Qian Wang, Richard James Maude, Nicholas Philip John Day, Benn Sartorius
{"title":"Methods for estimating the burden of acute tropical infectious diseases: A scoping review.","authors":"Qian Wang, Richard James Maude, Nicholas Philip John Day, Benn Sartorius","doi":"10.1371/journal.pntd.0013359","DOIUrl":"https://doi.org/10.1371/journal.pntd.0013359","url":null,"abstract":"<p><p>Acute infectious diseases, particularly lots of neglected tropical diseases (NTDs), pose significant public health challenges, especially in resource-limited settings where diagnostic and surveillance capacities are often inadequate. This scoping review systematically explores methodologies for estimating the burden of acute infectious NTDs, focusing on metrics such as incidence, mortality, and disability-adjusted life years (DALYs). We identified 60 studies, predominantly on malaria and dengue, with a growing emphasis on advanced computational approaches like machine learning and Bayesian geospatial modeling. Key findings highlight the evolution from traditional surveillance-based methods to integrated frameworks incorporating environmental, demographic, and health system covariates. However, challenges persist, including data sparsity, underreporting, and methodological uncertainties. The review underscores the need for improved data integration, standardized frameworks, and interdisciplinary collaboration to enhance the accuracy and utility of burden estimates.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0013359"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hubert Senanu Ahor, Venus Nana Boakyewaa Frimpong, Bernadette Agbavor, Kabiru Mohammed Abass, George Amofa, Elizabeth Ofori, Ahmed Abd El Wahed, Yaw Ampem Amoako, Richard Odame Phillips, Michael Frimpong
{"title":"Field deployment of a mobile suitcase laboratory for Buruli ulcer diagnosis in Ghana.","authors":"Hubert Senanu Ahor, Venus Nana Boakyewaa Frimpong, Bernadette Agbavor, Kabiru Mohammed Abass, George Amofa, Elizabeth Ofori, Ahmed Abd El Wahed, Yaw Ampem Amoako, Richard Odame Phillips, Michael Frimpong","doi":"10.1371/journal.pntd.0013683","DOIUrl":"https://doi.org/10.1371/journal.pntd.0013683","url":null,"abstract":"<p><p>Molecular diagnostics are the gold standard laboratory confirmation test for Buruli ulcer (BU), a severe necrotising skin disease caused by Mycobacterium ulcerans (M. ulcerans). However, current molecular tests are often performed outside endemic areas, which results in delayed diagnosis and increased patient management costs. To overcome these challenges and facilitate rapid diagnosis of clinically suspected BU lesions in affected communities, we developed a portable laboratory platform contained in two Pelican cases (each measuring 56 cm × 45.5 cm × 26.5 cm). We evaluated the feasibility of performing our earlier developed M. ulcerans Recombinase Polymerase Amplification (Mu-RPA) assay, along with a rapid DNA extraction method, using this mobile suitcase laboratory at BU clinics (BU-RPA mobile laboratory) in three endemic districts of Ghana. In the field, the entire process from sample collection to DNA extraction and amplification was completed in under one hour with this mobile setup. Among 39 PCR-confirmed BU cases, 32 (82%; 95% confidence interval [CI]: 67-91) were accurately identified by the BU-RPA mobile laboratory platform. All non-Buruli ulcer cases tested negative, resulting in a clinical specificity of 100% (95% CI: 90-100). Diagnostic performance varied by sample type: swabs demonstrated a sensitivity of 91%, whereas fine-needle aspirates (FNA) had a sensitivity of 69%. This mobile laboratory platform provides an effective workspace for the rapid, on-site diagnosis of BU, enabling timely results for healthcare providers at treatment centres. This mobile suitcase laboratory, together with its isothermal assays, presents a promising alternative to PCR for the swift diagnosis of suspected BU cases as well as other neglected tropical diseases in resource-limited settings.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0013683"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Chen, Meng Shang, Shengping Dou, Xiaoxu Wang, Haoqiang Ji, Xiuping Song, Jun Wang, Qiyong Liu
