Archives of current medical research (ACMR)最新文献

{"title":"Antimalarial activity of amodiaquine-moxifloxacin: A study in mice.","authors":"Elias ADIKWU>, Confidence Orgechi NWORGU, Simeon IGONO AJEKA","doi":"10.47482/acmr.1140050","DOIUrl":"https://doi.org/10.47482/acmr.1140050","url":null,"abstract":"Background: The search for new partner drugs to increase the therapeutic activity of existing antimalarial drugs is important because of decreased Plasmodium susceptibility. Amodiaquine (AQ) is an antimalarial drug. Moxifloxacin (MX) is a fluoroquinolone antibiotic with promising antiplasmodial activity. This study evaluated the benefit of MX as a partner drug with AQ for malaria treatment in Plasmodium berghei-infected mice. Methods: Adult Swiss albino mice (28-35g) of both sexes, randomly grouped and inoculated with Plasmodium berghei were used. The mice were treated orally with AQ (10 mg/kg), MX (6 mg/kg) and AQ-MX, respectively using the curative, prophylactic and suppressive protocols. Blood samples were collected and assessed for percentage parasitemia and hematological indices. Liver samples were assessed for histological changes. Mean survival time (MST) was observed in treated mice. Results: The curative, prophylactic and suppressive tests showed that AQ-MX decreased percentage parasitemia with difference observed at p","PeriodicalId":495147,"journal":{"name":"Archives of current medical research (ACMR)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135305483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological evaluation of parasitic infections in appendectomy specimens","authors":"Murat KARTAL>, Tolga KALAYCI>, Yaşar ÇÖPELCİ>, Ali KURT>","doi":"10.47482/acmr.1141714","DOIUrl":"https://doi.org/10.47482/acmr.1141714","url":null,"abstract":"Background: This study aimed to determine the incidence of parasitic infections in adult patients who underwent appendectomy and to evaluate the clinicopathological features of parasitic infections in appendectomy specimens.
 Methods: Patients who underwent appendectomy between January 2018 and December 2019 with a pre-diagnosis of acute appendicitis (AA) and reported parasitic infection in appendectomy specimens were evaluated retrospectively. Demographic data, comorbidities, clinical and radiological findings, laboratory results, surgical methods, length of hospital stay, postoperative complications, and histopathological examination reports were analyzed.
 Results: 939 adult patients underwent appendectomy with a pre-diagnosis of AA. Upon detecting parasitic infection in the histopathological examination, thirty-one (3.3%) patients were included in this study. Twenty (64.5%) patients were women, and the overall mean age was 31.9 years (18-70 years). Twenty-three (74.2%) patients had Enterobius vermicularis, and 8 (25.8%) patients had Tenia saginata. On laboratory examination, the mean percentage of monocytes was only higher in the Taenia saginata group (0.80 vs. 0.66; p=0.039). Both ultrasonography findings and tomography findings were similar in both groups. The morbidity rate of the study was 12.9% (n=4). There was no difference between the two groups regarding the length of hospital stay and morbidity. 
 Conclusions: Parasitic infections may cause symptoms mimicking acute appendicitis. It should be kept in mind that even in patients with a diagnosis of parasitic intestinal infection, symptoms may have been caused by acute appendicitis, not solely due to parasitic infection.","PeriodicalId":495147,"journal":{"name":"Archives of current medical research (ACMR)","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135305482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness Of Anakinra Therapy On Covid-19 Patients In Icu","authors":"Elmas UYSAL, Işıl ÖZKOÇAK TURAN, Handan ANKARALI","doi":"10.47482/acmr.1129700","DOIUrl":"https://doi.org/10.47482/acmr.1129700","url":null,"abstract":"Background: There is no consensus on effective treatments for COVID-19 disease yet. Our aim; To observe the clinical and laboratory results of anakinra treatment on intensive care patients and to contribute to the literature on its usefulness. Material and Methods: The characteristics of the patients receiving Anakinra treatment in the COVID ICU of xx were retrospectively reviewed. The patients' ages, gender, mechanical ventilation (MV) duration, length of stay in the intensive care unit, CRP, procalcitonin, LDH, IL-6, lymphocyte, Dv dimer, ferritin values and the corticosteroid doses they received in addition to Anakinra treatment were also evaluated. In addition, the data of the patient group who did not receive Anakinra but received high-dose (≥250 mg) methylprednisolone (MPZ) treatment were compared with the present patient data and evaluated in terms of treatment effectiveness. Results: When the patients that receiving Anakinra+high-dose MPZ are compared with the patient group receiving only high-dose MPZ,it was seen that the mortality rate is significantly higher (P=0.038), MV and hospitalization days in the intensive care unit were significantly longer in patients receiving Anakinra (p=0.001, p=0.004). However, there was no significant difference in secondary reproduction rates between the two groups (P=0.484). As the mean hospitalization days of the group receiving Anakinra + high-dose MPZ and the group receiving Anakinra + low-dose (<250mg) MPZ were found to be significantly longer in the group receiving Anakinra + high-dose steroids (p=0.018), there was no significant difference in terms of MV time and mortality rates (p=0.193, p=1.0). Conclusion: In our study, the patients who received Anakinra treatment had a longer hospitalization day and MV period, and the higher mortality rate was attributed to this patient group who had a more severe course. It was observed that the use of anakinra treatment after low-dose and high-dose MPZ treatment did not cause a significant difference in mortality rates. However, due to the small number of patients and the heterogeneity of the patient group, more comprehensive and randomized studies are needed.","PeriodicalId":495147,"journal":{"name":"Archives of current medical research (ACMR)","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135441441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of linear measurements made using panoramic radiography in pre-implant site assessment: actual vs. measured","authors":"Raif ALAN>, Ahmet ERBEYOĞLU>","doi":"10.47482/acmr.1174345","DOIUrl":"https://doi.org/10.47482/acmr.1174345","url":null,"abstract":"Background: In order to reduce post-operative failure and ensure successful rehabilitation, patients scheduled for dental implant treatment are often evaluated pre-operatively using radiographic images in addition to clinical examination. This study aimed to investigate the reliability of digital panoramic radiography in the pre-implant site assessment. 
 
