Nagoya Journal of Medical Science最新文献_第9页

Gender and age variations in the association between multigenerational cohabitation and self-rated health among middle-aged and older adults in Japan. 日本中老年人多代同居与自评健康之间的性别和年龄差异。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.262

Akane Nogimura, Takahiro Otani, Taiji Noguchi, Hiroko Nakagawa-Senda, Miki Watanabe, Tamaki Yamada, Sadao Suzuki

{"title":"Gender and age variations in the association between multigenerational cohabitation and self-rated health among middle-aged and older adults in Japan.","authors":"Akane Nogimura, Takahiro Otani, Taiji Noguchi, Hiroko Nakagawa-Senda, Miki Watanabe, Tamaki Yamada, Sadao Suzuki","doi":"10.18999/nagjms.86.2.262","DOIUrl":"10.18999/nagjms.86.2.262","url":null,"abstract":"Despite encouraging multi-generational cohabitation, the population of Japanese people living alone has increased. However, little is known about the association between health and multigenerational cohabitation. This study examined the relationship between self-rated health and living arrangements among Japanese adults using data from the Japan Multi-Institutional Collaborative Cohort Study (2013-2017). The analysis employed multivariate logistic regression to examine the associations. Our results showed no association between living arrangements and self-rated health when stratified by gender. Living alone was found to be associated with poor self-rated health among women aged 65 and above. A similar association may exist among men in the same age group. Among women aged < 65 years, two-generation cohabitation was associated with a good self-rated health, similar to those living alone. Among men aged < 65 years, neither living alone nor two-generation cohabitation was significantly associated with good self-rated health. We found no association between three- or plus-generation cohabitation and self-rated health. Therefore, our findings indicate associations between multigenerational cohabitation and self-rated health, but they vary by gender and age. Invested stakeholders in the public health field should consider the potential impact of living arrangements on health based on gender and age.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"262-279"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of surgical treatment for enterovesical fistula in Crohn's disease. 手术治疗克罗恩病肠瘘的效果。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.280

Norifumi Hattori, Goro Nakayama, Shinichi Umeda, Masanao Nakamura, Takeshi Yamamura, Tsunaki Sawada, Koki Nakanishi, Dai Shimizu, Mitsuro Kanda, Masamichi Hayashi, Chie Tanaka, Yasuhiro Kodera

{"title":"Outcomes of surgical treatment for enterovesical fistula in Crohn's disease.","authors":"Norifumi Hattori, Goro Nakayama, Shinichi Umeda, Masanao Nakamura, Takeshi Yamamura, Tsunaki Sawada, Koki Nakanishi, Dai Shimizu, Mitsuro Kanda, Masamichi Hayashi, Chie Tanaka, Yasuhiro Kodera","doi":"10.18999/nagjms.86.2.280","DOIUrl":"10.18999/nagjms.86.2.280","url":null,"abstract":"Enterovesical fistula (EVF) in Crohn's disease (CD) often does not improve with medical treatment and requires surgical treatment. The surgical treatment strategy for EVF in CD is definitive resection of the intestinal tract side, and performing a leak test using dye injection into the bladder after EVF dissection to determine the appropriate surgical procedure for the bladder side. This study aimed to evaluate the outcomes of surgical treatment for EVF in CD. Twenty-one patients who underwent surgery for EVF between 2006 and 2021 were included and retrospectively evaluated for clinical background, surgical procedures, and postoperative complications. The most common origin of EVF was the ileum (17 cases; 81%), and the most common site of EVF formation was the apex (12; 57%). Surgical approaches were laparotomy in 11 (52%) cases and laparoscopy in 10 (48%). Surgical procedures on the bladder side were fistula dissection in 13 (62%) cases and sutured closure of fistula in 8 (38%). A comparison of approaches revealed no significant difference in operative time, but the amount of blood loss was significantly less in the laparoscopy (p < 0.01). There was no significant difference in the occurrence of postoperative complications between approaches. Postoperative anti-TNF-α antibody agents were used in 17 (81%) cases, and there were no cases of recurrent EVF. In conclusion, definitive resection of the intestinal tract and minimal treatment on the bladder side were sufficient to achieve satisfactory outcomes for EVF in CD.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"280-291"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment escalation and de-escalation of de-novo metastatic castration-sensitive prostate cancer. 新发转移性阉割敏感性前列腺癌的治疗升级和降级。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.169

