PLoS Neglected Tropical Diseases最新文献

{"title":"Retraction: Body lice of homeless people reveal the presence of several emerging bacterial pathogens in northern Algeria.","authors":"","doi":"10.1371/journal.pntd.0014290","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014290","url":null,"abstract":"","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014290"},"PeriodicalIF":3.4,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of AI-assisted diagnostic tools for Schistosoma haematobium: A systematic review and meta-analysis.","authors":"Sisay Desale, Getaneh Alemu, Tadesse Hailu","doi":"10.1371/journal.pntd.0013703","DOIUrl":"https://doi.org/10.1371/journal.pntd.0013703","url":null,"abstract":"<p><strong>Background: </strong>Urogenital schistosomiasis caused by Schistosoma haematobium remains endemic in sub-Saharan Africa. Diagnosis traditionally relies on urine microscopy to detect parasite eggs; however, its sensitivity declines in low-intensity infections. Artificial intelligence (AI)-assisted image analysis offers a promising approach to automate egg detection and enhance diagnostic accuracy, but its performance compared with standard microscopy is not well established.</p><p><strong>Methods: </strong>We conducted a systematic review following the PRISMA guidelines and checklist. Studies evaluating AI-assisted detection of S. haematobium compared with microscopy and/or molecular reference standards, published up to August 2025, were identified through searches in PubMed/MEDLINE, HINARI, Epistemonikos, Science Direct, Google Scholar and grey literature sources. Eligible studies were selected based on pre-defined inclusion and exclusion criteria. The quality of included studies was assessed using the QUADAS-2 tool. Heterogeneity among studies was evaluated using the Cochrane Q test and I² statistic. Data was analyzed using STATA version 14.1 and Review Manager version 5.4.1.</p><p><strong>Results: </strong>Ten studies (15 datasets, 5,564 urine samples) conducted in sub-Saharan Africa met the inclusion criteria. AI-assisted tools demonstrated high diagnostic accuracy. The pooled sensitivity was 88% (95%CI 83%-91%) and pooled specificity was 89% (95% CI 83%-93%). The pooled diagnostic odds ratio was 54.00 (95% CI 30.41-95.88), indicating strong discrimination between infected and uninfected cases. The SROC curve yielded an AUC of 0.94 (95% CI 0.92-0.96), reflecting excellent overall accuracy. Heterogeneity across studies was high (I² = 100%), suggesting results varied by the specific AI platform and study context.</p><p><strong>Conclusion: </strong>AI-assisted microscopic diagnosis of S. haematobium achieved very good in this meta-analysis. These automated tools, whether smartphone-based or bench-top systems, showed promise for detecting infections and could help screen populations in endemic areas. With further validation in field settings and comparison to highly sensitive reference tests, AI diagnostic technology may become a valuable tool to improve case detection and support schistosomiasis control and elimination efforts.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0013703"},"PeriodicalIF":3.4,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sire risk factors for vertical transmission of Leishmania infantum by the dam.","authors":"Kayla R Duxbury, Luciana M Richer, Christine A Petersen","doi":"10.1371/journal.pntd.0014303","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014303","url":null,"abstract":"<p><p>Leishmania (L.) infantum causes visceral leishmaniasis (VL) in humans across the Mediterranean basin and in Central and South America. VL is a zoonotic disease, with dogs as the predominant domestic reservoir. Traditionally, this disease is transmitted via sand flies of the genus Phlebotomus or Lutzomyia as vectors. Case reports of transmission in non-endemic areas have increased, where transmission is predominantly vertical, sexual, or bloodborne. L. infantum has been shown to be enzootic in hunting hounds within the United States (U.S.), with no indication of vector borne transmission. In this population, there is very high risk of parasite spread if the dam's diagnostic status is positive. In comparison, very little is known about the risk if the sire not the dam is positive for L. infantum. This is a retrospective cohort study of 24 U.S. hunting hound sires' L. infantum exposure between 2013 and 2022 and the resultant evidence of infection in their 183 pups over that time. Offspring from sires who tested serologically positive for L. infantum during the year of birth had 1.59 times the risk of becoming diagnostically positive via serology or molecular detection for L. infantum during their lifetime (RR: 1.59 95% CI: 1.15-2.20 p-value: 0.0046) when compared to outcomes in pups from diagnostically negative sires. The basic reproductive number (R0) for the risk of the sire to indirectly transmit L. infantum to the pup within this cohort was 3.71. These results demonstrate the impact of sire's infection on transmission of L. infantum to offspring. There is a need for control efforts that address non-vectorial transmission from both parents. Control efforts targeting vector borne transmission of canine leishmaniosis in endemic countries are also needed.