International Journal of Paleopathology最新文献

{"title":"Multi-level spondylolysis at Egiin Gol: A case from Xiongnu period Mongolia","authors":"Angela R. Lieverse ,&nbsp;Iderkhangai Tumur-Ochir ,&nbsp;Orgilbayar Samdantsoodol ,&nbsp;Tatiana Nomokonova ,&nbsp;Robert Losey","doi":"10.1016/j.ijpp.2025.02.002","DOIUrl":"10.1016/j.ijpp.2025.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>This paper presents and discusses the aetiology of an extreme case of multi-level spondylolysis with unique presentation.</div></div><div><h3>Materials</h3><div>The affected individual is an adult male from Xiongnu period (209 BCE to 93 CE) Egiin Gol, northern Mongolia.</div></div><div><h3>Methods</h3><div>Analyses were limited to macroscopic and non-invasive methods.</div></div><div><h3>Results</h3><div>Seven complete spondylolytic clefts were documented on four vertebrae between T12 and L4, with only one located on L4, where most cases of spondylolysis occur, and four defects had atypical morphology. Evidence of spondylolisthesis was also observed.</div></div><div><h3>Conclusions</h3><div>Congenital susceptibility to spondylolysis, combined with a physically demanding lifestyle, likely account for the condition’s unusual manifestation.</div></div><div><h3>Significance</h3><div>The significance of this case its severity (one of the most extreme documented from archaeological contexts) and unusual presentation (location of the clefts and their atypical morphology).</div></div><div><h3>Limitations</h3><div>Only a small sample (&lt; 30) of Xiongnu period human remains were available for comparison.</div></div><div><h3>Suggestions for further research</h3><div>Interpretations from this case study would benefit from a more extensive analysis of spondylolysis, biomechanical stress, and acute trauma on the nomadic pastoral populations of northern Mongolia, including those pre-dating and post-dating the Xiongnu.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"48 ","pages":"Pages 64-70"},"PeriodicalIF":1.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143137051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schmorl’s nodes in two 19th-20th century Spanish osteological collections from Valladolid and Granada","authors":"Marcos Plischuk ,&nbsp;Gonzalo Garizoain ,&nbsp;Rocío García Mancuso","doi":"10.1016/j.ijpp.2025.01.001","DOIUrl":"10.1016/j.ijpp.2025.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>This study examines how age at death, sex, and socio-historical context relate to the frequency, location, and severity of Schmorl’s nodes.</div></div><div><h3>Materials</h3><div>The sample comprised thoracic and lumbar vertebrae of 192 skeletons from two contemporary documented osteological collections from Spain, in Valladolid and Granada, both of which contain individuals who died during the second half of the 20th century.</div></div><div><h3>Methods</h3><div>Schmorl’s nodes were recorded on the superior and inferior surfaces of vertebral bodies and their location was categorized in one of three areas: center, canal, and periphery.</div></div><div><h3>Results</h3><div>The prevalence of Schmorl’s nodes was 57.42 % for the Valladolid collection and 67.39 % for Granada, with no significant differences between collections. Statistically significant differences were found between the sexes, but age at death did not correlate with the presence of the lesion.</div></div><div><h3>Conclusions</h3><div>This analysis supports the absence of a direct relationship between the pathology and the aging process, but shows a greater predisposition in male individuals, suggesting that vertebral morphology and/or physical activity might be key etiological factors.</div></div><div><h3>Significance</h3><div>This research enhances our understanding of the etiology of Schmorl's nodes by highlighting sex as a key variable and suggesting a lack of association with age.</div></div><div><h3>Limitations</h3><div>The absence of data on occupational activity prevents correlating this variable with the presence of Schmorl’s nodes.</div></div><div><h3>Suggestions for further research</h3><div>Conduct studies on geometric morphometric data to corroborate the evolutionary hypothesis proposed by other authors.