International Journal of Paleopathology最新文献

{"title":"Histology of pulmonary tuberculosis in a 19th-century mummy from Comiso (Sicily, Italy)","authors":"Raffaele Gaeta ,&nbsp;Valentina Giuffra ,&nbsp;Frank Maixner ,&nbsp;Giacomo Aringhieri ,&nbsp;Antonio Fornaciari","doi":"10.1016/j.ijpp.2024.11.001","DOIUrl":"10.1016/j.ijpp.2024.11.001","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to investigate potential evidence of tuberculosis in mummified remains.</div></div><div><h3>Materials</h3><div>The natural mummy of an anonymous friar from the mortuary chapel of the church of Santa Maria della Grazia in Comiso (Sicily)</div></div><div><h3>Methods</h3><div>The mummy was studied through macroscopic examination; tissue sampling was conducted through breaches in the dorsal surface of the thorax. Radiological, histological and immunohistochemical analyses were performed on the pulmonary parenchyma.</div></div><div><h3>Results</h3><div>The mummified remains are those of an adult male approximately 25–45 years old. In the left lung, 7 intra parenchymal calcified nodules were detected. The fibrocalcific nodules showed some lacunae surrounded by fibrous tissue containing amorphous necrotic, most probably caseous, material.</div></div><div><h3>Conclusions</h3><div>These findings are compatible with a chronic infectious-inflammatory disease, likely a calcification of a previous Ghon complex of an apical nodular tuberculosis.</div></div><div><h3>Significance</h3><div>Our study supports the great spread of the disease in the 19th century; a time when it reached its maximum peak in Europe.</div></div><div><h3>Limitations</h3><div>Molecular investigations failed to detect traces of <em>Mycobacterium tuberculosis</em> DNA in the sample.</div></div><div><h3>Suggestions for further research</h3><div>The investigation on the mummies from Comiso is still in progress, and further analyses will potentially provide paleopathological data on this community of Modern Age which could be integrated with historical and archival sources.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"47 ","pages":"Pages 54-60"},"PeriodicalIF":1.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the diagnostic scope of paleopathology: Identification of Q fever (Coxiella burnetii) using a One Paleopathology approach","authors":"Christine Alvarez Jones","doi":"10.1016/j.ijpp.2024.10.001","DOIUrl":"10.1016/j.ijpp.2024.10.001","url":null,"abstract":"<div><h3>Objectives</h3><div>This project is an application of the One Paleopathology approach to the study of Q fever (<em>C. burnetii</em> infection), a disease which is underdiagnosed and largely unknown in paleopathology.</div></div><div><h3>Materials</h3><div>Clinical and veterinary pathological case reports and reviews, bioarcheological and zooarchaeological data, veterinary and environmental studies of wild and domestic animal pathology, clinical molecular pathogen data</div></div><div><h3>Methods</h3><div>One Paleopathology approach which combines data from people, animals, and their environment to understand disease in the past.</div></div><div><h3>Results</h3><div>Q fever in animals presents as reproductive failure, with no typical skeletal manifestations seen in animals. Persistent Q fever (<em>C. burnetii</em>) focalized infection affects the human skeleton in predictable ways, including spondylodiscitis and extravertebral osteomyelitis or osteitis which can occur more commonly in children. Evidence of skeletal involvement suggests <em>C. burnetii</em> infection in the past is underestimated and underdiagnosed in humans.</div></div><div><h3>Conclusion</h3><div>Using the One Paleopathology approach can improve the study of <em>C. burnetii</em> infection in the past, where both animal and human paleopathology and environmental factors are assessed in developing potential diagnoses.</div></div><div><h3>Significance</h3><div>This project is the first paleopathological study to specifically focus awareness on identification of <em>C. burnetii</em> in past skeletal samples, both animal and human.</div></div><div><h3>Limitations</h3><div>Lack of paleopathological studies and existing reference literature identifying skeletal involvement associated with <em>C. burnetii</em> infection.</div></div><div><h3>Suggestions for future research</h3><div>Future paleopathological genomic studies should focus on identification of <em>C. burnetii</em> genotypes.