Saudi Pharmaceutical Journal最新文献

{"title":"The utility of serum glucose potassium ratio as a predictive factor for haemorrhagic transformation, stroke recurrence, and mortality among ischemic stroke patients","authors":"Faisal F. Alamri ,&nbsp;Daniyah A. Almarghalani ,&nbsp;Eman A. Alraddadi ,&nbsp;Abdullah Alharbi ,&nbsp;Hajar S. Algarni ,&nbsp;Oyoon M. Mulla ,&nbsp;Abdullah M. Alhazmi ,&nbsp;Turki A. Alotaibi ,&nbsp;Deema H. Beheiry ,&nbsp;Abdullah S. Alsubaie ,&nbsp;Ahmed Alkhiri ,&nbsp;Yasser Alatawi ,&nbsp;Mohammad S. Alzahrani ,&nbsp;Alqassem Y. Hakami ,&nbsp;Aser Alamri ,&nbsp;Khalid Al Sulaiman","doi":"10.1016/j.jsps.2024.102082","DOIUrl":"https://doi.org/10.1016/j.jsps.2024.102082","url":null,"abstract":"<div><h3>Background and Objective</h3><p>Glucose-Potassium Ratio (GPR) has emerged as a biomarker in several pathophysiological conditions. However, the association between GPR and long-term outcomes in stroke patients has not been investigated. Our study evaluated the applicability of baseline GPR as a predictive prognostic tool for clinical outcomes in ischemic stroke patients.</p></div><div><h3>Methods</h3><p>The multicenter retrospective cohort study included acute-subacute adult ischemic stroke patients who had their baseline serum GPR levels measured. Eligible patients were categorized into two sub-cohorts based on the baseline GPR levels (&lt;1.67 vs. ≥ 1.67). The primary outcome was the incidence of 30-day hemorrhagic transformation, while stroke recurrence, and all-cause mortality within twelve months, were considered secondary.</p></div><div><h3>Results</h3><p>Among 4083 patients screened, 1047 were included in the current study. In comparison with GPR &lt; 1.67 group, patients with ≥ 1.67 GPR had a significantly higher ratio of all-cause mortality within twelve months (aHR 2.07 [95 % CI 1.21–3.75] <em>p</em> = 0.01), and higher ratio of 30-day hemorrhagic transformation but failed to reach the statistical significance (aHR 1.60 [95 % CI 0.95–2.79], <em>p</em> = 0.08).</p></div><div><h3>Conclusion</h3><p>Overall, baseline GPR serum is an independent predictor of all-cause mortality within twelve months in patients with acute and subacute ischemic stroke. Further clinical studies are necessary to validate these findings.</p></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102082"},"PeriodicalIF":4.1,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319016424001324/pdfft?md5=59a48c128559f3e7bf1dd2ccee472581&pid=1-s2.0-S1319016424001324-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special issues in forensic toxicology in the Middle East and North Africa (MENA) region: The importance of toxicology amid MENA drug challenges","authors":"Ahmed Ibrahim Al-Asmari PhD,&nbsp;Fawaz Alasmari,&nbsp;Sary Alsanea PhD","doi":"10.1016/j.jsps.2024.102071","DOIUrl":"https://doi.org/10.1016/j.jsps.2024.102071","url":null,"abstract":"","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102071"},"PeriodicalIF":4.1,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S131901642400121X/pdfft?md5=6aa98271416c8ba7b2fef936bc79893a&pid=1-s2.0-S131901642400121X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140633364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation of silymarin surface modified vesicles: In vitro characterization to cell viability assessment","authors":"Syed Sarim Imam,&nbsp;Sultan Owaid Alshammari,&nbsp;Sultan Alshehri,&nbsp;Wael A. Mahdi,&nbsp;Mohamed H. Al-Agamy","doi":"10.1016/j.jsps.2024.102072","DOIUrl":"10.1016/j.jsps.2024.102072","url":null,"abstract":"<div><p>Silymarin (SLR) is a poorly water-soluble bioactive compound with a wide range of therapeutic activities. Nanosized silymarin vesicles (F1–F6) were prepared by the solvent evaporation rehydration method. The silymarin vesicles were evaluated for vesicle size, surface charge, entrapment efficiency, and drug release studies. The optimized SLR lipid vesicle (F3) was further modified with the