Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland最新文献

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Anaesthetic gases and the environment: Is it time for a rethink? 麻醉气体与环境:是时候重新思考了吗?
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-08-01 DOI: 10.1016/j.surge.2024.04.014
{"title":"Anaesthetic gases and the environment: Is it time for a rethink?","authors":"","doi":"10.1016/j.surge.2024.04.014","DOIUrl":"10.1016/j.surge.2024.04.014","url":null,"abstract":"<div><h3>Background</h3><p><span>General anaesthesia<span> is in common use for patients undergoing surgical procedures, with the option of both inhalational and intravenous anaesthetic techniques. </span></span>Anaesthetic gases are often excluded from discussions on sustainable healthcare delivery, despite being a significant contributor to the overall environmental impact of healthcare services.</p></div><div><h3>Methods</h3><p>A literature review was carried out on previously published papers on the impact anaesthetic gases have on our environment and at ways to reduce their impact in current anaesthetic practice. The aim was to write a narrative review detailing the areas of concern as well as the current clinical situation in the European setting.</p></div><div><h3>Summary/conclusions</h3><p>The two classes of inhaled anaesthetic<span><span><span> agent most frequently used are nitrous oxide<span> and volatile agents (most commonly </span></span>sevoflurane, </span>isoflurane and desflurane). Both are recognised greenhouse gases that contribute to climate change.</span></p><p><span><span><span>Minor modifications in the use of anaesthetic gases can have a significant environmental impact. These modifications include avoiding nitrous oxide whenever possible, avoiding </span>desflurane<span> (and using sevoflurane<span> instead), using low flow anaesthesia during maintenance, swapping volatile-based anaesthesia for a </span></span></span>TIVA technique when clinically appropriate and considering the use of central neuraxial or </span>regional anaesthesia in place of general anaesthesia when possible.</p></div>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmentally sustainable kidney care through transplantation: Current status and future challenges 通过移植实现环境可持续的肾脏护理:现状与未来挑战
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-08-01 DOI: 10.1016/j.surge.2024.01.001
{"title":"Environmentally sustainable kidney care through transplantation: Current status and future challenges","authors":"","doi":"10.1016/j.surge.2024.01.001","DOIUrl":"10.1016/j.surge.2024.01.001","url":null,"abstract":"<div><p><span><span>The environmental impact of healthcare is an issue currently examined with increased scrutiny and on a global scale with multiple stakeholders seeking to identify the appropriate interventions to reduce it. Interestingly, a significant portion of healthcare's environmental impact stems from intensive modalities of treatment for chronic disease. There is no better example than End-Stage Renal Disease (ESRD), where dialysis or transplantation are the modalities of treatment offered to the vast majority of these patients. Kidney transplantation<span> (KTx) offers a longer life expectancy and improved quality of life<span> in comparison to dialysis. Cost-effectiveness analyses have proven its financial superiority, as well. PubMed and EMBASE literature search using keywords “kidney transplantation”, “carbon footprint”, “sustainability” showed that there is no published work in the field of environmental sustainability in kidney transplantation. Relevant literature was identified for surgical services and applied to transplantation. Assuming its environmental superiority to dialysis, maximising KTx rate would be an important action towards “green” renal care services. That could be achieved through living organ donation, systematic use of machine perfusion for extended criteria deceased donors and individualised immune </span></span></span>risk stratification techniques. All these measures aim towards implementing enhanced recovery protocols and two vital steps can be taken towards assessing their value. The first step is a detailed audit of the environmental impact of these novel techniques and secondly their impact in reducing the length of hospital stay and its subsequent environmental impact. Another key element is delivering appropriate post-operative care, substituting </span>allograft<span> biopsy with non-invasive techniques and reducing physical outpatient follow-up, using telemedicine. The gap in quantifying KTx services environmental impact needs to be addressed urgently, with development of strategies within the multidisciplinary transplant team. Introducing novel technologies can lead to donor pool expansion and improved organ utilisation rates, transforming transplant services in “green” hubs.</span></p></div>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139670100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An assessment of sustainable transport infrastructure in a national healthcare system 对国家医疗体系中可持续交通基础设施的评估。
