Anaesthesia Critical Care & Pain Medicine最新文献

{"title":"Effects of sub-anesthetic doses of esketamine on postoperative sleep disturbance and pain in patients undergoing lumbar interbody fusion—A randomized, double-blind, placebo-controlled, two-center trial","authors":"Zheping Chen ,&nbsp;Yongxu Gao ,&nbsp;Changli Gao ,&nbsp;Yizheng Zhang ,&nbsp;Le Zhang ,&nbsp;He Zhang ,&nbsp;Qianqian Wu ,&nbsp;Yuelong Jin ,&nbsp;Na Guo ,&nbsp;Lulu Liu ,&nbsp;Peilin Cong ,&nbsp;Yanwu Jin","doi":"10.1016/j.accpm.2025.101567","DOIUrl":"10.1016/j.accpm.2025.101567","url":null,"abstract":"<div><h3>Background</h3><div>Postoperative sleep disturbance (PSD) is a common postoperative complication that significantly impacts patients’ recovery, particularly after lumbar surgery.</div></div><div><h3>Methods</h3><div>This two-center, double-blind, placebo-controlled randomized trial was conducted between June 6, 2024, and November 26, 2024, in two hospitals in China. A total of 80 patients participated in this study and were randomly assigned to the esketamine group (<em>n</em> = 40) or the placebo group (<em>n</em> = 40). Patients in the esketamine group received 0.2 mg kg⁻¹ of esketamine for anesthesia induction, with a maintenance rate of 0.02 mg kg⁻¹ h⁻¹, followed by 1 mg kg⁻¹ of esketamine as an adjuvant in patient-controlled intravenous analgesia for 48 h after surgery. Saline was given to the placebo group of patients. The primary outcome of this study was the incidence of PSD on postoperative day (POD) 1. PSD was defined as a Numeric Rating Scale-sleep score of 6 or higher or an Athens Insomnia Scale score of 6 points or higher.</div></div><div><h3>Results</h3><div>The incidence of PSD on POD 1 was significantly lower in the esketamine group compared to the placebo group (33% <em>vs.</em> 67%; <em>P</em> = 0.003). The Visual Analog Scale (VAS)-pain score at rest was lower in the esketamine group compared to the placebo group at 1, 3, and 6 h after surgery (<em>P</em> &lt;  0.05). The VAS-pain score with movement was also lower in the esketamine group than the placebo group at 1, 3, 6, and 24 h after surgery (<em>P</em> &lt;  0.05). Furthermore, the Quality of Recovery-15 (QoR-15) scores were significantly higher in the esketamine group than in the placebo group on POD 1 (107 [103–117] <em>vs.</em> 99 [96−108]; <em>P</em> =  0.005) and POD 3 (130 [122−136] <em>vs.</em> 124 [117−127]; <em>P</em> =  0.003).</div></div><div><h3>Conclusion</h3><div>Sub-anesthetic doses of esketamine can reduce the incidence of PSD on POD 1, reduce postoperative pain, and improve QoR.</div></div><div><h3>Clinical trial registration</h3><div>Chinese Clinical Trial Registry <span><span>https://www.chictr.org.cn</span><svg><path></path></svg></span>, ChiCTR2400083156.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 5","pages":"Article 101567"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Watch out for postoperative pulmonary complications after emergency abdominal surgery!","authors":"Clément Monet ,&nbsp;Samir Jaber ,&nbsp;Thomas Fuchs-Buder","doi":"10.1016/j.accpm.2025.101583","DOIUrl":"10.1016/j.accpm.2025.101583","url":null,"abstract":"","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 5","pages":"Article 101583"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticoagulant management in Emergency settings: 2024 guidelines from the French Society of Emergency Medicine (SFMU), the French Society of Anaesthesia and Intensive Care Medicine (SFAR), the French Society of Thrombosis and Haemostasis (SFTH) and the French Working Group on Perioperative Haemostasis (GIHP), endorsed by the French Neurovascular Society","authors":"Delphine Douillet ,&nbsp;Alexandre Godon ,&nbsp;Geoffroy Rousseau ,&nbsp;Stéphanie Ruiz ,&nbsp;Fanny Vardon ,&nbsp;Emmanuel De Maistre ,&nbsp;Delphine Garrigue ,&nbsp;Isabelle Gouin ,&nbsp;Yves Gruel ,&nbsp;Julien Lanoiselée ,&nbsp;Frédéric Lapostolle ,&nbsp;Dominique Lasne ,&nbsp;Alexandre Mansour ,&nbsp;Anne-Céline Martin ,&nbsp;Mikaël Mazighi ,&nbsp;Patrick Mismetti ,&nbsp;Thomas Moumneh ,&nbsp;Farès Moustafa ,&nbsp;Andrea Penaloza ,&nbsp;Stéphanie Roullet ,&nbsp;Anne Godier","doi":"10.1016/j.accpm.2025.101584","DOIUrl":"10.1016/j.accpm.2025.101584","url":null,"abstract":"<div><h3>Objective</h3><div>The Société Française de Médecine d'Urgence (SFMU), the Société Française d'Anesthésie et de Réanimation (SFAR), the Groupe d'Intérêt en Hémostase Péri-opératoire (GIHP) and the Société Française de Thrombose et d'Hémostase (SFHT) have collaborated to propose a set of guidelines on the management of anticoagulants in an emergency setting.