 Methods: Panoramic images of 150 patients with the total of the 396 implants placed in the maxilla (n=165) and mandible (n=231), were examined in the study. Radiographic measurements (vertical and horizontal) were recorded on the computer using the automatic calibration tab for each radiograph and compared with the actual implant dimensions. Moreover, the effects of location, gender, and change in dimensions on magnification rate (MR) were also investigated. The measurements were made by two experienced observers. 
 
 Results: Panoramic vertical measurements were significantly higher in both the maxilla and mandible compared to the actual implant lengths (p","PeriodicalId":495147,"journal":{"name":"Archives of current medical research (ACMR)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135305481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Kidney Disease Observational Cohort Study And Assessment Of Baseline Characteristics And Their Relationship With Diabetes Status And Kidney Function","authors":"Sümeyra KOYUNCU, Koray ULUDAG, Ali İhsan GÜNAL","doi":"10.47482/acmr.1142775","DOIUrl":"https://doi.org/10.47482/acmr.1142775","url":null,"abstract":"Background: Chronic kidney disease (CKD) may result in end-stage renal disease (ESRD), and undesirable outcomes such as death and dialysis. We carried out an observational cohort study to ascertain risk factors for the renal outcomes, all-cause mortality in patients with CKD. In this report, we studied the baseline demographic and laboratory characteristics of the cohort. Methods: A single-center, retrospective, observational cohort study was conducted at the outpatient Nephrology Clinic of Health Sciences University, Kayseri Medical Faculty, from January 1, 2010, to December 31, 2020. Age 18 to 70 years and eGFR 15 to 59 mL/min/1.73 m2 were inclusion criteria. Baseline demographic and laboratory data were documented. Results: One thousand seventy-three patients with CKD were enrolled in the study. Mean (SD) age was 55.87 (8.83) years, and 53.2% were men. %45.9 and %84.4 had diabetes mellitus and hypertension, respectively. The mean body mass index was 26.73 (3.95) kg/m2. Mean eGFR was 34.14 (10.45) mL/min/1.73 m2 using chronic kidney disease epidemiology collaboration. Median (p25-p75) urinary protein-creatinine ratio was 48.80 [22.40, 89.00] mg/mmol. Older patients had a lower eGFR, and the male gender was more common at stage 3 patients. Stage 4 patients had lower hemoglobin and serum calcium levels. Also, low eGFR was associated with high uric acid levels. Conclusion: This study along with future analysis may elucidate the natural history and clinical consequences of CKD. Controllable factors could be understood, and CKD progression and adverse outcomes may be prevented in this way.","PeriodicalId":495147,"journal":{"name":"Archives of current medical research (ACMR)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135441443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}