Pharmacon Pub Date : 2023-08-31 DOI: 10.35799/pha.12.2023.49216

Maria Immaculata Tangkau, Fatimawali Fatimawali, None Elly Suoth

{"title":"UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BATANG LENGKUAS PUTIH (Alpinia galanga) DENGAN METODE ABTS","authors":"Maria Immaculata Tangkau, Fatimawali Fatimawali, None Elly Suoth","doi":"10.35799/pha.12.2023.49216","DOIUrl":"https://doi.org/10.35799/pha.12.2023.49216","url":null,"abstract":"Lengkuas biasa digunakan sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui kandungan fitokimia dan aktivitas antioksidan ekstrak etanol dari batang lengkuas (Alpinia galanga). Batang lengkuas diekstraksi menggunakan metode maserasi dengan pelarut etanol 95%. Skrining fitokimia yang dilakukan meliputi uji flavonoid, triterpenoid, saponin, polifenol secara kualitatif dengan metode uji warna. Uji aktivitas antioksidan menggunakan metode ABTS (2,2-Azinobis(3-ethylbenzothiazoline)-6-sulfonic acid) dan vitamin C sebagai pembanding, serapan diukur menggunakan spektrofotometer UV-Vis pada panjang gelombang 750 nm. Hasil Skrining fitokimia pada ekstrak etanol batang lengkuas (Alpinia galanga) menunjukkan hasil positif terhadap flavonoid, triterpenoid dan polifenol, sementara saponin menunjukkan hasil negatif. Aktivitas antioksidan dianalisis menggunakan persamaan garis regresi y = 3,293x + 40.606, diperoleh IC₅₀ 1,675 ppm dan pembanding vitamin C diperoleh IC₅₀ 2,0405 ppm. Dari hasil tersebut diketahui ekstrak etanol batang lengkuas (Alpinia galanga) dan pembanding vitamin C menunjukkan keduanya memiliki aktivitas antioksidan yang termasuk dalam kategori sangat kuat. Kata kunci : Antioksidan, ABTS, Alpinia galanga.","PeriodicalId":490956,"journal":{"name":"Pharmacon","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136036964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulasi dan Penentuan Nilai SPF Krim Tabir Surya Dari Ekstrak Daun Gedi (Abelmoschus manihot L.) 配方及确定基底叶提取物中的防晒霜(Abelmoschus manihot L)的价值。

Pharmacon Pub Date : 2023-08-31 DOI: 10.35799/pha.12.2023.49022

Hana Katili, Hosea Jaya Edy, Jainer Pasca Siampa

引用次数: 0

FORMULASI DAN PENENTUAN NILAI SPF KRIM TABIR SURYA EKSTRAK KULIT BUAH LEMON SUANGGI (Citrus limon (L.) Burm. f.) SECARA IN VITRO 枸橼酸柠檬（Citrus limon (L.) Burm.

Pharmacon Pub Date : 2023-08-31 DOI: 10.35799/pha.12.2023.49023

Valencia Lumantow, None Hosea Jaya Edy, None Jainer Pasca Siampa

{"title":"FORMULASI DAN PENENTUAN NILAI SPF KRIM TABIR SURYA EKSTRAK KULIT BUAH LEMON SUANGGI (Citrus limon (L.) Burm. f.) SECARA IN VITRO","authors":"Valencia Lumantow, None Hosea Jaya Edy, None Jainer Pasca Siampa","doi":"10.35799/pha.12.2023.49023","DOIUrl":"https://doi.org/10.35799/pha.12.2023.49023","url":null,"abstract":"Kulit buah lemon suanggi (Citrus limon (L.) Burm. f.) mengandung senyawa metabolit sekunder salah satunya flavonoid, yang memiliki aktivitas antioksidan yang dapat berperan menangkal radikal bebas seperti sinar ultraviolet (UV). Penelitian ini bertujuan untuk menguji krim ekstrak kulit buah lemon suanggi dalam potensinya sebagai tabir surya melalui penentuan nilai Sun Protection Factor (SPF) secara in vitro. Kulit buah lemon suanggi diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak kental yang diperoleh diformulasikan dalam bentuk sediaan krim yang kemudian dilanjutkan dengan evaluasi sediaan krim. Penentuan nilai SPF krim ekstrak etanol kulit buah lemon suanggi dilakukan secara in vitro menggunakan spektrofotometri UV-Vis dan dilanjukan perhitungan dengan persamaan Mansur. Hasil penelitian menunjukkan sifat fisik dari sediaan krim sudah memenuhi syarat untuk uji homogenitas, organoleptik, daya sebar, pH dan uji pemisahan fase, namun belum memenuhi syarat untuk uji daya lekat. Sediaan krim pada F1 memiliki SPF 14,24 ± 0,65 dengan proteksi maksimal, F2 dan F3 memiliki nilai SPF masing-masing 26,02 ± 0,77 dan 39,79 ± 0,10 dengan tipe proteksi ultra.","PeriodicalId":490956,"journal":{"name":"Pharmacon","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136036963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uji Aktivitas Antioksidan Ekstrak Etanol Spons Lamellodysidea herbacea yang Diperoleh dari Pantai Selatan Kabupaten Minahasa 米纳哈萨县南海岸采集的 Lamellodysidea herbacea 海绵乙醇提取物的抗氧化活性测试