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"47 ","pages":"Pages 43-53"},"PeriodicalIF":1.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rickets, resorption and revolution: An investigation into the relationship between vitamin D deficiency in childhood and osteoporosis in adulthood in an 18th-19th century population","authors":"Alexandra Bowers ,&nbsp;Rebecca Gowland ,&nbsp;Karen Hind","doi":"10.1016/j.ijpp.2024.09.002","DOIUrl":"10.1016/j.ijpp.2024.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study employs a Developmental Origins of Health and Disease (DOHaD) approach to assess the effect of vitamin D deficiency (VDD) in childhood on the risk of osteoporosis in adulthood in an archaeological sample of skeletons dating from the 18th to 19th centuries.</div></div><div><h3>Materials</h3><div>Femora and lumbar vertebrae of 65 adults aged 18+ years (26 diagnosed with residual rickets and 39 without) from an 18th-19th century Quaker burial ground at Coach Lane, North Shields, England.</div></div><div><h3>Methods</h3><div>Bone mineral density (BMD) was measured for the femoral neck and first four lumbar vertebrae of each individual using a dual energy X-ray absorptiometry (DXA) scanner as a proxy for assessing osteoporotic fracture risk.</div></div><div><h3>Results</h3><div>3-way ANOVA revealed no statistically significant differences in BMD between individuals with and without residual rickets across age and sex.</div></div><div><h3>Conclusions</h3><div>A combination of lifestyle and environmental factors likely influenced the BMD of people buried at Coach Lane across the life course. The impact of childhood VDD on BMD later in life can be mitigated through other factors such as physical activity and diet.</div></div><div><h3>Significance</h3><div>This is one of the first bioarchaeological studies to take a DOHaD approach to understand osteoporosis risk in 18th-19th century England. It highlights the complexity of aetiological factors for osteoporosis and that VDD in early life does not necessarily predispose a person to osteoporosis in adulthood.</div></div><div><h3>Limitations</h3><div>BMD is not the only indicator of osteoporosis. Microscopic methods for the assessment of childhood vitamin D deficiency, such as inter-globular dentine analysis, were not applied.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"47 ","pages":"Pages 27-42"},"PeriodicalIF":1.3,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of dental malocclusion in a 18th/19th century population from Radom (Poland)","authors":"Konrad Perkowski ,&nbsp;Magdalena Marczyńska-Stolarek ,&nbsp;Piotr Regulski ,&nbsp;Jacek Tomczyk","doi":"10.1016/j.ijpp.2024.09.001","DOIUrl":"10.1016/j.ijpp.2024.09.001","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of the study was to assess the diachronicity of factors that produce malocclusion from the 18th century to the present.</div></div><div><h3>Materials</h3><div>A total of 74 adult individuals Radom (Poland) of both sexes were examined (males: 46, females: 28).</div></div><div><h3>Methods</h3><div>The skulls were grouped according to the type of malocclusion found: i) anterio-posterior (skeletal Class I/II/III), ii) transverse (cross bite/scissor bite), and iii) vertical (open bite/deep bite).</div></div><div><h3>Results</h3><div>Normal bites were recorded in 14 % (10/74) of the study group. Malocclusion was observed in the remaining cases (64/74, 86 %). Class I was diagnosed most often (53 %), and Class III (8 %) was the least common in the study group.</div></div><div><h3>Conclusions</h3><div>The observed order of frequency of Angle’s Classes (I &gt; II &gt; III) in the population from Radom indicates malocclusion was similar to that of the contemporary population. In the population from Radom, similar to other contemporary European populations, Class II defects were found at a higher frequency than Class III defects.</div></div><div><h3>Significance</h3><div>The research demonstrates the diachronic nature of the factors that produce different types of malocclusion in Polish populations over the past four centuries, even if these factors cannot be identified.</div></div><div><h3>Limitation</h3><div>The main limitation of this research is the relatively small sample size.