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"48 ","pages":"Pages 57-63"},"PeriodicalIF":1.3,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ‘Index of Oro-dental Disease’: A holistic method for understanding the impacts of different risk factors on oral health in archaeological populations","authors":"Anna M. Davies-Barrett ,&nbsp;Richard Holliday ,&nbsp;Nicholas S. Jakubovics ,&nbsp;Sarah A. Inskip","doi":"10.1016/j.ijpp.2024.12.001","DOIUrl":"10.1016/j.ijpp.2024.12.001","url":null,"abstract":"<div><h3>Objective</h3><div>To gain a more holistic understanding of oral health in the past by producing an ‘Index of Oro-dental Disease’ (IOD), incorporating multiple oro-dental diseases and accounting for differences in antemortem/postmortem alveolar bone and tooth loss.</div></div><div><h3>Materials</h3><div>UK Adult Dental Health Survey, 2009 anonymised dataset (N = 6206). Archaeological dental data from skeletal individuals from medieval and post-medieval Barton-upon-Humber, North Lincolnshire (N = 214, 1150–1855) and St James’s Gardens Burial Ground, London (N = 281, 1789–1853).</div></div><div><h3>Methods</h3><div>Creation of a formula for the production of index values. Application of the formula to clinical, ‘mock archaeological’, and archaeological datasets.</div></div><div><h3>Results</h3><div>Patterns in mean IOD values within different groups were identifiable regardless of preservation. It was possible to identify potential differences between IOD scores related to aging, tobacco consumption, geographical location, and time period.</div></div><div><h3>Conclusions</h3><div>Innovative use of modern clinical data and the production of ‘mock archaeological’ datasets provides validation of the IOD method. The approach may be useful for understanding the impact of different risk factors on oral health in the past, whilst also accounting for missing data and increasing comparability between groups.</div></div><div><h3>Significance</h3><div>Allows for the investigation of risk factors that affect overall oral health but manifest in different ways in different individuals, whilst also producing larger sample sizes.</div></div><div><h3>Limitations</h3><div>Impacts of age and posterior/anterior site positioning within the mouth suggest a careful consideration of age distribution and preservation of samples is required.</div></div><div><h3>Future research</h3><div>Future adaption and testing of the method on a greater range of population groups and different variables/risk factors for oro-dental disease.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"48 ","pages":"Pages 43-56"},"PeriodicalIF":1.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143136980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of enlarged parietal foramina or foramina parietalia permagna in an individual from the Chinchorro Culture of northern Chile (4000 BP)","authors":"Vivien G. Standen ,&nbsp;Susana Monsalve ,&nbsp;Bernardo Arriaza ,&nbsp;John Verano ,&nbsp;Mario Rivera","doi":"10.1016/j.ijpp.2024.11.004","DOIUrl":"10.1016/j.ijpp.2024.11.004","url":null,"abstract":"<div><h3>Objective</h3><div>The goal of this study was to analyze and differentially diagnose the presence of two large holes noted in the parietal bones of an individual and the presence of traumatic lesions.</div></div><div><h3>Materials</h3><div>A partially mummified young adult female associated with the Chinchorro culture, 4000 BP, from the coast of the Atacama Desert (northern Chile).</div></div><div><h3>Methods</h3><div>The bone lesions were evaluated macroscopically and radiologically. In addition, Sr isotopic analyses were performed on 62 individuals from eight sites associated with the Chinchorro culture.</div></div><div><h3>Results</h3><div>The parietal orifices are compatible with a rare anomaly of genetic origin known as foramina parietalia permagna (FPP). In addition, the cranial fracture pattern appear compatible with perimortem trauma, and Sr isotopes indicate a marine signal for Chinchorro populations.</div></div><div><h3>Conclusions</h3><div>This case serves as evidence that FPP was present in the early Andean populations and that endogamy and mutagenic factors might have contributed to its presence.</div></div><div><h3>Significance</h3><div>This paper expands our knowledge of the genetic anomalies that affected past populations and may contribute to our understanding of the etiologies of the condition.</div></div><div><h3>Limitations</h3><div>The absence of comparative FPP data inhibits comparative studies (with the exception of cases from California, USA).</div></div><div><h3>Suggestions for future research</h3><div>To explore in depth the genetic component of this condition in the Chinchorro populations.