Pharmacon Pub Date : 2023-08-31 DOI: 10.35799/pha.12.2023.49217

Christian Alexandro Lanes, Adithya Yudistira, Meilani Jayanti

{"title":"Uji Aktivitas Antioksidan Ekstrak Etanol Spons Lamellodysidea herbacea yang Diperoleh dari Pantai Selatan Kabupaten Minahasa","authors":"Christian Alexandro Lanes, Adithya Yudistira, Meilani Jayanti","doi":"10.35799/pha.12.2023.49217","DOIUrl":"https://doi.org/10.35799/pha.12.2023.49217","url":null,"abstract":"Spons merupakan salah satu organisme laut yang mempunyai potensi untuk menghasilkan senyawa metabolit sekunder yang mempunyai banyak manfaat. Salah satu fungsi dari metabolit sekunder adalah sebagai antioksidan. Antioksidan merupakan senyawa yang dapat menghambat proses oksidasi yang diakibatkan oleh radikal bebas. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari spons Lamellodysidea herbacea yang diperoleh dari Pantai Selatan Kabupaten Minahasa. Penelitian ini merupakan eksperimental laboratorium dengan metode ekstraksi maserasi menggunakan pelarut etanol 95%. Pengujian antioksidan menggunakan metode DPPH (1.1-difenil-2-pikrihidrazil) dengan 4 seri konsentrasi sampel (25, 50, 75, 100 ppm) yang diukur menggunakan spektrofotometer UV-Vis dengan nilai absorbansi diukur pada panjang gelombang 517 nm. Hasil penelitian diperoleh rata-rata nilai persen inhibisi yang didapat pada konsentrasi 25, 50, 75, 100 ppm secara berturut-turut adalah 40,068%, 51,446%, 65,25%, 70,369%. Penelitian ini menyimpulkan bahwa ekstrak spons Lamellodysidea herbacea mempunyai aktivitas antioksidan pada konsentrasi 50, 75, dan 100 ppm.","PeriodicalId":490956,"journal":{"name":"Pharmacon","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136036967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULASI SEDIAAN KRIM DENGAN EKSTRAK ETANOL DAUN GEDI HIJAU (Abelmoschus manihot L.) TERHADAP Propionibacterium acnes FORMULASI SEDIAAN KRIM DENGAN EKSTRAK ETANOL DAUN GEDI HIJAU (Abelmoschus manihot L.) TERHADAP Propionibacterium acnes (痤疮丙酸杆菌)

Pharmacon Pub Date : 2023-08-31 DOI: 10.35799/pha.12.2023.49075

Missyeling Fransisca Saerang, Hosea Jaya Edy, Jainer Pasca Siampa

引用次数: 0

Uji Kualitatif Kandungan Senyawa Kimia Perasan Jeruk Nipis ( Citrus aurantifolia Swingle ) 酸橙汁（Citrus aurantifolia Swingle）化学成分含量的定性测试

Pharmacon Pub Date : 2023-08-31 DOI: 10.35799/pha.12.2023.49269

SELLYANA MAHARANI BAWEKES, Adithya Yudistira, Erladys Melindah Rumondor

{"title":"Uji Kualitatif Kandungan Senyawa Kimia Perasan Jeruk Nipis ( Citrus aurantifolia Swingle )","authors":"SELLYANA MAHARANI BAWEKES, Adithya Yudistira, Erladys Melindah Rumondor","doi":"10.35799/pha.12.2023.49269","DOIUrl":"https://doi.org/10.35799/pha.12.2023.49269","url":null,"abstract":"Jeruk Nipis (Citrus aurantifolia Swingle) merupakan salah satu tanaman yang memiliki efek terapeutik untuk mengatasi penyakit yang disebabkan oleh bakteri. Bagian tanaman jeruk nipis (Citrus aurantifolia Swingle) yang banyak dimanfaatkan saat ini adalah buahnya. Buah jeruk nipis (Citrus aurantifolia Swingle.) telah banyak digunakan sebagai obat batuk, peluruh dahak, influenza, obat jerawat, penurun panas (antipireutik), diare, antiinflamasi, antireumatik, antikoagulan, antiinfeksi, dan antibakteri. Penelitian ini merupakan eksperimental laboratorium dengan pengujian terhadap perasan Jeruk Nipis (Citrus aurantifolia Swingle) dengan metode uji kualitatif yang bertujuan untuk mengetahui ada atau tidaknya kandungan senyawa kimia pada perasan Jeruk Nipis (Citrus aurantifolia Swingle) dengan menggunakan metode uji alkaloid, flavonoid,tanin,fenol dan saponin. Hasil pengujian diperoleh kandungan senyawa kimia pada perasan jeruk nipis (Citrus aurantifolia Swingle) positif mengandung senyawa alkaloid, flavonoid, tanin dan fenol. Sedangkan pada saponin hasilnya negatif . Kata Kunci : Jeruk Nipis Citrus aurantifolia Swingle , Kualitatif","PeriodicalId":490956,"journal":{"name":"Pharmacon","volume":"384 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136036968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DETERMINATION OF VITAMIN C CONTENT OF ETHANOL EXTRACT OF GREEN BEAN (Phaseolus radiatus L.) USING SPECTROPHOTOMETRY UV-VIS 绿豆乙醇提取物中维生素C含量的测定采用分光光度法紫外可见

