{"title":"What Is the Evidence Behind Sarcoid Treatments?","authors":"Anna R Hollis","doi":"10.1016/j.cveq.2024.07.006","DOIUrl":"https://doi.org/10.1016/j.cveq.2024.07.006","url":null,"abstract":"<p><p>Despite the ubiquitous nature of sarcoids, robust data regarding the selection of treatment modalities are scarce, with many treatments having little or no published data to support their use. Treatment options are numerous and vary with the location and type of sarcoid, treatment accessibility, and the financial status of the owner. Many treatments are expensive and time-consuming, and some have health and safety implications. It is this author's belief that, based on the limited evidence base, appropriate treatment options vary with the location and type of the sarcoid, and no one treatment is universally appropriate.</p>","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Principles of Tumor Biology.","authors":"Suzanne Murphy","doi":"10.1016/j.cveq.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.cveq.2024.07.001","url":null,"abstract":"<p><p>Cancer is disease of the genome. The Hallmarks of cancer are a way of thinking of cancer to help rationalize what occurs in this disease process. A solid tumor is a complex of normal and neoplastic cells, arising through an evolutionary process to survive and grow. By understanding how normal cellular mechanisms are subverted to promote cancer we can refine our approach to improve outcomes. It gives us opportunities to prevent some cancers and allowing earlier diagnosis. We can refine conventional diagnostic tools and give more accurate prognoses. It offers novel targets to improve treatment of cancers, allowing personalized medicine.</p>","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiotherapy in Equine Practice.","authors":"Margaret C Mudge, Eric Green","doi":"10.1016/j.cveq.2024.07.005","DOIUrl":"https://doi.org/10.1016/j.cveq.2024.07.005","url":null,"abstract":"<p><p>Radiotherapy is a valuable treatment option for equine tumors that have a high rate of recurrence or where complete surgical resection may damage vital structures. Teletherapy, brachytherapy, and plesiotherapy have been used successfully for the treatment of a variety of tumors and locations in the horse. Radiobiology, treatment protocols, side effects, and patient management are reviewed, with a focus on linear accelerator-based teletherapy. There is evidence of good success rates for treatment of periocular sarcoids and squamous cell carcinoma but teletherapy treatment is often limited to tumors on the head and distal extremities.</p>","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Paraneoplastic Syndromes in Horses.","authors":"Imogen Johns","doi":"10.1016/j.cveq.2024.07.015","DOIUrl":"https://doi.org/10.1016/j.cveq.2024.07.015","url":null,"abstract":"<p><p>This article discusses the reported paraneoplastic syndromes (PNSs) in horses, including the possible pathogenesis, diagnostic methods, and any treatment options. The more commonly reported PNSs in horses include cancer anorexia and cachexia, fever and increased acute phase protein concentrations, and hypercalcemia and monoclonal gammopathy. As these conditions can often be more commonly diagnosed in non-neoplastic conditions, the diagnosis of a PNS and the accompanying neoplasia can be challenging. As signs of a PNS may precede signs of the underlying neoplasia, it is important that the clinician be aware of the possible presence of a PNS.</p>","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Squamous Cell Carcinomas in Horses: An Update of the Aetiopathogenesis and Treatment Options.","authors":"Anna R Hollis","doi":"10.1016/j.cveq.2024.07.007","DOIUrl":"https://doi.org/10.1016/j.cveq.2024.07.007","url":null,"abstract":"<p><p>Squamous cell carcinomas are a very common tumor type in horses, and are found in a variety of dermatologic and non-dermatologic locations. Metastasis is common, even at the first presentation of the disease, and a full staging workup is therefore strongly recommended to direct treatment and assist with prognostication. Wide surgical excision remains the treatment of choice in most cases, but recurrence is common, and adjunctive therapy may be indicated to improve the long-term prognosis.</p>","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Equine Gastrointestinal Neoplasia.","authors":"Ina Mersich, Pamela A Wilkins","doi":"10.1016/j.cveq.2024.07.011","DOIUrl":"https://doi.org/10.1016/j.cveq.2024.07.011","url":null,"abstract":"<p><p>Gastrointestinal neoplasia is uncommon in horses. Clinical signs can be vague and advanced testing, including biopsy, exploratory surgery, and/or advanced imaging may be required for diagnosis. Prognosis varies by location, organ involved and is frequently poor to grave.</p>","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chemotherapeutics in Equine Practice.","authors":"Fernando Malalana","doi":"10.1016/j.cveq.2024.07.004","DOIUrl":"https://doi.org/10.1016/j.cveq.2024.07.004","url":null,"abstract":"<p><p>Chemotherapy is the treatment of cancerous cells through the use of cytotoxic drugs. Whilst the use of systemic (intravenous) chemotherapy in equine practice is generally limited to the management of lymphoma, cytotoxic drugs are commonly used in the treatment of accessible skin tumors, either by topical application in the form of ointments or injected intralesionally. These drugs should be employed with caution due to the risk of serious adverse effects. In addition, extreme caution should be followed when preparing, handling, administering, and disposing them, due to their carcinogenic, mutagenic, and teratogenic properties.</p>","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Problem-Oriented Approach to Immunodeficiencies and Immune-Mediated Conditions in Horses","authors":"Lais R.R. Costa MV, MS, PhD","doi":"10.1016/j.cveq.2024.05.004","DOIUrl":"10.1016/j.cveq.2024.05.004","url":null,"abstract":"","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forthcoming Issues","authors":"","doi":"10.1016/S0749-0739(24)00044-0","DOIUrl":"https://doi.org/10.1016/S0749-0739(24)00044-0","url":null,"abstract":"","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Problem-Oriented Approach to Immunodeficiencies and Immune-Mediated Conditions in Horses","authors":"Lais R.R. Costa (Editor)","doi":"10.1016/S0749-0739(24)00040-3","DOIUrl":"https://doi.org/10.1016/S0749-0739(24)00040-3","url":null,"abstract":"","PeriodicalId":49382,"journal":{"name":"Veterinary Clinics of North America-Equine Practice","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}