Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry最新文献

{"title":"Shear bond strength of vat photopolymerization additive-manufactured zirconia to veneering ceramic.","authors":"Yue Zhu, Zidi Zhai, Ting Jiao, Jian Sun","doi":"10.1111/jopr.14034","DOIUrl":"https://doi.org/10.1111/jopr.14034","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the shear bond strength (SBS) of stereolithography (SLA), digital light processing (DLP) manufactured, and computer numerical control (CNC) milled zirconia to veneering ceramic.</p><p><strong>Materials and methods: </strong>Rectangular shaped zirconia substrates (10 × 5 × 5 mm³) were manufactured through SLA, DLP, and CNC technology separately. Their surface roughness was measured and the surface topography was analyzed by atomic force microscope (AFM). Then the veneering ceramic (5 × 5 × 5 mm³) was applied to carry out the SBS test. Failure modes were examined by a scanning electron microscope (SEM). The data of SBS and roughness were statistically analyzed with one-way ANOVA followed by S-N-K post hoc comparisons (a = 0.05).</p><p><strong>Results: </strong>The surface roughness of the SLA group (0.38 ± 0.03 µm) and the DLP group (0.37 ± 0.04 µm) were both significantly higher than the CNC group (0.16 ± 0.00 µm) (p < 0.001). AFM results revealed irregular surface of SLA and DLP zirconia. No significant difference was found in SBS value of the three groups (p = 0.253). SEM image showed different failure modes including cohesive, adhesive, and mixed failure.</p><p><strong>Conclusion: </strong>The bonding ability of SLA and DLP zirconia to veneering ceramic were comparable with that of CNC zirconia.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angulated titanium bases screw channel abutments for single implant restorations: A systematic review and meta-analysis","authors":"Paolo De Angelis DDS, MS, PhD,&nbsp;Edoardo Rella DDS,&nbsp;Margherita Giorgia Liguori DDS, MS, PhDc,&nbsp;Davide Piccirillo DDS,&nbsp;Alberto Palmieri DDS,&nbsp;Antonio D'addona DDS, MS,&nbsp;Paolo Francesco Manicone DDS","doi":"10.1111/jopr.14032","DOIUrl":"10.1111/jopr.14032","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Screw-retained implant crowns are a common solution to rehabilitate single or multiple edentulous sites. Angulated screw channel (ASC) abutments have been developed as a new system of connection to correct the angulation of the implant and avoid a possible undesired emergence of the access hole. The purpose of this systematic review was to examine available literature related to the effects of ASC abutments in rehabilitating single implant crowns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A protocol was registered in the PROSPERO database (ID = CRD42022295521). An electronic search of the Cochrane Central Register of Controlled Trials and Trial Protocols, MEDLINE, SCOPUS, and Web of Science was performed up to January 16, 2024. Additionally, a manual search was carried out. The meta-analysis used a fixed or a random effects model, based on the heterogeneity between the studies, focusing on binary and continuous data. A risk of bias assessment was performed (NOS or MOGA et al.) The outcomes assessed were peri-implant marginal bone level, probing pocket depth (PPD), the prevalence of technical and mechanical complications, implant and prosthesis survival rates, and esthetics. Statistical significance was set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The searches resulted in a total of 10 studies included in the meta-analysis. The mean implant and prosthesis survival rates were respectively 99% (absolute quantity = 243) and 100% (absolute quantity = 239) with non-statistically significant differences observed in single crowns supported by ASC abutments compared to cemented restorations, in terms of marginal bone loss (MBL) (<i>p</i> = 0.22), PPD (<i>p</i> = 0.08), risk of complications (<i>p</i> = 0.53), and esthetics (<i>p</i> = 0.47). Follow-up intervals ranged from 14 days to more than 3 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Data based on this systematic review suggest that the clinical and radiographic outcomes of single implants restored using ASC are promising if compared to the outcomes relating to screw-retained single crowns.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":"34 3","pages":"240-251"},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cleft palate type and manufacturing method on feeding plate adaptation: A volumetric micro-computed tomography analysis.","authors":"Osman Akıncı, Ece İrem Oğuz, Poyzan Bozkurt, Merve Berika Kadıoğlu, Mert Ocak, Kaan Orhan, Reha Şükrü Kişnişçi","doi":"10.1111/jopr.14027","DOIUrl":"https://doi.org/10.1111/jopr.14027","url":null,"abstract":"<p><strong>Purpose: </strong>Feeding plates for cleft palate patients have been used by clinicians for many years to temporarily close the oro-nasal communication until definitive treatment with surgical techniques. The current in vitro study aimed to evaluate the adaptation of the feeding plates manufactured by two different techniques for three cleft types.