发布求助
文献互助 智能选刊 最新文献

Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie最新文献

筛选
英文 中文
Burn-out in der Ärzteschaft 精力耗尽Ärzteschaft
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-12-01 DOI: 10.1007/s15202-022-5584-2
Redaktion Facharztmagazine
{"title":"Burn-out in der Ärzteschaft","authors":"Redaktion Facharztmagazine","doi":"10.1007/s15202-022-5584-2","DOIUrl":"https://doi.org/10.1007/s15202-022-5584-2","url":null,"abstract":"","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"13 1","pages":"8 - 8"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73687781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutzen der frühzeitigen MS-Behandlung mit Ofatumumab bestätigt 确认使用奥法图姆母早期处理
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-10-04 DOI: 10.1007/s15202-022-5521-4
Isabelle Linder
{"title":"Nutzen der frühzeitigen MS-Behandlung mit Ofatumumab bestätigt","authors":"Isabelle Linder","doi":"10.1007/s15202-022-5521-4","DOIUrl":"https://doi.org/10.1007/s15202-022-5521-4","url":null,"abstract":"","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"83 1","pages":"72 - 73"},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90635601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kognitive Probleme vor allem bei COVID-19-Anosmie
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-10-01 DOI: 10.1007/s15202-022-5511-6
T. Müller
{"title":"Kognitive Probleme vor allem bei COVID-19-Anosmie","authors":"T. Müller","doi":"10.1007/s15202-022-5511-6","DOIUrl":"https://doi.org/10.1007/s15202-022-5511-6","url":null,"abstract":"","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"124 3 1","pages":"14 - 14"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73009211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long- und Post-COVID versus Chronic Fatigue Syndrome covid - 19后长期与慢性疲劳综合征
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-10-01 DOI: 10.1007/s15202-022-5508-1
W. Hausotter
{"title":"Long- und Post-COVID versus Chronic Fatigue Syndrome","authors":"W. Hausotter","doi":"10.1007/s15202-022-5508-1","DOIUrl":"https://doi.org/10.1007/s15202-022-5508-1","url":null,"abstract":"","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"47 16 1","pages":"32 - 36"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77604145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impfung erhöht das Schlaganfallrisiko nicht 注射不会增加中风的风险
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-10-01 DOI: 10.1007/s15202-022-5536-x
Redaktion Facharztmagazine
{"title":"Impfung erhöht das Schlaganfallrisiko nicht","authors":"Redaktion Facharztmagazine","doi":"10.1007/s15202-022-5536-x","DOIUrl":"https://doi.org/10.1007/s15202-022-5536-x","url":null,"abstract":"","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"76 1","pages":"9 - 9"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72417416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eine interdisziplinäre Aufgabe 跨学科的任务
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-10-01 DOI: 10.1007/s15202-022-5528-x
I. Anghelescu
{"title":"Eine interdisziplinäre Aufgabe","authors":"I. Anghelescu","doi":"10.1007/s15202-022-5528-x","DOIUrl":"https://doi.org/10.1007/s15202-022-5528-x","url":null,"abstract":"","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"118 1","pages":"3 - 3"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87937546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cluster-Kopfschmerz nach COVID-19-Impfung? 海洛因!
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-10-01 DOI: 10.1007/s15202-022-5540-1
C. Gaul
{"title":"Cluster-Kopfschmerz nach COVID-19-Impfung?","authors":"C. Gaul","doi":"10.1007/s15202-022-5540-1","DOIUrl":"https://doi.org/10.1007/s15202-022-5540-1","url":null,"abstract":"","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"13 1","pages":"30 - 31"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84901726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pflegende Angehörige während der Pandemie 在流感中护理家属
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-10-01 DOI: 10.1007/s15202-022-5514-3
T. Müller
{"title":"Pflegende Angehörige während der Pandemie","authors":"T. Müller","doi":"10.1007/s15202-022-5514-3","DOIUrl":"https://doi.org/10.1007/s15202-022-5514-3","url":null,"abstract":"","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"138 1","pages":"16 - 17"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80098976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zwischen Frust und Fachkräftemangel 现在缺乏软性
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-10-01 DOI: 10.1007/s15202-022-5532-1
Hauke Gerlof
{"title":"Zwischen Frust und Fachkräftemangel","authors":"Hauke Gerlof","doi":"10.1007/s15202-022-5532-1","DOIUrl":"https://doi.org/10.1007/s15202-022-5532-1","url":null,"abstract":"","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"23 1","pages":"79 - 81"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85677670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALX1-transcribed LncRNA AC132217.4 promotes osteogenesis and bone healing via IGF-AKT signaling in mesenchymal stem cells. ALX1转录的LncRNA AC132217.4通过间充质干细胞中的IGF-AKT信号促进成骨和骨愈合。
IF 8
Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie Pub Date : 2022-05-31 DOI: 10.1007/s00018-022-04338-7
Cui Zhang, Shali Wu, Erman Chen, Luyang Yu, Jinfu Wang, Mengrui Wu
{"title":"ALX1-transcribed LncRNA AC132217.4 promotes osteogenesis and bone healing via IGF-AKT signaling in mesenchymal stem cells.","authors":"Cui Zhang, Shali Wu, Erman Chen, Luyang Yu, Jinfu Wang, Mengrui Wu","doi":"10.1007/s00018-022-04338-7","DOIUrl":"10.1007/s00018-022-04338-7","url":null,"abstract":"<p><p>The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) is critical for bone formation and regeneration. A high non-/delayed-union rate of fracture healing still occurs in specific populations, implying an urgent need to discover novel targets for promoting osteogenesis and bone regeneration. Long non-coding (lnc)RNAs are emerging regulators of multiple physiological processes, including osteogenesis. Based on differential expression analysis of RNA sequencing data, we found that lncRNA AC132217.4, a 3'UTR-overlapping lncRNA of insulin growth factor 2 (IGF2), was highly induced during osteogenic differentiation of BMSCs. Afterward, both gain-of-function and loss-of-function experiments proved that AC132217.4 promotes osteoblast development from BMSCs. As for its molecular mechanism, we found that AC132217.4 binds with IGF2 mRNA to regulate its expression and downstream AKT activation to control osteoblast maturation and function. Furthermore, we identified two splicing factors, splicing component 35 KDa (SC35) and heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), which regulate the biogenesis of AC132217.4 at the post-transcriptional level. We also identified a transcription factor, ALX1, which regulates AC132217.7 expression at the transcriptional level to promote osteogenesis. Importantly, in-vivo over-expression of AC132217.4 essentially promotes the bone healing process in a murine tibial drill-hole model. Our study demonstrates that lncRNA AC132217.4 is a novel anabolic regulator of BMSC osteogenesis and could be a plausible therapeutic target for improving bone regeneration.</p>","PeriodicalId":49348,"journal":{"name":"Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie","volume":"84 1","pages":"328"},"PeriodicalIF":8.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73953465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信