</div></div><div><h3>Design</h3><div>A group of French and Belgian experts from the French Societies of Emergency Medicine (SFMU), Anaesthesia and Intensive Care (SFAR), the working group on Perioperative Haemostasis (GIHP) and the French Society of Thrombosis and Haemostasis (SFHT) was convened. Any potential conflicts of interest were officially declared at the start of the recommendation development process, which was conducted independently of any industry funding. The authors used the GRADE (\"Grading of Recommendations Assessment, Development and Evaluation\") methodology to assess the level of evidence in the literature.</div></div><div><h3>Methods</h3><div>Five areas were defined: (1) The role of laboratory testing in determining anticoagulant use and the level of anticoagulation; (2) Management of anticoagulant-associated bleeding; (3) Management of asymptomatic overdoses; (4) Management of non-elective invasive procedures on anticoagulants; and (5) Thrombolysis for acute ischaemic stroke on anticoagulants. For each field, the aim of the recommendations was to answer a certain number of questions formulated by the experts according to the PICO model (\"Population, Intervention, Comparison, Outcome\"). Based on these questions, an extensive bibliographic search from 1990 onwards was carried out using predefined key words according to the PRISMA recommendations. Data quality was analysed using the GRADE method. Recommendations were formulated using the GRADE method and then voted on by all the experts using the GRADE grid method.</div></div><div><h3>Results</h3><div>The experts' summary work and application of the GRADE method resulted in 103 recommendations concerning 21 questions. After two rounds of voting and several amendments, strong agreement was reached on 97 recommendations. Out of these recommendations, 19 have a high level of evidence (19 GRADE 1), 35 have a low level of evidence (35 GRADE 2), and 48 are expert opinions. Finally, for one question, no recommendation could be made.</div></div><div><h3>Conclusions</h3><div>There was strong agreement among the experts to provide recommendations for clinicians to provide up-to-date management of patients on anticoagulants in an emergency setting.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 5","pages":"Article 101584"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delphi study to develop a core outcome set for inpatient pain assessment after cesarean delivery","authors":"S. Ciechanowicz ,&nbsp;B. Carvalho ,&nbsp;J.S. Berger ,&nbsp;P. Duch ,&nbsp;P. Flood ,&nbsp;R. Ffrench-O’Carroll ,&nbsp;H. Sviggum ,&nbsp;S. Hakimi ,&nbsp;D. Jethava ,&nbsp;M. Mieszkowski ,&nbsp;A. Merriam ,&nbsp;S. Osmundson ,&nbsp;U. Ituk ,&nbsp;J. Wagner Kovacec ,&nbsp;P. Sultan","doi":"10.1016/j.accpm.2025.101556","DOIUrl":"10.1016/j.accpm.2025.101556","url":null,"abstract":"<div><h3>Background</h3><div>Studies of cesarean delivery pain report different outcomes, restricting data pooling. This study aimed to develop a core outcome set for inpatient postoperative pain assessment after cesarean delivery to use for research and clinical practice, using the Delphi consensus methodology.</div></div><div><h3>Methods</h3><div>A scoping review identified 37 initial outcomes, with 2 additional outcomes developed from a patient focus group. These were rated in a two-round Delphi survey process completed by a panel consisting of authors of studies identified from a scoping review (<em>n</em> = 9), supplemented with other experts (<em>n</em> = 5) and patients with recent lived experience of post cesarean delivery pain (<em>n</em> = 7). Scores were collected usinga 1−5 Likert scale, 1–2 being ‘critical for inclusion’; 3 being ‘important but not critical’, and 4–5 of ‘limited importance/invalid’. Outcomes were included if recommended by ≥70% of stakeholders after voting. A third-round virtual meeting determined domains, and several further rounds of online surveys finalizedthe specific measures.</div></div><div><h3>Results</h3><div>Round one included 14 experts and 7 patients (100% response). Round two included 12 experts and 4 patients (76% response). The virtual meeting was attended by 11 experts and 3 patients (67%), and the 4 online surveys were completed by 67%, 52%, 67%, and 76%. The final domains included pain intensity: at rest, movement-evoked, and pain relief; pain interference; total consumption of opioids; and maternal adverse effects. 12 measures for domains were agreed upon. Getting out of a hospital bed was selected as the most relevant functional activity for movement-evoked pain after cesarean delivery.</div></div><div><h3>Conclusions</h3><div>This core outcome set may be applied to future research and clinical practice initiatives to evaluate post cesarean delivery pain.