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{"title":"Potential of Trans-Resveratrol in the Prevention of Menopausal Disorders and Age-Associated Morbidity","authors":"P.V. Kozlov","doi":"10.31550/1727-2378-2023-22-5-62-68","DOIUrl":"https://doi.org/10.31550/1727-2378-2023-22-5-62-68","url":null,"abstract":"Aim: to investigate alternative option to prevent age-associated pathology in women, caused, by progressive decrease of estrogen level during the menopausal transition period. Key points. If there are contraindications to the menopausal hormone therapy or at the examination stage, the choice of alternative methods for prevention and treatment of menopausal symptoms and systemic metabolic disorders should correspond to a high safety and efficacy profile. This review describes in detail the pharmacological effects of the phytoestrogen resveratrol, the mechanisms of the implementation of estrogen-like, antiproliferative, anti-inflammatory and antioxidant effects and the possibility of clinical use in the form of dietary supplements. Conclusion. The prescription of the phytoestrogen trans-resveratrol is an alternative approach to the relief of menopausal disorders and the prevention of systemic metabolic disorders. Possessing as high bio-active and optimal safe alternative due to trans-isomer form, it is the optimal non-hormonal remedy for correcting menopausal symptoms, inhibiting some aging processes, and also has a significant potential for preventing age-related diseases. Keywords: phytoestrogens, menopausal syndrome, postmenopause, resveratrol.","PeriodicalId":494981,"journal":{"name":"Доктор.ру","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135562006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomorphological Diagnostics of Infectious Diseases of the Female Genital Sphere from the Perspective of Personalized Medicine","authors":"S.O. Dubrovina, O.V. Voronova, M.A. Akimenko, D.Yu. Bogunova, E.I. Loginova","doi":"10.31550/1727-2378-2023-22-5-81-88","DOIUrl":"https://doi.org/10.31550/1727-2378-2023-22-5-81-88","url":null,"abstract":"To date, the course of urogenital infections is characterized by asymptomatic or erased forms, but sexually transmitted infections (STIs) do not become less dangerous and can cause severe complications such as infertility, ectopic pregnancy, chronic diseases, intrauterine fetal damage, congenital pathology and diseases in newborn children. Taking into account the extreme urgency of the problem of timely diagnosis and adequate correction of endocervix pathology, the lack of clear cytomorphological parallels with clinical data, a very significant practical and scientific interest is the comparison of the results of cytomorphological research with diagnostic data using polymerase chain reaction. This will expand the possibilities of interpreting the cytological method as a primary study for further diagnosis and treatment. Аim: to analyze the results of cytomorphological studies of the urogenital tract of women with sexually transmitted infections of various etiologies and to assess their significance for a personal approach to treatment. Design: Prospective cohort study. Materials and methods. For a comprehensive cytomorphological study, data on 335 female patients (mean age 31.6 ± 8.2 years) with uncomplicated urogenital chlamydia (n = 18), papillomavirus (n = 97), herpetic (n = 26), mycotic (n = 41) infections, trichomoniasis (n = 12) and mixed forms were analyzed infectious lesion (n = 141). Results. If there is a history of STIs, it becomes necessary to identify concomitant genital infections and vaginal dysbiosis. It is difficult to determine which pathogen caused the \"launch\" of inflammatory reactions, and which one joined a second time and aggravated the course of the disease. A combination of candidiasis and chlamydial infection, candidiasis and viral lesions, chlamydial infection and viral lesions is possible, therefore, in addition to molecular genetic and serological diagnostics, cytomorphological methods are necessary for the diagnosis of STIs. Conclusion. The modern cytomorphological methods used for the diagnosis of infections of the female genital sphere allow us to quickly and reliably determine the type of pathogen and the nature of the process, which could help clinicians to choose the appropriate therapy correctly, to prevent the transition of the disease to the chronic stage, to avoid complications and the development of neoplastic processes. Keywords: cytomorphological diagnostics, sexually transmitted infections, traditional cytology, liquid cytology, personalized medicine.","PeriodicalId":494981,"journal":{"name":"Доктор.