addition of the cationic polymer chitosan. After that, the modified vesicle (F3C1) was assessed for permeation flux, antimicrobial activity, cell viability, and molecular docking studies. The silymarin vesicles showed nanometric size (&lt;250 nm), low polydispersibility index (&lt;0.05), negative surface charge, and high SLR entrapment (85–95 %). The drug release study result demonstrated a maximum drug release of 91.2 ± 2.8 %. After adding chitosan to the surface, there was a significant change in the size, polydispersibility index, surface charge (positive), and encapsulation efficiency. The drug release was found to be prolonged, and the permeation flux was also increased in comparison to free SLR. A comparative antimicrobial result was observed in comparison to the free SLR and standard drug. The cell viability assay also demonstrated a low IC₅₀ value for F3C1 against the cell line.</p></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102072"},"PeriodicalIF":4.1,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319016424001221/pdfft?md5=49153dbbc0cf2fc2bb0ce96085da0b10&pid=1-s2.0-S1319016424001221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140785095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of kaempferol glucoside against lipopolysaccharide-caused acute lung injury via targeting Nrf2/NF-κB/NLRP3/GSDMD: Integrating experimental and computational studies","authors":"Wesam H. Abdulaal ,&nbsp;Ulfat M. Omar ,&nbsp;Mustafa Zeyadi ,&nbsp;Dina S. El-Agamy ,&nbsp;Nabil A. Alhakamy ,&nbsp;Naif A. R. Almalki ,&nbsp;Hani Z. Asfour ,&nbsp;Mohammed W. Al-Rabia ,&nbsp;Abdulrahim A. Alzain ,&nbsp;Gamal A. Mohamed ,&nbsp;Sabrin R.M. Ibrahim","doi":"10.1016/j.jsps.2024.102073","DOIUrl":"https://doi.org/10.1016/j.jsps.2024.102073","url":null,"abstract":"<div><p>The current study explored the protective potential of kaempferol 3-sophoroside-7-glucoside (KSG) against acute lung injury (ALI). Pre-treatment with KSG effectively secured mice from ALI and showed similar efficaciousness to dexamethasone. KSG markedly increased the survival rate and alleviated lung pathological lesions induced by lipopolysaccharide (LPS). Furthermore, KSG attenuated differential and total cell counts in BALF (bronchoalveolar lavage fluid) and MPO (myeloperoxidase) activity. KSG counteracted the NF-κB (nuclear factor-κB) activation and significantly ameliorated the downstream inflammatory cytokine, TNF-α (tumor necrosis factor-α). Simultaneously, KSG suppressed the over-expression of NLRP3 (NOD-like receptor protein 3<strong>)</strong>, caspase-1, and pro-inflammatory cytokine interleukin IL-1β (interleukine-1β) and prohibited the elevation of the pyroptotic parameter GSDMD-N (N-terminal domain of gasdermin D) induced by LPS challenge. In addition, KSG significantly enhanced Nrf2 (nuclear-factor erythroid-2-related factor) and HO-1 (heme-oxygenase-1) expression. Meanwhile, KSG mitigated lipid peroxidative markers (malondialdehyde, protein carbonyl and 4-hydroxynonenal) and boosted endogenous antioxidants (superoxide dismutase/reduced glutathione/catalase) in lung tissue. <em>In silico</em> analyses revealed that KSG disrupts Keap1-Nrf2 protein–protein interactions by binding to the KEAP1 domain, consequently activating Nrf2. Specifically, molecular docking demonstrated superior binding affinity of KSG to KEAP1 compared to the reference inhibitor, with docking scores of −9.576 and −6.633 Kcal/mol, respectively. Additionally, the MM-GBSA binding free energy of KSG (−67.25 Kcal/mol) surpassed that of the reference inhibitor (−56.36 Kcal/mol). Furthermore, MD simulation analysis revealed that the KSG-KEAP1 complex exhibits substantial and stable binding interactions with various amino acids over a duration of 100 ns. These findings showed the protective anti-inflammatory and anti-oxidative modulatory efficiencies of KSG that effectively counteracted LPS-induced ALI and encouraged future research and clinical applications of KSG as a protective strategy for ALI.