A. Manohar , A. Wong , E. Castillo , A. Gunderson , G. Mistelbauer , S. Bagherzadeh , F. Haddad , K. Caliskan , R. Budde , A. Hirsch , S. Lee , W. Lee , A. Owens , H. Litt , M. Wheeler , D. Kwon , W. Tang , K. Nieman
{"title":"Coronary Ct Angiography Fractal Analysis Differentiates Lv Noncompaction From Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy, And Controls","authors":"A. Manohar , A. Wong , E. Castillo , A. Gunderson , G. Mistelbauer , S. Bagherzadeh , F. Haddad , K. Caliskan , R. Budde , A. Hirsch , S. Lee , W. Lee , A. Owens , H. Litt , M. Wheeler , D. Kwon , W. Tang , K. Nieman","doi":"10.1016/j.jcct.2025.05.046","DOIUrl":"10.1016/j.jcct.2025.05.046","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"19 4","pages":"Pages S18-S19"},"PeriodicalIF":5.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel A. Lorenzatti , Annalisa Filtz , Pamela Piña , Jeirym Miranda , Siddarth Ragupathi , Felipe Contreras Yametti , Andrea Scotti , Winsome Elliott-Bailey , João L. Cavalcante , Thomas Ivanc , Azeem Latib , Mario J. Garcia , Leandro Slipczuk
{"title":"Comparison of dual-energy iodine and standard subtraction methods for myocardial extracellular volume quantification using cardiac computed tomography","authors":"Daniel A. Lorenzatti , Annalisa Filtz , Pamela Piña , Jeirym Miranda , Siddarth Ragupathi , Felipe Contreras Yametti , Andrea Scotti , Winsome Elliott-Bailey , João L. Cavalcante , Thomas Ivanc , Azeem Latib , Mario J. Garcia , Leandro Slipczuk","doi":"10.1016/j.jcct.2025.03.009","DOIUrl":"10.1016/j.jcct.2025.03.009","url":null,"abstract":"<div><h3>Background</h3><div><span>Computed tomography<span> (CT)-derived extracellular volume fraction (ECV) quantifies myocardial fibrosis noninvasively, comparable to </span></span>cardiovascular magnetic resonance<span>. The conventional subtraction method (ECV-conv) requires dedicated pre- and post-contrast acquisitions, while the dual-energy spectral method (ECV-spec) uses only the post-contrast phase. We aimed to compare these methods in patients undergoing CT planning for transcatheter aortic valve replacement (TAVR).</span></div></div><div><h3>Methods</h3><div>We prospectively included patients undergoing CT-TAVR evaluation on a dual-energy dual-layer detector scanner. Baseline pre-contrast and equilibrium delay phase (at 5 min) prospectively ECG-triggered acquisitions were co-registered for ECV-conv calculation. Equilibrium phase spectral iodine maps were derived for ECV-spec measurement and compared with ECV-con maps using a mid-septal and a global mid-ventricular region of interest.</div></div><div><h3>Results</h3><div>Overall, 78 patients (53 % female, mean age 77 years) were analyzed. There was a minor overestimation in global measurement by ECV-spec (31.8 ± 4.6 % vs 30.3 ± 5.3 %, p = 0.023. However, there were no significant differences between both methods for the mid-septal measurement (ECV-conv = 30.4 ± 5.3 % vs ECV-spec = 31.0 ± 5.6 %, p = 0.196).). Both methods demonstrated comparable 95 % limits of agreement, with a strong correlation for mid-septal (r = 0.75, p < 0.0001) and a moderate correlation for global measurements (r = 0.51, p < 0.0001).</div></div><div><h3>Conclusions</h3><div>Myocardial CT-ECV estimation using dual-energy spectral maps was comparable to the conventional subtraction method without the need of a pre-contrast acquisition. This approach may help reduce imaging and processing times, as well as minimize radiation exposure.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"19 4","pages":"Pages 483-487"},"PeriodicalIF":5.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan K. Tapley , Barry J. Doyle , Jamie W. Bellinge , Harrison T. Caddy , Dirk C. Blom , Thomas Churack , David E. Newby , Carl J. Schultz , Lachlan J. Kelsey
{"title":"Low endothelial shear stress is associated with increased coronary atherosclerotic plaque activity in patients that presented with acute coronary syndrome","authors":"Jonathan K. Tapley , Barry J. Doyle , Jamie W. Bellinge , Harrison T. Caddy , Dirk C. Blom , Thomas Churack , David E. Newby , Carl J. Schultz , Lachlan J. Kelsey","doi":"10.1016/j.jcct.2025.04.003","DOIUrl":"10.1016/j.jcct.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>Both coronary atherosclerotic plaque activity and low endothelial shear stress (ESS) are predictive of adverse cardiovascular events. We aimed to investigate their association and relationship with high-risk plaque features.</div></div><div><h3>Methods</h3><div><span><span>Coronary computed tomography angiography (CCTA) based flow simulations were used to compute ESS in patients presenting with </span>acute coronary syndrome proceeding percutaneous coronary intervention. Associations between ESS, CCTA plaque features and coronary plaque activity, measured by </span><sup>18</sup>F-sodium fluoride (<sup>18</sup><span>F–NaF) positron emission tomography (PET), were investigated at the coronary segment and vessel level.