Genetic Predictors of the Development of Autonomic Dysfunction

Abstract

Aim: To study the association of the HTR2C gene rs6318, rs6313 of the HTR2A gene, rs4680 of the COMT gene, rs3785143 of the SLC6A2 gene, rs1799913 of the TPH1 gene, rs7997012 of the HTR2A gene with the development of neurotic disorders in young people living in the Krasnoyarsk Territory. Design: A comparative study. Materials and methods. The study included 133 clinically healthy volunteers. The age of the participants ranged from 16 to 24 years. Molecular genetic studies were carried out on the basis of the Laboratory of Medical Genetics of the V.F. Voino-Yasenetsky Moscow State Medical University of the Ministry of Health of Russia. Psychological testing was performed using the questionnaire of depressive symptoms of Beck, the scale of socio-situational anxiety of O. Kondash in the modification of A.M. Parishioner, Hospital scale of anxiety and depression, as well as carrier study of the association of single nucleotide variants (ONV) rs7997012 of the HTR2A gene, rs6318 of the HTR2C gene, rs6313 of the HTR2A gene, rs4680 of the COMT gene, rs3785143 of the SLC6A2 gene, rs1799913 of the TPH1 gene with neurotic disorders (anxiety and subclinical depression). Results. According to multivariate analysis, the association of the COMT G gene allele carrier (odds ratio (OR) = 2.784; 95% confidence interval (CI): 1.291–6.001; χ2 = 6.986; p = 0.009) and the AH genotype (OR = 2,208; 95% CI: 1,032–4,724; χ2 = 16.716; p < 0.001) with subclinical depression according to the total index of the Beck scale. Carrying the SS genotype of the rs1799913 TRN1 gene increases the risk of learning anxiety by 3 times (OR = 3.011; 95% CI: 1.138–7.967; χ2 = 7.622; p = 0.023). Conclusion. The carriage of the G allele and the rs4680 genotype and AG of the COMT gene is associated with subclinical depression, and the carriage of the SS genotype of the rs1799913 TRN1 gene increases the risk of learning anxiety by 3 times. Thus, the ONV of these genes can be considered as predictors of neurotic disorders, significant already at the subclinical level. Keywords: COMT gene, TRN1 gene, anxiety, depression, neurotic disorders.