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-08-01 DOI: 10.1016/j.surge.2023.10.008
{"title":"An assessment of sustainable transport infrastructure in a national healthcare system","authors":"","doi":"10.1016/j.surge.2023.10.008","DOIUrl":"10.1016/j.surge.2023.10.008","url":null,"abstract":"<div><h3>Introduction</h3><p>Healthcare contributes significantly to carbon dioxide emissions, which can be reduced by promoting sustainable mobility amongst staff commuting. This study aims to investigate the national sustainable transport infrastructure for staff of healthcare facilities and utilise this data to develop a novel scoring and ranking system.</p></div><div><h3>Methods</h3><p>This was an empirical retrospective observational study. Data was collected on all 47 hospitals sustainable transport infrastructure. A working group calculated the weighted scores for each sustainable transport data point. These scores were used to calculate the Total and Active Sustainability Scores for each hospital, allowing a ranking to be formed.</p></div><div><h3>Results</h3><p>7 of 47 (15 %) hospitals had EV charging on campus. 17 of 47 (36 %) hospitals had secure bike parking. 2 of 47 (4 %) hospitals had a “bike hub”. 18 of 47 (38 %) hospitals had a bike lane. 13 of 22 (59 %) city hospitals had bike sharing facilities. 42 of 47 (89 %) hospitals had one public transport route. City hospitals ranked higher in both Total &amp; Active Sustainability Scores.</p></div><div><h3>Discussion</h3><p>This study explored a new concept of measuring sustainable transport infrastructure. Frameworks examining sustainability are available, however, none allowed for ranking of hospitals. This study highlights the lack of both research in this field and sustainable transport infrastructure in hospitals.</p></div>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1479666X23001208/pdfft?md5=f82cf4f24424ca805a422dda6c3cedcb&pid=1-s2.0-S1479666X23001208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective case series of vertebral artery injuries associated with cervical spine trauma. 与颈椎创伤相关的椎动脉损伤回顾性病例系列。
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-07-30 DOI: 10.1016/j.surge.2024.07.007
Leah Morris, Anna Lawless, Jake M McDonnell, Kielan V Wilson, Harry Marland, Stacey Darwish, Joseph S Butler
{"title":"Retrospective case series of vertebral artery injuries associated with cervical spine trauma.","authors":"Leah Morris, Anna Lawless, Jake M McDonnell, Kielan V Wilson, Harry Marland, Stacey Darwish, Joseph S Butler","doi":"10.1016/j.surge.2024.07.007","DOIUrl":"https://doi.org/10.1016/j.surge.2024.07.007","url":null,"abstract":"<p><strong>Background: </strong>Vertebral artery injuries (VAI) can occur due to cervical spine trauma. VAI can prove a serious complication and potentially compromise vascular supply to the posterior aspect of the brain. Currently, there is a paucity of evidence with regards to incidence, management, and outcomes for these patients. The purpose of this study is to investigate and elucidate the incidence of VAI associated with cervical trauma at a national tertiary referral centre for spinal pathology, their respective management, and associated outcomes.</p><p><strong>Methods: </strong>A retrospective review was conducted from 2012 to 2021 to identify patients with VAI secondary to cervical spine trauma. Demographic, clinical, and radiological data was collected to identify common traits in injury characteristics and management.</p><p><strong>Results: </strong>1013 spine patients presented to our institution across the 10-year period. 739/1013 (72.9 %) were trauma patients. 42/739 (5.7 %) were imaged for suspected VAI secondary to trauma. There were 14/739 (1.9 %) confirmed VAI. All patients had CT-angiography for diagnosis. Four of the confirmed VAI patients (28.6 %) had additional MR-angiography imaging. Right-side was the most common side of VAI injury (7/14; 50 %), followed by left (5/14; 35.7 %) and bilateral (2/14; 14.3 %) injuries. 8/14 (57.1 %) patients were prescribed anti-thrombotic therapy. Acute mortality within 3-months was noted to be 2/14 (14.3 %) and occurred at 49 days and 57 days respectively.</p><p><strong>Conclusion: </strong>VAI associated with cervical spine injury is rare in occurrence. However, it can be associated with high morbidity and mortality. As such, a multi-disciplinary approach to care is integral to ensuring good outcomes in these patients.</p>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of disability on recruitment to higher surgical specialty training: A retrospective cohort study. 残疾对高等外科专业培训招生的影响:一项回顾性队列研究。
