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Formulation and evaluation of tenoxicam ethosomes as a novel drug carrier 替诺昔康体作为新型药物载体的制备及评价
UPI journal of pharmaceutical, medical and health sciences Pub Date : 2023-11-08 DOI: 10.37022/jpmhs.v6i4.96
RamyaTeja Medarametla, Venkata Gopaiah K, N. Suresh Kumar J, Glory Ch, Neelima L, Samuel morise J, Venkateswarlu Naik B, Ayyappa Reddy B, Sudheer B
{"title":"Formulation and evaluation of tenoxicam ethosomes as a novel drug carrier","authors":"RamyaTeja Medarametla, Venkata Gopaiah K, N. Suresh Kumar J, Glory Ch, Neelima L, Samuel morise J, Venkateswarlu Naik B, Ayyappa Reddy B, Sudheer B","doi":"10.37022/jpmhs.v6i4.96","DOIUrl":"https://doi.org/10.37022/jpmhs.v6i4.96","url":null,"abstract":"The aim of this study is to create an alcohol-based tenoxicam gel for transversal delivery. Tenoxicam is a non-steroidal anti-inflammatory BCSII drug with low solubility and high permeability. It is prepared thermally using alcohol, phospholipids and ethanol. Alcosomes are phospholipid- based elastic nanoparticles containing high levels of ethanol (20-45%), which is known to be highly accessible. Ethanol systems are more effective at delivering the speed and depth of medication to the skin than liposomes or hydroalcoholic solutions. FTIR studies show that there is no interaction between the drug and the additive. Formulation F8 (ethanol 30% v/v and lecithin 1% w/w) was selected as the best formulation due to its small size, encapsulation efficiency, low turbidity, and highest in vitro release. A 3-month stability study was carried out on the F8 formulation using Carbopol 934 base (1,1.5, 2% w/w) at two different temperatures, 25°±2°C and 4°±2°C. The maximum in vitro release rate of carbomer concentration in rat skin at 1.5% w/w is 95.06 ± 0.15%, and the in vitro release rate is 86.65 ± 0.38%.","PeriodicalId":493504,"journal":{"name":"UPI journal of pharmaceutical, medical and health sciences","volume":"58 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135431420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transdermal patches: updated review as a novel drug delivery system 透皮贴剂:作为一种新型给药系统的最新综述
UPI journal of pharmaceutical, medical and health sciences Pub Date : 2023-11-04 DOI: 10.37022/jpmhs.v6i4.95
Iasht Kamal Vachhal, Kapil Kumar, Aparna Joshi, Vaishali Rajput
{"title":"Transdermal patches: updated review as a novel drug delivery system","authors":"Iasht Kamal Vachhal, Kapil Kumar, Aparna Joshi, Vaishali Rajput","doi":"10.37022/jpmhs.v6i4.95","DOIUrl":"https://doi.org/10.37022/jpmhs.v6i4.95","url":null,"abstract":"Transdermal patches are a non-invasive method of drug administration. It is an adhesive patch designed to deliver a specific dose of medication through the skin and into the bloodstream throughout the body. Transdermal drug delivery has several advantages over other routes of administration, for instance, it is less invasive, patient-friendly, and has the ability to bypass first-pass metabolism and the destructive acidic environment of the stomach that occurs upon the oral ingestion of drugs. Further offering a prolonged period of regulated medication release. The preparation procedures for various transdermal patch types, including membrane matrix, drug-in-adhesive, and micro reservoir patches, are covered in this review article. The various transdermal dosage form evaluation techniques have also been studied.","PeriodicalId":493504,"journal":{"name":"UPI journal of pharmaceutical, medical and health sciences","volume":"30 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135775504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive study on the review of virosomes As a novel drug delivery system 病毒体作为一种新型给药系统的综合研究综述
UPI journal of pharmaceutical, medical and health sciences Pub Date : 2023-10-15 DOI: 10.37022/jpmhs.v6i4.94
Ramya Teja Medarametla, Venkata Gopaiah K, N Suresh Kumar J, Kumar Sai A, Mohana chari G, Kranti Kiran A, Koteswarao Naik B, Sandya rani K