</p></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102073"},"PeriodicalIF":4.1,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319016424001233/pdfft?md5=2838ff40427d3a493238a9e6660eafb3&pid=1-s2.0-S1319016424001233-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140620730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic, and pharmacological prospects of nutmeg seed: A comprehensive review for novel drug potential insights","authors":"Sawsan S. Al-Rawi ,&nbsp;Ahmad Hamdy Ibrahim ,&nbsp;Heshu Jalal Ahmed ,&nbsp;Zhikal Omar Khudhur","doi":"10.1016/j.jsps.2024.102067","DOIUrl":"https://doi.org/10.1016/j.jsps.2024.102067","url":null,"abstract":"<div><h3>Background and objectives</h3><p>For centuries, plant seed extracts have been widely used and valued for their benefits. They have been used in food, perfumes, aromatherapy, and traditional medicine. These natural products are renowned for their therapeutic properties and are commonly used in medicinal treatments. Their significant pharmacological profiles provide an excellent hallmark for the prevention or treatment of various diseases. In this study, we comprehensively evaluated the biological and pharmacological properties of nutmeg seeds and explored their efficacy in treating various illnesses.</p></div><div><h3>Method</h3><p>Published articles in databases including Google Scholar, PubMed, Elsevier, Scopus, ScienceDirect, and Wiley, were analyzed using keywords related to nutmeg seed. The searched keywords were chemical compounds, antioxidants, anti-inflammatory, antibacterial, antifungal, antiviral, antidiabetic, anticancer properties, and their protective mechanisms in cardiovascular and Alzheimer’s diseases.</p></div><div><h3>Results &amp; discussion</h3><p>Nutmeg seeds have been reported to have potent antimicrobial properties against a wide range of various bacteria and fungi, thus showing potential for combating microbial infections and promoting overall health. Furthermore, nutmeg extract effectively reduces oxidative stress and inflammation by improving the body’s natural antioxidant defense mechanism. Nutmeg affected lipid peroxidation, reduced lipid oxidation, reduced low-density lipoprotein (LDL), and increased phospholipid and cholesterol excretion. In addition, nutmeg extract improves the modulation of cardiac metabolism, accelerates cardiac conductivity and ventricular contractility, and prevents cell apoptosis. This study elucidated the psychotropic, narcotic, antidepressant, and anxiogenic effects of nutmeg seeds and their potential as a pharmaceutical medicine. Notably, despite its sedative and toxic properties, nutmeg ingestion alone did not cause death or life-threatening effects within the dosage range of 20–80 g powder. However, chemical analysis of nutmeg extracts identified over 50 compounds, including flavonoids, alkaloids, and polyphenolic compounds, which exhibit antioxidant properties and can be used as phytomedicines. Moreover, the exceptional pharmacokinetics and bioavailability of nutmeg have been found different for different administration routes, yet, more clinical trials are still needed.</p></div><div><h3>Conclusion</h3><p>Understanding the chemical composition and pharmacological properties of nutmeg holds promise for novel drug discovery and therapeutic advancements. Nutmeg seed offers therapeutic and novel drug prospects that can revolutionize medicine. By delving into their pharmacological properties, we can uncover the vast potential possibilities of this natural wonder.