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 5","pages":"Article 101556"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of antimicrobial therapy in critically ill patients, what clinicians and searchers must know","authors":"Claire Roger ,&nbsp;Despoina Koulenti ,&nbsp;Emmanuel Novy ,&nbsp;Jason Roberts ,&nbsp;Claire Dahyot-Fizelier","doi":"10.1016/j.accpm.2025.101561","DOIUrl":"10.1016/j.accpm.2025.101561","url":null,"abstract":"<div><div>Effective sepsis treatment requires not only the timely administration of appropriate antimicrobials but also precise dosing to maximize patient survival in intensive care units (ICUs). However, the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics in critically ill patients differ significantly from those in the general population. Understanding these pathophysiological changes is essential for optimizing antibiotic therapy. In this context, adequate dosing refers to strategies that achieve therapeutic drug concentrations at the infection site, ensuring both clinical and microbiological effectiveness while minimizing the risk of antibiotic-related toxicity.</div><div>Additionally, optimizing the mode of antibiotic administration—particularly for beta-lactams—through continuous infusion has shown benefits, including improved achievement of PK/PD targets, higher clinical cure rates, and better microbiological eradication.</div><div>To ensure proper antimicrobial dosing, therapeutic drug monitoring (TDM) is the preferred approach. However, TDM is not universally available in all ICUs or for all antimicrobial agents. In its absence, clinicians must rely on factors such as the patient's clinical condition, the identified pathogen, the impact of organ dysfunction requiring extracorporeal therapies, and the physicochemical properties of antimicrobials to guide dosing decisions. The pharmacokinetics of antimicrobials can vary widely between critically ill patients and even within the same patient throughout their ICU stay, emphasizing the need for individualized dosing strategies and dynamic reassessments.</div><div>This review aims to outline the key pathophysiological changes observed in critically ill patients and their influence on antimicrobial dosing decisions, while also providing practical considerations to help clinicians optimize antimicrobial therapy in this patient population. Finally, the outstanding challenges in delivering optimal antimicrobial therapy to critically ill patients will be explored, highlighting areas for future research.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 5","pages":"Article 101561"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes and predictors of mortality in patients with severe COVID-19 and COPD admitted to ICU: A multicenter study","authors":"Laia Fernández-Barat ,&nbsp;Ana Motos ,&nbsp;Joan Canseco-Ribas ,&nbsp;Albert Gabarrús ,&nbsp;Ruben López-Aladid ,&nbsp;Alejandro Alvaro-Meca ,&nbsp;Adrián Ceccato ,&nbsp;Nadia García ,&nbsp;Miquel Ferrer ,&nbsp;Denise Battaglini ,&nbsp;Sergio Ávarez-Napagao ,&nbsp;Dario García-Gasulla ,&nbsp;Ricard Ferrer ,&nbsp;David de Gonzalo-Calvo ,&nbsp;José Ángel Lorente ,&nbsp;Rosario Menéndez ,&nbsp;Oscar Peñuelas ,&nbsp;Jordi Riera ,&nbsp;Alejandro Rodríguez ,&nbsp;Rosario Amaya Villar ,&nbsp;Antoni Torres","doi":"10.1016/j.accpm.2025.101558","DOIUrl":"10.1016/j.accpm.2025.101558","url":null,"abstract":"<div><h3>Background</h3><div>High mortality rates among patients with chronic obstructive pulmonary disease (COPD) admitted to intensive care units (ICUs) during the COVID-19 pandemic highlight the need for tailored clinical management strategies.</div></div><div><h3>Study Design and Methods</h3><div>Epidemiological, clinical, and laboratory data were collected in REDCap for 6512 patients hospitalized with COVID-19 across 55 Spanish ICUs. Patients were stratified into three groups: those with COPD, those with other chronic respiratory diseases (CRD), and those without respiratory comorbidities (No CRD). The primary outcome was to determine clinical predictors for 90-day mortality, focusing on the COPD group. A propensity score matching (PSM) method was applied to analyze the effects of respiratory support, biomarkers, and immunomarkers.</div></div><div><h3>Results</h3><div>Patients with COPD (n = 328) exhibited a 50% mortality rate compared to 33% of those with other chronic respiratory diseases (CRD, n = 547), and those without respiratory comorbidities (No CRD, n = 5124). Among COPD patients, 95% of whom had Acute Respiratory Distress Syndrome (ARDS) due to COVID-19, the use of a high-flow nasal cannula (HFNC) was associated with reduced 90-day mortality (hazard ratio: 0.54 (95% Confidence Interval [0.31–0.95]). At a molecular scale, lower IgG levels but higher viral load and TNF-alpha, Vascular Cell Adhesion Molecule-1 (VCAM-1), and Fas Cell Surface Death Receptor (Fas) were associated with mortality in the COPD group.