Cell and Bioscience最新文献

{"title":"Lactate metabolic reprogramming and lactylation modification: molecular mechanisms reshaping the tumor immunosuppressive microenvironment.","authors":"Yuzhang Yuan, Yaping Gao, Jinhui Xue, Haozhe Zhang, Ruiting Liang, Luying Huang, Zehua Wang, Liang Song, Yanru Qin, Jiaoyu Ai","doi":"10.1186/s13578-026-01572-5","DOIUrl":"https://doi.org/10.1186/s13578-026-01572-5","url":null,"abstract":"","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircRSPRY1 regulates calcium oxalate crystal-induced necrotic apoptosis in renal tubules via miR-21-5p/PTEN.","authors":"Xudong Shen, Xike Mao, Hu Liang, Bingbing Hou, Yuexian Xu, Zhenyu Song, Yang Chen, Wei Wang, Zongyao Hao","doi":"10.1186/s13578-026-01549-4","DOIUrl":"https://doi.org/10.1186/s13578-026-01549-4","url":null,"abstract":"","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dapagliflozin-intermittent fasting combination maximizes weight and metabolic regulation through AMPK/sirtuins/clock genes and gut microbiota signaling in high-fat diet-induced obesity: a novel anti-obesity approach.","authors":"Mahmoud A Senousy, Rana Mohamed Abo-Elmaaty, Nesreen Nabil Omar, Hanan M Abdelgawad","doi":"10.1186/s13578-026-01557-4","DOIUrl":"10.1186/s13578-026-01557-4","url":null,"abstract":"","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating single-cell and spatial transcriptomics to reveal the spatiotemporal dynamics of retinal cells during ischemia-reperfusion injury progression in rats.","authors":"Yijia Huang, Junhong Guo, Fei Yao, Bingkai Feng, Di Gong, Kuanrong Dang, Tingyu Hu, Simin Deng, Yong Liu, Chunyan Tan, Jiantao Wang","doi":"10.1186/s13578-026-01571-6","DOIUrl":"https://doi.org/10.1186/s13578-026-01571-6","url":null,"abstract":"","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpression of ONECUT1 suppresses hepatoblastoma progression via modulating tumor cell growth and tumor microenvironment.","authors":"Yu Qiao, Meng Xu, Yanhui Wu, Guofei Cui, Shanshan Deng, Liangliang Bai, Xiaoshuang Song, Jian Zhong, Weijie Bian, Gang Yu, Matthias Evert, Xue Wang, Diego F Calvisi, Xin Chen, Lin Li, Weiting Liao","doi":"10.1186/s13578-026-01569-0","DOIUrl":"10.1186/s13578-026-01569-0","url":null,"abstract":"<p><strong>Background: </strong>Hepatoblastoma is the most common malignant liver tumor in children. Our previous work showed that enforced expression of the transcription factor One Cut Homeobox 1 (ONECUT1) suppresses the initiation of hepatoblastoma. However, it remains unclear whether increasing ONECUT1 expression can also inhibit tumor progression after tumors have already formed. The purpose of this study was to determine the effects of ONECUT1 induction on tumor cell behavior and tumor growth during established hepatoblastoma progression.</p><p><strong>Results: </strong>We generated doxycycline-inducible expression systems to upregulate ONECUT1 in hepatoblastoma cells in culture and in mouse models. In human hepatoblastoma cells, induction of ONECUT1 promoted apoptotic cell death and reduced cell cycle progression. In a subcutaneous xenograft model using immunodeficient mice, ONECUT1 induction slowed tumor growth but did not cause tumor regression. We then established an orthotopic HB model in FVB/N mice by tail-vein injection of YAP/β-catenin/TRE-ONECUT1 plasmids. ONECUT1 expression in existing mouse HB cells was induced by feeding the mice with DOX-water. Remarkably, tumor regression was observed following ONECUT1 induction. Histological analyses showed extensive necrosis and apoptosis in tumor lesions following induction of ONECUT1, accompanied by robust macrophage infiltration and moderate T cell infiltration. Depletion of T cells using antibodies against CD4 and CD8 weakened the antitumor effect of ONECUT1, indicating that T-cell activity contributes to tumor suppression. Transcriptomic analysis further suggested that ONECUT1 may promote antitumor immune responses in part by increasing expression of immune-related cytokines.</p><p><strong>Conclusions: </strong>Induction of ONECUT1 suppresses hepatoblastoma progression by inhibiting tumor cell growth and by reshaping the tumor immune microenvironment. These findings reveal a previously unrecognized antitumor role of ONECUT1 during hepatoblastoma progression and suggest that restoring ONECUT1 activity may represent a promising therapeutic strategy for this pediatric malignancy.</p>","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PFV Tas protein recruits hnRNPF to promote the splicing of tas/bet pre-mRNA.","authors":"Shishun Wu, Chenxi Liu, Manman Qiu, Juan Tan, Wentao Qiao","doi":"10.1186/s13578-026-01567-2","DOIUrl":"https://doi.org/10.1186/s13578-026-01567-2","url":null,"abstract":"<p><strong>Background: </strong>Foamy viruses (FVs) are capable of cross-species transmission to humans and establish latent infections without causing diseases. The transition between latent and lytic FV replication is regulated by the viral proteins Bet and Tas, which are expressed predominantly from the internal promoter (IP). Bet suppresses basal IP activity and initiates latency, whereas Tas activates the IP and the long terminal repeat (LTR) promoter and enables lytic infection. However, the mechanisms regulating the relative levels of Tas and Bet are not completely understood.