Ticks and Tick-borne Diseases最新文献

{"title":"IxsS7: A novel biomarker for Ixodes scapularis tick bite exposure in humans","authors":"Patrick H. Kelly ,&nbsp;Derek A.T. Cummings ,&nbsp;Eva Iniguez ,&nbsp;Tiago Donatelli ,&nbsp;Luana Rogerio ,&nbsp;Jan Kotál ,&nbsp;Larissa Almeida Martins ,&nbsp;Markus Berger ,&nbsp;Lucas C Sousa-Paula ,&nbsp;Stephen Lu ,&nbsp;James H. Stark ,&nbsp;Siu-Ping Ng ,&nbsp;Adriana Marques ,&nbsp;Jesus G. Valenzuela ,&nbsp;Lucas Tirloni","doi":"10.1016/j.ttbdis.2025.102514","DOIUrl":"10.1016/j.ttbdis.2025.102514","url":null,"abstract":"<div><div><em>Ixodes scapularis</em> is a primary vector of several important tick-borne pathogens including <em>Borrelia burgdorferi</em> sensu lato, the causative bacterial genospecies complex of Lyme disease, <em>Babesia microti, Anaplasma phagocytophilum, Borrelia miyamotoi, Ehrlichia muris eauclarensis,</em> and Powassan virus. Salivary compounds secreted by <em>I. scapularis</em> during blood feeding are immunogenic and can elicit robust antibody responses in humans which can potentially be leveraged as surrogate markers of prior tick bite exposure. In this study, we investigate the potential of a tick secreted salivary serine protease inhibitor, <em>Ixs</em>S7, as a novel antigenic biomarker of <em>I. scapularis</em> exposure in humans. We demonstrate that the <em>Ixs</em>S7 protein-coding sequence is highly conserved (&gt;90 % identity) among other important <em>Ixodes</em> species (e.g., <em>Ixodes ricinus, Ixodes persulcatus</em>, and <em>Ixodes pacificus</em>) and poorly conserved (&lt;50 % identity) with homologs from other tick genera, such as <em>Amblyomma</em> spp., <em>Dermacentor</em> spp., <em>Rhipicephalus</em> spp., and <em>Haemaphysalis</em> spp. Antibodies in sera from rabbits immunized with recombinant <em>Ixs</em>S7 (r<em>Ixs</em>S7) strongly recognize native <em>Ixs</em>S7 when challenged with salivary gland homogenate (SGH) from blood-fed <em>I. scapularis</em> females, while showing minimal cross-reactivity with SGH from other hard tick (Ixodidae) genera. Western blot and ELISA analyses revealed that human subjects who reported recent prior exposure to ticks possessed IgG antibodies that recognized r<em>Ixs</em>S7, highlighting its potential as a biomarker of exposure specifically against <em>I. scapularis.</em> Further development of serological tools that can measure human antibody responses to <em>Ixodes</em>-specific salivary antigens is essential to better quantify individual- and population-level risk of important tick-borne diseases such as Lyme disease.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102514"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living with ticks: Results of an online survey of the knowledge, attitudes and practices (KAP) regarding ticks and tick-borne pathogens in academic environments across Europe","authors":"Agustín Estrada-Peña ,&nbsp;Sandra Antunes ,&nbsp;Ana Domingos ,&nbsp;Helen Esser ,&nbsp;Gábor Földvári ,&nbsp;Hans-Peter Fuehrer ,&nbsp;Aysen Gargili ,&nbsp;Mats van Gestel ,&nbsp;Giulio Grandi ,&nbsp;Maria Kazimirova ,&nbsp;Dorota Kiewra ,&nbsp;Tero Klemola ,&nbsp;Lene Jung Kjær ,&nbsp;Vivian Kjelland ,&nbsp;Katarzyna Kubiak ,&nbsp;Daniele de Meneghi ,&nbsp;Andrei Daniel Mihalca ,&nbsp;Sarah Moutailler ,&nbsp;Aleksandar Potkonjak ,&nbsp;Pavel Prokop ,&nbsp;Annetta Zintl","doi":"10.1016/j.ttbdis.2025.102515","DOIUrl":"10.1016/j.ttbdis.2025.102515","url":null,"abstract":"<div><div>We prepared a digital questionnaire to capture knowledge, attitudes and practices (KAP) regarding ticks and tick-borne pathogens (TBPs) in 20 languages. The questionnaire was distributed to 21 universities and research institutions in 22 European countries and 9401 valid responses were collected. Most survey participants identified ticks correctly and regarded ticks as a serious health risk. There was also a good level of knowledge regarding tick activity, habitats and the predominant TBPs in the country or region. Moreover, most respondents were familiar with effective tick protection and removal measures. Over 75 % of respondents had been bitten by ticks and up to 12 % of participants had been diagnosed with a tick-borne infection in the past. Respondents from northern and central European countries who reported engaging in outdoor activities more frequently, reported increased frequencies of tick bites and infection with TBPs compared to respondents from southern Europe. Awareness of national information campaigns on ticks and TBPs was also greater among respondents from northern and central European countries than among Mediterranean countries.