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014303"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual role of Japanese encephalitis virus fusion loop peptide antibodies in Zika virus infection.","authors":"Kexin Xi, Xuenan Zhang, Jingshu Li, Yuqi Zhao, Xiaoting Xie, Chenguang Shen, Bao Zhang, Li Zhu, Weiwei Xiao, Chengsong Wan, Yifan Lin, Linqing Wang, Yingfang Liu, Yuyan Wang, Jianhai Yu, Qinghua Wu, Wei Zhao","doi":"10.1371/journal.pntd.0014296","DOIUrl":"10.1371/journal.pntd.0014296","url":null,"abstract":"<p><p>Zika virus (ZIKV) is a key member of the Flavivirus genus that has emerged as a major global public health concern. The fusion loop region (residues 98-110), located within domain II of the envelope protein, is highly conserved among flaviviruses, including ZIKV and Japanese encephalitis virus (JEV). However, the functional consequences of such conservation for cross-reactive immunity remains unclear. Here, we integrated bioinformatic analyses, functional assays in vitro and mouse models in vivo to systematically determine the effects of antibodies directed against the JEV fusion loop (FL) region on ZIKV infection. Sequence alignment and structural analysis revealed complete amino acid identity and almost identical three-dimensional conformations between the FL regions of the two viruses, providing a molecular basis for cross-reactivity. Antisera generated against the JEV FL region recognized ZIKV particles and displayed concentration-dependent bidirectional effects. Increased and decreased antibody levels respectively neutralized viral entry and replication, and facilitated infection via antibody-dependent enhancement (ADE). These effects were confirmed in vivo, in which high and low antibody doses reduced tissue pathology and improved survival, and increased viremia and exacerbated inflammatory responses, respectively. These findings highlight the importance of antibody concentration in determining whether cross-reactive responses to conserved structural elements engender neutralization or enhancement response. Our findings provide experimental evidence for assessing ZIKV susceptibility in JEV-vaccinated populations and offer structural insights for designing flavivirus vaccines that maximize protection while minimizing ADE risk. These findings further highlight potential pathogenic and clinical considerations for optimizing vaccine formulations to reduce cross-reactive enhancement risks.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014296"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and characterization of a Wolbachia (wAlbB)-infected Aedes aegypti line (Tw-Kao) for dengue control.","authors":"Hui-Ying Yu, Bo-Yu Chen, Ying-Tsong Chen, Wei-Kang Huang, Cheng-Hao Yang, Yung-Chieh Wu, Mei-Hsiu Wan, Wen-Sheng Yeh, Feng-Guang Goh, Xinjun Hou, Pui-Kuan Toh, Sui-Hann Ng, Yu Cai, Jian-Chiuan Li, Chun-Hong Chen, Wei-Liang Liu","doi":"10.1371/journal.pntd.0014222","DOIUrl":"10.1371/journal.pntd.0014222","url":null,"abstract":"<p><p>Global trade and climate change are driving the geographic expansion of dengue vectors, contributing to the global spread of dengue. Conventional vector control measures have proven insufficient to prevent substantial disease burdens, highlighting the need for innovative and sustainable strategies. The release of Wolbachia-infected mosquitoes offers a promising alternative for dengue suppression. Here, we developed a locally derived Ae. aegypti line carrying the wAlbB strain (wAlbB-Tw-Kao) and systematically evaluated its fitness, viral interference, and potential for vector population control. The strain was generated through embryonic microinjection of cytoplasm containing the intact wAlbB endosymbiont from field-collected Ae. albopictus in Kaohsiung, Taiwan, resulting in a stably infected mosquito line with 100% maternal transmission. Whole-genome sequencing confirmed a high similarity to the reference wAlbB genome. Cross-mating experiments demonstrated complete cytoplasmic incompatibility (CI, 0% egg hatch) when wAlbB-Tw-Kao males were mated with uninfected females. Antiviral assays against dengue virus serotype 2 (DENV-2) and Zika virus showed significant reductions in viral titers in the midgut, salivary glands, and saliva. In cage experiments, increasing release ratios of wAlbB-Tw-Kao males led to significant suppression of wild-type populations, achieving up to approximately 90% reduction in egg hatch. These findings demonstrate the successful development of a locally derived wAlbB-infected Ae. aegypti line with strong CI, stable maternal transmission, and effective DENV and ZIKV blocking. These properties provide a foundation for future field-relevant evaluation under both suppression and replacement deployment frameworks.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014222"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIDS patients with Talaromycosis Marneffei exhibit inflammatory activation and depletion in their peripheral blood monocytes.","authors":"Pengle Guo, Yingyin Yang, Xiejie Chen, Qingqing Li, Huihua Zhang, Xin Chen, Feilong Xu, Quanmin Li, Jingyi Ou, Xiaoping Tang, Linghua Li","doi":"10.1371/journal.pntd.0014306","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014306","url":null,"abstract":"<p><strong>Objectives: </strong>This study seeks to investigate the characteristics, dynamics, and association with disease progression of monocyte inflammation in patients with AIDS/Talaromycosis Marneffei (TSM). The findings are expected to contribute to a deeper understanding of the disease's pathogenesis and prognostic factors, offering substantial potential for advancing diagnostic and therapeutic approaches and identifying new targets for immunotherapy.