Current Problems in Pediatric and Adolescent Health Care最新文献

{"title":"Foreword-parenting styles","authors":"John M. Pascoe MD, MPH (Associate Editor)","doi":"10.1016/j.cppeds.2025.101863","DOIUrl":"10.1016/j.cppeds.2025.101863","url":null,"abstract":"","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 10","pages":"Article 101863"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenting styles, parenting interventions, and childhood obesity","authors":"Rohan Sachdeva BS , Nadia Markie Sneed PhD, APRN, FNP-BC","doi":"10.1016/j.cppeds.2025.101865","DOIUrl":"10.1016/j.cppeds.2025.101865","url":null,"abstract":"","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 10","pages":"Article 101865"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S1538-5442(25)00144-0","DOIUrl":"10.1016/S1538-5442(25)00144-0","url":null,"abstract":"","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 10","pages":"Article 101870"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenting styles and interventions for the child health clinician","authors":"Ellen L. McMahon ,&nbsp;Brian T. Ward ,&nbsp;Heath Aston ,&nbsp;Seth J. Scholer","doi":"10.1016/j.cppeds.2025.101864","DOIUrl":"10.1016/j.cppeds.2025.101864","url":null,"abstract":"<div><div>Parenting practices significantly influence child development and long-term health outcomes, with extensive evidence linking responsive caregiving to positive cognitive, behavioral, and emotional development, while harsh or inconsistent parenting is associated with adverse effects. This paper reviews the history of parenting research and synthesizes current research on parenting styles, interventions, and their neurobiological mechanisms, emphasizing actionable strategies for children’s healthcare. Key findings highlight the efficacy of tiered, trauma-informed approaches - from universal prevention to targeted interventions - in promoting early relational health. However, disparities persist in access to evidence-based parenting support, particularly among marginalized populations, underscoring the need for culturally adapted programs and equitable implementation.</div><div>A child’s clinician is uniquely positioned to deliver parenting support, given their wide reach and preventive focus. The American Academy of Pediatrics (AAP) endorses integrating early relational health frameworks into well-child care, including universal screening for caregiver-child interaction quality, social determinants of health, and caregiver mental health. Effective models combine vertical integration (matching intervention intensity to family needs) and horizontal integration (linking medical homes to community resources). Critical gaps remain, including the need for validated, clinically feasible parenting assessments and expanded clinician training in emotional trauma-informed relational health practices. By embedding parenting support into routine child health care, health systems can foster resilience, advance health equity, and optimize lifelong outcomes for children and families.</div></div>","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 10","pages":"Article 101864"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of infection and microbial exposures on pediatric cancer","authors":"Kensie Soule BS ,&nbsp;Nina Nelson BS ,&nbsp;Joseph Wiemels PhD ,&nbsp;Rachel Gallant MD MS","doi":"10.1016/j.cppeds.2025.101819","DOIUrl":"10.1016/j.cppeds.2025.101819","url":null,"abstract":"<div><div>The etiology of pediatric cancer is likely multifactorial including a combination of genetic alterations and environmental exposures. Infection and antigenic exposures have been identified as contributors to the development of pediatric cancers particularly acute lymphoblastic leukemia (ALL), the most common pediatric malignancy. Viral infections such as Epstein-Barr virus (EBV) and human papilloma virus (HPV) have a well-established association with Hodgkin lymphoma (EBV), Burkitt lymphoma (EBV), and head and neck cancers (HPV). More recent evidence suggests CMV is associated with glioblastoma multiforme and ALL. The incidence of pediatric cancer is much lower than the incidence of these viral infections, indicating that there are likely other factors at play. Aside from these specific viral infections, antigenic exposures in general have been associated with pediatric cancers as well. Early life antigenic exposures are known to impact the gut microbiome which is a crucial component to developing a competent immune system. Higher microbial exposure in early life, such as vaginal delivery (versus cesarean delivery), daycare attendance, and breastfeeding have been associated with lower incidence of pediatric ALL, and this effect is hypothesized to be mediated by the gut microbiome. In this review, we highlight the association between infection, antigenic exposures, and pediatric cancer and potential underlying mechanisms that facilitate this association.