</div><div>This study identified knowledge gaps among respondents from some European countries where TBPs have not been prioritised historically. These knowledge gaps should be addressed by reputable bodies to encourage personal protective behaviours without causing alarm and to forestall the spreading of incorrect and unreliable information propagated by some social media sources.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102515"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel variants of tick-borne encephalitis virus from patient and tick samples in Norway","authors":"Urusha Maharjan ,&nbsp;Hilde Kristin Skudal ,&nbsp;Naveed Asghar ,&nbsp;Arnulf Soleng ,&nbsp;Magnus Johansson ,&nbsp;Heidi Elisabeth Heggen Lindstedt ,&nbsp;Anita Koskela von Sydow ,&nbsp;John H.-O. Pettersson ,&nbsp;Wenche Johansen ,&nbsp;Børre Fevang ,&nbsp;Randi Bjerkreim ,&nbsp;Suyog Basnet ,&nbsp;Rose Vikse ,&nbsp;Åshild K. Andreassen ,&nbsp;Kristian Alfsnes","doi":"10.1016/j.ttbdis.2025.102501","DOIUrl":"10.1016/j.ttbdis.2025.102501","url":null,"abstract":"<div><div>The annual number of tick-borne encephalitis (TBE) cases in Norway has increased dramatically from 1 case in 1998 to 113 in 2023<em>.</em> Characterization of TBE virus (TBEV) genomes from both clinical samples and tick vectors is necessary to understand disease severity and transmission dynamics. However, clinical samples with intact virus are rare because TBE is usually diagnosed by serology in the post-viremic phase, when the viral load is low and undetectable by molecular methods such as polymerase chain reaction (PCR). To date, Mandal-2009 is the only TBEV sequence from Norway with complete virus genome, sequenced directly from the tick vector. We used a combined approach with newly designed overlapping primer pairs and nanopore sequencing together with Sanger sequencing to obtain nearly complete TBEV genomes from both patient and tick samples from Norway. The patient had severe TBE complicated with hemophagocytic lymphohistiocytosis (HLH). The patient and tick samples were collected 16 km apart, from Telemark and Vestfold Counties, respectively. Pairwise genomic comparison showed 99.7 % identity, and phylogenetic analysis revealed that these sequences were closely related to the TBEV strain from Kumlinge in Åland, Finland, rather than to the previously published Norwegian variant Mandal-2009. These findings confirm the existence of novel TBEV variants in the endemic areas of Telemark and Vestfold Counties of Norway. Our findings highlight the need for continuous monitoring and characterization of novel TBEV genomes in Norway and Europe.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102501"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermacentor ticks and their human pathogens in various ecosystems of eastern France","authors":"C. Barthel ,&nbsp;J. Stynen ,&nbsp;M. Grau ,&nbsp;M-L. Poulle ,&nbsp;P. Bauda ,&nbsp;N. Boulanger","doi":"10.1016/j.ttbdis.2025.102520","DOIUrl":"10.1016/j.ttbdis.2025.102520","url":null,"abstract":"<div><div><em>Dermacentor</em> is Europe’s second most important tick genus. It comprises two species: <em>Dermacentor reticulatus</em>, which has a more northerly range, and <em>Dermacentor marginatus</em>, which is typically found in Mediterranean regions. In France, especially in the east, the presence of <em>Dermacentor</em> remains understudied. Leveraging projects on <em>Ixodes ricinus</em>, we identified high-risk ecosystems for <em>Dermacentor</em> ticks. Both species were present, but <em>D. reticulatus</em> was dominant (96.3 %), always coexisting with <em>Ixodes</em>, at densities reaching 30.3 questing adults/100 m² in Bas-Rhin. This species was found to thrive in wet meadows, alluvial forests, and lakes, where wild