</p><p><strong>Methods: </strong>We conducted a cross-sectional study to compare individuals with AIDS/TSM to those with AIDS/Pneumocystis Pneumonia(PCP), AIDS/tuberculosis(TB), uncomplicated AIDS, and healthy controls by analyzing the ratios and absolute values of peripheral blood mononuclear cells. Correlation analyses were employed to elucidate the relationship between monocyte levels and disease progression and prognosis. Flow cytometry and transcriptome sequencing were utilized to characterize the monocytes in patients with AIDS/TSM. Subsequently, a prospective study was undertaken on the TSM cohort to observe changes in monocyte numbers and proportions.</p><p><strong>Results: </strong>We observed a significant reduction in both the number and proportion of these cells in TSM patients. This reduction was correlated with disease progression indicators such as platelet count (PLT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and albumin (ALB). Furthermore, the baseline absolute monocyte count was found to be a significant predictor of mortality. Utilizing flow cytometry to analyze monocyte subpopulations, we found that the decrease in monocytes in TSM patients was characterized by an increase in classical monocytes and a decrease in intermediate and non-classical monocytes. Transcriptome sequencing data of monocytes revealed that those in TSM patients exhibited inflammatory activation, which was more pronounced in patients who succumbed to the disease. Subsequently, we conducted a prospective study on the TSM cohort and observed that antifungal treatment led to a gradual normalization of monocyte numbers and proportions.</p><p><strong>Conclusions: </strong>The peripheral blood monocytes of patients with AIDS and TSM exhibit a significant reduction, which correlates with disease progression and prognosis. Furthermore, these mononuclear cells demonstrate signs of inflammatory activation alongside a quantitative depletion.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014306"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and risk factors of soil-transmitted nematode-schistosome co-occurrence: An analysis of the global burden of disease study.","authors":"Ruoyao Wang, Bin Le, Chao Chen, Huiyu Xia, Xiaobin Fan, Chao Zhu, Xing He","doi":"10.1371/journal.pntd.0014224","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014224","url":null,"abstract":"<p><strong>Objective: </strong>Soil-transmitted nematode (STN) infections and schistosomiasis frequently co-occur in endemic regions, imposing substantial combined health burdens. This study aimed to characterize the global co-occurrence patterns, long-term trajectories, and key risk factors of STN-schistosome co-occurrence using Global Burden of Disease (GBD) data.</p><p><strong>Methods: </strong>We analyzed GBD 1990-2021 data from 69 countries and territories with available STN infections and schistosomiasis prevalence data. Co-occurrence patterns were classified into consistent, schistosomiasis-dominant, and STN infection-dominant regions based on global prevalence quartiles. Group-based trajectory modeling (GBTM) and similarity network clustering identified long-term evolutionary trajectories and epidemiological clusters. Negative binomial regression and population-attributable fraction (PAF) analysis quantified associations between 22 risk factors and disease burden.</p><p><strong>Results: </strong>Global co-occurrence patterns remained stable over 32 years, with 68.1% of countries and territories showing concordant high or low burdens of both diseases. GBTM identified three distinct trajectories for each disease, with sub-Saharan Africa dominating high-burden groups. Similarity network clustering partitioned countries into six epidemiological clusters, ranging from persistently high co-burden to near-eliminated schistosomiasis with low STN prevalence. Key shared drivers included inadequate water, sanitation, and hygiene (WASH) factors, while nutritional deficiencies (iron deficiency, child growth failure) were specific risk factors for STN infections, particularly in co-endemic regions (PAF = 19.08% and 8.82%, respectively). Both high and low temperatures exerted protective effects against both infections.</p><p><strong>Conclusion: </strong>STN-schistosome co-occurrence exhibits distinct global epidemiological clusters with heterogeneous drivers. Integrated control strategies should combine WASH improvements, preventive chemotherapy, and targeted nutritional interventions, especially in co-endemic regions, to align with the WHO 2021-2030 Neglected Tropical Diseases Roadmap and accelerate elimination efforts.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014224"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling approaches for predicting the distribution of skin NTDs: A systematic review.","authors":"Mesoud A Bushara, Rowa Hassan, Rana Ahmed, Jorge Cano, Gail Davey, Eltayeb Ganawa, Hope Simpson","doi":"10.1371/journal.pntd.0013662","DOIUrl":"10.1371/journal.pntd.0013662","url":null,"abstract":"<p><strong>Background: </strong>Skin neglected tropical diseases (NTDs) such as cutaneous leishmaniasis, lymphatic filariasis, mycetoma, and podoconiosis affect millions in endemic regions, but are under-recorded despite causing significant burdens. Predictive modelling has been used to estimate the distribution and prevalence of some of these diseases, and predictions may be useful for identifying at-risk populations and guiding interventions. This review synthesises the literature on modelling approaches to predict skin NTD distributions, aiming to identify prevalent methodologies, evaluate their strengths and limitations, highlight research gaps, and provide recommendations for enhancing their utility.