ру","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135561994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of Occurrence, Main Risk Factors and Effectiveness of Treatment of Patients with Postpartum Hemorrhage","authors":"N.V. Artymuk, T.Yu. Marochko, S.V. Apresyan, D.A. Artymuk, N.M. Shibelgut, N.A. Batina, A.A. Khludentsova","doi":"10.31550/1727-2378-2023-22-5-14-19","DOIUrl":"https://doi.org/10.31550/1727-2378-2023-22-5-14-19","url":null,"abstract":"Aim: to evaluate the frequency of postpartum hemorrhage (PPH) in a high risk hospital, to conduct a comparative assessment of the clinical, historical and laboratory features of patients with PPH, and the effectiveness of the algorithm of PPH management after vaginal birth (VB) and caesarean section (CS). Design: retrospective study. Material and methods. The study included 15,480 patients. The frequency of early PPH and the effectiveness of applying a local stepwise algorithm for management of PPH were evaluated. Clinical historical and laboratory data were obtained by copying from the primary documentation. Results. The incidence of PPH in a high risk hospital is 0.67%. The most significant risk factor for PPH is the induction of labor, but more than a third of women do not have significant risk factors. The volume of blood loss after CS was 1218.29 ± 728.15 ml, after VB — 784.12 ± 304.44 ml (p<0.001). Uterine balloon tamponade was used in 28 (44.4%) women with PPH after VB and in 27 (65.9%) after CS (χ2 = 4.600; p = 0.142). Compression sutures on the uterus were used in 12 (29.3%) patients after CS and in 3 (2.9%) puerperas after VB (χ2 = 2.8; p = 0.001). Hysterectomy was performed in 4 (9.8%) cases only after CS. Conclusion: The existing algorithms for management PPH are highly effective and allow avoiding hysterectomy in VB in 100% of cases, in CS — in 90.2%. Keywords: postpartum hemorrhage, uterotonics, controlled balloon tamponade, complex compression haemostasis.","PeriodicalId":494981,"journal":{"name":"Доктор.ру","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135562005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Forms of Psychotic Disorders Associated with Synthetic Cathinones Consumption","authors":"V.V. Severtsev, A.A. Budanova","doi":"10.31550/1727-2378-2023-22-6-21-27","DOIUrl":"https://doi.org/10.31550/1727-2378-2023-22-6-21-27","url":null,"abstract":"Aim: study and analysis of psychopathological and clinical features of psychotic disorders associated with the use of synthetic cathinones. Materials and methods. The study design was observational, comparative, prospective. The study involved 98 patients treated in the Acute Poisoning Unit, the Emergency Addiction Treatment Unit and the Line Addiction Treatment Unit. In terms of gender, males predominated (n = 58; 59.2%), females accounted for 40.8% (n = 40). Median age — 30 years (Q1–Q3 — 22–33). In the first phase of the study, patients were screened and included in the study according to inclusion/non-inclusion criteria; in the second phase, the clinical picture of psychosis was analysed, depending on the leading syndrome patients were divided into three groups; In the third stage, patients were monitored for 12 months. The Brief Psychiatric Rating Scale (BPRS) was used to objectify the assessment of the severity and dynamics of psychotic symptoms. In the third stage there was 79 participants in the study, the rest of the patients refused to continue participation after 2 months or more. Results. There are three main clinical forms of psychotic disorders developing due to the use of synthetic cathinones: delirious, delusional, polymorphic. Each form had its own clinical and dynamical features. The delirious form was the heaviest: in the 1st day, patients had the highest score on the BPRS scale (Me = 80 (73–87)), but transient: psychosis was resolved within 1 day. With delusional form, the median score in the 1st day on the BPRS scale was 65 (59–82), in polymorphic — 66 (43–76). The vast majority of psychoses (91.8%) developed during intoxication. Some psychoses of delusional and polymorphic form, which developed beyond intoxication lasted notebly longer. The polymorphic form is the longest lasting, with symptoms lasting more than 2 weeks. Postpsychotic disorders were presented as asthenic and neurotic (anxiety-depressive) disorders, most pronounced and lasting (more than 6 months) in patients with a polymorphic form of psychosis. Conclusion. The study showed that psychoses with a «exogenous» clinical picture (psychomotor agitation and nonspecific psychopathological symptoms) pass faster and psychopathological disorders go away simultaneously with agitation. At the same time, psychoses with a predominance of psychopathological disorders (delusions, hallucinations) are characterized by a longer course and require long-term therapy. Key words: synthetic cathinones, SCath-induced psychoses, stimulant dependence, clinical forms of psychoses.","PeriodicalId":494981,"journal":{"name":"Доктор.ру","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135508301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Predictors of the Development of Autonomic Dysfunction","authors":"K.A. Gazenkampf, E.А. Domoratskaya, D.V. Dmitrenko","doi":"10.31550/1727-2378-2023-22-6-54-59","DOIUrl":"https://doi.org/10.31550/1727-2378-2023-22-6-54-59","url":null,"abstract":"Aim: To study the association of the HTR2C gene rs6318, rs6313 of the HTR2A gene, rs4680 of the COMT gene, rs3785143 of the SLC6A2 gene, rs1799913 of the TPH1 gene, rs7997012 of the HTR2A gene with the development of neurotic disorders in young people living in the Krasnoyarsk Territory. Design: A comparative study. Materials and methods. The study included 133 clinically healthy volunteers. The age of the participants ranged from 16 to 24 years. Molecular genetic studies were carried out on the basis of the Laboratory of Medical Genetics of the V.F. Voino-Yasenetsky Moscow State Medical University of the Ministry of Health of Russia. Psychological testing was performed using the questionnaire of depressive symptoms of Beck, the scale of socio-situational anxiety of O. Kondash in the modification of A.M. Parishioner, Hospital scale of anxiety and depression, as well as carrier study of the association of single nucleotide variants (ONV) rs7997012 of the HTR2A gene, rs6318 of the HTR2C gene, rs6313 of the HTR2A gene, rs4680 of the COMT gene, rs3785143 of the SLC6A2 gene, rs1799913 of the TPH1 gene with neurotic disorders (anxiety and subclinical depression). Results. According to multivariate analysis, the association of the COMT G gene allele carrier (odds ratio (OR) = 2.784; 95% confidence interval (CI): 1.291–6.001; χ2 = 6.986; p = 0.009) and the AH genotype (OR = 2,208; 95% CI: 1,032–4,724; χ2 = 16.716; p < 0.001) with subclinical depression according to the total index of the Beck scale. Carrying the SS genotype of the rs1799913 TRN1 gene increases the risk of learning anxiety by 3 times (OR = 3.011; 95% CI: 1.138–7.967; χ2 = 7.622; p = 0.023). Conclusion. The carriage of the G allele and the rs4680 genotype and AG of the COMT gene is associated with subclinical depression, and the carriage of the SS genotype of the rs1799913 TRN1 gene increases the risk of learning anxiety by 3 times. Thus, the ONV of these genes can be considered as predictors of neurotic disorders, significant already at the subclinical level. Keywords: COMT gene, TRN1 gene, anxiety, depression, neurotic disorders.","PeriodicalId":494981,"journal":{"name":"Доктор.ру","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135508303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibilities of Drug Correction of Menopausal Syndrome in Reproductive Cancer Patients","authors":"O.V. Shabalova, S.V. Yureneva, Zh.R. Gardanova, E.I. Ermakova, S.V. Khokhlova","doi":"10.31550/1727-2378-2023-22-5-54-61","DOIUrl":"https://doi.org/10.31550/1727-2378-2023-22-5-54-61","url":null,"abstract":"Aim: To assess the severity of menopausal symptoms and quality of life in patients with iatrogenic menopause depending on the therapy. Design: A randomised parallel group clinical study. Materials and methods. The study enrolled 60 patients of reproductive age with iatrogenic menopause following bilateral ovariectomy who had a history of