{"title":"A comprehensive study on the review of virosomes As a novel drug delivery system","authors":"Ramya Teja Medarametla, Venkata Gopaiah K, N Suresh Kumar J, Kumar Sai A, Mohana chari G, Kranti Kiran A, Koteswarao Naik B, Sandya rani K","doi":"10.37022/jpmhs.v6i4.94","DOIUrl":"https://doi.org/10.37022/jpmhs.v6i4.94","url":null,"abstract":"Virosomes can be used as vaccines and vehicles for the cellular transport of various macromolecular molecules. The potential for drug delivery and targeting systems to be implemented using virosomes represents an exciting area of ​​research. Virosomes are biocompatible, biodegradable, nontoxic, and nonimmunogenic, so efforts have been made to utilize them as anti-inflammatory or adjuvant agents, as well as drug and organic delivery frameworks for therapeutic applications. The success of virosomal drug delivery depends on the strategy used to assemble and fuse typeable bioactive materials into virosomes. Potential innovations of virosomes could be used to transport peptides and nucleic acids or qualities and drugs such as antitoxins, anticancer agents, and steroids.","PeriodicalId":493504,"journal":{"name":"UPI journal of pharmaceutical, medical and health sciences","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135761092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on different types of detectors used in chromatography techniques 色谱技术中不同类型检测器的综述
UPI journal of pharmaceutical, medical and health sciences Pub Date : 2023-09-26 DOI: 10.37022/jpmhs.v6i3.92
Sireesha Badri, Jasmin Rani G, Dharani P, Sreehitha D, Saniya SK, Veeresh C, Chandu K
{"title":"A review on different types of detectors used in chromatography techniques","authors":"Sireesha Badri, Jasmin Rani G, Dharani P, Sreehitha D, Saniya SK, Veeresh C, Chandu K","doi":"10.37022/jpmhs.v6i3.92","DOIUrl":"https://doi.org/10.37022/jpmhs.v6i3.92","url":null,"abstract":"High Performance Thin layer Chromatography (HPTLC) technique is a sophisticated and automated form of the thin-layer chromatography (TLC) with better and advanced separation efficiency and detection limits. The analytical method should be sensitive, specific, fast and accurate to establish the assurance that the equipments used in manufacturing are free of the unwanted impurity, presence of which may alter the safety and efficacy of the drug product. The developed method was based on RP-HPLC leave-taking and quantification of the drug on C-18 column using a mobile phase at flow rate of 1 ml/ min. Quantitation was attained with PDA detector at 200-400 nm based on peak area with linear calibration curves at concentration ranges 5-25 μg/ml for the drug. The method as per ICH guidelines was validated for specificity, linearity, detection limit, quantitation limit, precision, accuracy, robustness, solution stability, and can be effectively used for routine analysis.","PeriodicalId":493504,"journal":{"name":"UPI journal of pharmaceutical, medical and health sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135721638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on medicinal plants containing glycosides 含糖苷类药用植物研究进展
UPI journal of pharmaceutical, medical and health sciences Pub Date : 2023-09-15 DOI: 10.37022/jpmhs.v6i3.91
Sireesha Badri, Pavitra P, Sameena D, Anitha G, Asifa S.K, Mahesh K, Pushpalatha E
{"title":"A review on medicinal plants containing glycosides","authors":"Sireesha Badri, Pavitra P, Sameena D, Anitha G, Asifa S.K, Mahesh K, Pushpalatha E","doi":"10.37022/jpmhs.v6i3.91","DOIUrl":"https://doi.org/10.37022/jpmhs.v6i3.91","url":null,"abstract":"Plant-active metabolites are under intensive examination around the world to supplement the drugs with minimal side effects. Thus, there is vast potential to explore the possible medicine from plant sources. Cardiac glycosides are a unique group of secondary metabolites that are considered one of the most useful drugs in therapeutics. In this review, cardiac glycosides and their analogs are presented. The structure and distribution in plants, as well as structure elucidations, synthetic routes, and chemical analysis, are shown. In addition, the pharmacological activities, mode of action studies, and structure-activity relationships are cardiac glycosides.","PeriodicalId":493504,"journal":{"name":"UPI journal of pharmaceutical, medical and health sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135484701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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