Complementary Therapies in Clinical Practice最新文献

{"title":"Pilot of an animal-assisted activity program to support intergenerational and intercultural community connections to reduce loneliness and social isolation","authors":"Em Bould ,&nbsp;Natasha K. Brusco ,&nbsp;Libby Callaway","doi":"10.1016/j.ctcp.2025.101970","DOIUrl":"10.1016/j.ctcp.2025.101970","url":null,"abstract":"<div><h3>Background and purpose</h3><div>The COVID-19 pandemic challenged social support systems leading to loneliness and social isolation, particularly for older adults and international university students. This study explored the potential of using a shared interest in pets to support intergenerational and intercultural social connections, with a hypothesis that such interactions could enhance health-related quality of life and wellbeing and reduce feelings of loneliness.</div></div><div><h3>Methods</h3><div>The study adopted an action research approach to co-design and pilot an Animal-Assisted Activity (AAA) group intervention (called the ‘Pets and People program’) across two aged care facilities in Melbourne, Australia. The 18-week program was designed to facilitate social connections through the presence of live or robotic pets, and/or animal-assisted activities. The program was evaluated using mixed methods.</div></div><div><h3>Results</h3><div>Thirty older adults and 11 international students participated in the program. Six older adults, 10 international university students and three senior management staff participated in the evaluation. Both the older adult and student groups experienced a significant decrease in feelings of loneliness and a significant and clinically meaningful increase in the EQ-5D-5L utility index after program completion. The cost of implementation was $237 per person who participated in 10 weeks or more of the 18-week program. The explorative cost-utility analysis indicated a cost of $4,017 per quality adjusted life year gained, which is well below the threshold for the Australian Government's health related expenditure.</div></div><div><h3>Conclusions</h3><div>The Pets and People program holds potential to be replicated and scaled in aged care settings both in Australia and internationally.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101970"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of olive leaf extract (Olea europaea L.) for glycaemic control in adults with type 2 diabetes mellitus (ESOLED): A pilot randomised controlled trial","authors":"Matthew J. Leach ,&nbsp;Ian Breakspear","doi":"10.1016/j.ctcp.2025.101949","DOIUrl":"10.1016/j.ctcp.2025.101949","url":null,"abstract":"<div><h3>Background</h3><div>Maintaining optimum glycaemic control is essential to reducing comorbidity and mortality in diabetes. However, research indicates that &lt;50 % of patients achieve their target HbA1c ranges. Laboratory studies suggest that olive leaf extract (OLE) may improve glycaemic control, however clinical studies in persons with diabetes are lacking.</div></div><div><h3>Methods</h3><div>ESOLED is a pilot, randomised, placebo-controlled trial. Adults with a diagnosis of type 2 diabetes of ≥12 months duration, and not receiving insulin therapy, were eligible to participate. Participants were randomised to receive OLE or placebo capsules for 24 weeks. The primary outcome was change in HbA1c. Secondary outcomes included changes in the homeostasis model assessment of insulin resistance, diabetes-related stress, health-related quality of life, and safety.</div></div><div><h3>Results</h3><div>Thirty-one participants were randomly assigned to the OLE (n = 16) and placebo (n = 15) groups. Analyses found no statistically significant time-group interactions for HbA1c, diabetes-related distress or health-related quality of life. Although participants receiving OLE demonstrated greater improvements in insulin sensitivity than those on placebo, there was no significant difference between groups over time. OLE and placebo were found to be well-tolerated, with no severe or serious adverse events reported in either group.</div></div><div><h3>Conclusion</h3><div>The ESOLED trial has provided preliminary evidence on the tolerability of OLE in adults with type 2 diabetes, but was inconclusive in determining whether OLE is effective at improving glycaemic control, insulin sensitivity, diabetes-related distress and quality of life. Larger trials and further exploration of the bioavailability of OLE are needed to fully assess the therapeutic potential of OLE in diabetes.</div></div><div><h3>Trial registration</h3><div>Australian New Zealand Clinical Trials Registry (ACTRN12622000616774).