Therapeutic Advances in Gastroenterology最新文献

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A brave new world for capsule-based colonic investigations. 一个以胶囊为基础的结肠调查的美丽新世界。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241303310
Pablo Cortegoso Valdivia, Gunnar Baatrup, Anastasios Koulaouzidis
{"title":"A brave new world for capsule-based colonic investigations.","authors":"Pablo Cortegoso Valdivia, Gunnar Baatrup, Anastasios Koulaouzidis","doi":"10.1177/17562848241303310","DOIUrl":"https://doi.org/10.1177/17562848241303310","url":null,"abstract":"","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241303310"},"PeriodicalIF":3.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Raising the bar in ulcerative colitis management. 提高溃疡性结肠炎管理水平。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-24 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241273066
Fabrizio Fanizzi, Mariangela Allocca, Gionata Fiorino, Alessandra Zilli, Federica Furfaro, Tommaso Lorenzo Parigi, Laurent Peyrin-Biroulet, Silvio Danese, Ferdinando D'Amico
{"title":"Raising the bar in ulcerative colitis management.","authors":"Fabrizio Fanizzi, Mariangela Allocca, Gionata Fiorino, Alessandra Zilli, Federica Furfaro, Tommaso Lorenzo Parigi, Laurent Peyrin-Biroulet, Silvio Danese, Ferdinando D'Amico","doi":"10.1177/17562848241273066","DOIUrl":"10.1177/17562848241273066","url":null,"abstract":"<p><p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by growing incidence and prevalence around the world in the last few decades. The range of available existing treatment and strategies for its management is being implemented. Given the introduction of newly developed molecules and the lack of specific guidelines, drug positioning may represent a tough clinical challenge. UC management is mostly medical, and it has been shifting toward a more personalized approach with the aim to create a tailored strategy depending on the patient's profile. A treat-to target strategy seems to be the best approach to reach disease control as it allows to carry out therapeutic choices based on objective and specific parameters: histological, ultrasonographic, and molecular targets may add to the already used clinical, endoscopic, and biochemical targets. In addition, dual-targeted therapy has emerged as an attractive therapeutic strategy for patients not achieving remission. This review aims to provide an overview of the available strategies to raise the bar in UC.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241273066"},"PeriodicalIF":3.9,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colonic transendoscopic enteral tubing is revolutionizing intestinal therapeutics, diagnosis, and microbiome research. 结肠经内镜肠管正在为肠道治疗、诊断和微生物组研究带来革命性的变化。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-23 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241301574
Zheyu Wang, Xia Wu, Yaxue Wang, Quan Wen, Bota Cui, Faming Zhang
{"title":"Colonic transendoscopic enteral tubing is revolutionizing intestinal therapeutics, diagnosis, and microbiome research.","authors":"Zheyu Wang, Xia Wu, Yaxue Wang, Quan Wen, Bota Cui, Faming Zhang","doi":"10.1177/17562848241301574","DOIUrl":"10.1177/17562848241301574","url":null,"abstract":"<p><p>The intestine, as a crucial organ of the human body, has remained enigmatic despite the remarkable advancements in modern medical technology. Over the past decades, the invention of endoscopic technology has made the noninvasive intervention of the intestine a reality, expanding diagnostic and therapeutic options for diseases. However, due to the single-treatment feature of endoscopic procedures, continuous or repeated medication administration, sampling, and decompression drainage within the intestine have yet to be fulfilled. These limitations persisted until the invention of colonic transendoscopic enteral tubing (TET) in 2014, which realized repeated fecal microbiota transplantation, medication administration, and decompression drainage for the treatment of colon perforation and intestinal obstruction, as well as in situ dynamic sampling. These breakthroughs have not gone unnoticed, gaining global attention and recommendations from guidelines and consensuses. TET has emerged as a novel microbial research tool that offers new paradigms for human microbiome research. This review aims to update the research progress based on TET.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241301574"},"PeriodicalIF":3.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical course for pancreatic necrosis and pancreatic pseudocysts due to severe acute or chronic pancreatitis. 重症急性或慢性胰腺炎引起的胰腺坏死和胰腺假性囊肿的临床过程。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-23 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241301945
