{"title":"Myocardial extracellular volume by CT: Assessing the state of the union","authors":"Gary R. Small","doi":"10.1016/j.jcct.2024.07.014","DOIUrl":"10.1016/j.jcct.2024.07.014","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FFRCT: Decision-maker or innocent bystander?","authors":"Rishi Chandiramani, Jeffrey C. Trost","doi":"10.1016/j.jcct.2024.07.006","DOIUrl":"10.1016/j.jcct.2024.07.006","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validation of a fully automated deep learning-enabled solution for CCTA atherosclerotic plaque and stenosis quantification in a diverse real-world cohort","authors":"","doi":"10.1016/j.jcct.2024.03.012","DOIUrl":"10.1016/j.jcct.2024.03.012","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Table of contents-4C","authors":"","doi":"10.1016/S1934-5925(24)00411-8","DOIUrl":"10.1016/S1934-5925(24)00411-8","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1934592524004118/pdfft?md5=ea60a70016cd4707bfcffb0721163b10&pid=1-s2.0-S1934592524004118-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalie Soszyn, Michael Shorofsky, Salvador Rodriguez Franco, Jenny E. Zablah, Gareth J. Morgan
{"title":"Computed tomography-derived normative values and z-scores of the pulmonary valve annulus and sino-tubular junction in the pediatric population","authors":"Natalie Soszyn, Michael Shorofsky, Salvador Rodriguez Franco, Jenny E. Zablah, Gareth J. Morgan","doi":"10.1016/j.jcct.2024.07.003","DOIUrl":"10.1016/j.jcct.2024.07.003","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Accurate assessment of the pulmonary valve can dictate clinical management of patients with right </span>ventricular outflow tract (RVOT) anomalies. Comparisons with available normal reference values are essential for accurate evaluation. The aim of the study was to generate normative data for the pulmonary valve annulus and sino-tubular (ST) junction using </span>CT<span> measurements derived from a heterogeneous pediatric population and create z-scores useful for clinical practice.</span></p></div><div><h3>Methods</h3><p><span>Patients without heart disease who underwent cardiac CT between April 2014 and February 2021 at Children's Hospital Colorado were included. Minimum and maximum diameter (mm) and cross-sectional area (mm</span><sup>2</sup>) for the pulmonary valve annulus and ST junction were measured. Previously validated models were used to normalize the measurements and calculate <em>z</em>-scores. Each measurement was plotted against BSA, and <em>z</em>-score distributions were used as reference lines.</p></div><div><h3>Results</h3><p>Three-hundred-sixty-seven healthy patients with a mean age of 8.8 years (1–21), 56% male, and BSA of 1.1 m<sup>2</sup> (0.4–2.1) were analyzed. The Haycock formula was used to present data as predicted values for a given BSA and within equations relating each measurement to BSA. Predicted values and <em>z</em>-score boundaries for all measurements are graphically re-presented.</p></div><div><h3>Conclusions</h3><p>CT-derived normative data for the pulmonary valve annulus and ST junction is reported from a heterogenous cohort of healthy children.</p></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Variation of computed tomography-derived extracellular volume fraction and the impact of protocol parameters: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.jcct.2024.06.002","DOIUrl":"10.1016/j.jcct.2024.06.002","url":null,"abstract":"<div><h3>Background</h3><p>Cardiac computed tomography quantification of extracellular volume fraction (CT-ECV) is an emerging biomarker of myocardial fibrosis which has demonstrated high reproducibility, diagnostic and prognostic utility. However, there has been wide variation in the CT-ECV protocol in the literature and useful disease cut-offs are yet to be established. The objectives of this meta-analysis were to describe mean CT-ECV estimates and to estimate the effect of CT-ECV protocol parameters on between-study variation.</p></div><div><h3>Methods</h3><p>We conducted a meta-analysis of studies assessing CT-ECV in healthy and diseased participants. We used meta-analytic methods to pool estimates of CT-ECV and performed meta-regression to identify the contribution of protocol parameters to CT-ECV heterogeneity.</p></div><div><h3>Results</h3><p>Thirteen studies had a total of 248 healthy participants who underwent CT-ECV assessment. Studies of healthy participants had high variation in CT-ECV protocol parameters. The pooled estimate of CT-ECV in healthy participants was 27.6% (95%CI 25.7%–29.4%) with significant heterogeneity (I<sup>2</sup> = 93%) compared to 50.2% (95%CI 46.2%–54.2%) in amyloidosis, 31.2% (28.5%–33.8%) in severe aortic stenosis and 36.9% (31.6%–42.3%) in non-ischaemic dilated cardiomyopathies. Meta-regression revealed that CT protocol parameters account for approximately 25% of the heterogeneity in CT-ECV estimates.</p></div><div><h3>Conclusion</h3><p>CT-ECV estimates for healthy individuals vary widely in the literature and there is significant overlap with estimates in cardiac disease. One quarter of this heterogeneity is explained by differences in CT-ECV protocol parameters. Standardization of CT-ECV protocols is necessary for widespread implementation of CT-ECV assessment for diagnosis and prognosis.