boars (<em>Sus scrofa</em>) are common. Among domestic animals, dogs and horses were the preferred hosts. Regarding human pathogens, we focused on the circulation of rickettsiae responsible for tick-borne lymphadenopathy. Acarological risk varied by region, with <em>Rickettsia raoultii</em> being the most prevalent bacterial species in all the departments, whereas <em>Rickettsia slovaca</em> was rarer and present only in 2 Bas-Rhin nature reserves. At the peak of tick activity, up to 18.7 % of <em>Dermacentor</em> adult ticks carried <em>R. raoultii</em>. In the studied region, <em>D. reticulatus</em> is the only known vector of these potentially pathogenic microorganisms.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102520"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental factors determining the survival of winter ticks (Dermacentor albipictus) at different life stages in Québec, Canada","authors":"Morgane Le Goff ,&nbsp;Christian Dussault ,&nbsp;Julien H. Richard ,&nbsp;Steeve D. Côté","doi":"10.1016/j.ttbdis.2025.102519","DOIUrl":"10.1016/j.ttbdis.2025.102519","url":null,"abstract":"<div><div>Ticks are responsible for large economic losses because of their impact on livestock and wildlife. In recent years, winter ticks (<em>Dermacentor albipictus)</em> have caused mass mortalities in moose (<em>alces</em>) populations of North America, leading to host mortality due to severe blood loss. During their off-host stages (i.e. egg and larvae), winter ticks are particularly vulnerable to mortality because of potential exposure to stressful abiotic conditions that could dehydrate eggs or freeze larvae. We conducted a field experiment in Québec, Canada, to better understand larval questing behaviour and assess the ability of unfed larvae to survive over the winter to the following fall. In the laboratory, we tested the tolerance of eggs to different saturation deficits reflected by combinations of temperature and humidity and evaluated the tolerance of larvae to sub-freezing temperatures. We found that unfed winter tick larvae did not survive until a second fall regardless of habitat types (open, closed or sheltered from the snow) and thus could not quest for a host for two consecutive years. However, unfed larvae withstood short-term exposure to low sub-freezing temperatures, potentially prolonging their questing period and increasing the likelihood of moose infestations. Egg survival varied among saturation deficits, but survival tended to be higher at 30 °C and lower at 22 °C regardless of the saturation deficit. Overall, we found that the free stages of winter ticks are highly tolerant of extreme conditions, reinforcing the concern that winter ticks represent for moose populations.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102519"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An official South African species checklist from the National Tick Collection of South Africa (Gertrud Theiler Tick Museum)","authors":"Ronel Pienaar ,&nbsp;Dikeledi Matloa ,&nbsp;Ben J. Mans","doi":"10.1016/j.ttbdis.2025.102510","DOIUrl":"10.1016/j.ttbdis.2025.102510","url":null,"abstract":"<div><div>Ticks play a crucial role in ecosystem dynamics and disease transmission, necessitating accurate species identification for epidemiological and ecological research. South Africa, despite occupying only 0.82 % of the world's land area, harbors approximately 11 % of global tick species richness. This study provides an updated, authoritative checklist of South African tick species curated by the National Tick Collection of South Africa (NTCSA), housed at the Agricultural Research Council – Onderstepoort Veterinary Research (ARC<img>OVR). Previous lists for South Africa presented outdated taxonomic classifications and incomplete data on taxonomic taxa. The NTCSA checklist aims to correct inaccuracies, incorporating the most recent literature, molecular systematics, and expert curation. A total of 110 tick species across three families (Ixodidae, Argasidae, Nuttalliellidae) are documented, with corrections to genera classifications and species distributions indicated. This list serves as a reference for researchers, veterinarians, and policymakers involved in tick diversity, vector control, and conservation efforts. Continuous updates integrating morphological and molecular assessments will further enhance our understanding of tick diversity and distribution in South Africa. The wide extralimital distribution of various species extend the taxonomic observations to the African continent, while the general taxonomic observations presented summarize our understanding of tick taxonomy at global level.