reproductive tumours. The patients were randomised into 2 groups. Group 1 (n = 34) was treated with escitalopram as follows: 5 mg once daily — 7 days, 10 mg once daily — 2 weeks, then 10 mg daily (subgroup 1а) or 20 mg daily (subgroup 1b) — 12 weeks. A dose of 20 mg daily was used where the frequency and severity of menopausal symptoms did not fall below 50 % in 3 weeks with a dose of 10 mg daily. Group 2 patients (n = 26) were prescribed an herbal product called cimicifuga racemosa essence (BNO 1055) at a dose of 6.5 mg 1 tablet once daily for 15 weeks. The patients' condition was assessed using a daily hot flash questionnaire; Quality of Life Questionnaire SF-36; Greene Climacteric Scale; and Insomnia Severity Index. Results. The number of hot flushes reduced in all subgroups; however, the reduction was statistically significant only in subgroup 1a. Greene Climacteric Scale showed that following 15 weeks of therapy in subgroup 1a there was significant reduction in the intensity of menopausal symptoms, anxiety and depression, improved somatic signs, reduced severity of vasomotor symptoms, and improved libido vs. baseline. Subgroup 1b patients demonstrated statistically significant reduction in menopausal symptoms and anxiety. Group 2 had marked reduction in menopausal symptoms and depression. Intergroup comparison demonstrates that the most marked effect from the therapy on menopausal symptoms, anxiety, depression and severity of vasomotor symptoms was observed in subgroup 1а vs. subgroup 1b and group 2. Quality-of-life assessment showed significant improvement in the physical component in group 2 patients, while psychological improvements were better in subgroup 1а after 15 weeks of therapy. Subgroup 1a patients had significant reduction in Insomnia Severity Index, while subgroup 1b and group 2 patients did not demonstrate any significant reduction in this parameter. Conclusion. Patients, for whom hormonal menopause therapy is contraindicated, including patients with hormone-driven malignancies, require therapy to improve their quality of life, manage their menopausal syndrome, correct psychoemotional state and improve sleep. The study demonstrated efficacy both of non-hormonal antidepressant escitalopram (a selective serotonin reuptake inhibitor) and BNO 1055 essence (a medicinal product). In mild and moderate menopausal syndrome, it is recommended to use BNO essence, while severe cases should be treated with 10 mg escitalopram daily, and therapy efficacy should be assessed after 3 weeks of therapy. Key words: menopause, malignancies, menopausal syndrome, selective serotonin reuptake inhibitor, antidepressants","PeriodicalId":494981,"journal":{"name":"Доктор.ру","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135562253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Affective Disorders During the Diagnosis of Multiple Sclerosis","authors":"N.V. Zarubina","doi":"10.31550/1727-2378-2023-22-6-35-39","DOIUrl":"https://doi.org/10.31550/1727-2378-2023-22-6-35-39","url":null,"abstract":"Aim: To study emotional disorders and response to stress in patients with multiple sclerosis (MS) at the diagnostic stage. Design: Comparative prospective study. Materials and methods. We examined 30 MS patients who were not taking any disease-modifying drugs. The age of patients was 34 ± 9 years; Kurtzke Expanded Disability Status Scale: 1.7 ± 1.3 points. Beck Self-Rating Depression Inventory and V. M. Bekhterev Self-Rating Depression Inventory, State-Trait Anxiety Inventory, Asthenic State Scale, Psychological Diagnostics of Coping Mechanisms, Coping Strategies questionnaire, were used. Results. MS patients were divided into groups depending on the presence/absence of symptoms of depression (n = 18 and n = 12). The patients with depression had statistically higher (р < 0.05) number of asthenic manifestations and anxiety disorders, emotional releases with fixation on negative events. In order to reduce stress, patients chose to avoid the problem. Conclusion. Identified emotional disorders aggravate the overall condition of MS patients, reduce stress tolerance and ability to social adaptation; they lead to more complex symptoms and possible disease progression. Keywords: multiple sclerosis, depression, anxiety, copin mechanisms, ways of coping with stress.","PeriodicalId":494981,"journal":{"name":"Доктор.