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-07-30 DOI: 10.1016/j.surge.2024.07.006
Ricky Ellis, Yasin Al-Tawarah, Peter A Brennan, Amanda J Lee, John Hines, Duncan Sg Scrimgeour, Jennifer Cleland
{"title":"The impact of disability on recruitment to higher surgical specialty training: A retrospective cohort study.","authors":"Ricky Ellis, Yasin Al-Tawarah, Peter A Brennan, Amanda J Lee, John Hines, Duncan Sg Scrimgeour, Jennifer Cleland","doi":"10.1016/j.surge.2024.07.006","DOIUrl":"https://doi.org/10.1016/j.surge.2024.07.006","url":null,"abstract":"<p><strong>Background: </strong>UK examining bodies are required to eliminate discrimination against people with protected characteristics. To achieve this in surgery, differential attainment (DA) in assessments used as gatekeepers to career progression must be ruled out. This study investigated the impact of disability status on the likelihood of success at national selection for Higher Surgical Training (HST).</p><p><strong>Methods: </strong>A retrospective cohort study of all UK graduates in the UKMED database (https://www.ukmed.ac.uk) who underwent selection for HST (ST3) from 2012 to 2019 (n = 2875). Univariate analysis identified differences in success rates at first-application. Logistic regression models identified whether disability was a predictor of success after adjusting for sociodemographic factors and prior MRCS performance.</p><p><strong>Results: </strong>There was no significant difference in success rates between candidates with and without disabilities (all p > 0.05) for any surgical specialty. Disability status was not a statistically significant predictor of success. Female candidates were 25 % more likely to be successful (OR 1.25 [95%CI 1.05 to 1.49]) and Non-White candidates were 20 % less likely to be successful (OR 0.80 [95%CI 0.68 to 0.96]). Candidates who passed MRCS Part A and Part B at the first attempt were 49 % (OR 1.49 [95%CI 1.25 to 1.77]) and 90 % (OR 1.90 [95%CI 1.58 to 2.28]) more likely to be successful.</p><p><strong>Conclusion: </strong>No significant difference was found in the likelihood of being successful at HST selection for any surgical specialty between applicants with and without disabilities, regardless of type of disability. DA was identified between other sociodemographic groups which requires further exploration.</p>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative use of TXA and protamine-infused hydrogels to reduce postoperative bleeding in breast surgery for heparin-anticoagulated patients "创新性地使用注入 TXA 和原胺的水凝胶来减少肝素抗凝患者乳房手术的术后出血"。
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-07-22 DOI: 10.1016/j.surge.2024.07.002
{"title":"Innovative use of TXA and protamine-infused hydrogels to reduce postoperative bleeding in breast surgery for heparin-anticoagulated patients","authors":"","doi":"10.1016/j.surge.2024.07.002","DOIUrl":"10.1016/j.surge.2024.07.002","url":null,"abstract":"","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The place of splenectomy in the therapeutic management of patients with infective endocarditis and splenic abscess: A single center experience and a literature review. 脾切除术在感染性心内膜炎和脾脓肿患者治疗中的地位:单中心经验与文献综述。
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-07-18 DOI: 10.1016/j.surge.2024.06.008
Corina-Elena Minciuna, Beatrice Tivadar, Vlad Costin Ilie, Ruxandra Daniela Fota, Alina Teodora Timisescu, Vlad Anton Iliescu, Ioan Mircea Coman, Gabriela Droc, Andrei George Iosifescu, Catalin Vasilescu
{"title":"The place of splenectomy in the therapeutic management of patients with infective endocarditis and splenic abscess: A single center experience and a literature review.","authors":"Corina-Elena Minciuna, Beatrice Tivadar, Vlad Costin Ilie, Ruxandra Daniela Fota, Alina Teodora Timisescu, Vlad Anton Iliescu, Ioan Mircea Coman, Gabriela Droc, Andrei George Iosifescu, Catalin Vasilescu","doi":"10.1016/j.surge.2024.06.008","DOIUrl":"https://doi.org/10.1016/j.surge.2024.06.008","url":null,"abstract":"<p><strong>Introduction: </strong>Infective endocarditis(IE) has a low incidence, but it remains a serious disease with high mortality rates. Only 5 % of these patients will develop a splenic abscess, and the number of patients that have IE and a splenic abscess requiring surgery is low. The current guidelines recommend that splenectomy should be performed prior to valve replacement, but there is no strong evidence to support this statement and no evidence to clearly endorse the order in which the surgical interventions should be performed. The objective of this review and case series is to establish the proper treatment strategy, to assess the adequate order of the surgical interventions and to clarify the role of percutaneous drainage in the management of these patients.