{"title":"Incidence of acute pancreatitis among hospitalized patients with dengue: A systematic review and meta-analysis.","authors":"Yu Chen, Meng Shang, Shengping Dou, Xiaoxu Wang, Haoqiang Ji, Xiuping Song, Jun Wang, Qiyong Liu","doi":"10.1371/journal.pntd.0014304","DOIUrl":"10.1371/journal.pntd.0014304","url":null,"abstract":"<p><strong>Background: </strong>Acute pancreatitis (AP) is an under-recognized but clinically relevant complication of dengue fever (DF), associated with rapid clinical deterioration and increased risk of mortality. However, the true incidence of this condition remains uncertain.</p><p><strong>Methods: </strong>Following PRISMA 2020 guidelines, we systematically searched PubMed, Web of Science, Embase and China National Knowledge Infrastructure (CNKI) up to May 2025 for observational studies reporting AP among DF hospitalized patients. Eligible studies were identified according to predefined inclusion and exclusion criteria based on the Population, Intervention, Comparison, Outcome, and Study design (PICOS) framework. Two reviewers independently screened the literature and assessed study quality using the Newcastle-Ottawa Scale (NOS). Pooled incidence rates were estimated using random or common effect models depending on heterogeneity.</p><p><strong>Results: </strong>Eight observational studies from five countries, comprising 1,078 hospitalized patients with DF, were included. Among them, 135 were diagnosed with AP. The pooled incidence of AP complicating DF was 12.4% (95% CI: 10.5-14.4%). Subgroup analysis suggested a higher incidence in studies with ≥100 participants compared to smaller cohorts (13.5% vs. 8.3%, P = 0.03). No evidence of significant publication bias was detected.</p><p><strong>Conclusion: </strong>DF-associated AP represents a clinically important complication, given the global burden of dengue and the potential severity of AP. Our findings underscore the importance of considering pancreatic enzyme testing, supplemented by imaging when clinically warranted, in dengue patients with persistent or severe abdominal symptoms and/or features of severe dengue. Large-scale, multicenter prospective studies are warranted to establish the true incidence and case-fatality risk, thereby informing evidence-based prevention and management strategies.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014304"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Liu, Jie Xu, Jiahui Xu, Jingqi Zhang, Yinyue Li, Wenjie Huang, Fang Tian, Xinlong He, Ting Zhang, Jun-Hu Chen, Feng Lu
{"title":"The hydatid cyst fluid protein EgAgB8/1 demonstrates potent immunogenicity by eliciting robust humoral and cellular immune responses in mice.","authors":"Jie Liu, Jie Xu, Jiahui Xu, Jingqi Zhang, Yinyue Li, Wenjie Huang, Fang Tian, Xinlong He, Ting Zhang, Jun-Hu Chen, Feng Lu","doi":"10.1371/journal.pntd.0014260","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014260","url":null,"abstract":"<p><strong>Background: </strong>Cystic echinococcosis (CE), a neglected zoonotic disease caused by the larval stage of Echinococcus granulosus, requires effective vaccine strategies for sustainable control. This study evaluated the immunogenic profiles of two antigenic targets: EgAgB8/1, a dominant immunogenic component of hydatid cyst fluid, and Eg-01883, a protoscolex-specific antigen identified through bioinformatic screening.</p><p><strong>Methodology/principal findings: </strong>E. granulosus strains were isolated from infected dogs for genomic DNA extraction. Recombinant proteins rEgAgB8/1 and rEg-01883 were expressed in E. coli, purified, and validated by SDS-PAGE and western blot. Initial protein microarray screening identified rEgAgB8/1 as exhibiting markedly higher immunoreactivity with cystic echinococcosis (CE) patient sera compared to the minimally reactive Eg-01883. Based on this finding, subsequent investigation focused on rEgAgB8/1 using a BALB/c mouse immunization model. The recombinant protein elicited potent humoral immunity, with antigen-specific IgG titers reaching 1:16,000, and stimulated significant lymphocyte proliferation. Immunized mouse sera specifically recognized native EgAgB8/1 in hydatid crude antigen preparations, confirming natural antigenicity. Flow cytometric analysis demonstrated that rEgAgB8/1 immunization significantly expanded splenic plasmablasts, memory B cells, and T follicular helper cells. Furthermore, it enhanced IFN-γ production in both CD4⁺ and CD8 ⁺ T cells while maintaining baseline IL-10 ⁺ T cell frequencies, and induced robust T cell memory responses. Statistical analyses were performed using Student's t-test for comparative evaluation.</p><p><strong>Conclusions: </strong>These findings establish rEgAgB8/1 as a highly immunogenic antigen capable of eliciting a cellular immune response characterized by dominant IFN-γ production without concomitant IL-10 elevation, alongside durable humoral responses in mice. The comprehensive immunogenicity profile supports further research into its immunological potential against cystic echinococcosis.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014260"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maurice R Odiere, Stella Kepha, Jimmy Kihara, Chitiavi Juma, Dickson Kioko, Florence Wakesho, Dollycate N Wanja, Martin Muchangi, Ivy Sempele, Irene Chami, Sultani Hadley Matendechero, Wyckliff Omondi