ру","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135508309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2-Associated Psychoneurological Manifestations","authors":"I.V. Lapko, A.V. Zheglova","doi":"10.31550/1727-2378-2023-22-6-49-53","DOIUrl":"https://doi.org/10.31550/1727-2378-2023-22-6-49-53","url":null,"abstract":"Objective: To evaluate the psychoneurological status of post-COVID-19 patients using diagnostic tests for psychoemotional state, cognitive functions, sleep disorders. Design: a retrospective study. Materials and methods. We conducted psychoneurological tests on 68 post-COVID-19 patients (38 women and 30 men) (mean age: women — 44.6 ± 6.4 years old, men — 46.8 ± 7.8 years old). The control group included 30 persons without a history of coronavirus infection. Neuropsychological tests were performed using the asthenia scale developed by L. D. Malkova and adapted by T. G. Chertova, Hospital Anxiety and Depression Scale, Spiegel Sleep Questionnaire, Epworth Sleepiness Scale, cognitive function testing (memorising 10 words, Munsterberg test, mechanical memory test). Results. The main psychoneurological manifestations in post-COVID-19 patients are asthenoneurotic or anxiodepressive symptoms (57.4 %), insomnia (39.7 %) and cognitive-mnestic disorders (32.4 %) associated with somatic-vegetative disorders (hyperhydrosis, palpitations, blood pressure fluctuations, dispeptric disorders, episodes of dizziness). A lot of patients had persistent smell and taste disorders (26.5 %), impaired visual acuity (25 %), impaired hearing (23.5 %), limb numbness and paresthesia (20.6 %). Conclusion. Management of patients with coronavirus infection requires a comprehensive diagnostic approach involving assessment of their mental health. Psychoneurological features of post-COVID-19 patients demonstrate the need in improved efficiency of rehabilitation and therapeutic measures due to restoration of mental, cognitive, somatic-vegetative functions. SARS-CoV-2-associated symptoms of neural system involvement are a sign of unfavourable disease progression and outcome. Keywords: psychoneurological disorders, coronavirus infection, neuropsychological testing, psychological assessment, post-COVID syndrome.","PeriodicalId":494981,"journal":{"name":"Доктор.ру","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135508314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local Hormonal Therapy for Genitourinary Menopausal Syndrome","authors":"S.V. Yureneva, G.Yu. Knorring","doi":"10.31550/1727-2378-2023-22-5-95-100","DOIUrl":"https://doi.org/10.31550/1727-2378-2023-22-5-95-100","url":null,"abstract":"Aim: To justify the viability and safety of local hormonal therapy with oestrogens in genitourinary syndrome of menopause. Key points. The overall ageing of the population results in an increased number of women who have problems during menopause associated with gradual reduction and switching-off of ovarian function and cessation of oestrogen generation by ovaries. Local changes at the pelvic level (urethra, bladder, vagina) are described as genitourinary syndrome of menopause. The most effective therapies for the syndrome include local hormonal therapy with oestrogens, including oestriol which is of interest due to its specific targeted action and lack of proliferative effect on endometrium and mammary glands. The use of oestriol eliminates a number of problems caused by oestrogen insufficiency: it minimises or eliminates dyspareunea, dryness and itching in vagina and lower section of the urogenital tract, inappropriate urination, enuresis, and recurring vulvovaginitis and cystitis. Conclusion. It has been proven that the local use of oestriol is efficient and safe for the management of genitourinary syndrome of menopause. The selection of a specific medicinal product should be evidence-based and should take into account the route of administration and pharmacological properties, including preparation of the active ingredient, and excipients contributing to the overall efficiency and safety. Keywords: genitourinary syndrome, menopause, estriol, micronization.","PeriodicalId":494981,"journal":{"name":"Доктор.ру","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135562001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}