Pharmacon Pub Date : 2023-08-25 DOI: 10.35799/pha.12.2023.48971

Hayatul Rohimah, Rahmawaty Hasan

引用次数: 0

ANTIOXIDANT ACTIVITY TEST OF ETANOL EXTRACT OF ALGA (Halimeda opuntia) TAKEN FROM THE SHORE OF POOPOH VILLAGE, MINAHASA DISTRICT 米那沙区普波村海岸海藻乙醇提取物的抗氧化活性试验

Pharmacon Pub Date : 2023-08-24 DOI: 10.35799/pha.12.2023.49272

Mikhael Versen Onthoni, Adithya Yudistira, Deby Afriani Mpila

{"title":"ANTIOXIDANT ACTIVITY TEST OF ETANOL EXTRACT OF ALGA (Halimeda opuntia) TAKEN FROM THE SHORE OF POOPOH VILLAGE, MINAHASA DISTRICT","authors":"Mikhael Versen Onthoni, Adithya Yudistira, Deby Afriani Mpila","doi":"10.35799/pha.12.2023.49272","DOIUrl":"https://doi.org/10.35799/pha.12.2023.49272","url":null,"abstract":"Antioxidants are compounds that can protect body cells from damage caused by free radicals. Free radicals are unstable molecules that can damage body cells and cause oxidative stress. Antioxidants work by neutralizing free radicals to protect cells from damage and help maintain overall health. This study aims to test the antioxidant potential of ethanol extract of Halimeda opuntia algae taken from the southern coast of Minahasa Regency, North Sulawesi. Antioxidant activity was tested using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The decrease in absorbance value observed directly illustrates the decrease in the number of DPPH radicals remaining after the reaction between the extract and DPPH. The test results showed antioxidant levels that occurred at concentrations of 25 ppm (52.925%), 50 ppm (61.659%), 75 ppm (65.304%), and 100 ppm (70.112%). The test results show that the higher the concentration of ethanol extract of Halimeda opuntia algae, the stronger its ability to inhibit DPPH radicals. Therefore, it can be concluded that the highest antioxidant content is found at a concentration of 100 ppm with an average percent inhibition of 70.112%.","PeriodicalId":490956,"journal":{"name":"Pharmacon","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135471564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Effectiveness Test of Water Hyacinth Leaf Extract (Eichhornia Crassipes) Against the Growth of Porphyromonas gingivalis Bacteria 水葫芦叶提取物对牙龈卟啉单胞菌生长的抑菌效果试验

Pharmacon Pub Date : 2023-08-24 DOI: 10.35799/pha.12.2023.48993

None Juliantri, Ni Wayan Mariati, Jacklyn Rumondor

引用次数: 0

EVALUATION OF IMPLEMENTATION OF PHARMACY SERVICES STANDARDS AT TK II. HOSPITAL R.W. MONGISIDI MANADO 评估tk 2药房服务标准的执行情况。马纳多蒙西迪医院

Pharmacon Pub Date : 2023-08-24 DOI: 10.35799/pha.12.2023.48958

Sergio Christiano Mandagi JR, Widya Astuty Lolo, Gerald Edward Rundengan

{"title":"EVALUATION OF IMPLEMENTATION OF PHARMACY SERVICES STANDARDS AT TK II. HOSPITAL R.W. MONGISIDI MANADO","authors":"Sergio Christiano Mandagi JR, Widya Astuty Lolo, Gerald Edward Rundengan","doi":"10.35799/pha.12.2023.48958","DOIUrl":"https://doi.org/10.35799/pha.12.2023.48958","url":null,"abstract":"Pharmaceutical services focus on responsible services for patients related to the management of pharmaceutical preparations, medical devices, consumable medical materials and clinical pharmacy services with the aim of increasing the quality of life of patients. The aim of the study was to evaluate the application of pharmaceutical services from the management of pharmaceutical preparations, medical devices and consumable medical materials at the TK II. hospital R.W. Mongisidi Manado based on the pharmaceutical service standards of the Republic of Indonesia Minister of Health no 72 of 2016. This research is descriptive qualitative using the observation method (checklist) supplemented by interviews, the results are processed descriptively, analyzed by grouping each part and presented in the form of a percent score. The results showed that the average total score was 82.18%. This study concludes that pharmaceutical services are from the management of pharmaceutical preparations, medical devices and consumable medical materials at the TK II. hospital R.W. Mongisidi Manado is in accordance with the standards of the Minister of Health of the Republic of Indonesia no 72 of 2016 with a total score of more than 75%, which is in the good category.","PeriodicalId":490956,"journal":{"name":"Pharmacon","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135471567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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