</div></div>","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 9","pages":"Article 101819"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the environment on childhood cancer clinical outcomes","authors":"Catherine Metayer","doi":"10.1016/j.cppeds.2025.101801","DOIUrl":"10.1016/j.cppeds.2025.101801","url":null,"abstract":"<div><div>Incidence rates of several childhood cancers have increased in the past decades in high- and middle-income countries, and epidemiologic studies worldwide have documented the important role of several environmental factors contributing to these trends, such as sources of air pollution and pesticides. What is less known is whether these chemicals also affect clinical outcomes in childhood cancer patients and survivors, via biological pathways involving DNA damage, epigenetic changes, oxidative stress, pro-inflammatory and immune responses which may operate across the cancer continuum from etiology, response to treatment, survival and survivorship. Despite overall improvement in cancer cure rates, children of color and underserved backgrounds still experience poorer prognosis than their white and affluent counterparts. While social determinants largely explain these observations, the independent effect of chemical exposures is not well-characterized. Drawing from adult studies, we present emerging evidence from epidemiologic childhood cancer studies on the impact of pre- and post-natal exposures to ubiquitous chemicals such as tobacco smoke, traffic-and industry-related air pollution, and pesticides on the health of childhood cancer patients and survivors. Data presented in this review provide the foundation to consider integrating environmental health into the treatment plan for childhood cancer patients and survivors, alongside other known therapeutic and modifiable prognostic factors.</div></div>","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 9","pages":"Article 101801"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating extreme weather and air pollution risk reduction into pediatric cancer care","authors":"Hannah M. Thompson MD MPH ,&nbsp;Omar Shakeel MD ,&nbsp;Mark Miller MD MPH ,&nbsp;Perry Sheffield MD MPH","doi":"10.1016/j.cppeds.2025.101807","DOIUrl":"10.1016/j.cppeds.2025.101807","url":null,"abstract":"<div><div>The health impacts of extreme weather and air pollution are expected to worsen into the future. There is growing evidence that vulnerable populations, including pediatric patients with cancer, may be at increased risk. There is limited progress, however, on translating these growing risks into clinical prevention strategies. We describe the utilization of a simple risk communication framework and list resources to help pediatric oncology providers engage in discussion of extreme weather and air pollution with patients to reduce their risk.</div></div>","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 9","pages":"Article 101807"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S1538-5442(25)00132-4","DOIUrl":"10.1016/S1538-5442(25)00132-4","url":null,"abstract":"","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 9","pages":"Article 101858"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreword - Moving toward prevention of childhood cancers","authors":"Mark D. Miller MD","doi":"10.1016/j.cppeds.2025.101837","DOIUrl":"10.1016/j.cppeds.2025.101837","url":null,"abstract":"","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 9","pages":"Article 101837"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the causes of childhood acute lymphoblastic leukemia through mutational epidemiology","authors":"Adam J. de Smith,&nbsp;Naying Zhou,&nbsp;Yunqi Li,&nbsp;Tanxin Liu,&nbsp;Nathan Patrus,&nbsp;Joseph L. Wiemels","doi":"10.1016/j.cppeds.2025.101818","DOIUrl":"10.1016/j.cppeds.2025.101818","url":null,"abstract":"<div><div>Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and prevention of this disease would significantly reduce childhood mortality and morbidity. While the role of germline genetic variation in the etiology of ALL is well established, the contribution of modifiable risk factors is less well known. Epidemiologic studies have identified several environmental and infectious or immune-related factors associated with childhood ALL, although studies often relied on questionnaire data, which can be prone to recall bias, and/or provided limited information on the potential leukemogenic role of these exogenous exposures.</div><div>Environmental exposures that have carcinogenic properties (e.g., tobacco smoke, ultraviolet radiation) can leave behind molecular footprints in tumor samples that have specific patterns of mutations, and these mutational signatures can be leveraged to study cancer etiology. Mutational epidemiology has thus emerged as a novel approach to investigate the potential carcinogenic role of exogenous exposures in cancer development, by leveraging the availability of sequencing data in large numbers of patients and combining epidemiological methods with analysis of mutational signatures, which may reveal a personalized history of causative exposures. Such studies have already yielded discoveries in adult solid tumors, identifying novel risk factors and providing insights into environmental factors that may underlie global variation in cancer incidence. However, this approach has yet to be applied to childhood cancer epidemiology.</div><div>Sequencing studies of childhood ALL have revealed specific patterns of somatic alterations, including mutational signatures related to APOBEC enzymes, reactive oxygen species, and ultraviolet radiation, as well as deletions mediated by illegitimate V(D)J recombination. In this review, we discuss current knowledge on the modifiable and non-modifiable risk factors for childhood ALL, the patterns of somatic genomic alterations that have been identified in ALL patient samples, and how mutational epidemiology could help to pinpoint the leukemogenic role of environmental exposures which will be critical for future prevention strategies.</div></div>","PeriodicalId":49086,"journal":{"name":"Current Problems in Pediatric and Adolescent Health Care","volume":"55 9","pages":"Article 101818"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}