</p><p><strong>Materials and methods: </strong>Feeding plates were manufactured with conventional compression molding (CM) and 3-dimensional (3D) additive manufacturing on main models representing bilateral cleft, unilateral right, and unilateral left cleft types (n = 10). The 3D volumetric space between the feeding plate and the corresponding main model was measured by micro-CT to evaluate the adaptation. The adaptation of the plates was assessed based on three different measurement regions: anterior, left, and right. Repeated measure analysis of variance (ANOVA), three factorial ANOVA, and post hoc Bonferroni tests were used as statistical analysis (α = 0.05).</p><p><strong>Results: </strong>CM groups showed higher volumetric space measurements between the base and master model than 3D groups regardless of measurement region and cleft type, which refers to misfit (p ˂ 0.05). Cleft type differed in the adaptation of 3D groups yet not in CM groups (p ˂ 0.05). The volumetric space evaluation for the right measurement region resulted in higher values regardless of manufacturing method and cleft type (p ˂ 0.05).</p><p><strong>Conclusion: </strong>Considering that 3D-printed feeding plates showed better adaptation compared to conventionally manufactured plates for all cleft types, 3D printing can be suggested as the manufacturing method of choice for feeding plates.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the mouth: An overview of obstructive sleep apnea in adults for dentists","authors":"Valerie Cacho MD","doi":"10.1111/jopr.14020","DOIUrl":"10.1111/jopr.14020","url":null,"abstract":"<p>Obstructive sleep apnea (OSA) is a common and complex medical sleep condition in adults that is associated with chronic medical and mental health conditions. Left undiagnosed and untreated it can decrease quality of life and increase morbidity and mortality. Dentists are at the forefront for screening OSA in their role to maintain the health of the oral cavity. Clinical experience in the management of OSA in dentists is limited. The aim of this article is to provide dentists with foundational knowledge about OSA to empower them to play an active role in the care management of screening and treating OSA.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":"34 S1","pages":"4-9"},"PeriodicalIF":3.4,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jopr.14020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing surface energy and characterizing optical properties of ultra-high translucency zirconia via an innovative heat treatment process.","authors":"Chien-Ming Kang, Sheng-Han Wu, Sheng-Wei Feng, Chenxuan Wei, Tzu-Yu Peng","doi":"10.1111/jopr.14033","DOIUrl":"https://doi.org/10.1111/jopr.14033","url":null,"abstract":"<p><strong>Purpose: </strong>Ultra-high translucency zirconia (UT-Zr) is known for its high esthetic quality; however, its inert surface results in low hydrophilicity and surface energy (SE). To address this limitation, this study proposes an innovative zirconia heat treatment process (ZHTP) and aims to evaluate the effects of ZHTP on the surface characteristics of UT-Zr, offering a novel and practical approach for surface pretreatment in dental practice.</p><p><strong>Material and methods: </strong>The plate-shaped UT-Zr samples were fabricated. After sintering, the samples without additional staining or polishing were divided into the following nine groups: NT (no additional pretreatment), AB (airborne-particle abrasion), PL (nonthermal plasma), PO (polishing), HPO (fine-polishing), NTH (treat with ZHTP), POPL (PL followed by PO), POH (ZHTP followed by PO), and HPOH (ZHTP followed by HPO). The surface roughness (Ra), microstructure, transmittance, glossiness, wettability, and SE of the samples (n = 10), and statistical analyses were conducted.</p><p><strong>Results: </strong>AB showed the highest Ra and lowest glossiness (P < 0.05), while HPO and HPOH yielded the smoothest surfaces, with HPOH achieving the highest glossiness (P < 0.05). Although the ZHTP approach slightly improved transmittance, it did not affect the microstructure. PO reduced hydrophilicity and SE (P < 0.05), and HPO slightly increased them. PL significantly enhanced both properties (P < 0.05), and ZHTP also increased them (P < 0.05) to levels similar to PL. Notably, hydrophilicity in nonthermal plasma and ZHTP-treated samples decreased similarly after 24 h.