{"title":"Investigation of Pharyngeal Swallow Function of Healthy Older Adults Using Visual Analysis of Swallowing Efficiency and Safety Scale.","authors":"Sivaranjani Palani, N Swapna, T K Prakash","doi":"10.1007/s12070-024-05030-x","DOIUrl":"10.1007/s12070-024-05030-x","url":null,"abstract":"<p><p>To assess the pharyngeal swallow function of older adults in terms of safety and efficiency using the VASES scale. Twenty healthy individuals aged 60-80 years were included. They were evaluated using the EAT-10 K and VVST, followed by the FEES assessment. VASES was used to assess the residue in the oropharynx, hypopharynx, Epiglottis, Laryngeal vestibule, Vocal folds, and Sub glottis, and the aspiration and penetration during swallowing. Residue was present in the oropharynx, hypopharynx, epiglottis, and laryngeal vestibule for 95%, 85%, 45%, and 15% of the swallowing trials. The median residue amount was found to be 2% in the oropharynx and 1% in the hypopharynx. 70% of swallows yielded a score of PAS score of 1, followed by PAS 3 for 20% and PAS 2 for 10%. VASES facilitated the quantification of the residue across anatomical sites. Older adults did have compromised swallow safety and efficiency.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"5549-5556"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nurul Najwa Mohd Zakir, Norhafiza Mat Lazim, Anani Aila Mat Zin, Ali Haron, Baharudin Abdullah
{"title":"The Expressions of p16, HPV16-L1 and HPV18-E6 in Salivary Gland Tumours.","authors":"Nurul Najwa Mohd Zakir, Norhafiza Mat Lazim, Anani Aila Mat Zin, Ali Haron, Baharudin Abdullah","doi":"10.1007/s12070-024-05007-w","DOIUrl":"10.1007/s12070-024-05007-w","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to investigate the relationship between human papillomavirus (HPV) infection and the development of salivary gland tumour (SGT) by evaluating the expression of p16 and the oncoproteins HPV16-L1 and HPV18-E6 using immunohistochemical (IHC) staining. Additionally, we assess the agreement between these oncoproteins and p16 in diagnosing HPV-infected SGT.</p><p><strong>Methods: </strong>This cross-sectional study included all SGT cases undergoing surgical resection at Hospital Universiti Sains Malaysia (HUSM) and Hospital Raja Perempuan Zainab II (HRPZ) in Malaysia from April 2022 to April 2023. IHC staining was performed on paraffin-embedded tissues at the Pathology Laboratory, HUSM, to evaluate the expression of p16, HPV16-L1, and HPV18-E6 oncoproteins. The clinicopathological data were correlated with the staining results.</p><p><strong>Results: </strong>49 SGT cases were identified, mainly in middle-aged Malay women, with most tumours originating from the parotid gland. Malignant tumours included mucoepidermoid carcinoma (22.4%), adenoid cystic carcinoma (4.1%), acinic cell carcinoma (4.1%), and adenocarcinoma (2%). Benign tumours primarily consisted of pleomorphic adenoma (49%) and Warthin tumours (16.3%). Positive p16 expression was detected in 67% of cases, while HPV16 and HPV18 were detected in 65% and 90% of tumours, respectively. HPV16-L1 exhibited 75.8% sensitivity and 56.3% specificity, while HPV18-E6 showed 100% sensitivity and 31.2% specificity compared to p16.</p><p><strong>Conclusion: </strong>The study findings suggest a correlation between the presence of high-risk HPV types 16 and 18 and the development of SGT, as evidenced by the overexpression of p16, HPV16-L1, and HPV18-E6 oncoproteins. Both HPV16-L1 and HPV18-E6 tests are acceptable, reliable, and sensitive for detecting high-risk HPV in SGT.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"5470-5477"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Late-Onset Metastasis of Renal Cell Carcinoma: A Rare Case of Sinonasal Malignancy Post-Nephrectomy.","authors":"Swati Vashisth, Ayushi Gupta, Ankita Chaudhary, Poonam Aggarwal","doi":"10.1007/s12070-024-05090-z","DOIUrl":"10.1007/s12070-024-05090-z","url":null,"abstract":"<p><p>This case report highlights a rare case of renal cell carcinoma metastasis to nose and paranasal sinuses in a 55-year-old male 8 years post-nephrectomy. Contrast imaging revealed a vascular mass and histopathology confirmed metastatic RCC. Partial maxillectomy was done and patient remained disease free at 6 month follow up.