</div></div><div><h3>Suggestions for further research</h3><div>Future studies should evaluate malocclusion in older populations from Radom and other areas of Poland and Europe.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"47 ","pages":"Pages 21-26"},"PeriodicalIF":1.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A severe case of bilateral humerus varus deformity from the Middle Bronze age necropolis of Olmo di Nogara, Northeast Italy. The contribution of biomechanical analysis to paleopathological study","authors":"Alessandro Canci ,&nbsp;Damiano Marchi ,&nbsp;Davide Caramella ,&nbsp;Vitale S. Sparacello","doi":"10.1016/j.ijpp.2024.07.005","DOIUrl":"10.1016/j.ijpp.2024.07.005","url":null,"abstract":"<div><h3>Objective</h3><div>To gain insights on possible impairment of a Middle Bronze Age individual with bilateral humerus varus buried with a sword in Northeastern Italy.</div></div><div><h3>Materials</h3><div>A skeleton of a 40–50-year-old male from Olmo di Nogara (Italy) compared to other males from the same necropolis and to Neolithic and Iron Age samples from Italy.</div></div><div><h3>Methods</h3><div>Macroscopic/X-rays analysis for pathological diagnosis and cross-sectional geometric analysis.</div></div><div><h3>Results</h3><div>Both humeri of the individual appear short with destruction of the humeral heads, showing severe osteoarthrosis and flattening of the scapular glenoid cavities. The individual showed appreciable humeral bilateral asymmetry; there is no evidence for sustained immobilization.</div></div><div><h3>Conclusions</h3><div>The pathological modifications suggest a diagnosis of bilateral humeral varism probably following an injury at birth. The individual’s life was likely not significantly affected, as evidence suggests that he remained active and possibly used weapons.</div></div><div><h3>Significance</h3><div>Biomechanical analyses provided a useful tool to reconstruct the life of the subject within the community, showing that this individual’s apparent upper limb abnormalities did not exempt him from a role as a warrior and highlighting the importance of the warrior identity in this Bronze Age society.</div></div><div><h3>Limitations</h3><div>The complex interaction between epiphyseal damage and shortening of the humerus makes it difficult to assess activity patterns. Only severe impairment leading to long-term immobilization can be excluded for this individual.</div></div><div><h3>Suggestions for Further Research</h3><div>Cross-sectional geometry may be used in other cases of humerus varus or bone dysplasia to investigate functional impairment.</div></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"47 ","pages":"Pages 12-20"},"PeriodicalIF":1.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879981724003048/pdfft?md5=fbb12b538b225ff2f1f5b34731a97835&pid=1-s2.0-S1879981724003048-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplement to the International Journal of Paleopathology. Abstracts for contributions presented at the Paleopathology Association meetings in 2023.","authors":"","doi":"10.1016/j.ijpp.2024.02.003","DOIUrl":"10.1016/j.ijpp.2024.02.003","url":null,"abstract":"","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"46 ","pages":"Pages 1-8"},"PeriodicalIF":1.3,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142075796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity in experiences of vitamin D deficiency in an early to mid-19th century population from Montreal, Quebec","authors":"Rose-Ann Bigué ,&nbsp;Isabelle Ribot ,&nbsp;Megan B. Brickley ,&nbsp;Bonnie Kahlon ,&nbsp;Charlotte A. Roberts","doi":"10.1016/j.ijpp.2024.07.003","DOIUrl":"10.1016/j.ijpp.2024.07.003","url":null,"abstract":"<div><h3>Objective</h3><p>To use the prevalence of prenatal/infancy interglobular dentine (IGD) as a proxy for suboptimal vitamin D status and explore its link to mortality, biological sex, cultural behaviours and environmental factors during the end of the pre-industrial/ beginning of the industrial period.</p></div><div><h3>Materials</h3><p>50 skeletons from the St. Antoine cemetery (1799–1854), Montreal, Quebec with a well-preserved first mandibular molar.</p></div><div><h3>Methods</h3><p>Thin sections were prepared for histological examination of IGD in crown dentine.