</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101949"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the impact of various exercise modalities on old adults with Alzheimer's disease: A Bayesian network meta-analysis","authors":"Fengting Hu ,&nbsp;Jin Peng ,&nbsp;Weiran Wang ,&nbsp;Lin Shen ,&nbsp;Mingyuan Jia","doi":"10.1016/j.ctcp.2025.101968","DOIUrl":"10.1016/j.ctcp.2025.101968","url":null,"abstract":"<div><h3>Background and purpose</h3><div>The global prevalence of Alzheimer's disease (AD) in the elderly is rising, and exercise is increasingly used as a non-pharmacological intervention. However, the most effective exercise modality for improving quality of life, alleviating depression, and reducing neuropsychiatric symptoms in AD patients remains unclear. This study aims to identify the optimal exercise modality for addressing these symptoms through a network meta-analysis.</div></div><div><h3>Methods</h3><div>As of November 2024, we conducted a comprehensive search across six databases: PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials, CINAHL, and PsycINFO. This study included only randomized controlled trials (RCTs), with study durations ranging from 2 to 24 weeks, primarily set in clinical or community environments. Following the PRISMA-NMA guidelines, we conducted statistical analysis using the \"gemtc\" package in R and assessed evidence quality via the CINeMA online platform.</div></div><div><h3>Results</h3><div>A network meta-analysis of 29 RCTs with 1507 participants showed that for global cognition, Aerobic exercise (AE) [MD = 2.83, 95 % CI (0.66, 4.85)] ranked first with 79.5 % probability; for quality of daily life, Resistance Training (RT) [SMD = 0.96, 95 % CI (−0.14, 2.07)] ranked first with 83.7 %; for depression, Physical Activity Program (PAP) [SMD = −3.76, 95 % CI (−7.06, −0.47)] ranked first with 96.0 %; and for neuropsychiatric inventory outcomes, AE [SMD = −2.35, 95 % CI (−5.95, 1.06)] ranked first with 71.1 %.</div></div><div><h3>Conclusions</h3><div>Based on the findings from retrospective studies, aerobic exercise may be an effective intervention for improving overall cognition and quality of life in individuals aged 60 and above with Alzheimer's disease.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101968"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, practice, and perceived barriers to antenatal yoga among obstetricians and gynecologists in Bangladesh: A cross-sectional survey","authors":"Farhana Sultana Karim ,&nbsp;Satyapriya Maharana ,&nbsp;Sayeba Akhter ,&nbsp;Shahin Rahman Chowdhury","doi":"10.1016/j.ctcp.2025.101981","DOIUrl":"10.1016/j.ctcp.2025.101981","url":null,"abstract":"<div><h3>Aim</h3><div>To examine obstetricians' and gynecologists’ knowledge, attitudes, and practices regarding antenatal yoga and to explore the factors contributing to their hesitancy in recommending it.</div></div><div><h3>Methods</h3><div>A cross-sectional survey was conducted among 71 obstetricians and gynecologists in Bangladesh using online and offline modes. Demographic data, professionals’ knowledge, attitudes, practices, and perceived barriers to antenatal yoga were collected. Descriptive statistics and correlation matrix analyses were performed.</div></div><div><h3>Results</h3><div>83.1 % of respondents recognised the benefits of antenatal yoga; however, only 50 % routinely recommended it to pregnant women. Key barriers identified included a lack of standardised training, insufficient knowledge of antenatal yoga practices, and cultural resistance. Despite these challenges, all participants (100 %) expressed interest in attending antenatal yoga-related workshops and training.</div></div><div><h3>Conclusion</h3><div>While obstetricians and gynecologists in Bangladesh were optimistic about the benefits of antenatal yoga (AY), a lack of standardised guidelines and training, insufficient family support, and cultural factors hinder its widespread recommendation. To enhance the integration of AY into maternal care, this study recommends developing a standardised protocol for AY practices and incorporating specialised training for obstetricians and gynecologists to improve awareness and competency.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101981"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of dry needling for patellofemoral pain syndrome: a systematic review and meta-analysis","authors":"Zilin Sun,&nbsp;Renyi Liu","doi":"10.1016/j.ctcp.2025.101938","DOIUrl":"10.1016/j.ctcp.2025.101938","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Dry needling has been increasingly used as an adjunctive therapy for patellofemoral pain syndrome in clinical practice. This study aimed to summarize the available evidence about the effects of dry needling in managing patellofemoral pain syndrome.