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"48 ","pages":"Pages 34-42"},"PeriodicalIF":1.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracing Leprosy: The paleopathological study of the individuals excavated from the Sant Llàtzer leprosarium in Barcelona, Spain (12th-18th c.)","authors":"Núria Montes ,&nbsp;Clara Jáuregui ,&nbsp;Rosa Dinarès ,&nbsp;Vanesa Triay ,&nbsp;Andrea Fernández-Vilela ,&nbsp;Jordi Ruiz ,&nbsp;M. Eulàlia Subirà ,&nbsp;Maria Fontanals-Coll","doi":"10.1016/j.ijpp.2024.11.005","DOIUrl":"10.1016/j.ijpp.2024.11.005","url":null,"abstract":"<div><h3>Objective</h3><div>Our objectives are twofold: to analyse the frequency of leprosy-related pathological lesions in the cemetery of Sant Llàtzer Hospital (12th-18th c.); and to examine how individuals affected by the disease were perceived and integrated into society during that period in Barcelona.</div></div><div><h3>Materials</h3><div>The skeletal remains of 87 individuals recovered from the cemetery.</div></div><div><h3>Methods</h3><div>All remains were analysed macroscopically and, when required, radiographed.</div></div><div><h3>Results</h3><div>Of the total number of individuals (n=87), 21 (24.1 %) showed evidence indicative of leprosy. Notably, the frequency of leprosy cases was lower in the 13th-15th c. (10 %; n = 50), the only period for which multi-person graves were documented.</div></div><div><h3>Conclusions</h3><div>The frequency of leprosy-related lesions in Sant Llàtzer is similar to that observed in other European Christian leprosaria, although it varies across the centuries. There is no funerary evidence that leprosy sufferers were treated differently than other citizens.</div></div><div><h3>Significance</h3><div>The cemetery of Sant Llàtzer, the first in Spain directly linked to a leprosarium, uniquely spans a significant period of activity. Its exceptionally preserved remains and rich records have offered unparalleled insight into the disease and its profound social implications.</div></div><div><h3>Limitations</h3><div>Leprosy affects the bone in only a small percentage of untreated cases. Moreover, poor preservation of skeletal remains may prevent diagnosis.</div></div><div><h3>Suggestions for Further Research</h3><div>Biochemistry, genomics, and proteomics might provide new insights into the disease, the origin and migrations of the individuals buried in Sant Llàtzer, as well as other aspects of their daily lives.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"48 ","pages":"Pages 23-33"},"PeriodicalIF":1.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the antiquity of rheumatoid arthritis: A case study from medieval Transylvania","authors":"Megan A. Heron ,&nbsp;Joseph Z. Forstot ,&nbsp;Zsolt Nyárádi ,&nbsp;Jonathan D. Bethard","doi":"10.1016/j.ijpp.2024.11.002","DOIUrl":"10.1016/j.ijpp.2024.11.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate erosive pathological lesions on a skeleton from medieval Transylvania.</div></div><div><h3>Materials</h3><div>A skeleton from a Székely archaeological site in Transylvania was examined and radiocarbon dated to Cal 1300 CE - 1415 CE.</div></div><div><h3>Methods</h3><div>The skeletal remains were examined macroscopically and with radiographic imaging. A differential diagnosis was conducted following established protocols.</div></div><div><h3>Results</h3><div>The individual was estimated to be a probable adult female. Periarticular erosive lesions involving multiple synovial joints, particularly on the small joints of the hands and feet, were observed.</div></div><div><h3>Conclusions</h3><div>A differential diagnosis identifies lesions characteristic of rheumatoid arthritis dating prior to the mid-15th century.</div></div><div><h3>Significance</h3><div>The significance of this diagnosis is great since researchers debate the antiquity and spread of rheumatoid arthritis. Some researchers hypothesize that RA originated in the Americas and spread to Europe after the mid-15th century. However, this study asserts that RA existed in Europe prior to European colonization of the Americas.</div></div><div><h3>Limitations</h3><div>Only 30–40 % of the skeletal material was excavated, potentially impacting the differential diagnosis.</div></div><div><h3>Suggestions for further research</h3><div>This case encourages researchers to explore the presence of RA in other medieval groups within and beyond Transylvania as a means to reconstruct the antiquity and geographical distribution of the condition.