</span></div></div><div><h3>Results</h3><div>ESS and coronary plaque activity were both analyzed in 330 coronary segments and 123 vessels. The area of low ESS (<0.4 Pa), termed low shear area (LSA), was larger in <sup>18</sup>F–NaF positive regions increasing from median 11.7 mm<sup>2</sup> (IQR: 4.6–27.4) to 29.0 mm<sup>2</sup> (IQR: 14.1–55.2) at the segment level (<em>P</em> < 0.0001) and from median 27.3 mm<sup>2</sup> (IQR: 8.6–65.3) to 57.8 mm<sup>2</sup> (26.6–108.2) at the vessel level (<em>P</em> = 0.0049). The maximum tissue-to-background ratio of <sup>18</sup>F–NaF activity positively correlated with LSA at the segment level (<em>r</em><sub>s</sub> = 0.27; <em>P</em> < 0.0001) and at the vessel level (<em>r</em><sub>s</sub> = 0.38; <em>P</em> < 0.0001). LSA was associated with spotty calcification at both the segment (<em>P</em> <0.0001) and vessel level (<em>P</em> = 0.0042) and positive remodeling at the vessel level (<em>P</em> = 0.025).</div></div><div><h3>Conclusions</h3><div><span>In patients with acute coronary syndrome, LSA is associated with increased coronary atherosclerotic plaque activity, as measured by </span><sup>18</sup>F–NaF PET.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"19 4","pages":"Pages 455-463"},"PeriodicalIF":5.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sung Woo Cho , Tina Torbati , Su Nam Lee , Heidi Gransar , Damini Dey , Piotr Slomka , Sean W. Hayes , John D. Friedman , Louise E.J. Thomson , Alan Rozanski , Rebekah Park , Daniel S. Berman , Donghee Han
{"title":"Prognostic value of plaque burden assessed by coronary CT angiography in known coronary artery disease","authors":"Sung Woo Cho , Tina Torbati , Su Nam Lee , Heidi Gransar , Damini Dey , Piotr Slomka , Sean W. Hayes , John D. Friedman , Louise E.J. Thomson , Alan Rozanski , Rebekah Park , Daniel S. Berman , Donghee Han","doi":"10.1016/j.jcct.2025.05.239","DOIUrl":"10.1016/j.jcct.2025.05.239","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to investigate in patients with known coronary artery<span> disease (CAD) whether plaque burden assessed by coronary computed tomography angiography (CCTA) can predict subsequent all-cause mortality (ACM).</span></div></div><div><h3>Methods</h3><div>Consecutive patients with known CAD who underwent CCTA and coronary artery calcium (CAC) scans for CAD evaluation were enrolled. Known CAD was defined as history of myocardial infarction (MI) or percutaneous coronary intervention (PCI). Plaque burden was assessed by CAC (categorized as 0–100, 101–300, 301–999, ≥1000), degree of stenosis<span> (DS) (0–24 %, 25–49 %, 50–69 %, and ≥70 %) and segmental involvement score (SIS) (≤2, 3–4, 5–7, and ≥8) on CCTA. Multivariable Cox regression analysis was used to determine the association between plaque burden and ACM.</span></div></div><div><h3>Results</h3><div>963 patients were included (age 66.1 ± 11.5, 72.0 % male) of whom 707 had PCI, 586 had MI, and 330 had both. During median follow-up of 3.0 years (interquartile range 1.0–6.5), 91 patients (9.4 %) died. By Kaplan-Meier analysis, higher CAC score was associated with a higher risk of ACM (p < 0.001), but DS and SIS were not. In multivariable Cox regression analysis, CAC scores 301–999 (HR:3.10, 95%CI:1.23–7.80, p = 0.017) and ≥1000 (HR:5.81, 95%CI:2.25–15.04, p < 0.001) along with age, current smoking, and aspirin use were independently associated with increased risk of ACM, but DS and SIS were not.</div></div><div><h3>Conclusion</h3><div>In patients with known CAD undergoing CCTA, CAC score>300 was an independent predictor of ACM. CAC may provide additional guidance for the intensity of secondary preventive treatments than the degree of residual stenosis or the number of segments with CAD.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"19 4","pages":"Pages 409-415"},"PeriodicalIF":5.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Bhatia , J. Pedraza i Garriga , F. Contreras Yametti , M. Qureshi , A. Filtz , D. Lorenzatti , J. Johannesen , C. Gongora , A. Schenone , L. Slipczuk
{"title":"Coronary CT Angiography Vs. Invasive Angiography For Screening For Coronary Artery Disease Prior To Valvular Interventions","authors":"K. Bhatia , J. Pedraza i Garriga , F. Contreras Yametti , M. Qureshi , A. Filtz , D. Lorenzatti , J. Johannesen , C. Gongora , A. Schenone , L. Slipczuk","doi":"10.1016/j.jcct.2025.05.057","DOIUrl":"10.1016/j.jcct.2025.05.057","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"19 4","pages":"Page S23"},"PeriodicalIF":5.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}