{"title":"Biomphalaria pfeifferi infected with Schistosoma spp. in Kakamega and Bungoma counties, western Kenya confirms autochthonous transmission of intestinal schistosomiasis.","authors":"Maurice R Odiere, Stella Kepha, Jimmy Kihara, Chitiavi Juma, Dickson Kioko, Florence Wakesho, Dollycate N Wanja, Martin Muchangi, Ivy Sempele, Irene Chami, Sultani Hadley Matendechero, Wyckliff Omondi","doi":"10.1371/journal.pntd.0014276","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014276","url":null,"abstract":"<p><strong>Background: </strong>Granular mapping conducted in Kakamega and Bungoma counties of western Kenya provided strong evidence of intestinal schistosomiasis among school-age children in this area. However, it was unclear whether the observed infections were due to active transmission. To address this gap, a follow-up malacology survey was conducted to determine the presence of snail vectors and ascertain active transmission.</p><p><strong>Methods: </strong>Nineteen Wards with ≥10% prevalence of Schistosoma mansoni were selected from Kakamega and Bungoma counties. From these Wards, 42 primary schools with the highest prevalence of S. mansoni were used to identify nearby water bodies with human-water contact activities for sampling snail vectors. Live snails were sampled by experienced collectors using a handheld dip-net scoop in standardized sampling frames for ~30 minutes at each water body. Snails were counted and identified to species-level based on shell morphology. Site locations sampled for snails were mapped using a geographical information system, and the type of water body recorded. All Biomphalaria and Bulinus snails were transported to the laboratory where they were screened for cercariae. Cercariae were identified to basic taxonomic groups using standard identification keys. The relative and mean abundance and prevalence of Schistosoma sp. infection in snails was determined.</p><p><strong>Results: </strong>Out of 4,245 snails collected, 3,341 (78.7%, 95% CI: 77.5-79.9) were putatively identified as Biomphalaria pfeifferi, 88 (2.1%, 95% CI: 1.7-2.5) as Bulinus globosus, 664 (15.6%, 95% CI: 14.6-16.7) as Lymnaea natalensis and 152 (3.6%) as other species. B. pfeifferi were found in 36 out of the 42 primary school regions (85.7%), with the highest number (605 snails) recorded at Indangalasia in Lusheya-Lubinu Ward. A total of 87 (2.6%, 95% CI: 2.07-3.14) B. pfeifferi shed Schistosoma sp. cercariae. The mean abundance of B. pfeifferi was similar between streams (16 ± 35) and swamps/marshes (20 ± 31) (P = 0.356), but was higher compared to rivers (4 ± 10) (P = 0.005).</p><p><strong>Conclusions: </strong>The high abundance of B. pfeifferi coupled with the observation of field-caught snails shedding cercariae confirms autochthonous schistosomiasis transmission corroborating the reported human infections in Kakamega and Bungoma counties. Incorporation of focal snail control to complement chemotherapy will accelerate interruption of transmission in these areas.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014276"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chikungunya virus in dengue-suspected patients: Molecular evidence from the 2019 outbreak in Yangon, Myanmar.","authors":"Merveille Kapandji, Htin Lin, Maurine Mumo Mutua, Qiang Xu, Ryosaku Oshiro, Catarina Harumi Oda Ibrahim, Micheal Teron Pillay, Kei Yamasato, Khine Mya Nwe, Muhareva Raekiansyah, Shyam Prakash Dumre, Kyaw Zin Thant, Wah Wah Aung, Aye Aye Khin, Hlaing Myat Thu, Takeshi Urano, Kouichi Morita, Yuki Takamatsu, Mya Myat Ngwe Tun","doi":"10.1371/journal.pntd.0014258","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014258","url":null,"abstract":"<p><strong>Background: </strong>Chikungunya virus (CHIKV) and dengue virus (DENV) frequently co-occur in Myanmar and present with overlapping symptoms, complicating diagnosis. During the 2019 dengue outbreak in Yangon, Myanmar, molecular data on CHIKV were limited among dengue-suspected patients and there were no publicly available CHIKV genome sequences from Yangon in international databases. To address this gap and potential diagnostic overlap, we investigated the prevalence of CHIKV infection and described the genomic characteristics of detected strains.