Stefano Fusco, Greta M Hanke, Karsten Büringer, Lisa Minn, Gunnar Blumenstock, Ulrike Schempf, Martin Götz, Nisar P Malek, Dörte Wichmann, Christoph R Werner
{"title":"Clinical course for pancreatic necrosis and pancreatic pseudocysts due to severe acute or chronic pancreatitis.","authors":"Stefano Fusco, Greta M Hanke, Karsten Büringer, Lisa Minn, Gunnar Blumenstock, Ulrike Schempf, Martin Götz, Nisar P Malek, Dörte Wichmann, Christoph R Werner","doi":"10.1177/17562848241301945","DOIUrl":"10.1177/17562848241301945","url":null,"abstract":"<p><strong>Background: </strong>The acute and chronic pancreatitis (CP) can lead to severe complications like walled-off necrosis, large symptomatic pseudocyst or multiorgan failure. The treatment of these complications is multivariate and can differ from conservative, symptomatic treatment or minimal-invasive, endoscopic transgastral stenting to transgastral necrosectomy.</p><p><strong>Objectives: </strong>This study aims to analyse the clinical course for patients that develop local complications of severe pancreatitis.</p><p><strong>Design: </strong>This is a retrospective observational single-centre study on 46 patients with severe pancreatitis.</p><p><strong>Methods: </strong>In this retrospective single-centre study, 46 out of 474 inpatients from January 2014 to December 2020, who were treated because of an acute or CP, developed acute pancreatitis complications and could be included. We analysed and compared the clinical course of different treatments (lumen apposing metal stents, transgastral double pigtail stent, endoscopic retrograde cholangiopancreatography, operation, conservative treatment) and different complications (walled-off necrosis (WON), pancreatic pseudocyst (PPC)).</p><p><strong>Results: </strong>Forty-six patients developed an acute complication due to severe pancreatitis. Twenty-seven patients developed a WON, while 19 patients suffered from PPC. 48% of the whole cohort had an alcoholic aetiology of pancreatitis. 78% were treated with antibiotics, 48% suffered from infected pancreatitis and 22% needed intensive care treatment. WON patients more often had a longer hospitalization of more than 21 days. PPC patients were correlated with an alcoholic aetiology, whereas WON patients were inversely correlated with an alcoholic aetiology. Increased lactate dehydrogenase, lipase, and C-reactive protein levels as well as leucocyte count could be associated with a higher probability to exhibit a WON instead of another local complication. The mortality rate was low with 7% in our study.</p><p><strong>Conclusion: </strong>WON and PPC differ in certain patients and laboratory characteristics such as aetiology, elevated laboratory values, antibiotic treatment or the duration of hospitalization. Invasive treatment is not required in all severe pancreatitis cases.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241301945"},"PeriodicalIF":3.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First-line treatment with zolbetuximab plus CAPOX for ClDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: a cost-effectiveness analysis. 唑贝妥昔单抗加CAPOX治疗ClDN18.2阳性胃癌或胃食管交界腺癌的一线治疗:成本效益分析。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-22 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241297052
Jianying Lei, Jiahao Zhang, Caicong You, Wu Fu, Maobai Liu, Na Li
