Seminars in Radiation Oncology最新文献_第2页

Biological Effects of Low-Dose Radiation Therapy: From Mechanistic Aspects to Translational Approaches and Challenges 低剂量放射治疗的生物学效应：从机制方面到转化方法和挑战

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2026-01-01 Epub Date: 2025-12-12 DOI: 10.1016/j.semradonc.2025.10.001

Anna-Jasmina Donaubauer PhD , Lia Mogge MSc , Philipp Schubert PhD , Rainer Fietkau PhD , Oliver J. Ott PhD , Benjamin Frey PhD , Udo S. Gaipl PhD

{"title":"Biological Effects of Low-Dose Radiation Therapy: From Mechanistic Aspects to Translational Approaches and Challenges","authors":"Anna-Jasmina Donaubauer PhD , Lia Mogge MSc , Philipp Schubert PhD , Rainer Fietkau PhD , Oliver J. Ott PhD , Benjamin Frey PhD , Udo S. Gaipl PhD","doi":"10.1016/j.semradonc.2025.10.001","DOIUrl":"10.1016/j.semradonc.2025.10.001","url":null,"abstract":"<div><div>Low dose radiation therapy (LDRT) is commonly applied for its pain and symptom-relieving effects in the treatment of different benign diseases, such as chronic degenerative and inflammatory, or hyperproliferative disorders. Most clinical trials report a beneficial therapeutic effect of LDRT and further, robust preclinical evidence on the biological modes of action of LDRT is existent. In chronic degenerative and inflammatory diseases such as osteoarthritis, LDRT can ameliorate inflammatory processes and impacts positively on the bone metabolism. A key mechanism is the modulation of the endothelium and the phenotype of macrophages. In the bone, the deposition of new bone matrix is supported, while bone degradation is diminished. In hyperproliferative disorders, the main mode of action is the inhibition of the differentiation and proliferation of fibroblasts and myofibroblasts, along with a modulation of inflammatory mediators, such as cytokines. Even though comprehensive preclinical evidence supports the use of LDRT, biological mechanistic insights from randomized clinical trials is mostly missing for LDRT and indicates a significant translational gap. Apart from preclinical data, the evidence for LDRT is based largely on observational clinical trials, with only limited randomized and placebo-controlled trials available. In the future, rigorously designed randomized disease-specific studies with standardized protocols, translational research programs and objectifiable clinical and biological endpoints are needed to establish LDRT as precise and evidence-based therapy.</div></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"36 ","pages":"Pages 23-38"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Radiotherapy for Non-Malignant Diseases: The Potential of Ionizing Radiation Beyond Cancer Treatment 非恶性疾病的功能放疗：电离辐射在癌症治疗之外的潜力

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2026-01-01 Epub Date: 2025-12-12 DOI: 10.1016/j.semradonc.2025.11.002

Alexander Rühle MD, MHBA , Thomas F. DeLaney MD

{"title":"Functional Radiotherapy for Non-Malignant Diseases: The Potential of Ionizing Radiation Beyond Cancer Treatment","authors":"Alexander Rühle MD, MHBA , Thomas F. DeLaney MD","doi":"10.1016/j.semradonc.2025.11.002","DOIUrl":"10.1016/j.semradonc.2025.11.002","url":null,"abstract":"<div><div>This special issue, “<em>Functional Radiotherapy for Non-Malignant Diseases – The Potential of Ionizing Radiation Beyond Cancer Treatment”</em>, addresses one of the oldest yet often overlooked areas of radiation medicine: the therapeutic use of ionizing radiation for non-malignant disorders. More than a century after the first medical use of X-rays, functional radiotherapy for non-malignant diseases is experiencing a renaissance, supported by growing clinical and biological evidence. The articles in this issue span the historical evolution, mechanistic underpinnings, and modern clinical applications of radiotherapy across diverse indications. They address topics such as the biological effects and potential carcinogenic risks of low-dose irradiation, radiotherapy for osteoarthritis and periarticular soft-tissue disorders, benign and premalignant tumors, Graves’ ophthalmopathy, and hyperproliferative diseases including Dupuytren’s and Ledderhose’s disease, among others. Emerging applications such as stereotactic arrhythmia radioablation and functional radiotherapy for neurological or psychiatric disorders further extend its scope. Together, these contributions illustrate how radiotherapy for non-malignant diseases has evolved from empirical practice to a scientifically grounded therapy aimed at functional restoration. In the future, the establishment of standardized protocols, international registries, and prospective clinical trials will be essential to validate efficacy and safety, thereby defining the evolving role of radiotherapy beyond cancer treatment.</div></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"36 ","pages":"Pages 1-2"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