</p><p><strong>Material and methods: </strong>All patients with infective endocarditis and splenic abscess who underwent surgery in our institution, between January 2008 and December 2020 were included in this study, excluding patients which had cardiac device related endocarditis. Literature review on the matter included a number of 30 studies which were selected from the PubMed database.</p><p><strong>Results: </strong>Assessing the literature and case series no reinfection was reported for simultaneously performing splenectomy(S) and valvular surgery(VS) nor for VS followed by S.</p><p><strong>Conclusion: </strong>Percutaneous drainage of the splenic abscesses is a feasible solution as definitive therapy in high-risk patients or as bridge therapy. Additional studies are needed, even though they are difficult to conduct, therefore a national/international infectious endocarditis register may be of use to clarify these challenges.</p>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender more than ethnicity or disability influences the choice of a career in cardiothoracic surgery by United Kingdom medical students 性别比种族或残疾更能影响英国医科学生对心胸外科职业的选择。
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-07-18 DOI: 10.1016/j.surge.2024.06.002
{"title":"Gender more than ethnicity or disability influences the choice of a career in cardiothoracic surgery by United Kingdom medical students","authors":"","doi":"10.1016/j.surge.2024.06.002","DOIUrl":"10.1016/j.surge.2024.06.002","url":null,"abstract":"<div><h3>Objectives</h3><p>Cardiothoracic surgery has reported poor equality, diversity, and inclusion amongst its faculty [1–3]. We explored how gender, ethnicity, and disability influence medical students’ interest in cardiothoracic surgery as a career choice, as well as overall exposure to cardiothoracic surgery in the undergraduate curriculum.</p></div><div><h3>Methods</h3><p>We distributed a 26-item Google Forms online survey to student members of a medical education group from all 37 UK medical schools via social media. Respondents were asked to rank different ‘factors of interest’ on a 1–5 Likert scale (1 ​= ​not important at all, 5 ​= ​very important) and were encouraged to add free-text comments. Quantitative data were analysed using SPSS.</p></div><div><h3>Results</h3><p>There were 258 respondents, 62% identifying as female and 38% male. Respondents' ethnicities were 45% White, 44% Asian or Asian British, and 11% from other ethnic groups. 11% of respondents confirmed ‘long-standing illness or disability’.</p><p>Men were almost twice as likely to consider a career in cardiothoracic surgery than women (33% vs 19%; p ​&lt; ​0.001). Women were more likely than men to feel that their gender, lack of a similarly gendered mentor, and long working hours were important factors when considering cardiothoracic surgery as a career.</p><p>Ethnicity of the respondent did not appear to affect how they perceived the challenges of a career in cardiothoracic surgery. Interestingly, ‘long-standing illness or disability’ did not significantly affect the decision making to consider this specialty as a career.</p><p>Overall, 73% of respondents reported not having adequate exposure to cardiothoracic surgery at medical school and agreed they would benefit from more time.</p></div><div><h3>Conclusions</h3><p>Female medical students felt their gender, lack of same-sex role models, and perceived long working hours were barriers in considering cardiothoracic surgery as a career. All students felt the need for more exposure to Cardiothoracic Surgery in the undergraduate curriculum.</p></div>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1479666X2400060X/pdfft?md5=b6cce12e3ac79e335c27393ba4763dfd&pid=1-s2.0-S1479666X2400060X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of perioperative intravenous iron infusion in femoral fracture surgery: A systematic review and meta-analysis of randomised controlled trials 股骨骨折手术围手术期静脉输注铁剂的结果:随机对照试验的系统回顾和荟萃分析。
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-07-14 DOI: 10.1016/j.surge.2024.07.005