</p><p><strong>Results: </strong>We performed a yeast two-hybrid screen to identify Tas-interacting proteins and discovered an association of the splicing factor heterogeneous nuclear ribonucleoprotein F (hnRNPF) with Tas. We found that hnRNPF inhibits prototype foamy virus (PFV) replication by shifting the viral expression profile from Tas to Bet. Importantly, hnRNPF specifically recognizes a G-cluster II cis-acting element (GC-II) within the tas/bet pre-mRNA to promote its splicing into bet mRNA, thereby reducing the levels of the unspliced tas transcript. The viral Tas protein, which interacts with hnRNPF, also possesses this splicing-promoting activity. Tas acts by binding to its DNA target, the Tas responsive element (TRE), thereby recruiting the hnRNPF to nascent viral RNA to enhance splicing efficiency.</p><p><strong>Conclusions: </strong>We conclude that PFV Tas regulates the expression of itself and the viral Bet protein through splicing of tas/bet pre-mRNA by recruiting the cellular splicing factor hnRNPF. We further propose that hnRNPF may play an important role in establishing PFV latency by assisting Tas in decreasing Tas levels and increasing Bet expression to shut down viral gene expression.</p>","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gordonibacter-associated regulatory T cell dysfunction and S100A11-mediated neural impairment in Hirschsprung's disease: a microbiota-immune-neural axis.","authors":"Ting Yao, Meili Fan, Zenghui Hao, Zaiqun Jiang, Xu Li, Shuyu Wang, Zhilin Xu","doi":"10.1186/s13578-026-01562-7","DOIUrl":"https://doi.org/10.1186/s13578-026-01562-7","url":null,"abstract":"<p><strong>Background: </strong>Hirschsprung's disease (HSCR) is a congenital disorder characterized by intestinal aganglionosis. Despite evidence linking gut microbiota and immune cells to various gastrointestinal diseases, their role in HSCR pathogenesis remains poorly understood. We investigated associations between gut microbiota composition, immune cell phenotypes, and neural impairment in HSCR patients.</p><p><strong>Results: </strong>Mendelian randomization analysis identified associations between Gordonibacter species and elevated HSCR risk (OR = 2.74, 95% CI 1.42-5.28), potentially mediated through CD28⁺CD39⁺ regulatory T cells. Multi-omics profiling revealed notable S100A11 upregulation in HSCR tissues. CD28⁺CD39⁺ Tregs from HSCR patients exhibited functional alterations, including reduced suppressive capacity alongside elevated S100A11 production. Both CD4⁺ T cells and CD68⁺ macrophages expressed S100A11 by immunohistochemistry. S100A11 treatment activated RAGE-NF-κB signaling in vitro, accompanied by suppression of neural developmental markers (SOX10, RET, PHOX2B) and impaired neuronal migration. Serum S100A11 showed diagnostic potential (AUC = 0.947). Microbiome profiling demonstrated differential bacterial enrichment, while antibiotic depletion experiments indicated microbiota-dependent modulation of immune-neural interactions.</p><p><strong>Conclusion: </strong>Our findings link gut microbiota alterations, immune dysregulation, and neural developmental impairment in HSCR, implicating S100A11-RAGE-NF-κB signaling as a pathway deserving mechanistic investigation.</p>","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative genomic profiling of iron homeostasis predicts clinical outcomes and identifies HAMP/hepcidin as a therapeutic target in colorectal cancer.","authors":"Yanfei Shao, Chaozhao Chen, Xian Zhang, Nanqin Liu, Xiaodong Fan, Xin Yi Tan, Buyu Deng, Ruitian Gao, Songchang Shi, Haoran Zhao, Huang Zheng, Cixiang Zhou, Qianru Yu, Xin Zhang, Jiao Wang, Joshua Lin, Xueliang Zhou, Yi Yang, Yi Lu, Batuer Aikemu, Sen Zhang, Qian Zhao, Jing Sun","doi":"10.1186/s13578-026-01568-1","DOIUrl":"https://doi.org/10.1186/s13578-026-01568-1","url":null,"abstract":"","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function.","authors":"Seung Pyo Hong, Seong Hyeon Hong, Gwidong Han, Seung Jae Lee, Youngsoo Oh, Chunghee Cho","doi":"10.1186/s13578-026-01563-6","DOIUrl":"10.1186/s13578-026-01563-6","url":null,"abstract":"","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rapid and highly sensitive CRISPR-Cas12a ortholog-assisted assay for genotyping of myostatin knockout pigs.","authors":"Yuan Wang, Hui Yang, Wenhua Zhang, Dagang Tao, Suyu Shi, Sheng Li, Xiao Wu, Yunlong Ma, Jinxue Ruan, Lu Jing, Kang Ma, Xinyun Li, Xiaosong Han, Xuewen Xu, Shengsong Xie","doi":"10.1186/s13578-026-01559-2","DOIUrl":"10.1186/s13578-026-01559-2","url":null,"abstract":"","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}