{"title":"First-line treatment with zolbetuximab plus CAPOX for ClDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: a cost-effectiveness analysis.","authors":"Jianying Lei, Jiahao Zhang, Caicong You, Wu Fu, Maobai Liu, Na Li","doi":"10.1177/17562848241297052","DOIUrl":"10.1177/17562848241297052","url":null,"abstract":"<p><strong>Background: </strong>Patients with HER2-negative locally advanced or unresectable metastatic gastric cancer and gastroesophageal junction (G/GEJ) adenocarcinoma have limited first-line treatment options and a poor prognosis. The GLOW clinical trial showed that zolbetuximab plus capecitabine plus oxaliplatin (CAPOX) significantly prolonged these patients' overall survival (OS) and progression-free survival (PFS).</p><p><strong>Objectives: </strong>This study evaluated the cost-effectiveness of zolbetuximab plus CAPOX as a first-line treatment for HER2-negative locally advanced or unresectable metastatic G/GEJ adenocarcinoma in the United States and China.</p><p><strong>Design: </strong>The cost-effective analysis.</p><p><strong>Methods: </strong>Based on the GLOW clinical trial data (NCT03653507), we constructed a 10-year Markov model to assess the cost-effectiveness of the zolbetuximab or placebo plus CAPOX treatment regimen. Only direct medical costs were considered. The primary outcomes of the model were quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICERs). One-way and probabilistic sensitivity analyses were employed to assess the robustness of the model.</p><p><strong>Results: </strong>In the United States, zolbetuximab plus CAPOX added 0.24 QALYs and resulted in an incremental cost of $196,791.11 compared with placebo plus CAPOX, which had an ICER of $821,515.65 per QALY gained. For China, the zolbetuximab group gained 0.23 QALYs at an incremental cost of $62,822.69, resulting in an ICER of $273,568.01/QALY. One-way sensitivity analysis revealed that the results were most sensitive to the price of zolbetuximab. Zolbetuximab plus CAPOX had 0% cost-effectiveness at the willingness-to-pay thresholds of $150,000/QALY in the United States and $38,188/QALY in China.</p><p><strong>Conclusion: </strong>Zolbetuximab plus CAPOX may be a cost-effective option for patients with locally advanced, unresectable, or metastatic G/GEJ adenocarcinoma when the price of zolbetuximab reduced by 83.37% ($367.7/100 mg) in the United States and 82.25% ($110.8/100 mg) in China.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241297052"},"PeriodicalIF":3.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriasis and inflammatory bowel disease: concomitant IMID or paradoxical therapeutic effect? A scoping review on anti-IL-12/23 and anti-IL-23 antibodies. 银屑病和炎症性肠病:并发的 IMID 还是矛盾的治疗效果?抗IL-12/23和抗IL-23抗体的范围综述。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-21 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241299564
Cristina Bezzio, Carolina Aliai Micol Cavalli, Gianluca Franchellucci, Arianna Dal Buono, Roberto Gabbiadini, Davide Scalvini, Sofia Manara, Alessandra Narcisi, Alessandro Armuzzi, Simone Saibeni
{"title":"Psoriasis and inflammatory bowel disease: concomitant IMID or paradoxical therapeutic effect? A scoping review on anti-IL-12/23 and anti-IL-23 antibodies.","authors":"Cristina Bezzio, Carolina Aliai Micol Cavalli, Gianluca Franchellucci, Arianna Dal Buono, Roberto Gabbiadini, Davide Scalvini, Sofia Manara, Alessandra Narcisi, Alessandro Armuzzi, Simone Saibeni","doi":"10.1177/17562848241299564","DOIUrl":"10.1177/17562848241299564","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBD) and psoriasis are chronic inflammatory conditions belonging to the heterogeneous group of immune-mediated inflammatory diseases (IMIDs). A significant bidirectional link between these two entities has been observed, conditioning an increased risk of IBD in patients with psoriasis and vice-versa. Biological therapies used for IBD may lead to the occurrence of psoriasis as a \"paradoxical reaction.\" The objective of this study is to analyze the current evidence on the association between psoriasis and IBD, particularly finding case reports of the appearance or aggravation of psoriasis under therapy with interleukin-12/23 (IL-12/23) and IL-23 inhibitors. We conducted comprehensive research to identify studies examining the association between psoriasis and IBD and to find case presentations that reported the appearance or aggravation of psoriasis under biologic therapy with IL-12/23 and IL-23 inhibitors up to March 2024. Clinical trials for IL-12/23 and IL-23 inhibitors in IBD were analyzed to find cases of paradoxical psoriasis as registered adverse events. The sources