</p><p><strong>Methods: </strong>Serum samples from 267 dengue-suspected patients collected in 2019 were screened for anti-CHIKV IgM and IgG by in-house ELISA and 211 samples with sufficient remaining volume were further analyzed by RT-qPCR, isolation of the virus, and whole-genome sequencing for mutation analysis.</p><p><strong>Results: </strong>CHIKV antibodies were found in 24.7% (66/267) of samples (IgM 3.4%, IgG 21.3%), and viral RNA was detected in 10.9% (23/211) of samples. Fifteen viral isolates were successfully obtained (7.1% of those tested), including two co-detections with DENV-2 by RT-PCR. All isolates belonged to the East/Central/South African genotype, Indian Ocean Lineage (ECSA-IOL), and clustered with strains from Thailand, China, and Mandalay, Myanmar. Whole-genome analysis identified 33 non-synonymous mutations across nonstructural and structural proteins, including mutations previously reported in regional ECSA-IOL strains such as E1:K211E and E2:V264A, with 11 amino acid changes not previously reported in available Myanmar reference sequences.</p><p><strong>Discussion: </strong>Serological and molecular findings indicate CHIKV circulation during the 2019 dengue outbreak in Yangon and highlight the limitations of single-target testing. Serological evidence indicate the presence of anti-CHIKV IgM and IgG antibodies, reflecting CHIKV exposure within the study population. Notably, all RNA-positive cases were seronegative for both IgM and IgG, a pattern consistent with the temporal dynamics of infection and the inherent constraints of serological detection in co-endemic settings. Molecular co-detection with DENV-2 and genomic findings highlight the potential value of multiplex diagnostic approaches in co-endemic settings.</p><p><strong>Conclusion: </strong>This study documents CHIKV detection and genomic characterization in dengue-suspected patients in Yangon and highlights the potential value of multiplex diagnostic approaches and continued genomic surveillance as broader public health considerations for arboviral detection in Myanmar.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014258"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina Sandra Natasha Ngowi, Pacifique Ufitinema, Maria Albin Qambayot, Janna M Schurer
{"title":"\"I called people to carry me to the latrine\": Podoconiosis patients' access to water, sanitation, and hygiene in Butaro, Rwanda.","authors":"Nina Sandra Natasha Ngowi, Pacifique Ufitinema, Maria Albin Qambayot, Janna M Schurer","doi":"10.1371/journal.pntd.0014158","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014158","url":null,"abstract":"<p><p>Podoconiosis is a preventable Neglected Tropical Disease (NTD) that results in significant lower limb swelling and chronic disability. Its management can be done at home by regularly washing feet with clean water and soap and using protective footwear. This study aimed to explore podoconiosis patients' experiences with access to water, sanitation, and hygiene (WASH) and to identify barriers and facilitators of home-based management (HBM). In this qualitative phenomenological study, participants were recruited following a screening conducted in Butaro Sector (Rwanda) to identify individuals with lower limb lymphedema. Randomly selected individuals underwent a clinical assessment, and only those confirmed to have podoconiosis were invited for an interview. In-depth interviews, supplemented by observation and photographs, were conducted. Transcripts were inductively coded using Dedoose (version 9.0.80) and analyzed through thematic analysis. Overall, 26 interviews were conducted across all five cells of Butaro Sector. Poverty and physical discomfort were major barriers in accessing WASH and HBM essentials, with many relying on family or neighbors for support. Shame, laughter, and discrimination from community members further hindered access to WASH. However, some participants found a financial solution in selling animal and household waste. Moreover, participants demonstrated little or no knowledge about podoconiosis which influenced their treatment choices. Many attributed the disease to witchcraft, blood infection, or God's will. Common care choices included traditional healers, self-care, or health centers. These findings demonstrate the need to integrate community education into podoconiosis management programs to address misconceptions and stigma while promoting income-generating activities to ensure consistent access to HBM essentials.