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"6055-6058"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolving Trends in Safe Surgery in Otolaryngology: Experience from a Tertiary Care Centre.","authors":"Sanjay Kumar, Debmita Dutta, Angshuman Dutta, Surjeet Dwivedi, Roohie Singh","doi":"10.1007/s12070-024-05075-y","DOIUrl":"10.1007/s12070-024-05075-y","url":null,"abstract":"<p><p>Surgical outcomes in otolaryngology have improved with advancements in safety protocols, technology, and patient-centered care. Despite these improvements, surgical complications remain a concern, necessitating continuous evaluation. This study aimed to examine the trends in safe surgery practices and patient outcomes over two years at a tertiary care otolaryngology center, focusing on preoperative, intraoperative, and postoperative phases, as well as patient involvement in decision-making. A retrospective observational study was conducted at a tertiary care otolaryngology center from January 2022 to December 2023. The study included 200 patients who underwent various otolaryngological procedures. Data were collected from hospital records, patient surveys, and follow-up assessments. Key data points included demographics, preoperative assessments, intraoperative details, postoperative outcomes, and patient involvement. Statistical analysis was performed using SPSS version 27, with descriptive statistics, chi-square tests, t-tests, and regression analysis to assess the impact of safety protocols and advanced tools on outcomes. Adherence to safety protocols reduced intraoperative complications from 20 to 10% and postoperative complications from 40 to 20%. Advanced technological tools reduced mean surgery duration from 125 to 100 min and mean recovery time from 8 to 7 days. Shared decision-making improved patient satisfaction scores, averaging 8.5 compared to 6.5 for those without it. The complication rate was also lower in patients involved in shared decision-making (13.3%) compared to those who were not (60%). The results highlight the importance of safety protocols, advanced technology, and patient involvement in improving surgical outcomes in otolaryngology. The reduction in complications and enhanced patient satisfaction underscore the need for continuous implementation of these practices. This study provides valuable insights into optimizing surgical care and supports patient-centered approaches to further improve outcomes.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12070-024-05075-y.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"5731-5739"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N N Madkikar, Shailesh Pandey, Virendra Ghaisas, Ajit Agashe, Himanshu Chitre
{"title":"Multilevel-Single Stage-Functional Rhinoplasty & BRP (Barb Reposition Palatoplasty) in Surgical Management of Primary Snorers, UARS and Mild OSA.","authors":"N N Madkikar, Shailesh Pandey, Virendra Ghaisas, Ajit Agashe, Himanshu Chitre","doi":"10.1007/s12070-024-05059-y","DOIUrl":"10.1007/s12070-024-05059-y","url":null,"abstract":"<p><p>Obstructive sleep apnoea syndrome (OSA) is a multi-factorial disorder, with quite complex endotypes, consisting of anatomical and non-anatomical pathophysiological factors. Continuous positive airway pressure (CPAP) is recognized as the first-line standard treatment for OSA, whereas upper airway (UA) surgery is often recommended for treating mild OSA patients who have refused or cannot tolerate CPAP, mild and primary snorers. The main results achievable by the surgery are UA expansion, and/or stabilization, and/or removal of the obstructive tissue to different UA levels. The site and pattern of UA collapse identification is of upmost importance in selecting the customized surgical procedure to perform, as well as the identification of the relation between anatomical and non-anatomical factors in each patient. It has become increasingly clear in the past decade that surgical management of OSA is most successfully managed with multilevel surgery (Cahali in Laryngoscope, 113(11):1961-1968, 2003; Friedman et al. in Otolaryngol Head Neck Surg 131(1):89-100, 2004; Laryngoscope 114(3):441-449, 2004; Pang Woodson in Otolaryngol Head Neck Surg 137(1):110-114, 2007; Li Lee in Laryngoscope 119(12):2472-2477, 2009; Vicini et al. in Head Neck 36(1):77-78, 2014; Mantovani et al. in Acta Otorhinolaryngol Ital 32:48-53, 2012; Morgenthaler in Sleep 30(4):519-529, 2007). Drug-induced sleep endoscopy (DISE) has shown that the nose amounting more than 50% of flow limitation and soft palatal collapse are important anatomic components of obstruction in OSAHS and therefore should be treated as far as possible as a single stage procedure. The nasal patency being pivotal in the outcome of the sleep apnoea surgery. Choosing the