130 Years of Radiotherapy for Nonmalignant Diseases: A Historical Overview 130年来非恶性疾病放疗的历史回顾

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2026-01-01 Epub Date: 2025-12-12 DOI: 10.1016/j.semradonc.2025.11.004

Oliver Micke PhD , Michael Oertel PhD , Ralph Muecke PhD , Hans T. Eich PhD , Jan Kriz PhD

{"title":"130 Years of Radiotherapy for Nonmalignant Diseases: A Historical Overview","authors":"Oliver Micke PhD , Michael Oertel PhD , Ralph Muecke PhD , Hans T. Eich PhD , Jan Kriz PhD","doi":"10.1016/j.semradonc.2025.11.004","DOIUrl":"10.1016/j.semradonc.2025.11.004","url":null,"abstract":"<div><div>Radiotherapy has long been associated with the treatment of malignant tumors, yet its application in nonmalignant (benign) diseases predates many contemporary oncologic indications and has played a critical role in shaping the broader field of radiation medicine in early times. As of 2025, roughly 130 years have elapsed since the first experimental clinical applications of X‑rays and radium for non‑malignant conditions, and a review of this period may provide insights both into medical innovation and the trade‑offs inherent in using potentially harmful agents for nonmalignant indications. Such a historical overview can help us understand past missteps, guide present practice, and shape future research, especially in defining indications, optimizing dose/fractionation schedules, and ensuring long‑term monitoring of outcomes and risks. Our review will touch cornerstones and landmarks of the long and widely branched history of radiotherapy and also looks at the biographies of important pioneers of the field, so that we can learn from their thinking, research and experience.</div></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"36 ","pages":"Pages 3-17"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative Radiation for Pancreatic Cancer 胰腺癌术中放射治疗

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2025-10-01 Epub Date: 2025-09-09 DOI: 10.1016/j.semradonc.2025.07.008

Ahmed Elguindy , Dukagjin Blakaj , John Grecula , Eric D. Miller

引用次数: 0

Emerging Systemic Therapy Considerations for Pancreatic Cancer 胰腺癌新出现的全身治疗考虑

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2025-10-01 Epub Date: 2025-09-09 DOI: 10.1016/j.semradonc.2025.07.006

Kai-li Liang , Matthew Z. Guo , Neeha Zaidi

引用次数: 0

Driving Precision Medicine in Pancreatic Cancer With Molecular Genetics 分子遗传学推动胰腺癌精准医疗

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2025-10-01 Epub Date: 2025-09-09 DOI: 10.1016/j.semradonc.2025.08.004

Maria Farooq , Michael J. Pishvaian

引用次数: 0

Adjuvant Radiation for Resected Pancreatic Cancer: Historical Review and Current State 胰腺癌切除术的辅助放疗：历史回顾与现状

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2025-10-01 Epub Date: 2025-09-09 DOI: 10.1016/j.semradonc.2025.07.009

John Starner , Yen-Ruh Wuu , Nicholas Hornstein , Karyn A. Goodman , Joseph M. Herman , Ross Abrams , Leila T. Tchelebi