</p></div><div><h3>Results</h3><p>IGD prevalence was 74 % (37/50) and not significantly correlated statistically to sex and age-at-death. Most IGD occurred at birth and up to 3 years-old, six individuals were affected <em>in utero</em>, 54 % of the sample (27/50) presented longstanding IGD and six individuals displayed multiple IGD episodes.</p></div><div><h3>Conclusions</h3><p>Prenatal IGD episodes revealed suboptimal maternal vitamin D levels, which, alongside a high frequency of IGD episodes around birth/from birth until a certain age, suggest cultural influences. Multiple and longstanding IGD episodes might also reflect suboptimal seasonal vitamin D attainment.</p></div><div><h3>Significance</h3><p>This study provides in-depth data on IGD within a relatively large archaeological North American sample, proving relevant to epidemiological studies on suboptimal vitamin status in 19th century Montreal.</p></div><div><h3>Limitations</h3><p>The total number of IGD episodes is underestimated due to methodological biases; first-generation migrants in this study could not be identified and excluded from the sample.</p></div><div><h3>Suggestions for further research</h3><p>Use of a larger sample with a wider age-at-death range; further research on infants and children to investigate links between growth and lesion formation and visibility.</p></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"47 ","pages":"Pages 1-11"},"PeriodicalIF":1.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879981724003012/pdfft?md5=4e228e54e52590893ea387624e51062a&pid=1-s2.0-S1879981724003012-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranial fluctuating asymmetry and its relationship with non-specific physiological stress indicators in a contemporary South African cadaveric skeletal sample","authors":"M. Harripershad ,&nbsp;C.E.G. Theye ,&nbsp;A.F. Ridel ,&nbsp;L. Liebenberg","doi":"10.1016/j.ijpp.2024.07.004","DOIUrl":"10.1016/j.ijpp.2024.07.004","url":null,"abstract":"<div><h3>Objectives</h3><p>Biological anthropologists frequently explore skeletal asymmetry, together with population health and disease. Given the conflicting findings in existing literature, this study aimed to clarify whether an association exists in a South African sample.</p></div><div><h3>Materials</h3><p>Dry bone and cranial micro-focus X-ray Computed Tomography (micro-XCT) scans of 115 South African individuals were assessed.</p></div><div><h3>Methods</h3><p>Fluctuating asymmetry (FA) indices were calculated from interlandmark distances, and the frequency of four types of non-specific signs of physiological stress were documented to explore the relationship between FA and disease.</p></div><div><h3>Results</h3><p>Black South Africans did not exhibit a high FA index; however, they had the highest prevalence of non-specific signs of physiological stress. However, no significant correlations were detected between FA indices and pathological lesions.</p></div><div><h3>Conclusion</h3><p>No correlation was observed between FA and populations from different socio-economic backgrounds. However, individuals of lower socio-economic status (SES) demonstrated a greater prevalence of non-specific signs of physiological stress.</p></div><div><h3>Significance</h3><p>This research suggests that skeletal indicators of stress may be a suitable biological marker for assessing differences in SES among population groups, while indicating that levels of cranial FA is an inadequate biological marker.</p></div><div><h3>Limitations</h3><p>Possible limitations may include measurement error, and the lack of information on the life history and medical records of individuals in this sample.</p></div><div><h3>Suggestions for further research</h3><p>Future research should include a larger sample with more South African groups, and should evaluate the potential association among age, FA, and expression of skeletal markers of disease.</p></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"46 ","pages":"Pages 50-61"},"PeriodicalIF":1.3,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879981724003036/pdfft?md5=0afb233837cf0a4b80c9b8d0d4273a55&pid=1-s2.0-S1879981724003036-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing the Digital Atlas of Ancient Rare Diseases (DAARD) using a new case of Legg-Calvé-Perthes disease from Early Byzantine (500–700 CE) Olympia, Greece","authors":"Yannick Ahlbrecht ,&nbsp;Oliver Pilz ,&nbsp;Julia Gresky","doi":"10.1016/j.ijpp.2024.07.002","DOIUrl":"10.1016/j.ijpp.2024.07.002","url":null,"abstract":"<div><h3>Objective</h3><p>The first case of Legg-Calvé-Perthes disease (LCPD) in Greece is presented. LCPD, a rare disease, is discussed using the Digital Atlas of Ancient Rare Diseases (DAARD), which tests the benefits of the database for diagnosing and contextualizing the new case with 42 archaeological cases of LCPD recorded in the DAARD.