right patient and the right surgical approach for such patients is extremely important to decrease the overall burden of the disease. We have chosen functional rhinoplasty or an open approach septoplasty for management of various nasal deformities that lead to significant obstruction in patients suffering from snoring and mild OSA. While the palatal component of obstruction being treated with BRP (BARB Relocation Palatoplasty) for anterior- posterior, lateral and concentric collapses at retro palatal level. (1) To be able to offer an effective and reliable surgical management to simple snorers, Mild OSA, upper airway resistance patients, PAP non-compliant or non-adherent patients. (2) To ascertain the effectiveness and ease of carrying out multilevel single stage procedure in above mentioned patients of snorers to mild obstructive sleep apnoea, and to use Functional Rhinoplasty & BARB sutures for relocation and suspension Palatoplasty to address retro palatal collapse without excising soft palatal tissue. (3) To make minor modification in the surgical steps namely - bundling of the posterior pillar after release to avoid cut through or spillage of the barb suture from point of relocation. (4) Identifying surgical candidacy for better outcomes","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"5672-5681"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute Supraglottitis Causing Airway Obstruction in Adults - A Case Series.","authors":"Haritha S, Shanthi Priya Dhanasekaran, Nandhini Radhakrishnan","doi":"10.1007/s12070-024-05094-9","DOIUrl":"10.1007/s12070-024-05094-9","url":null,"abstract":"<p><p>Acute adult supraglottitis is a serious and potentially life-threatening condition marked by inflammation of the supraglottic structures, posing a significant risk for rapid airway compromise. This case series highlights the varied presentations and management challenges associated with adult supraglottitis. The four cases involve adult males, most with uncontrolled diabetes mellitus, presenting with symptoms such as difficulty breathing, sore throat, dysphagia, and voice changes. Diagnostic approaches included soft-tissue neck radiographs and video laryngoscopy, with common findings of an edematous epiglottis and \"thumbprint\" sign. Management strategies ranged from conservative treatment with antibiotics and steroids to emergent airway interventions like tracheostomy. These cases underscore the importance of early diagnosis, close monitoring, and tailored treatment to prevent severe outcomes. The series emphasizes the need for high clinical suspicion and prompt action in cases of adult supraglottitis, especially given its potential for rapid deterioration and significant morbidity.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"6059-6063"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Our Experience with EXIT Procedures: A Case Series.","authors":"Darshil Vaishnav, Sachin Gandhi, Snehpali Bansode","doi":"10.1007/s12070-024-05034-7","DOIUrl":"10.1007/s12070-024-05034-7","url":null,"abstract":"<p><p>Respiratory distress in neonates presents challenges necessitating immediate airway management. This case series explores two instances of Ex-Utero Intra Partum Procedure (EXIT) for newborns with congenital airway obstructions. Case 1 describes a 34-year-old gravida 2 para 1 at 35 + 1 weeks with micrognathia. Due to failed intubation, an EXIT tracheostomy was performed successfully within 18 min, maintaining foetal oxygenation through utero-placental circulation. Case 2 involves a 29-year-old primigravida at 34 + 1 weeks with Congenital High Airway Obstruction Syndrome (CHAOS), where a planned EXIT tracheostomy was executed. These cases highlight the crucial role of multidisciplinary teams comprising obstetricians, anaesthetists, neonatologists, and specialized surgeons. Discussion emphasizes early prenatal diagnosis, meticulous planning, and parental counselling. The EXIT procedure is crucial for various indications such as oropharyngeal masses and CHAOS. Challenges like fetal tissue pliability and maintaining utero-placental circulation are addressed. Early detection, pathology understanding, and thorough planning are vital for successful outcomes. Psychological support for parents and a multidisciplinary approach ensure optimal maternal and neonatal outcomes. This series underscores the significance of the EXIT procedure in managing neonatal airway emergencies, particularly in preterm births.