引用次数: 0

Optimal Target Volume Delineation for Pancreatic Cancer: Triangulating What Should be Targeted 胰腺癌的最佳靶体积描绘：三角定位应该是什么

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2025-10-01 Epub Date: 2025-09-09 DOI: 10.1016/j.semradonc.2025.08.003

Amol Narang

引用次数: 0

Beyond Opioids in Pancreatic Cancer: Palliative Radiotherapy and Celiac Plexus Radiosurgery 胰腺癌中的阿片类药物：姑息性放疗和腹腔丛放射手术

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2025-10-01 Epub Date: 2025-09-09 DOI: 10.1016/j.semradonc.2025.07.005

Marcin Miszczyk , Ross A. Abrams , Yaacov R. Lawrence

{"title":"Beyond Opioids in Pancreatic Cancer: Palliative Radiotherapy and Celiac Plexus Radiosurgery","authors":"Marcin Miszczyk , Ross A. Abrams , Yaacov R. Lawrence","doi":"10.1016/j.semradonc.2025.07.005","DOIUrl":"10.1016/j.semradonc.2025.07.005","url":null,"abstract":"<div><div>This review examines established and evolving approaches for radiation therapy as a palliative treatment modality in patients with pancreatic cancer within the context of effective patient-provider communication and early palliative care team based management. At presentation most patients with pancreatic cancer have advanced disease and a limited life expectancy. Typically, they suffer from multiple disease-related symptoms. Systemic therapies have limited palliative efficacy against symptoms associated with local disease. This is in contrast to radiation therapy, which appears efficient in achieving local symptom control. In addition to more conventional tumour-targeting stereotactic body radiation therapy (SBRT), and short-course conventional radiotherapy, a recent clinical trial demonstrated the effectiveness of a new approach - celiac plexus radiosurgery. In this article, we evaluate and compare the effectiveness of these treatment methods, demonstrating the important, yet underappreciated, role that hypofractionated radiation therapy has within the multidisciplinary management of patients with pancreatic cancer, including those with metastatic disease.</div></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"35 4","pages":"Pages 546-555"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality and Quantity: Dual Benefits of Ablative Radiation in Oligometastatic Pancreatic Cancer 质与量：消融放疗治疗少转移性胰腺癌的双重益处

IF 3.2 3区医学

Seminars in Radiation Oncology Pub Date : 2025-10-01 Epub Date: 2025-09-09 DOI: 10.1016/j.semradonc.2025.07.004

Todd A. Aguilera , Ahmed M. Elamir , Ethan B. Ludmir

{"title":"Quality and Quantity: Dual Benefits of Ablative Radiation in Oligometastatic Pancreatic Cancer","authors":"Todd A. Aguilera , Ahmed M. Elamir , Ethan B. Ludmir","doi":"10.1016/j.semradonc.2025.07.004","DOIUrl":"10.1016/j.semradonc.2025.07.004","url":null,"abstract":"<div><div>Oligometastatic pancreatic cancer (OPanc) poses significant opportunities in management, as increasingly metastases can be safely and effectively targeted with local therapy. We review the existing literature on SABR for OPanc, highlighting its potential benefits and limitations with an aim to define the trajectory of opportunity. SABR may offer a meaningful benefit to patients with OPanc, improving quality of life by enabling breaks from systemic therapy while potentially enhancing quantity of life or survival. Patient selection and clearly defined goals will be critical to demonstrate the value of this approach, and well powered prospective studies may be key. The most intriguing aspect of this discussion is the potential for SABR to enhance antitumor immunity that may play a role in prolonged minimal residual disease that can be achieved in some patients. This can translate to improved quality of life by reducing the need for systemic therapy. This approach may offer a novel solution to the treatment challenges associated with OPanc. Further research is needed to confirm the hypotheses and establish the definitive role of SABR in OPanc treatment.</div></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"35 4","pages":"Pages 538-545"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0