{"title":"Measuring What Matters: Patient-Reported Outcomes in Colon Cancer Care.","authors":"Claire M Sokas, Srinivas Joga Ivatury","doi":"10.1055/s-0044-1801393","DOIUrl":"10.1055/s-0044-1801393","url":null,"abstract":"<p><p>Patients have common and personalized questions about expected outcomes after colon cancer treatment. Surgeons and oncologists can use high-quality clinical counseling and patient-reported outcomes to identify what matters most to each patient. This article reviews common patient-centered outcomes and how to elicit personalized outcomes, preferences, and values for patients facing colon cancer.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"38 5","pages":"343-348"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Personalizing Perioperative Chemotherapy in Colon Cancer.","authors":"Joyce H Pang, Charles A Baldi, Daniel O Herzig","doi":"10.1055/s-0044-1801391","DOIUrl":"10.1055/s-0044-1801391","url":null,"abstract":"<p><p>The traditional, surgery-first approach for colon cancer is increasingly challenged by our evolving understanding of tumor biology and a growing number of measurable tumor features that can help guide contemporary treatment plans. Certain tumor characteristics now make it practical to challenge locally advanced colon cancer with neoadjuvant chemotherapy or immunotherapy, and allow for targeted postoperative therapies. The contemporary data supporting these tailored approaches to integrating systemic therapy before or after resection are summarized in this article.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"38 5","pages":"339-342"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Technical Considerations for Oncologic Colectomy.","authors":"Philip S Bauer, Jordan Wlodarczyk, Maria Widmar","doi":"10.1055/s-0044-1801356","DOIUrl":"10.1055/s-0044-1801356","url":null,"abstract":"<p><p>Colectomy for malignant tumors or unresectable benign tumors requires preoperative planning based on cross-sectional imaging, consideration of neoadjuvant therapy, a decision on the extent of lymphadenectomy, and comprehensive knowledge of the relevant anatomy. Imaging review is critical for determining resectability and noting any aberrant anatomy. Based on the imaging, neoadjuvant therapy should be considered for bulky or locally advanced disease. The anatomical resection of the colon, mesentery, and lymph node basins is performed in accordance with the concept of complete mesocolic excision (CME), entailing the resection of the mesentery with visceral peritoneum intact, appropriate proximal and distal margins taken en bloc, and high ligation of the primary feeding vessels along which the lymph nodes are positioned. High ligation of the colic arteries is part of a standard lymphadenectomy and is intended to address possible micrometastatic nodal disease and proper staging for adjuvant therapy. Extended lymphadenectomy in the form of CME with central vascular ligation is indicated for patients with advanced T stage or clinical lymphadenopathy. Whether extended lymphadenectomy should be performed routinely is subject to debate. In this article, we review the indications and operative strategies for management of colon cancer in various locations in the colon, as well as key considerations for minimally invasive colectomy and advanced techniques such as CME with central vascular ligation.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"38 5","pages":"305-311"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contemporary Colon Cancer Care.","authors":"Vlad Valentin Simianu","doi":"10.1055/s-0044-1801368","DOIUrl":"10.1055/s-0044-1801368","url":null,"abstract":"","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"38 5","pages":"303-304"},"PeriodicalIF":1.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Minimally Invasive Surgery for Colon Cancer: Surgical and Oncologic Outcomes since the Clinical Outcomes of Surgical Therapy Trial.","authors":"Maggie Westfal, Thomas Curran","doi":"10.1055/s-0044-1801357","DOIUrl":"10.1055/s-0044-1801357","url":null,"abstract":"<p><p>Multiple randomized controlled trials have demonstrated the short-term recovery benefits of laparoscopic colectomy for colon cancer while maintaining noninferior long-term oncologic outcomes relative to open surgery. These short- and long-term results have been validated in large observational trials with the widespread adoption of laparoscopic colectomy for colon cancer. Subsequent advances in minimally invasive technique including robotic colectomy, intracorporeal anastomosis, and natural orifice extraction may preserve or augment the benefits of minimally invasive surgical treatment for colon cancer although data in these areas are less robust.