</p></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102067"},"PeriodicalIF":4.1,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319016424001178/pdfft?md5=6652b1b4978190473104026dd0f72582&pid=1-s2.0-S1319016424001178-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140633353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissolution enhancement of Gefitinib by solid dispersion and complexation with β-cyclodextrins: In vitro testing, cytotoxic activity, and tablet formulation","authors":"Adel F. Alghaith ,&nbsp;Gamal M. Mahrous ,&nbsp;Ahmed S. Alenazi ,&nbsp;Suliaman M. ALMufarrij ,&nbsp;Mohammed S. Alhazzaa ,&nbsp;Awwad A. Radwan ,&nbsp;Abdullah S. Alhamed ,&nbsp;Mohamed S. Bin Salamah ,&nbsp;Sultan Alshehri","doi":"10.1016/j.jsps.2024.102070","DOIUrl":"https://doi.org/10.1016/j.jsps.2024.102070","url":null,"abstract":"<div><p>Cancer is the leading cause of mortality worldwide. In patients with metastatic non-small cell lung cancer, epidermal growth factor receptor (EGFR) is often overexpressed. Gefitinib (GEF), an inhibitor of EGFR, is approved for the treatment of patients with metastatic non-small cell lung cancer (NSCLC). However, the low solubility and dissolution of GEF limits its bioavailability. Numerous methods, including solid dispersion (SD) and complexation, have been reported to enhance the dissolution of poorly soluble drugs. In this study, GEF complexes were prepared using methyl-β-cyclodextrin (MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) in two molar ratios (1:1 and 1:2), furthermore, GEF SDs were prepared using polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), and poloxamer-188(PXM) in three different ratios (1:2, 1:4 and 1:6 w/w). Dissolution studies were conducted on the prepared formulations. Dissolution results showed a 1.22–2.17-fold enhancement in drug dissolution after one hour compared to untreated GEF. Two formulations that showed higher dissolution enhancement were subsequently evaluated for in-vitro cytotoxicity and were formulated into tablets. The selected PVP–GEF (1:4 w/w) and MβCD–GEF (1:1M) formulas displayed improved cytotoxicity compared to untreated GEF. The IC₅₀ values of the PVP–GEF and MβCD–GEF were 4.33 ± 0.66 and 4.84 ± 0.38 µM, respectively which are significantly lower (p &lt; 0.05) than free GEF. In addition, the formulated tablets exhibited enhanced dissolution compared to pure GEF tablets. PVP–GEF SD tablets released (35.1 %<em>±0</em>.4) of GEF after one hour, while GEF-MβCD tablets released (42.2 % <em>± 0.7)</em> after one hour. In the meantime, tablets containing pure GEF showed only 15 % <em>±</em> 0.5 release at the same time. The findings of this study offer valuable insights for optimizing the dissolution and hence therapeutic capabilities of GEF while mitigating its limitations.</p></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102070"},"PeriodicalIF":4.1,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319016424001208/pdfft?md5=5e7d0845d40ef62a9216841ca91d88fc&pid=1-s2.0-S1319016424001208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140605830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes-related lower limb wounds: Antibiotic susceptibility pattern and biofilm formation","authors":"Raha Orfali ,&nbsp;Safina Ghaffar ,&nbsp;Lateefa AlAjlan ,&nbsp;Shagufta Perveen ,&nbsp;Eman Al-Turki ,&nbsp;Fuad Ameen","doi":"10.1016/j.jsps.2024.102069","DOIUrl":"https://doi.org/10.1016/j.jsps.2024.102069","url":null,"abstract":"<div><p>The expeditious incidence of diabetes mellitus in Riyadh, Saudi Arabia, there is a significant increase in the total number of people with diabetic foot ulcers. For diabetic lower limb wound infections (DLWs) to be effectively treated, information on the prevalence of bacteria that cause in this region as well as their patterns of antibiotic resistance is significant. Growing evidence indicates that biofilm formers are present in chronic DFU and that these biofilm formers promote the emergence of multi-drug antibiotic resistant (MDR) strains and therapeutic rejection. The current study targeted to isolate bacteria from wounds caused by diabetes specifically at hospitals in Riyadh and assess the bacterium's resistance to antibiotics and propensity to develop biofilms. Totally 63 pathogenic microbes were identified from 70 