</p><p><strong>Conclusions: </strong>The ZHTP approach enhances UT-Zr wettability and SE, with slight transmittance improvement. HPOH achieves hydrophilicity and SE comparable to PL, validating ZHTP as a promising strategy for UT-Zr surface optimization in dental applications.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of conversion prosthesis in immediately loaded implants: A retrospective study.","authors":"Karolina M Migus, Avinash S Bidra, Chia-Ling Kuo","doi":"10.1111/jopr.14019","DOIUrl":"https://doi.org/10.1111/jopr.14019","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The primary objective of this retrospective study was to evaluate the survival outcomes of immediately loaded acrylic resin complete arch fixed implant-supported prosthesis (CAFIP) fabricated from the denture conversion protocol. The secondary objective was to evaluate the early implant survival outcomes associated with these prostheses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;A retrospective chart review was conducted to study the clinical outcomes data of immediately loaded conversion prostheses and immediately loaded implants. All patients who had been treated with immediately loaded acrylic resin CAFIP using the denture conversion protocol over a 9-year period were included in the study. All dentures were fabricated by conventional processing using compression molded or injection molded techniques. These patients were treated by numerous clinicians but adhering to the same protocol, over the entire 9-year follow-up period. Clinical outcome data related to the number of early fractures during the initial implant healing period of 4 months, early implant failures, late fractures (after 4 months), late implant failures (after 4 months), technical complications, number and type of implants placed, the arch in which the implants and prosthesis were placed and the type of opposing dentition were recorded and analyzed. A p-value &lt; 0.05 was determined to be statistically significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 153 prostheses (97 in maxilla, 56 in mandible) in 117 patients (60 males, 57 females) and 768 implants (298 in maxilla, 470 in mandible) were evaluated. All conversion prostheses were followed up for a minimum of 4 months (range of 4-20 months). There were a total of 15 implant failures yielding a survival rate of 98% survival rate during the observation period with the conversion prostheses. Only 3 of the failed implants were associated with a failure (crack or fracture) of the conversion prosthesis (maxilla) during the 4-month healing period. There were a total of 9 conversion prostheses with cracks or fractures during the 4-month healing period (early critical complication), yielding a complication-free survival rate of 94.1%. There were 6 additional early noncritical prosthetic complications such as tooth debonding or chipping during the 4-month period. Only the early critical prosthetic complication rates comparing maxilla and mandible were statistically significant (p = 0.037).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The findings from this retrospective study revealed a high early survival rate for dental implants (98%) and for the immediately loaded acrylic resin CAFIP fabricated from the denture conversion protocol (94%). There were minimal additional implant failures and noncritical complications related to the conversion prosthesis. The denture conversion protocol is a simple evidence-based technique and serves as an excellent and predictable method for the immediate loading of dental impl","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter to the editor “Evaluating the impact of scan aid color on digital scan trueness: Insights and recommendations”","authors":"Özay Önöral DDS, PhD(C),&nbsp;Selin Çakır DDS","doi":"10.1111/jopr.14031","DOIUrl":"10.1111/jopr.14031","url":null,"abstract":"","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":"34 3","pages":"229-231"},"PeriodicalIF":3.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of crystallization temperature on the flexural strength of lithium disilicate glass ceramics.","authors":"Mohammed A Akl, Hashem Dashtti, Jood Akl, Fengyuan Zheng","doi":"10.1111/jopr.14028","DOIUrl":"https://doi.org/10.1111/jopr.14028","url":null,"abstract":"<p><strong>Purpose: </strong>This pilot study aimed to compare the flexural strength of Amber Mill CAD to IPS e.max CAD and to determine the impact of different crystallization protocols on the flexural strength of Amber Mill CAD ceramics.