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"38 5","pages":"312-316"},"PeriodicalIF":1.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Segmental versus Extended Resection for Colon Cancer in Lynch Syndrome.","authors":"Jared R Hendren, Josh Sommovilla","doi":"10.1055/s-0044-1801380","DOIUrl":"10.1055/s-0044-1801380","url":null,"abstract":"<p><p>Lynch's syndrome is a common cause of hereditary colorectal cancer (CRC), resulting in higher risk of CRC and development of subsequent, metachronous CRC (mCRC). Beyond treating the primary cancer, surgeons and patients must decide on whether performing an extended colectomy, to reduce the risk of mCRC, is worth the change in function that comes with the larger operation. Considerations include likelihood for mCRC, morbidity and quality of life after resection, impact of pathogenic variant, and certain other cancer risk reduction options. The contemporary evidence to guide these decisions is reviewed herein.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"38 5","pages":"317-321"},"PeriodicalIF":1.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contemporary Management of Malignant Bowel Obstruction.","authors":"Alexandra Onyiego, Justin Maykel","doi":"10.1055/s-0044-1801402","DOIUrl":"10.1055/s-0044-1801402","url":null,"abstract":"<p><p>Malignant bowel obstruction (MBO) is a complex problem in patients with advanced malignancies, one that poses difficult decision-making involving a patient's clinical status, extent of disease, and overall goals of care. This article will present common clinical presentations of MBO, initial resuscitation efforts, and helpful diagnostic tools. It will also review the contemporary data on medical, endoscopic, and surgical interventions used for the management of MBO. Our goal is to delineate benefits, common pitfalls, and limiting factors for these interventions while taking into consideration quality of life, patient wishes, and palliative care to support decision-making for clinicians treating patients with MBO.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"38 5","pages":"327-333"},"PeriodicalIF":1.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contemporary Use of ctDNA for the Colorectal Surgeon.","authors":"Madilyn Heit, Stacey A Cohen","doi":"10.1055/s-0044-1801379","DOIUrl":"10.1055/s-0044-1801379","url":null,"abstract":"<p><p>While advances in treatment and diagnostics have improved prognosis in colorectal cancer (CRC), room for advancement remains, highlighting the importance of improving tools for early detection and treatment guidance. Current national guidelines rely on stage-based treatment recommendations but fail to identify patients with lower stage disease who have a higher likelihood of recurrence or those for whom additional therapy may not be beneficial. Circulating tumor DNA (ctDNA) is an emerging noninvasive blood-based assay, which can inform cancer status as a single time point and/or longitudinal biomarker. ctDNA can be used for the diagnosis of cancer, detection of minimal/molecular residual disease, molecular profiling, and assessing treatment response. In patients for whom operative management is indicated, detectable ctDNA is associated with worse survival outcomes. This review highlights the expanding field of ctDNA in CRC, underlining pivotal data and areas with the need for more research that are key for colorectal surgeons to understand.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"38 5","pages":"334-338"},"PeriodicalIF":1.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Defining and Achieving High-Quality Colon Cancer Surgery.","authors":"Arden M Morris, Cindy J Kin","doi":"10.1055/s-0044-1801401","DOIUrl":"10.1055/s-0044-1801401","url":null,"abstract":"<p><p>There have been extensive efforts to improve the quality of colon cancer surgery to reduce variation in practice and improve outcomes. Providing the most appropriate care begins with following guidelines for preoperative diagnostics and staging, which should lead to risk stratification, high-quality counselling, and even prehabilitation before an operation. Intraoperatively, adherence to standardized surgical protocols can enhance delivery of high-quality care, and documenting using synoptic formats can reduce ambiguity. Participating in programs that track data and provide feedback can further allow hospitals and surgeons to identify patterns and opportunities to improve the care they deliver.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"38 5","pages":"354-358"},"PeriodicalIF":1.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}