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"5992-5996"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Hidden Giant: A Report of an Enormous Rhinolith.","authors":"Nimish Gupta, Shreya Agarwal","doi":"10.1007/s12070-024-04990-4","DOIUrl":"10.1007/s12070-024-04990-4","url":null,"abstract":"<p><p>Rhinolith, commonly addressed as nasal stone is quite unusual and rare entity. It is actually a calcified mass that form within the nasal cavity, typically as a result of mineral deposits accumulating around a core of foreign material (which can be exogenous or endogenous in origin). Although often small and asymptomatic, rhinolith can occasionally grow to significant size, causing severe clinical symptoms. Case description: We report a case of this clinical entity, a tribal woman from interior Himalayan regions, where the lack of medical facilities and expertise led to missed diagnosis, years of suffering and a rhinolith of humongous proportions.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12070-024-04990-4.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"5917-5920"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Afena Apandi, Hardip Singh Gendeh, Siti Nor Asiah Zakaria, Amran Mohamad, Nor Diana Borian
{"title":"Recurrent neck Abscess by Migrating Fishbone Penetrating Thyroid Found in Subcutaneous Tissue: Case Report.","authors":"Afena Apandi, Hardip Singh Gendeh, Siti Nor Asiah Zakaria, Amran Mohamad, Nor Diana Borian","doi":"10.1007/s12070-024-04779-5","DOIUrl":"10.1007/s12070-024-04779-5","url":null,"abstract":"<p><p>Extraluminal foreign bodies are rare. Fish bone is the most common foreign body ingested by adults, while coin is the most common foreign body ingested among children. Sharp pricking pain is a sign of sharp foreign body (FB) ingestion. If the symptom persists, one should keep in mind the possibility of a migratory foreign body, even if the esophagoscopy results are negative. In order to ensure that foreign bodies are not missed radiologically, there is the role of consultation from a second radiologist to correlate with the patient's symptoms. Here we present an atypical case of recurrent neck abscess due to a migrating fishbone that penetrated the left thyroid lobe and settled in the left lower third neck subcutaneous tissue within two months.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12070-024-04779-5.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"5839-5842"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contralateral Ear in Patients with Chronic Otitis Media.","authors":"Kourosh Eftekharian, Ali Eftekharian, Farhad Mokhtarinejad, Maryam Amizadeh, Abolfazl Ghobadi, Masoumeh Saeedi, Sepehr Sahraiyan","doi":"10.1007/s12070-024-05073-0","DOIUrl":"10.1007/s12070-024-05073-0","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the opposite ear in patients operated for chronic otitis media (COM).<b>Methods:</b> In a cross-sectional study involving three tertiary hospitals, patients who underwent surgery for COM were examined for abnormalities of the contralateral ear at the time of the surgery. <b>Results:</b> Out of 228 patients, 182 (79.8%) were operated on for non-cholesteatomatous or simple chronic pars tensa perforation of the tympanic membrane (PTP), and 46 (20.2%) for cholesteatoma. 113 (49.56%) patients had normal contralateral ears under oto-microscopic exam. PTP was statistically more prevalent in females than males (F/M:118/64), whereas cholesteatoma was more prevalent in males (21/25). In the PTP group, 82 (45.3%) had normal contralateral ears, whereas patients with cholesteatoma had 31 (67.4%) normal opposite ears (<i>P</i> = 0.01). The most frequent abnormal findings in the PTP group were pars tensa perforation and sclerotic plaques, and in the cholesteatoma group were cholesteatoma and pars tensa perforation. Patients with cholesteatoma had significantly lower contralateral ear perforation than patients with tympanic membrane perforation (<i>P</i> = 0.02). The most frequent size of eardrum perforation in the contralateral ear of the PTP group was more than 50 percent. No significant difference existed between the large and small perforations for contralateral abnormality. <b>Conclusion:</b> Bilateral pathophysiology seems to be more prominent in PTPs than in cholesteatomas. Tympanic membrane perforation tends to be accompanied by a large perforation. The larger perforation on one side did not predict having more problems on the opposite side.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"76 6","pages":"5725-5730"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}