</p><p><strong>Materials and methods: </strong>Amber Mill CAD ceramic blocks of a known Vita Classic shade were selected for testing against control IPS e.max CAD blocks of the same shade. Four different translucencies were selected for Amber Mill CAD blocks: high translucency (HT), medium translucency (MT), low translucency (LT), and medium opacity (MO). Two different translucencies were selected for IPS e.max CAD blocks: HT and LT. The partially crystallized blocks were sectioned and placed into six groups for each temperature protocol for a total of 36 samples for Amber Mill CAD and 18 samples for IPS e.max CAD. The samples were sectioned at a thickness of 1.5 mm to simulate the material thickness recommended by the manufacturer for posterior lithium disilicate (LD) crowns. Four crystallization protocols, as recommended by the manufacturer, were used with Amber Mill CAD blocks, and one crystallization protocol was used with IPS e.max CAD blocks. The samples from each group were subjected to 3-point bending test. A two-way analysis of variance (ANOVA) and Tukey pairwise comparison tests were used for statistical analysis and interpretation of collected data.</p><p><strong>Results: </strong>The mean averages of maximum flexural strength for Amber Mill CAD samples were 269.54 MPa, 280.10 MPa, 277.55 MPa, and 254.16 MPa for HT, MT, LT, and MO, respectively. The mean averages of maximum flexural strength for the IPS e.max CAD samples were 302.99 MPa and 283.49 MPa for HT and LT, respectively. No significant differences in the mean average flexural strength were found between the Amber Mill CAD and IPS e.max CAD blocks (p > 0.05). Further, there were no statistical differences in flexural strength between the four crystallization protocols of Amber Mill CAD (p > 0.05).</p><p><strong>Conclusion: </strong>Amber Mill CAD shows similar flexural strength to IPS e.max CAD. Further, altering crystallization protocols of the same shade to obtain different translucencies did not affect the flexural strength of Amber Mill CAD.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture resistance of endodontically treated teeth restored with CAD-CAM milled and prefabricated post-and-core systems.","authors":"Betül Hamitoglu, Zeynep Ozkurt-Kayahan","doi":"10.1111/jopr.14023","DOIUrl":"https://doi.org/10.1111/jopr.14023","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effect of post-and-core material type and production technique on the fracture resistance of teeth.</p><p><strong>Materials and methods: </strong>Sixty human maxillary central incisors were used for the study. Root canal treatments were performed, and the post cavities were created. The teeth were divided into six groups (n = 10) according to post material and production method: prefabricated glass-fiber post (PF), zirconia post (PZ), titanium post (PT), and CAD-CAM produced glass-fiber post (CF), zirconia post (CZ), titanium post (CT). All post-and-core restorations were luted with resin cement (RelyX U200). Static loading was applied on the luted metal copings using a universal testing machine to measure fracture resistance. The effect of material and production method on fracture resistance was evaluated with two-way ANOVA test. Tukey HSD test was used in post hoc analyses. Significance was evaluated at p < 0.05 level.</p><p><strong>Results: </strong>In the CAD-CAM post-and-cores, the fracture resistance of zirconia was significantly higher (809 N) than titanium (569 N) and glass-fiber (342 N). In the prefabricated posts, the fracture resistance of zirconia was significantly higher than glass-fiber (445 N), while there was no significant difference between zirconia (605 N) and titanium (538 N) materials.</p><p><strong>Conclusion: </strong>Zirconia posts demonstrated the highest and CAD-CAM glass-fiber posts demonstrated the lowest fracture resistance compared to other types of post materials. Additional studies are needed to confirm if CAD-CAM glass-fiber posts may be considered an effective alternative treatment.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving full-arch implant scanning accuracy with a Meccano-like device for scan bodies splinting: A dental technique.","authors":"Basem Tarek Fadl, Mohamed Sherine Ibrahim El-Attar, Alfredo Mikail Melo Mesquita, Amany Elhadary, Ingy Saied Soliman","doi":"10.1111/jopr.14022","DOIUrl":"https://doi.org/10.1111/jopr.14022","url":null,"abstract":"<p><p>A long-term successful implant-supported prosthesis requires the creation of a passively fitting framework, based on an accurate intraoral digital implant scan. According to dental literature, splinted implant scan bodies (ISBs) provide higher intraoral scanning accuracy than non-splinted techniques. This technique presents a structured approach for splinting multi-unit abutment scan bodies (MUASBs) using customized manufactured devices to facilitate the recording of definitive intraoral implant scans.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}