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102510"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhipicephalus microplus voraxin-alpha contains B-cell epitopes that reduce ticks’ biological fitness in immunized cattle","authors":"Daniel Gustavo López-Díaz ,&nbsp;María Martina Esperanza Pérez-Soria ,&nbsp;José Rodrigo Morales-García ,&nbsp;Rafael Jiménez-Ocampo ,&nbsp;Gabriela Aguilar-Tipacamú ,&nbsp;Massaro W. Ueti ,&nbsp;Juan Mosqueda","doi":"10.1016/j.ttbdis.2025.102516","DOIUrl":"10.1016/j.ttbdis.2025.102516","url":null,"abstract":"<div><div><em>Rhipicephalus microplus</em> ticks are a serious pest of cattle in tropical and subtropical regions, mainly due to the losses they cause by reducing meat and milk production, as well as causing hide damage, in addition to their role as vectors of babesiosis and anaplasmosis. Integrated tick control must include the use of anti-tick vaccines to reduce tick populations and mitigate the ecological impact associated with the extensive use of acaricides. To develop improved vaccines, evaluation of new tick antigens is essential. Voraxin, mainly described as a testes-derived protein, is transferred from males to females during copulation, and it is crucial for stimulating engorgement in female ticks and for the development of their organs. In this study, <em>R. microplus</em> voraxin-alpha (voraxin-α) was amplified and sequenced, four peptides with predicted B-cell epitopes were designed and their immunogenic properties were evaluated. Each peptide was mixed with a commercial adjuvant and inoculated into two cattle from a tick-free region to corroborate if they were truly immunogenic. The antibody responses to each peptide were assessed using indirect ELISA. Two peptides were immunogenic and were selected for further testing involving immunization and experimental infestation with 10,000 larvae and two cattle per evaluated peptide. Immunization with peptide 3 reduced tick survival in 17 %, oviposition in 14 % and egg hatching in 22 %, while peptide 4 impaired oviposition in 18 % and egg hatching in 18 %. No effect on weight was observed. In conclusion, ticks fed on cattle producing specific antibodies against voraxin-α B-cell epitopes, have a reduced survival, oviposition and fertility, which are important biological parameters, related to tick fitness. Vaccine trials are required to evaluate this antigen as a vaccine candidate against <em>R. microplus</em>.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102516"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and diversity of Borrelia spp. in questing ticks from urban green spaces in Lithuania","authors":"Justina Snegiriovaitė,&nbsp;Indrė Lipatova,&nbsp;Miglė Razgūnaitė,&nbsp;Algimantas Paulauskas,&nbsp;Jana Radzijevskaja","doi":"10.1016/j.ttbdis.2025.102512","DOIUrl":"10.1016/j.ttbdis.2025.102512","url":null,"abstract":"<div><div>Lithuania is a highly endemic area for Lyme borreliosis (LB), and <em>Ixodes ricinus</em>, the primary vector of <em>Borrelia burgdorferi</em> sensu lato (s.l.) in Europe, is widespread throughout the country. While previous studies conducted in Lithuania have examined the prevalence of <em>B. burgdorferi</em> s.l. in natural habitats, comprehensive data on the distribution of ticks and their infection with tick-borne pathogens in urban areas remain largely unknown. This study aimed to assess the risk of LB by analyzing tick abundance and the prevalence of <em>Borrelia</em> spp. in ticks collected from urban green spaces across ten Lithuanian counties. A total of 3628 ticks were collected, comprising two species: <em>I. ricinus</em> (<em>n</em> = 3599) and <em>Dermacentor reticulatus</em> (<em>n</em> = 29). Ticks were found in 43 out of 52 