Shusuke Akamatsu, Yushi Naito, Jun Nagayama, Yuta Sano, Satoshi Inoue, Kazuna Matsuo, Tomoyasu Sano, Shohei Ishida, Yoshihisa Matsukawa, Masashi Kato

{"title":"Treatment escalation and de-escalation of de-novo metastatic castration-sensitive prostate cancer.","authors":"Shusuke Akamatsu, Yushi Naito, Jun Nagayama, Yuta Sano, Satoshi Inoue, Kazuna Matsuo, Tomoyasu Sano, Shohei Ishida, Yoshihisa Matsukawa, Masashi Kato","doi":"10.18999/nagjms.86.2.169","DOIUrl":"10.18999/nagjms.86.2.169","url":null,"abstract":"Androgen receptor signaling inhibitors combined with androgen deprivation therapy have become the standard of care for metastatic castration-sensitive prostate cancer (mCSPC), regardless of tumor volume or risk. However, survival of approximately one-third of these patients has not improved, necessitating further treatment escalation. On the other hand, for patients with oligometastatic mCSPC, there is an emerging role for local radiation therapy. Although data remain scarce, it is expected that treatment of both primary tumor as well as metastasis-directed therapy may improve survival outcomes. In these patients, systemic therapy may be de-escalated to intermittent therapy. However, precise risk stratification is necessary for risk-based treatment escalation or de-escalation. In addition to risk stratification based on clinical parameters, research has been conducted to incorporate genomic and/or transcriptomic data into risk stratification. In future, an integrated risk model is expected to precisely stratify patients and guide treatment strategies. Here, we first review the transition of the standard treatment for mCSPC over the last decade and further discuss the newest concept of escalating or de-escalating treatment using a multi-modal approach based on the currently available literature.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"169-180"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uneventful vaginal delivery using epidural anesthesia in patient with exercise induced anaphylaxis: a case report and literature review. 在运动诱发过敏性休克患者中使用硬膜外麻醉进行无痛阴道分娩：病例报告和文献综述。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.345

Kanon Morimoto, Kenichiro Tatsumi, Yoshitsugu Chigusa, Maya Komatsu, Moritoki Egi, Masaki Mandai, Haruta Mogami

{"title":"Uneventful vaginal delivery using epidural anesthesia in patient with exercise induced anaphylaxis: a case report and literature review.","authors":"Kanon Morimoto, Kenichiro Tatsumi, Yoshitsugu Chigusa, Maya Komatsu, Moritoki Egi, Masaki Mandai, Haruta Mogami","doi":"10.18999/nagjms.86.2.345","DOIUrl":"10.18999/nagjms.86.2.345","url":null,"abstract":"Exercise induced anaphylaxis (EIA) is a rare and potentially life-threatening syndrome characterized by anaphylaxis provoked by exercise. Although vaginal delivery with labor pain is a physical strain for women and a possible trigger for EIA, no consensus exists on the management strategy of delivery in patients with EIA. A 28-year-old primigravida was referred to our hospital because of history of EIA, associated with pruritus, urticaria, and respiratory distress, exacerbated during physical activity. To avoid physical stress, we chose scheduled labor induction with epidural anesthesia, and administered prophylactic intravenous hydrocortisone. She delivered vaginally with no symptoms suggestive of EIA during labor. Since it is quite possible for patients with EIA to develop anaphylaxis during vaginal delivery with labor pain, epidural anesthesia and prophylactic steroid administration may be the most rational approaches for delivery in pregnant women with EIA.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"345-350"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the genetic association between selected 3q29 region genes and schizophrenia and autism spectrum disorder in the Japanese population. 日本人群中部分 3q29 区域基因与精神分裂症和自闭症谱系障碍之间的遗传关联研究。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.216