</p></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1934592524003447/pdfft?md5=7df1f06754067cfc2b88360cc60def0f&pid=1-s2.0-S1934592524003447-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Standards for quantitative assessments by coronary computed tomography angiography (CCTA)","authors":"","doi":"10.1016/j.jcct.2024.05.232","DOIUrl":"10.1016/j.jcct.2024.05.232","url":null,"abstract":"<div><p>In current clinical practice, qualitative or semi-quantitative measures are primarily used to report coronary artery disease on cardiac CT. With advancements in cardiac CT technology and automated post-processing tools, quantitative measures of coronary disease severity have become more broadly available. Quantitative coronary CT angiography has great potential value for clinical management of patients, but also for research. This document aims to provide definitions and standards for the performance and reporting of quantitative measures of coronary artery disease by cardiac CT.</p></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1934592524003411/pdfft?md5=f59abd76ebe6dd197d3897aae72a5e6b&pid=1-s2.0-S1934592524003411-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141289057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristian Tækker Madsen , Bjarne Linde Nørgaard , Kristian Altern Øvrehus , Jesper Møller Jensen , Erik Parner , Erik Lerkevang Grove , Martin B. Mortensen , Nadia Iraqi , Timothy A. Fairbairn , Koen Nieman , Manesh R. Patel , Campbell Rogers , Sarah Mullen , Hans Mickley , Kristian Korsgaard Thomsen , Hans Erik Bøtker , Jonathon Leipsic , Niels Peter Rønnow Sand
{"title":"Completeness of revascularization by FFRCT in stable angina: Association to adverse cardiovascular outcomes","authors":"Kristian Tækker Madsen , Bjarne Linde Nørgaard , Kristian Altern Øvrehus , Jesper Møller Jensen , Erik Parner , Erik Lerkevang Grove , Martin B. Mortensen , Nadia Iraqi , Timothy A. Fairbairn , Koen Nieman , Manesh R. Patel , Campbell Rogers , Sarah Mullen , Hans Mickley , Kristian Korsgaard Thomsen , Hans Erik Bøtker , Jonathon Leipsic , Niels Peter Rønnow Sand","doi":"10.1016/j.jcct.2024.07.007","DOIUrl":"10.1016/j.jcct.2024.07.007","url":null,"abstract":"<div><h3>Background</h3><p>The prognostic impact of complete coronary revascularization relative to non-invasive testing methods is unknown.</p></div><div><h3>Objectives</h3><p>To assess the association between completeness of revascularization defined by CTA-derived fractional flow reserve (FFR<sub>CT</sub>) and cardiovascular outcomes in patients with stable angina.</p></div><div><h3>Methods</h3><p>Multicenter 3-year follow-up study of patients with new onset stable angina and ≥ 30% stenosis by CTA. The lesion-specific FFR<sub>CT</sub> value (two cm-distal-to-stenosis) was registered in all vessels with stenosis and considered abnormal when ≤ 0.80. Patients with FFR<sub>CT</sub> ≤ 0.80 were categorized as: Completely revascularized (CR-FFR<sub>CT</sub>), all vessels with FFR<sub>CT</sub> ≤ 0.80 revascularized; incompletely revascularized (IR-FFR<sub>CT</sub>), ≥ 1 vessels with FFR<sub>CT</sub> ≤ 0.80 non-revascularized. Early revascularization (< 90 days from index CTA) categorized vessels as revascularized. The primary endpoint comprised cardiovascular death and non-fatal myocardial infarction; the secondary endpoint vessel-specific late revascularization and non-fatal myocardial infarction.</p></div><div><h3>Results</h3><p>Amongst 900 patients and 1759 vessels, FFR<sub>CT</sub> was ≤ 0.80 in 377 (42%) patients, 536 (30%) vessels; revascularization was performed in 244 (27%) patients, 340 (19%) vessels. Risk of the primary endpoint was higher for IR-FFR<sub>CT</sub> (15/210 [7.1%]) compared to CR-FFR<sub>CT</sub> (4/167 [2.4%]), RR: 2.98; 95% CI: 1.01–8.8, p = 0.036, and to normal FFR<sub>CT</sub> (3/523 [0.6%]), RR: 12.45; 95% CI: 3.6–42.6, p < 0.001. Incidence of the secondary endpoint was higher in non-revascularized vessels with FFR<sub>CT</sub> ≤ 0.80 (29/250 [12%]) compared to revascularized vessels with FFR<sub>CT</sub> ≤ 0.80 (5/286 [1.7%]), p = 0.001, and to vessels with FFR<sub>CT</sub> > 0.80 (10/1223 [0.8%]), p < 0.001.</p></div><div><h3>Conclusion</h3><p>Incomplete revascularization of patients with lesion-specific FFR<sub>CT</sub> ≤ 0.80 is associated to unfavorable cardiovascular outcomes compared to those with complete revascularization or FFR<sub>CT</sub> > 0.80.</p></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1934592524003952/pdfft?md5=c2cbb17e53d2423dfd396564a4f7159a&pid=1-s2.0-S1934592524003952-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141725413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter Regarding Article “The effect of CTCA guided selective invasive graft assessment on coronary angiographic parameters and outcomes: Insights from the BYPASS-CTCA trial”","authors":"Matthew Kelham, Anthony Mathur, Daniel A. Jones","doi":"10.1016/j.jcct.2024.06.005","DOIUrl":"10.1016/j.jcct.2024.06.005","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comments on CTCA-guided selective invasive graft assessment in BYPASS-CTCA trial","authors":"","doi":"10.1016/j.jcct.2024.06.006","DOIUrl":"10.1016/j.jcct.2024.06.006","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}