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 4","pages":"e0014158"},"PeriodicalIF":3.4,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geoffrey Akena, Marie Pascaline Sabine Ishimwe, Theodore Nteziyaremye, Maxwell Okello, Ahmed Kiswezi Kazigo, Theoneste Hakizimana
{"title":"Maternal anemia in helminth-infected pregnant women: Dose-response with hookworm intensity and other risk factors in a Ugandan cross-sectional study.","authors":"Geoffrey Akena, Marie Pascaline Sabine Ishimwe, Theodore Nteziyaremye, Maxwell Okello, Ahmed Kiswezi Kazigo, Theoneste Hakizimana","doi":"10.1371/journal.pntd.0014277","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014277","url":null,"abstract":"<p><p></p><p><strong>Background: </strong>Anemia remains a significant global public health challenge, affecting approximately 25% of the world's population and disproportionately impacting pregnant women, with an estimated 40% prevalence worldwide. Intestinal helminth infections exacerbate this burden, with anemia prevalence reported as high as 55.6% among infected pregnant women compared to 16.4% in those uninfected. This study aimed to determine the burden of anemia and its determinants among pregnant women with helminthiasis attending antenatal care at tertiary Hospitals in western Uganda. Methods: A hospital-based cross-sectional study was conducted from 1st November 2022-1st March 2023, enrolling 420 pregnant women diagnosed with helminthiasis attending antenatal clinics. Data were collected via interviewer-administered questionnaires and laboratory records. Descriptive statistics and multivariable logistic regression analyses were performed using IBM SPSS version 23 to identify factors independently associated with anemia. Results: The prevalence of anemia was 26.2% (95% CI: 22.2-30.6), with 39.1% (95% CI: 30.5-48.4) mild, 35.5% (95% CI: 27.1-44.7) moderate, and 25.5% (95% CI: 18.2-34.3) severe cases. Multivariate analysis showed that moderate and heavy hookworm intensities increased anemia risk nearly two-fold (aOR = 1.90, 95% CI: 1.16-3.54; p = 0.028) and 2.4-fold (aOR = 2.40, 95% CI: 1.06-5.41; p = 0.041), respectively. Protective factors included being a student (aOR = 0.17, 95% CI: 0.05-0.63; p = 0.008), deworming ≥3 months prior (aOR = 0.11, 95% CI: 0.01-0.88; p = 0.038), using borehole water (aOR = 0.60, 95% CI: 0.36-1.00; p = 0.048), and gestational age 14-27 weeks (aOR = 0.57, 95% CI: 0.35-0.92; p = 0.020). Conclusions: Maternal anemia showed a clear dose-response with hookworm intensity, with risk increasing from moderate to heavy infection. Delayed deworming and unsafe water increased odds, whereas being a student and second-trimester gestation were protective. Timely anthelminthic treatment, improved water access, and strengthened antenatal care are critical in endemic settings.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 4","pages":"e0014277"},"PeriodicalIF":3.4,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arnob Saha, Mahir Anjum, Shyrin Jebun Labiba, Mirza Jaman, Abdullah Al Sayed, Rafsun Jany Rahat
{"title":"A Global Perspective on the Emerging Threat of Zika and Dengue Co-infection.","authors":"Arnob Saha, Mahir Anjum, Shyrin Jebun Labiba, Mirza Jaman, Abdullah Al Sayed, Rafsun Jany Rahat","doi":"10.1371/journal.pntd.0014257","DOIUrl":"10.1371/journal.pntd.0014257","url":null,"abstract":"","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 4","pages":"e0014257"},"PeriodicalIF":3.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Socioeconomic drivers of human Brucellosis in Ningxia, China: A one health and spatiotemporal analysis for targeted intervention.","authors":"Ping Zhang, Xiaojuan Ma, Ting Pan, Jingxia Dang, Dongfeng Pan, Mingbo Chen, Peifeng Liang","doi":"10.1371/journal.pntd.0014271","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014271","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pntd.0014124.].</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 4","pages":"e0014271"},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}