Gantsooj Otgonbayar, Tzuyao Lo, Yu Hayashi, Sho Furuta, Branko Aleksic, Yoshihiro Nawa, Itaru Kushima, Hidekazu Kato, Hiroki Kimura, Norio Ozaki

{"title":"Study of the genetic association between selected 3q29 region genes and schizophrenia and autism spectrum disorder in the Japanese population.","authors":"Gantsooj Otgonbayar, Tzuyao Lo, Yu Hayashi, Sho Furuta, Branko Aleksic, Yoshihiro Nawa, Itaru Kushima, Hidekazu Kato, Hiroki Kimura, Norio Ozaki","doi":"10.18999/nagjms.86.2.216","DOIUrl":"10.18999/nagjms.86.2.216","url":null,"abstract":"Psychiatric disorders are highly inheritable, and most psychiatric disorders exhibit genetic overlap. Recent studies associated the 3q29 recurrent deletion with schizophrenia (SCZ) and autism spectrum disorder (ASD). In this study, we investigated the association of genes in the 3q29 region with SCZ and ASD. TM4SF19 and PAK2 were chosen as candidate genes for this study based on evidence from previous research. We sequenced TM4SF19 and PAK2 in 437 SCZ cases, 187 ASD cases and 524 controls in the Japanese population. Through targeted sequencing, we identified 6 missense variants among the cases (ASD & SCZ), 3 missense variants among controls, and 1 variant common to both cases and controls; however, no loss-of-function variants were identified. Fisher's exact test showed a significant association of variants in TM4SF19 among cases (p=0.0160). These results suggest TM4SF19 variants affect the etiology of SCZ and ASD in the Japanese population. Further research examining 3q29 region genes and their association with SCZ and ASD is thus needed.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"216-222"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospital-associated complications in frail older adults. 年老体弱者的医院相关并发症。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.181

Hiroyuki Umegaki

{"title":"Hospital-associated complications in frail older adults.","authors":"Hiroyuki Umegaki","doi":"10.18999/nagjms.86.2.181","DOIUrl":"10.18999/nagjms.86.2.181","url":null,"abstract":"As the Japanese population continues to age steadily, the number of older adults requiring healthcare has increased. Evidence demonstrates that hospitalization for acute care has a negative impact on the health outcomes of older adults. Frail older adults tend to have multifactorial conditions collectively known as \"geriatric syndromes.\" When those with these premorbid conditions are hospitalized for acute care, they tend to develop new problems such as delirium and new functional impairments. Adverse consequences of hospitalization include the risk of loss of functional independence and chronic disability. In 2019, the new concept of \"hospital-associated complications\" (HACs) was proposed to describe these new problems. HACs comprise five conditions: hospital-associated falls, delirium, functional decline, incontinence, and pressure injuries. This review discusses the important issues of HACs in relation to their classification, prevalence, risk factors, prevention, and management in older adults hospitalized for acute care. Robust prevention and management are imperative to address the serious consequences and escalating medical costs associated with HACs, and a multidimensional and multidisciplinary approach is key to achieving this goal. Comprehensive geriatric assessment (CGA) is the cornerstone of geriatric medicine and offers a holistic approach involving multidisciplinary and multidimensional assessments. Considerable evidence is accumulating regarding how CGA and coordinated care can improve the prognosis of hospitalized older adults. Further research is needed to understand the occurrence of HACs in this population and to develop effective preventive measures.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"181-188"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established. 从原发性血小板增多症到急性髓性白血病的克隆进化过程，CALR 突变的 Marimo 细胞系就是从该患者身上建立起来的。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.326

Yoko Ushijima, Yuichi Ishikawa, Takahiro Nishiyama, Naomi Kawashima, Takashi Kanamori, Masashi Sanada, Hitoshi Kiyoi