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"48 ","pages":"Pages 13-22"},"PeriodicalIF":1.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic bone disease in an extinct neotropical primate","authors":"André Vieira Araújo ,&nbsp;Mário André Trindade Dantas ,&nbsp;Alexandre Liparini ,&nbsp;Mario Alberto Cozzuol ,&nbsp;Lauren B. Halenar-Price ,&nbsp;Rodrigo Martins Ribeiro ,&nbsp;Fernando Henrique de Souza Barbosa ,&nbsp;Francisco Bandeira ,&nbsp;Hermínio Ismael de Araújo Júnior","doi":"10.1016/j.ijpp.2024.11.003","DOIUrl":"10.1016/j.ijpp.2024.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>This work evaluates the potential presence of bone disease in an extinct primate from late Pleistocene of Brazil.</div></div><div><h3>Materials</h3><div>The skull and post crania of an extinct platyrrhine primate, curated by the Museu de Ciências Naturais PUC, Brazil.</div></div><div><h3>Methods</h3><div>Pathological changes were noted via analysis of radiographic images and CT of the affected bones.</div></div><div><h3>Results</h3><div>The lesions noted include cortical thickening, sclerosis, and coarse trabeculae in the skull and long bones.</div></div><div><h3>Conclusions</h3><div>The features observed support the diagnosis of metabolic bone disease with lesions comparable to those seen in Paget's disease.</div></div><div><h3>Significance</h3><div>This specimen appears to be the only case is of metabolic bone disease in an extinct New World monkey and adds data to the paleopathological record of South American primates.</div></div><div><h3>Limitations</h3><div>The absence of other skeletal materials from individuals of the same genus for comparison makes differential diagnosis challenging, and conclusions must be drawn with caution.</div></div><div><h3>Suggestions for further research</h3><div>A more complete comparative sample of images involving more genera of living and extinct platyrrhines can help to rule out morphological oddities and design a more accurate diagnosis.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"48 ","pages":"Pages 1-12"},"PeriodicalIF":1.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histology of pulmonary tuberculosis in a 19th-century mummy from Comiso (Sicily, Italy)","authors":"Raffaele Gaeta ,&nbsp;Valentina Giuffra ,&nbsp;Frank Maixner ,&nbsp;Giacomo Aringhieri ,&nbsp;Antonio Fornaciari","doi":"10.1016/j.ijpp.2024.11.001","DOIUrl":"10.1016/j.ijpp.2024.11.001","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to investigate potential evidence of tuberculosis in mummified remains.</div></div><div><h3>Materials</h3><div>The natural mummy of an anonymous friar from the mortuary chapel of the church of Santa Maria della Grazia in Comiso (Sicily)</div></div><div><h3>Methods</h3><div>The mummy was studied through macroscopic examination; tissue sampling was conducted through breaches in the dorsal surface of the thorax. Radiological, histological and immunohistochemical analyses were performed on the pulmonary parenchyma.</div></div><div><h3>Results</h3><div>The mummified remains are those of an adult male approximately 25–45 years old. In the left lung, 7 intra parenchymal calcified nodules were detected. The fibrocalcific nodules showed some lacunae surrounded by fibrous tissue containing amorphous necrotic, most probably caseous, material.</div></div><div><h3>Conclusions</h3><div>These findings are compatible with a chronic infectious-inflammatory disease, likely a calcification of a previous Ghon complex of an apical nodular tuberculosis.</div></div><div><h3>Significance</h3><div>Our study supports the great spread of the disease in the 19th century; a time when it reached its maximum peak in Europe.</div></div><div><h3>Limitations</h3><div>Molecular investigations failed to detect traces of <em>Mycobacterium tuberculosis</em> DNA in the sample.</div></div><div><h3>Suggestions for further research</h3><div>The investigation on the mummies from Comiso is still in progress, and further analyses will potentially provide paleopathological data on this community of Modern Age which could be integrated with historical and archival sources.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"47 ","pages":"Pages 54-60"},"PeriodicalIF":1.