</p></div><div><h3>Materials</h3><p>A 30–40-year-old, probable male individual was found at the archaeological site of Olympia, Greece, dating to 500–700 CE.</p></div><div><h3>Methods</h3><p>Biological sex, age-at-death and pathological changes were investigated using macroscopic and osteometric methods. The DAARD provided the typical characteristics of LCPD.</p></div><div><h3>Results</h3><p>Pathological changes in both hip joints without any other related changes in the skeleton corresponded to the skeletal features of LCPD. The DAARD produced 42 cases of LCPD, most of which from Europe, with a preference for male sex and unilateral involvement of the hip joint.</p></div><div><h3>Conclusions</h3><p>The DAARD aids in diagnosing rare diseases and interpreting new cases in the context of already known studies.</p></div><div><h3>Significance</h3><p>This study shows that the DAARD has the potential to help researchers move beyond the level of single case studies and create a broader picture of the history of rare diseases.</p></div><div><h3>Limitations</h3><p>This paper focuses on the benefits of the DAARD in relation to LCPD but not all rare diseases have been included in the database.</p></div><div><h3>Suggestions for further research</h3><p>More rare diseases from archaeological contexts should be added to the DAARD to create a base for the interpretation of their history and expand our understanding of rare diseases in the past.</p></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"46 ","pages":"Pages 62-73"},"PeriodicalIF":1.3,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879981724003024/pdfft?md5=851d4e0f5ec666d9063355fc1c1fb512&pid=1-s2.0-S1879981724003024-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal indicators of pathology in the context of early tooth loss in children: A systematic literature review","authors":"Ana Ribeiro ,&nbsp;Pierre-Hadrien Decaup ,&nbsp;Marion Andriantavy ,&nbsp;Christine Couture ,&nbsp;Elsa Garot","doi":"10.1016/j.ijpp.2024.07.001","DOIUrl":"10.1016/j.ijpp.2024.07.001","url":null,"abstract":"<div><h3>Objective</h3><p>To provide an evidence-based resource for paleopathologists to consider multiple skeletal indicators of pathology associated with early tooth loss in children to aid in diagnosis.</p></div><div><h3>Materials</h3><p>Three databases (Cochrane Library, MedLine, and Scopus) were used for a review.</p></div><div><h3>Methods</h3><p>According to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria, a systematic review guideline, 85 articles were selected.</p></div><div><h3>Results</h3><p>A total of 189 children had a syndrome or disease associated with early tooth loss. Our review, based on 25 diseases, lists the bone and dental lesions observable in archeological remains.</p></div><div><h3>Conclusions</h3><p>Based on a review of the literature, a synthesis of 25 diseases and syndromes that may be associated with premature loss of permanent or deciduous teeth in children was developed for paleopathologists. It highlights the importance of a thorough dental examination by paleopathologists to further assess past health conditions.</p></div><div><h3>Significance</h3><p>This paper provides an extensive resource addressing early tooth loss in childhood to assist researchers with differential diagnosis.</p></div><div><h3>Limitations</h3><p>The articles included in this review are case reports based on living populations.</p></div><div><h3>Suggestions for further research</h3><p>Further studies into diseases and their association with early tooth loss would complement this work, as would utilizing the differential diagnoses on archeological individuals to clarify its value and limitations.</p></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"46 ","pages":"Pages 37-49"},"PeriodicalIF":1.3,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879981724003000/pdfft?md5=5c55bd966e1545a809a5f47513e256ef&pid=1-s2.0-S1879981724003000-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}