{"title":"Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established.","authors":"Yoko Ushijima, Yuichi Ishikawa, Takahiro Nishiyama, Naomi Kawashima, Takashi Kanamori, Masashi Sanada, Hitoshi Kiyoi","doi":"10.18999/nagjms.86.2.326","DOIUrl":"10.18999/nagjms.86.2.326","url":null,"abstract":"We previously reported the Marimo cell line, which was established from the bone marrow cells of a patient with essential thrombocythemia (ET) at the last stage after transformation to acute myeloid leukemia (AML). This cell line is widely used for the biological analysis of ET because it harbors CALR mutation. However, genetic processes during disease progression in the original patient were not analyzed. We sequentially analyzed the genetic status in the original patient samples during disease progression. The ET clone had already acquired CALR and MPL mutations, and TP53 and NRAS mutations affected the disease progression from ET to AML in this patient. Particularly, the variant allele frequency of the NRAS mutation increased along with the disease progression after transformation, and the NRAS-mutated clone selectively proliferated in vitro, resulting in the establishment of the Marimo cell line. Although CALR and MPL mutations co-existed, MPL was not expressed in Marimo cells or any clinical samples. Furthermore, mitogen-activated protein kinase (MAPK) but not the JAK2-STAT pathway was activated. These results collectively indicate that MAPK activation is mainly associated with the proliferation ability of Marimo cells.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"326-332"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for nausea and vomiting requiring the daily administration of 5-HT₃ receptor antagonists in radiotherapy combined with temozolomide for high-grade glioma. 放疗联合替莫唑胺治疗高级别胶质瘤时，需要每天服用 5-HT3 受体拮抗剂的恶心和呕吐风险因素。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.304

Mai Takagi, Atsunobu Sagara, Yasuo Kumakura, Minako Watanabe, Rikako Inoue, Masayuki Miyazaki, Fumiharu Ohka, Kazuya Motomura, Atsushi Natsume, Toshihiko Wakabayashi, Ryuta Saito, Kiyofumi Yamada

{"title":"Risk factors for nausea and vomiting requiring the daily administration of 5-HT3 receptor antagonists in radiotherapy combined with temozolomide for high-grade glioma.","authors":"Mai Takagi, Atsunobu Sagara, Yasuo Kumakura, Minako Watanabe, Rikako Inoue, Masayuki Miyazaki, Fumiharu Ohka, Kazuya Motomura, Atsushi Natsume, Toshihiko Wakabayashi, Ryuta Saito, Kiyofumi Yamada","doi":"10.18999/nagjms.86.2.304","DOIUrl":"10.18999/nagjms.86.2.304","url":null,"abstract":"Radiotherapy combined with temozolomide (TMZ+RT) is the primary treatment for high-grade glioma. TMZ is classified as a moderate emetic risk agent and, thus, supportive care for nausea and vomiting is important. In Nagoya University Hospital, all patients are treated with a 5-hydroxy-tryptamine 3 receptor antagonist (5-HT3RA) for the first 3 days. The daily administration of 5-HT3RA is resumed after the 4th day based on the condition of patients during TMZ+RT. Therefore, the present study investigated risk factors for nausea and vomiting in patients requiring the daily administration of 5-HT3RA. Patients with high-grade glioma who received TMZ+RT between January 2014 and December 2019 at our hospital were included. Patients were divided into two groups: a control group (patients who did not resume 5-HT3RA) and resuming 5-HT3RA group (patients who resumed 5-HT3RA after the 4th day), and both groups were compared to identify risk factors for nausea and vomiting during TMZ+RT. There were 78 patients in the control group (68%) and 36 in the resuming 5-HT3RA group (32%). A multivariate analysis of patient backgrounds in the two groups identified age <18 years, PS 2 or more, and occipital lobe tumors as risk factors for nausea and vomiting. Nausea and vomiting were attenuated in 30 patients (83%) in the resuming 5-HT3RA group following the resumption of 5-HT3RA. The results obtained highlight the importance of extracting patients with these risk factors before the initiation of therapy and the early resumption or daily administration of 5-HT3RA according to the condition of each patient.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"304-313"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care. 切实可行的体重管理，最大限度地减少妊娠并发症，促进妇女健康：孕期保健的可能性。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.160