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the diagnostic scope of paleopathology: Identification of Q fever (Coxiella burnetii) using a One Paleopathology approach","authors":"Christine Alvarez Jones","doi":"10.1016/j.ijpp.2024.10.001","DOIUrl":"10.1016/j.ijpp.2024.10.001","url":null,"abstract":"<div><h3>Objectives</h3><div>This project is an application of the One Paleopathology approach to the study of Q fever (<em>C. burnetii</em> infection), a disease which is underdiagnosed and largely unknown in paleopathology.</div></div><div><h3>Materials</h3><div>Clinical and veterinary pathological case reports and reviews, bioarcheological and zooarchaeological data, veterinary and environmental studies of wild and domestic animal pathology, clinical molecular pathogen data</div></div><div><h3>Methods</h3><div>One Paleopathology approach which combines data from people, animals, and their environment to understand disease in the past.</div></div><div><h3>Results</h3><div>Q fever in animals presents as reproductive failure, with no typical skeletal manifestations seen in animals. Persistent Q fever (<em>C. burnetii</em>) focalized infection affects the human skeleton in predictable ways, including spondylodiscitis and extravertebral osteomyelitis or osteitis which can occur more commonly in children. Evidence of skeletal involvement suggests <em>C. burnetii</em> infection in the past is underestimated and underdiagnosed in humans.</div></div><div><h3>Conclusion</h3><div>Using the One Paleopathology approach can improve the study of <em>C. burnetii</em> infection in the past, where both animal and human paleopathology and environmental factors are assessed in developing potential diagnoses.</div></div><div><h3>Significance</h3><div>This project is the first paleopathological study to specifically focus awareness on identification of <em>C. burnetii</em> in past skeletal samples, both animal and human.</div></div><div><h3>Limitations</h3><div>Lack of paleopathological studies and existing reference literature identifying skeletal involvement associated with <em>C. burnetii</em> infection.</div></div><div><h3>Suggestions for future research</h3><div>Future paleopathological genomic studies should focus on identification of <em>C. burnetii</em> genotypes.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"47 ","pages":"Pages 43-53"},"PeriodicalIF":1.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rickets, resorption and revolution: An investigation into the relationship between vitamin D deficiency in childhood and osteoporosis in adulthood in an 18th-19th century population","authors":"Alexandra Bowers ,&nbsp;Rebecca Gowland ,&nbsp;Karen Hind","doi":"10.1016/j.ijpp.2024.09.002","DOIUrl":"10.1016/j.ijpp.2024.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study employs a Developmental Origins of Health and Disease (DOHaD) approach to assess the effect of vitamin D deficiency (VDD) in childhood on the risk of osteoporosis in adulthood in an archaeological sample of skeletons dating from the 18th to 19th centuries.</div></div><div><h3>Materials</h3><div>Femora and lumbar vertebrae of 65 adults aged 18+ years (26 diagnosed with residual rickets and 39 without) from an 18th-19th century Quaker burial ground at Coach Lane, North Shields, England.</div></div><div><h3>Methods</h3><div>Bone mineral density (BMD) was measured for the femoral neck and first four lumbar vertebrae of each individual using a dual energy X-ray absorptiometry (DXA) scanner as a proxy for assessing osteoporotic fracture risk.</div></div><div><h3>Results</h3><div>3-way ANOVA revealed no statistically significant differences in BMD between individuals with and without residual rickets across age and sex.</div></div><div><h3>Conclusions</h3><div>A combination of lifestyle and environmental factors likely influenced the BMD of people buried at Coach Lane across the life course. The impact of childhood VDD on BMD later in life can be mitigated through other factors such as physical activity and diet.</div></div><div><h3>Significance</h3><div>This is one of the first bioarchaeological studies to take a DOHaD approach to understand osteoporosis risk in 18th-19th century England. It highlights the complexity of aetiological factors for osteoporosis and that VDD in early life does not necessarily predispose a person to osteoporosis in adulthood.</div></div><div><h3>Limitations</h3><div>BMD is not the only indicator of osteoporosis. Microscopic methods for the assessment of childhood vitamin D deficiency, such as inter-globular dentine analysis, were not applied.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"47 ","pages":"Pages 27-42"},"PeriodicalIF":1.3,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}