patients suffering from DFU. Sixteen (25.4%) of the 63 bacterial strains were gram-positive, and 47 (74.6%) were gram-negative. Most of the gram-negative bacteria were resistant to tigecycline, nitrofurantoin, ampicillin, amoxicillin, cefalotin, and cefoxitin. Several gram-negative bacteria are susceptible to piperacillin, meropenem, amikacin, gentamicin, imipenem, ciprofloxacin, and trimethoprim. The most significant antibiotic that demonstrated 100% susceptibility to all pathogens was meropenem. <em>Serratia marcescens</em> and <em>Staphylococcus aureus</em> were shown to have significant biofilm formers. MDR bacterial strains comprised about 87.5% of the biofilm former strains. To the best of our knowledge, Riyadh, Saudi Arabia is the first region where <em>Serratia marcescens</em> was the most common bacteria from DFU infections. Our research findings would deliver information on evidence-based alternative strategies to develop effective treatment approaches for DFU treatment.</p></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102069"},"PeriodicalIF":4.1,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319016424001191/pdfft?md5=f16c50ce48c39ad9af772475e7507c8e&pid=1-s2.0-S1319016424001191-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140620727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical modeling, optimization and characterization of andrographolide loaded emulgel for its therapeutic application on skin cancer through enhancing its skin permeability","authors":"N. V. L. Sirisha Mulukuri ,&nbsp;Sujeet Kumar ,&nbsp;Moumita Dhara ,&nbsp;Gupta Dheeraj Rajesh ,&nbsp;Pankaj Kumar","doi":"10.1016/j.jsps.2024.102068","DOIUrl":"https://doi.org/10.1016/j.jsps.2024.102068","url":null,"abstract":"<div><p>Andrographolide is a natural diterpene lactone with multiple biological effects. In the present study, a total of 11 andrographolide-loaded emulgels (ANG 1- ANG 11) were prepared by emulsification and solvent evaporation method using flaxseed oil and xanthan gum in different ratios, as suggested by the Design-Expert software. A 2-factor-5-level design was employed with different responses including spreadability, extrudability, viscosity, and drug release after 1 h (h) and 24 h. Based on the Design-Expert software response, the optimized emulgel ANG 12 was formulated and evaluated. The 24 h <em>In-vitro</em> drug release was found to be 95.7 % following Higuchi kinetics. <em>Ex-vivo</em> skin retention of 784.78 ug/cm² was observed during the study. MTT assay performed on Human epidermoid carcinoma (A-431) cells demonstrated cell growth arrest at G0/G1 and G2/M phase after 24 h of ANG 12 treatment (IC₅₀: 11.5 µg/ml). The cellular permeability of ANG-12 was assessed by Fluorescein isothiocyanate (FITC) assay. Compared to untreated cells (0.54 % uptake) the ANG-12 treated cells had shown 87.17 % FITC permeation. The biocompatibility study performed on non-cancerous human dermal fibroblast cells (HDF cells) shows 91.54 % viability after 24 h of the treatment showing the non-toxic nature of ANG-12. Confocal imaging had shown a significant time-dependent increase in <em>in-vivo</em> cellular uptake with enhanced, progressive penetration of the emulgel into the skin. An <em>in-vivo</em> skin irritation study conducted on Swiss albino mice confirmed the safety aspects of the ANG 12. Hence, it can be concluded that nanoemulgel of andrographolide (ANG 12) could be a novel approach to treating skin cancer.</p></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102068"},"PeriodicalIF":4.