of evidence are PubMed and ClinicalTrials.gov. For each included case report, data on patient characteristics concerning their age, sex, and comorbidities were selected. Moreover, information regarding the indication for biologic therapy, time to onset of paradoxical psoriasis after starting treatment, clinical presentation, and management of the paradoxical psoriasis was extracted. We found 10 reported cases of ustekinumab-induced new-onset or worsening psoriasis and one reported case of paradoxical psoriasis induced by risankizumab in the literature. Four cases of paradoxical psoriasis have been also registered in clinical trials involving ustekinumab treatment in IBD. Psoriasis can constitute a rare paradoxical adverse event of ustekinumab treatment, but further studies are needed to better clarify the cytokine imbalance that leads to this phenomenon induced by inhibition of IL-12/23 and IL-23. Still, few real-world data exist to draw any conclusions, but risankizumab may positively treat psoriasis induced by ustekinumab.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241299564"},"PeriodicalIF":3.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and safety outcomes after long-term (54 weeks) vedolizumab therapy for Crohn's disease: a prospective, real-world observational study including patient-reported outcomes (POLONEZ II). 长期(54 周)维多利珠单抗治疗克罗恩病的疗效和安全性结果:一项包括患者报告结果在内的前瞻性真实世界观察研究(POLONEZ II)。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241293938
Ariel Liebert, Maria Kłopocka, Agata Michalak, Halina Cichoz-Lach, Renata Talar-Wojnarowska, Danuta Domz Ał-Magrowska, Łukasz Konecki, Aleksandra Filipiuk, Michał Krogulecki, Maria Kopertowska-Majchrzak, Kamila Stawczyk-Eder, Katarzyna Waszak, Piotr Eder, Edyta Zagórowicz, Izabela Smoła, Krzysztof Wojciechowski, Szymon Drygała
{"title":"Effectiveness and safety outcomes after long-term (54 weeks) vedolizumab therapy for Crohn's disease: a prospective, real-world observational study including patient-reported outcomes (POLONEZ II).","authors":"Ariel Liebert, Maria Kłopocka, Agata Michalak, Halina Cichoz-Lach, Renata Talar-Wojnarowska, Danuta Domz Ał-Magrowska, Łukasz Konecki, Aleksandra Filipiuk, Michał Krogulecki, Maria Kopertowska-Majchrzak, Kamila Stawczyk-Eder, Katarzyna Waszak, Piotr Eder, Edyta Zagórowicz, Izabela Smoła, Krzysztof Wojciechowski, Szymon Drygała","doi":"10.1177/17562848241293938","DOIUrl":"10.1177/17562848241293938","url":null,"abstract":"<p><strong>Background: </strong>The Crohn's Disease (CD) Activity Index (CDAI), Inflammatory Bowel Disease (IBD) Questionnaire (IBDQ), and IBD-Fatigue (IBD-F) scale are useful patient-reported outcome (PRO) tools for assessing the treatment benefits of vedolizumab (VDZ) beyond clinical trial endpoints in patients with CD.</p><p><strong>Objectives: </strong>To assess clinical response, clinical remission, steroid-free remission, changes from baseline for PROs, and safety in a real-world cohort of patients with moderate-to-severe active CD treated with VDZ.</p><p><strong>Design: </strong>POLONEZ II was a multicenter, observational, prospective study across 10 Polish centers from April 2020 to October 2023 for 54 weeks in patients with CD eligible for reimbursed VDZ.</p><p><strong>Methods: </strong>Primary endpoints at week 54 (W54) were clinical response (⩾70-point reduction in CDAI and >25% reduction vs baseline), remission (CDAI score ⩽150), and steroid-free remission. Other outcomes were changes in PROs (CDAI score and health-related quality of life) and safety. Kaplan-Meier survival analyses were performed.</p><p><strong>Results: </strong>Of 98 patients with CD, the mean age was 35.2 years, 57.1% were male, and 72.4% had an ileocolonic disease. At W54 (<i>n</i> = 98), 63.3% of patients achieved clinical response, 48.0% remission, and 36.0% steroid-free remission. The durability of clinical response, remission, and steroid-free remission (W14-W54) were 68.9%, 62.9%, and 57.1%, respectively. By W54, a significant reduction in the PROs, such as the total CDAI score (<i>p</i> < 0.001), stool frequency (<i>p</i> < 0.001), abdominal pain score (<i>p</i> < 0.001), IBDQ (<i>p</i> < 0.001), IBD-F (<i>p</i> < 0.05), and fatigue impact on daily activities (<i>p</i> < 0.001), was observed. During VDZ treatment, arthralgia (23.7%-8.7%) and anemia (22.6%-15.9%) decreased between baseline and W54. Non-serious adverse events (SAEs; 12.2%), SAEs (7.1%), and VDZ-related rash (1.0%) were reported. Mean CD-related hospitalization duration decreased from baseline (10.2 days) to the end of the study (5.3 days).