investigated locations. Molecular analyses detected <em>B. burgdorferi</em> s.l. in 22.89 % of <em>I. ricinus</em> and 3.45 % of <em>D. reticulatus</em> specimens, while <em>Borrelia miyamotoi</em> was found in 3.97 % of <em>I. ricinus</em> and 3.45 % of <em>D. reticulatus</em>. Five species from <em>B. burgdorferi</em> s.l. complex were identified: <em>B. afzelii, B. garinii, B. burgdorferi</em> s.s., <em>B. lusitaniae</em>, and <em>B. valaisiana</em>. Co-infections with different <em>Borrelia</em> spp. were observed in 0.72 % of <em>I. ricinus</em> ticks. <em>Borrelia-</em>infected ticks were detected at 38 of 43 locations (88.37 %), with the prevalence of infection ranging from 3.70 % to 41.53 %. These findings indicate that urban green spaces in Lithuania provide suitable habitats for ticks, with varying risks of human-tick contact and tick-borne infections, underscoring the potential public health risk of LB in Lithuanian cities. Further evaluation of tick distribution and the prevalence of <em>Borrelia</em> spp. is necessary to monitor how climate change and urbanization affect pathogen circulation and infection risk.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102512"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A full-length 16S survey using Nanopore sequencing to uncover the bacterial microbiome in Ixodes ricinus ticks from a single UK woodland, collected across three springs (2019-2021)","authors":"Mia L. White ,&nbsp;Jack M. Crook ,&nbsp;Kayleigh M. Hansford ,&nbsp;Daniel P. Carter ,&nbsp;Michael J. Elmore ,&nbsp;Colin Johnston ,&nbsp;Sara Gandy ,&nbsp;Kuiama Lewandowski ,&nbsp;Alexander Vaux ,&nbsp;Karen L. Osman ,&nbsp;Richard Vipond ,&nbsp;Jolyon M. Medlock ,&nbsp;Edward J Feil ,&nbsp;Steven T. Pullan","doi":"10.1016/j.ttbdis.2025.102506","DOIUrl":"10.1016/j.ttbdis.2025.102506","url":null,"abstract":"<div><div><em>Ixodes ricinus</em> is a key vector of several bacterial pathogens, including <em>Borrelia</em> and <em>Rickettsia</em> species. To assess bacterial prevalence and diversity, we characterised the microbiome of ticks collected from a single UK woodland, comparing different woodland types, life stages (adult male, female, and nymph), and sampling years (spring 2019–2021). Unlike previous studies that target short regions of the <em>16S rRNA</em> gene, we used Nanopore sequencing to generate full-length 16S reads, allowing for higher taxonomic resolution. Our results showed significant microbiome differences across life stages, but not by woodland type or year. <em>Rickettsia</em> was the most abundant taxon, with prevalence varying by life stage and year. <em>Borrelia</em> was present in all life stages but absent in 2021 samples. <em>Anaplasma</em> abundance varied significantly by year and life stage, peaking in nymphs from Pine woodland. <em>Bartonella</em> was found across all woodland types, with the highest abundance in nymphs from Oak-dominated areas.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102506"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we consider tularemia in travelers returning from North Africa?","authors":"Souheil Zayet ,&nbsp;Isabelle Pelloux ,&nbsp;Max Maurin ,&nbsp;Vincent Gendrin ,&nbsp;Jean-Baptiste Vuillemenot ,&nbsp;Pauline Granier ,&nbsp;Julie Plantin ,&nbsp;Thierry Spicarolen ,&nbsp;Timothée Klopfenstein","doi":"10.1016/j.ttbdis.2025.102511","DOIUrl":"10.1016/j.ttbdis.2025.102511","url":null,"abstract":"<div><div>We report a rare case of cervical lymphadenopathy tularemia from North Africa in a French immunocompromised traveler returning from Egypt after participating in an outdoor travel involving dromedary camels. The timeline and clinical course support tularemia as a cause of infection in this patient. The diagnosis was confirmed by serology and polymerase chain reaction methods. A concurrent Epstein-Barr virus-infectious mononucleosis complicated the diagnosis of tularemia. Treatment was successful after surgical procedures in addition to two different antimicrobial regimens: doxycycline followed by fluoroquinolones.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 4","pages":"Article 102511"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}