to the success of these interventions.</p></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 3","pages":"Article 151421"},"PeriodicalIF":1.7,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141095221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perianal disease: Updates and controversies in closing the gaps 肛周疾病：缩小差距的最新进展与争议
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-04-01 DOI: 10.1016/j.sempedsurg.2024.151402
Samir K. Gadepalli , Jeremy Adler
{"title":"Perianal disease: Updates and controversies in closing the gaps","authors":"Samir K. Gadepalli ,&nbsp;Jeremy Adler","doi":"10.1016/j.sempedsurg.2024.151402","DOIUrl":"10.1016/j.sempedsurg.2024.151402","url":null,"abstract":"<div><p>Perianal complications are common and morbid in children with Crohn’s disease. In this review, we describe the epidemiology, the presentation and diagnosis, evaluation and management. We focus on updates such as the increasing frequency of biologic medications and MRI for evaluation. We also highlight controversies on the timing and approaches to surgical techniques. Finally, perianal disease requires the coordination of multidisciplinary care with nursing, radiology, gastroenterology, and surgery to optimize outcomes – both medical and patient-centered.</p></div>","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 2","pages":"Article 151402"},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140401662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory bowel disease – evolving therapeutic approaches to a hidden epidemic 炎症性肠病--针对隐性流行病的不断演变的治疗方法
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-04-01 DOI: 10.1016/j.sempedsurg.2024.151407
Lisa McMahon , Samir K. Gadepalli
{"title":"Inflammatory bowel disease – evolving therapeutic approaches to a hidden epidemic","authors":"Lisa McMahon ,&nbsp;Samir K. Gadepalli","doi":"10.1016/j.sempedsurg.2024.151407","DOIUrl":"https://doi.org/10.1016/j.sempedsurg.2024.151407","url":null,"abstract":"","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 2","pages":"Article 151407"},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140539137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
fm i -- Contents FM I -- 目录
IF 1.7 3区 医学
Seminars in Pediatric Surgery Pub Date : 2024-04-01 DOI: 10.1053/S1055-8586(24)00032-5
{"title":"fm i -- Contents","authors":"","doi":"10.1053/S1055-8586(24)00032-5","DOIUrl":"https://doi.org/10.1053/S1055-8586(24)00032-5","url":null,"abstract":"","PeriodicalId":49543,"journal":{"name":"Seminars in Pediatric Surgery","volume":"33 2","pages":"Article 151411"},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140818492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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