</p><p><strong>Conclusion: </strong>POLONEZ II demonstrated long-term real-world benefits of VDZ toward effectiveness, safety, and improved PROs and patients' quality of life.</p><p><strong>Trial registration: </strong>ENCePP (EUPAS32716).</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241293938"},"PeriodicalIF":3.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory bowel disease: a narrative review of disease evolution in South Asia and India over the last decade. 炎症性肠病:过去十年南亚和印度疾病演变的叙述性回顾。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241258360
Sahana Shankar, Snehali Majumder, Suparna Mukherjee, Anirban Bhaduri, Rangarajan Kasturi, Subrata Ghosh, Marietta Iacucci, Uday N Shivaji
{"title":"Inflammatory bowel disease: a narrative review of disease evolution in South Asia and India over the last decade.","authors":"Sahana Shankar, Snehali Majumder, Suparna Mukherjee, Anirban Bhaduri, Rangarajan Kasturi, Subrata Ghosh, Marietta Iacucci, Uday N Shivaji","doi":"10.1177/17562848241258360","DOIUrl":"10.1177/17562848241258360","url":null,"abstract":"<p><p>The rapid emergence of inflammatory bowel disease (IBD) in Asia in the last two decades is anticipated to pose significant challenges to the healthcare systems of developing countries including India. Several epidemiological factors in the Asia Pacific region have been explored as risk factors for the development of IBD. In this narrative review, we discuss the evolution of adult-onset and paediatric IBD in South Asia and India, in relation to the current global epidemiology, over the last decade. The focus lies on the changing epidemiological landscape of IBD in Asia which signals a paradigm shift in the disease trajectory of a chronic, relapsing, complex disease. We enumerate the disease burden of IBD in India and Asia, analyse the risk factors for its recent rise in incidence and briefly discuss the unique entity of very early-onset IBD. We also list the locoregional challenges in diagnosis and management along with suggestions to overcome them. We highlight the lacunae in data which warrants further research. The anticipated infrastructural challenges and disease evolution are likely to be similar in most newly industrialized countries across South Asia. A combined effort led by IBD experts in the region to understand the true disease burden is important. A strong collaborative network on research and formulation of preventive strategies relevant to the region will help reduce the burden in the future.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241258360"},"PeriodicalIF":3.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The efficacy and safety of a simple 14-day vonoprazan-minocycline dual therapy for Helicobacter pylori eradication: a retrospective pilot study. 简单的 14 天醋氯吡嗪-米诺环素双重疗法根除幽门螺杆菌的有效性和安全性:一项回顾性试点研究。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-19 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241299734
Xiaolei Wang, Guigen Teng, Xinhong Dong, Yun Dai, Weihong Wang
{"title":"The efficacy and safety of a simple 14-day vonoprazan-minocycline dual therapy for <i>Helicobacter pylori</i> eradication: a retrospective pilot study.","authors":"Xiaolei Wang, Guigen Teng, Xinhong Dong, Yun Dai, Weihong Wang","doi":"10.1177/17562848241299734","DOIUrl":"10.1177/17562848241299734","url":null,"abstract":"<p><strong>Background: </strong>Current eradication regimens are not ideal for <i>Helicobacter pylori</i> infected patients who have difficulty choosing antibiotics due to penicillin allergy or antibiotic resistance.</p><p><strong>Objective: </strong>To explore the efficacy and safety of a simple vonoprazan-minocycline dual therapy (VM dual therapy) in <i>H. pylori</i> eradication.