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S131901642400118X/pdfft?md5=70da1db50ff86c260b041adb66e5034f&pid=1-s2.0-S131901642400118X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotretinoin self-nano-emulsifying drug delivery system: Preparation, optimization and antibacterial evaluation","authors":"Rihaf Alfaraj ,&nbsp;Sandra Hababah ,&nbsp;Esra K. Eltayb ,&nbsp;Fulwah Y. Alqahtani ,&nbsp;Fadilah S. Aleanizy","doi":"10.1016/j.jsps.2024.102063","DOIUrl":"https://doi.org/10.1016/j.jsps.2024.102063","url":null,"abstract":"<div><h3>Purpose</h3><p>Isotretinoin (ITN) is a poorly water-soluble drug. The objective of this study was to design a successful liquid self-nanoemulsifying drug delivery system (L-SNEDDS) for ITN to improve its solubility, dissolution rate, and antibacterial activity.</p></div><div><h3>Methods</h3><p>According to solubility and emulsification studies, castor oil, Cremophor EL, and Transcutol HP were selected as system excipients. A pseudo ternary phase diagram was constructed to reveal the self-emulsification area. The developed SNEDDS were visually assessed, and the droplet size was measured. In vitro release studies and stability studies were conducted. The antimicrobial effectiveness against multiple bacterial strains, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and different accessory gene regulator (Agr) variants were investigated for the optimum ITN-loaded SNEDDS formulation.</p></div><div><h3>Results</h3><p>Characterization studies showed emulsion homogeneity and stability (%T 95.40–99.20, A graded) with low droplet sizes (31.87 ± 1.23 nm–115.47 ± 0.36 nm). It was found that the developed ITN-SNEDDS provided significantly a higher release rate (&gt;96 % in 1 h) as compared to the raw drug (&lt;10 % in 1 h). The in vitro antimicrobial activities of pure ITN and ITN-loaded SNEDDS demonstrated a remarkable inhibitory effect on bacterial growth with statistically significant findings (p &lt; 0.0001) for all tested strains when treated with ITN-SNEDDS as compared to the raw drug.</p></div><div><h3>Conclusion</h3><p>These outcomes suggested that SNEDDS could be a potential approach for improving solubility, dissolution rates, and antibacterial activity of ITN.</p></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102063"},"PeriodicalIF":4.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319016424001130/pdfft?md5=33ce1210b76e28145c211db8f048967b&pid=1-s2.0-S1319016424001130-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140554723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatible gelatin-coated ferrite nanoparticles: A magnetic approach to advanced drug delivery","authors":"Varda Shakeel ,&nbsp;Iftikhar Hussain Gul ,&nbsp;Peter John ,&nbsp;Attya Bhatti","doi":"10.1016/j.jsps.2024.102066","DOIUrl":"https://doi.org/10.1016/j.jsps.2024.102066","url":null,"abstract":"<div><p>Nanotechnology has transformed drug delivery, offering opportunities to enhance treatment outcomes while minimizing adverse effects. This study focuses on gelatin-coated cobalt and manganese ferrite nanoparticles for potential drug delivery applications. The synthesis involved a co-precipitation method, and the nanoparticles were characterized using various techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, and vibrating sample magnetometer (VSM). Results revealed stable structures, distinct chemical features introduced by gelatin coating, and unique magnetic properties. The hemolysis assay demonstrated reduced hemolytic activity with gelatin coating, enhancing biocompatibility. Drug release studies indicated differential release profiles, with gelatin-coated cobalt ferrite exhibiting higher drug release compared to gelatin-coated manganese ferrite. The Higuchi model supported diffusion-controlled drug release for gelatin-coated cobalt ferrite. These findings suggest the potential of gelatin-coated ferrite nanoparticles for controlled and targeted drug delivery, highlighting their significance in advancing nanomedicine.</p></div>","PeriodicalId":49257,"journal":{"name":"Saudi Pharmaceutical Journal","volume":"32 6","pages":"Article 102066"},"PeriodicalIF":4.1,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1319016424001166/pdfft?md5=ccda88027e67e784e526d3315ceb5b4e&pid=1-s2.0-S1319016424001166-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}