</div></div><div><h3>Conclusions</h3><div>In COPD patients with ARDS due to COVID-19, the use of HFNC was associated with a better prognosis. The dysregulation in biomarkers and immunomarkers in COPD patients and its association with mortality highlight the need for further targeted therapeutic strategies.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 5","pages":"Article 101558"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dexmedetomidine versus propofol on outcomes in critically ill patients with different sedation depths: Correspondence","authors":"Hinpetch Daungsupawong ,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.accpm.2025.101574","DOIUrl":"10.1016/j.accpm.2025.101574","url":null,"abstract":"","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 5","pages":"Article 101574"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High risk, high reward: Postoperative trajectories of frail older adults","authors":"Donna Ron ,&nbsp;Stacie G. Deiner","doi":"10.1016/j.accpm.2025.101585","DOIUrl":"10.1016/j.accpm.2025.101585","url":null,"abstract":"","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 5","pages":"Article 101585"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Pain intensity after robotic-assisted urological surgery: The PAIROU study an international prospective cohort study’ [ACCPM (2025) 101546]","authors":"Pauline Rouxel ,&nbsp;Emilien Rayon ,&nbsp;Anne-Sophie Bellocq ,&nbsp;Morgan le Guen ,&nbsp;Julien Fessler ,&nbsp;Cédric Cirenei ,&nbsp;Raïko Blondonnet ,&nbsp;Emmanuel Parfait ,&nbsp;Ana-Gabriela Patrubani ,&nbsp;Andersen Ramorasata ,&nbsp;Aurélie Gouel ,&nbsp;Nicolas Brogly ,&nbsp;Guillaume Devoldere ,&nbsp;Mélanie Dupont ,&nbsp;Elodie Gaultier ,&nbsp;Martin Dupuis ,&nbsp;Pierre Bouzat ,&nbsp;Mathilde Cattenoz ,&nbsp;Sophie Prieur ,&nbsp;Philippe Cuvillon ,&nbsp;Helene Beloeil","doi":"10.1016/j.accpm.2025.101594","DOIUrl":"10.1016/j.accpm.2025.101594","url":null,"abstract":"","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 5","pages":"Article 101594"},"PeriodicalIF":4.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current post-tonsillectomy analgesia practices among Australian and New Zealand anesthetists, and opinions on non-opioid alternatives","authors":"Daisy Evans ,&nbsp;Aine Sommerfield ,&nbsp;David Sommerfield ,&nbsp;Neil Hauser ,&nbsp;Britta S. von Ungern-Sternberg","doi":"10.1016/j.accpm.2025.101598","DOIUrl":"10.1016/j.accpm.2025.101598","url":null,"abstract":"<div><h3>Introduction</h3><div>Children experience significant pain following extracapsular tonsillectomy surgery, and while opioids are often prescribed to treat this, clinicians may be wary of their adverse side effects, leading to variation in practice. There is a need for improved post-tonsillectomy pain management in children. To plan clinical trials into alternative analgesia, it is important to understand clinician opinions on post-tonsillectomy pain and its management, including the difference in pain scores that would convince them to begin prescribing alternative analgesia.</div></div><div><h3>Methods</h3><div>Anesthetists in Australia and New Zealand were surveyed on their expectations of children’s pain five-days post tonsillectomy. They were asked about their analgesic drug prescribing practices for these patients, as well as their expectations of the efficacy of three non-opioid treatments (clonidine, gabapentin, and honey).</div></div><div><h3>Results</h3><div>Responses from 109 anesthetists practicing pediatrics with experience ranging from &lt;5 years to &gt;20 years revealed variation in opinions on post-tonsillectomy opioid requirements and prescribing practices. 44% of respondents believed that “most children” should be prescribed opioids to manage their post-tonsillectomy pain, while 16% believed that no children should. On average, a pain decrease of 2-points on day five “might” convince respondents to change their practice to include clonidine, gabapentin or honey in their post-tonsillectomy analgesia regimen.</div></div><div><h3>Discussion</h3><div>These results reveal the variation in practice in pediatric post-tonsillectomy analgesia prescribing by Australian and New Zealand anesthetists. They can provide guidance when planning clinical trials into non-opioid treatments of post-tonsillectomy pain and understanding into the variation in practice among anesthetists in post-tonsillectomy pain management.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"44 6","pages":"Article 101598"},"PeriodicalIF":4.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}