</p><p><strong>Design: </strong>Clinical data of patients who were prescribed 14-day VM dual therapy were retrospectively collected. The included patients were 18-70 years old and positive for <sup>13</sup>C urea breath test (<sup>13</sup>C-UBT). They were allergic to penicillin or had a history of repeated antibiotic exposure or had failed eradication with multiple regimens containing amoxicillin. VM dual therapy consists of vonoprazan 20 mg twice daily and minocycline 100 mg twice daily. <sup>13</sup>C-UBT was repeated 4-6 weeks after treatment to evaluate the therapeutic outcome.</p><p><strong>Results: </strong>Of the 88 enrolled patients, 54 were treatment naïve, 13 had one prior eradication failure, and 21 had multiple eradication failures. The overall intention to treat (ITT) and per-protocol (PP) eradication rates were 90.9% (95% CI: 82.4-95.7) and 95.2% (95% CI: 87.6-98.5). The ITT eradication rates were 90.7% (95% CI: 78.9-96.5) in treatment-naïve patients, 84.6% (95% CI: 53.7-97.3) in patients with one prior treatment failure, and 95.2% (95% CI: 74.1-99.8) in patients with multiple failures. The PP eradication rates were 94.2% (95% CI: 83.1-98.5), 91.7% (95% CI: 59.8-99.6), and 100%, respectively. The overall incidence of adverse events was 23.0%. The common adverse reactions were nausea and mild dizziness, which could be resolved without intervention.</p><p><strong>Conclusion: </strong>Simple VM dual therapy exhibited a good eradication rate, low incidence of adverse effects, and good adherence. It is a potential new regimen for both first-line and rescue therapy.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241299734"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of safety and adverse events in endoscopic radiofrequency ablation for malignant biliary obstruction. 评估内镜射频消融治疗恶性胆道梗阻的安全性和不良事件。
IF 3.9 3区 医学
Therapeutic Advances in Gastroenterology Pub Date : 2024-11-19 eCollection Date: 2024-01-01 DOI: 10.1177/17562848241294002
Hayat Khizar, Yufei Hu, Weigang Gu, Jin Yang, Hangbin Jin, Xiayin He, Xiaofeng Zhang, Jianfeng Yang
{"title":"Assessment of safety and adverse events in endoscopic radiofrequency ablation for malignant biliary obstruction.","authors":"Hayat Khizar, Yufei Hu, Weigang Gu, Jin Yang, Hangbin Jin, Xiayin He, Xiaofeng Zhang, Jianfeng Yang","doi":"10.1177/17562848241294002","DOIUrl":"10.1177/17562848241294002","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic radiofrequency ablation (RFA) is used for the treatment of unresectable malignant biliary obstruction (MBO). The postoperative adverse events associated with RFA treatment have gained importance.</p><p><strong>Objective: </strong>To investigate the early adverse events and their risk factors associated with RFA for the treatment of MBO.</p><p><strong>Design: </strong>Observational retrospective study.</p><p><strong>Methods: </strong>We collected data from patients diagnosed with MBO and treated with endoscopic RFA at our hospital between January 2010 and June 2022. Based on the collected data, the patients were divided into two groups: the adverse event group and the nonadverse event group. Early postoperative adverse events were recorded, and risk factors were assessed.</p><p><strong>Results: </strong>One hundred and twenty patients with MBO underwent endoscopic RFA, with 20 developing adverse events (16.6%; 20/120). Among these, 13 patients (10.8%) developed biliary infection after RFA treatment, while 7 (5.8%) developed acute pancreatitis, and no bleeding or perforation occurred. Type 2 diabetes mellitus, bile duct stricture length >2.5 cm, segmental RFA, and the proportion of patients receiving single stent drainage were all significantly greater in the adverse event group compared to the nonadverse event group (<i>p</i> < 0.05). The results of the logistic regression analysis showed that type 2 diabetes, segmental RFA, and single stent drainage were the three independent risk factors for getting a biliary infection after RFA therapy.</p><p><strong>Conclusion: </strong>Unresectable MBO combined with type 2 diabetes mellitus, segmental RFA, and postoperative single stent drainage can be the risk factors for adverse events after RFA. More attention should be paid to patients with multiple risk factors and preventive measures should be taken.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"17 ","pages":"17562848241294002"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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