</p><p><strong>Methods: </strong>We conducted a systematic literature review from three databases and included studies published from 2000-2024. Studies were included if they employed statistical models or machine learning algorithms to predict the distribution of skin NTDs. Two independent reviewers screened titles, abstracts, and full texts. Data extracted included disease, study region, source of epidemiological data, model types and predictors.</p><p><strong>Results: </strong>From 2,870 retrieved records, 68 met the inclusion criteria. The most modelled skin NTDs were cutaneous leishmaniasis (n = 26) and lymphatic filariasis (n = 18). Geostatistical modelling was the most common approach, followed by ecological niche modelling, with MaxEnt and generalised linear models constituting the predominant model types. Common environmental covariates included climate, land cover and land use, elevation, and soil data. The types of epidemiological data varied, with many studies relying on passive surveillance and pseudoabsence data. The risk of bias was high among ecological niche models.</p><p><strong>Conclusions: </strong>Environmental and geostatistical models can inform targeted interventions for skin NTDs, aiding efficient resource allocation and public health planning. However, data limitations, especially the absence of true absence data, underreporting and variations in surveillance sensitivity, can reduce model accuracy and undermine decision-makers' confidence. Future studies should focus on incorporating information about case identification into modelling frameworks, including a broader spectrum of environmental and socio-economic determinants, and ensuring validation across diverse geographic regions.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0013662"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syndromic management of sexually transmitted infections in the Brazilian Amazon: A 10-year retrospective study.","authors":"Ana Claudia Chaves Camilo, Valderiza Lourenço Pedrosa, José Carlos Sardinha, Silvana Paiva da Costa, Celília de Lima Borges, Angelica Espinosa Miranda, Adriana Bindá, André Luiz Leturiondo, Camila Gurgel Dos Santos Silva, Cynthia de Oliveira Ferreira, Maria das Graças Barbosa Guerra, Sinesio Talhari, Carolina Talhari","doi":"10.1371/journal.pntd.0014282","DOIUrl":"10.1371/journal.pntd.0014282","url":null,"abstract":"<p><strong>Background: </strong>The syndromic approach is a widely applied strategy for managing sexually transmitted infections (STIs) in settings where laboratory diagnostics are limited. This study aimed to describe temporal patterns in syndromic STI diagnoses and identify factors independently associated with these diagnoses over a period of 10 years at a reference center in the state of Amazonas, Brazilian Amazon.</p><p><strong>Methodology/principal findings: </strong>A retrospective review was conducted using medical records from patients attending a reference center for STI care in Amazonas, Brazil, from 2014 to 2023. Sociodemographic, clinical, and behavioral data were analyzed. The syndromic classification followed World Health Organization guidelines and included vaginal discharge, cervical discharge, urethral discharge, genital ulcers, and genital warts. A total of 32,485 medical records were reviewed, with 14,931 (46.0%) syndromic diagnoses identified. The most frequent syndromes were genital warts (41.0%), urethral discharge (31.5%), genital ulcer (21.3%), cervical discharge (3.8%), and vaginal discharge (2.3%). In multivariate analysis, factors independently associated with receiving a syndromic diagnosis were age ≥ 30 years (OR = 1.16; 95% CI: 1.05-1.20), male sex (OR = 2.31; 95% CI: 1.75-2.45), single marital status (OR = 1.82; 95% CI: 1.43-2.21), irregular condom use (OR = 3.21; 95% CI: 2.46-3.60), and having two or more casual partners (OR = 3.42; 95% CI: 2.94-3.90).</p><p><strong>Conclusions/significance: </strong>Despite inherent limitations, the syndromic approach remains an essential strategy for STI control in resource-constrained contexts such as the Amazon. It facilitates prompt treatment and broadens access to care where laboratory confirmation is unavailable. Integrating syndromic and etiological approaches is vital to improve diagnostic accuracy, optimize antimicrobial use, and strengthen public health responses to STIs in the region.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014282"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Orientia tsutsugamushi Stimulates an Original Gene Expression Program in Monocytes: Relationship with Gene Expression in Patients with Scrub Typhus.","authors":"","doi":"10.1371/journal.pntd.0014279","DOIUrl":"https://doi.org/10.1371/journal.pntd.0014279","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pntd.0001028.].</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"20 5","pages":"e0014279"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}