Tomomi Kotani, Sho Tano, Takafumi Ushida, Kenji Imai, Hiroaki Kajiyama

{"title":"Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care.","authors":"Tomomi Kotani, Sho Tano, Takafumi Ushida, Kenji Imai, Hiroaki Kajiyama","doi":"10.18999/nagjms.86.2.160","DOIUrl":"10.18999/nagjms.86.2.160","url":null,"abstract":"Pregnancy is an excellent opportunity to provide medical interventions to women. It is also a stress test used to predict health. Numerous studies have demonstrated that the pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are critical factors for pregnancy complications such as hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), large or small gestational age infants, and spontaneous preterm birth (sPTB). These complications are associated with an increased risk of cardiovascular disease (CVD), which is a leading cause of mortality in women. In addition, complications adversely affect the short- and long-term prognoses of children. Optimal GWG to reduce complications is recommended based on pre-pregnancy BMI; however, racial differences should also be noted. The values in the Japanese guidelines are lower than those in the American Institute of Medicine guidelines. The Asian BMI thresholds for CVD risk are also lower than those in Europe. Therefore, weight management should be based on racial/genetic background. Interpregnancy weight gain or loss has also been reported to be associated with the risk of pregnancy complications; however, few studies have been conducted in Asian populations. Our previous reports suggested that avoiding an excess of 0.6 kg/m2/year of annual BMI gain may reduce the risk of HDP or GDM, and insufficient gain of < 0.25 kg/m2/year may increase sPTB recurrence. Annual BMI is useful for practical weight control during interpregnancy. Based on these findings, effective approaches should be established to improve the health of women and their offspring.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"160-168"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between locomotive syndrome and advanced glycation end products measured by skin autofluorescence in community-dwelling patients: the Yakumo Study. 社区居民患者的运动综合征与通过皮肤自发荧光测量的高级糖化终产物之间的关系：Yakumo 研究。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.314

Yuto Ozawa, Yasuhiko Takegami, Taisuke Seki, Yusuke Osawa, Hiroki Iida, Masanori Okamoto, Hiroaki Nakashima, Shinya Ishizuka, Yukiharu Hasegawa, Shiro Imagama

{"title":"Relationship between locomotive syndrome and advanced glycation end products measured by skin autofluorescence in community-dwelling patients: the Yakumo Study.","authors":"Yuto Ozawa, Yasuhiko Takegami, Taisuke Seki, Yusuke Osawa, Hiroki Iida, Masanori Okamoto, Hiroaki Nakashima, Shinya Ishizuka, Yukiharu Hasegawa, Shiro Imagama","doi":"10.18999/nagjms.86.2.314","DOIUrl":"10.18999/nagjms.86.2.314","url":null,"abstract":"Advanced glycation end products (AGEs) have been reported to be associated with osteoporosis, aging, sarcopenia, and frailty. This study aimed to investigate the association AGEs with locomotive syndrome (LS). Participants were Japanese individuals aged 39 years or older who participated in the Yakumo Study (n=230). AGEs were measured by skin autofluorescence (SAF) using an AGE reader. We investigated SAF values for each locomotive stage. Multivariate logistic regression models were used to calculate the odds ratios of LS-associated factors. The relationships between SAF and physical performance and bone mineral density (BMD) were investigated. A receiver operating characteristic (ROC) curves were generated to determine the optimal cut-off value of SAF for predicting LS. SAF values tended to increase correspondingly with LS severity. SAF was an independently explanatory factor for LS (odds ratio 2.70; 95% confidence interval [CI] 1.040-6.990). SAF was positively correlated with the 10-m walking speed, The Timed Up and Go test results, and was negatively correlated with BMD. ROC curve represented by SAF for the presence or absence of LS risk had an area under the curve of 0.648 (95% CI: 0.571-0.726). High SAF values were identified as an independent risk factor for LS. AGEs could be a potential screening tool for people for LS.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"314-325"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0