{"title":"Outcomes of perioperative intravenous iron infusion in femoral fracture surgery: A systematic review and meta-analysis of randomised controlled trials","authors":"","doi":"10.1016/j.surge.2024.07.005","DOIUrl":"10.1016/j.surge.2024.07.005","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Patient blood management recommends the use of intravenous (IV) iron infusion to reduce inappropriate blood transfusion perioperatively for anaemic surgical patients. However, evidence regarding its use in urgent </span>femoral fracture surgery is limited. This </span>systematic review<span> aims to collate the current evidence regarding the utilisation of IV iron in femoral fracture surgery.</span></p></div><div><h3>Method</h3><p><span>MEDLINE, Embase, Cochrane CENTRAL, Clinicaltrials.gov, and the WHO ICTRP databases were systematically searched for </span>randomised controlled trials (RCT) comparing the outcomes of perioperative IV iron infusion with placebo in adults requiring surgical management for femoral fractures. Risk ratios (RR) were calculated using the Mantel-Haenszel method for dichotomous outcomes, and mean differences (MD) were calculated with the inverse-variance method for continuous outcomes.</p></div><div><h3>Results</h3><p><span>Six RCTs with 1292 patients were included. No statistically significant difference was found in the proportion of patients receiving red blood cell (RBC) transfusion (RR = 0.87, 95%CI: 0.75; 1.01, p = 0.058) between groups. Statistically significant difference in postoperative haemoglobin concentration was found between groups measured between day 4–7 of admission (MD = 1.93 g/L, 95%CI: 0.48; 3.39, p = 0.024), but not clinically significant. No statistically significant differences were found between groups in </span>mortality rate, length of hospital stay, infection rate, or return to home rate.</p></div><div><h3>Conclusion</h3><p><span>Current evidence indicates that IV iron infusion alone does not provide any clinically significant benefit in femoral fracture surgery. Further high-quality RCTs are needed to explore its synergistic potential when used in combination with other perioperative optimisation methods, including tranexamic acid, </span>erythropoietin and cell salvage.</p></div>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distant lymph node metastasis in differentiated thyroid cancer: A population-based cohort study. 分化型甲状腺癌的远处淋巴结转移:基于人群的队列研究
IF 2.3 4区 医学
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland Pub Date : 2024-07-11 DOI: 10.1016/j.surge.2024.07.004
Ying Ding, Ruixin Zhou
{"title":"Distant lymph node metastasis in differentiated thyroid cancer: A population-based cohort study.","authors":"Ying Ding, Ruixin Zhou","doi":"10.1016/j.surge.2024.07.004","DOIUrl":"https://doi.org/10.1016/j.surge.2024.07.004","url":null,"abstract":"<p><strong>Background: </strong>Cervical lymph node metastasis (LNM) is the most common clinical event in patients with differentiated thyroid cancer (DTC). However, the incidence, pattern, treatment, and prognosis of distant LNM are yet to be reported.</p><p><strong>Methods: </strong>DTC patients with distant LNM were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2016 and 2020. Multivariate models and propensity score matching (PSM) were used to account for the effects of covariates. The Kaplan-Meier method was used to evaluate the overall survival (OS) and cancer-specific survival (CSS). A nomogram was established to predict the probability of distant LNM in DTC patients, with calibration and Receiver Operating Characteristic (ROC) curves utilized to validate the nomogram's accuracy.</p><p><strong>Results: </strong>Of the 42,339 DTC patients screened, 100 (0.24 %) patients presented with distant LNM. Risk factors including age, sex, T stage, N stage, bone metastasis, brain metastasis, and lung metastasis were included in the nomogram to predict the probability of distant LNM. The calibration curve of the nomogram was close to the ideal diagonal line and the area under the curve (AUC) of the ROC curve is 0.953. Distant LNM showed a worse prognosis after adjusting for confounders compared with non-distant LNM (P < 0.05). Remarkably, radioactive iodine (RAI) therapy did not improve the OS and CSS in DTC patients with distant LNM in the overall or PSM cohort.</p><p><strong>Conclusions: </strong>Distant LNM presents as a comparatively rare but grave condition with a substantial negative impact on prognosis in patients with DTC. Identified risk factors of distant LNM are older age, male, advanced T stage and N stage, bone metastasis, brain metastasis, and lung metastasis. Remarkably, the current RAI therapy does not appear to significantly improve the survival outcome of DTC patients with distant LNM.</p>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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