</div></div><div><h3>Methods</h3><div>Seven English-language databases and three Chinese-language databases were searched. Two researchers independently screened the literature, extracted data, and assessed the risk of bias using the PEDro scale and the Cochrane Risk of Bias Assessment Tool. The quality of evidence was evaluated using the GRADE approach.</div></div><div><h3>Results</h3><div>A total of 12 studies were included, involving 624 participants. Dry needling significantly improved knee pain (MD = −0.86, 95%CI -1.17 to −0.55) and physical function (MD = 5.33, 95%CI 3.88 to 6.78) compared to comparative groups. When combined with exercise therapy, dry needling resulted in large reduction in knee pain(MD = −2.02, 95%CI -2.36 to −1.67) and small improvement in physical function (MD = 9.56, 95%CI 7.84 to 11.27) compared to exercise therapy alone. However, negligible or no additional benefits were observed when dry needling was added to extracorporeal shock wave therapy or multimodal interventions. Furthermore, dry needling showed no significant advantage over other trigger point therapies in terms of pain reduction and functional improvement.</div></div><div><h3>Conclusion</h3><div>Dry needling is effective in reducing pain and improving function for patients with patellofemoral pain syndrome, particularly when combined with exercise therapy. However, more high-quality studies are required to draw a definitive conclusion.</div></div><div><h3>Clinical trial registration number</h3><div>CRD42023490627 on PROSPERO.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101938"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the prescription of benzodiazepines and related drugs at month 12 after E2R hypnotherapy in previously treated patients: A descriptive study","authors":"B. Bastian ,&nbsp;F. Martineau ,&nbsp;M. Esvan ,&nbsp;S.L. Mamoune ,&nbsp;E. Mener","doi":"10.1016/j.ctcp.2025.101971","DOIUrl":"10.1016/j.ctcp.2025.101971","url":null,"abstract":"<div><h3>Background and purpose</h3><div>In France, benzodiazepines are widely prescribed and consumed for anxiety and sleep disorders. E2R (Emotion, Regression, Repair) hypnotherapy could be an alternative non-pharmacological method to reduce their long-term use. The aim of this study was to estimate indirectly the effect of E2R hypnosis on the withdrawal rate at month 12 post-hypnotherapy in patients on long-term treatment (&gt;3 months) with benzodiazepines or related drugs.</div></div><div><h3>Materials and methods</h3><div>Retrospective observational study using data on 73 patients treated with E2R hypnotherapy for anxiety, depression or sleep disorders extracted from the patient databases of some French general practitioners trained in E2R hypnosis. Prescription of benzodiazepines or related drugs was analyzed at inclusion and at month 12 after E2R hypnotherapy.</div></div><div><h3>Results</h3><div>At month 12, 79.5 % had reduced or stopped their consumption (mean reduction of 55 %): 57.5 % of patients had completely stopped taking benzodiazepines or related drugs (95 % CI: 45.4 %–69.0 %) and 21.9 % were using them occasionally, based on the general practitioners' prescriptions. The percentage of patients with antidepressant prescriptions also decreased from 49.3 % to 31.5 % and 44.4 % of initial users stopped taking antidepressants. No factor associated with drug withdrawal was identified.</div></div><div><h3>Conclusion</h3><div>This observational study suggests that E2R hypnotherapy might be a promising and rapid approach for reducing or discontinuing benzodiazepines or related drugs, with results similar to those obtained with other non-pharmacological interventions. Controlled trials are needed to confirm its efficacy.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101971"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical manipulation accelerates recovery and further correction of cervical alignment in mechanical neck pain (MNP) patients with neck exercise: A randomized controlled trial","authors":"Ke Wu ,&nbsp;Rongrong Deng ,&nbsp;Xu Zhao ,&nbsp;Zihan Wang ,&nbsp;Qingyuan Ru ,&nbsp;Xin Chen ,&nbsp;Botao Zhang ,&nbsp;Liping Chen ,&nbsp;Ran Kang","doi":"10.1016/j.ctcp.2025.101969","DOIUrl":"10.1016/j.ctcp.2025.101969","url":null,"abstract":"<div><h3>Background</h3><div>Mechanical neck pain (MNP) is often associated with changes in cervical sagittal alignment, causing pain and functional limitations.</div></div><div><h3>Objective</h3><div>This study evaluated the additional effects of cervical manipulation in patients with MNP undergoing neck retraction exercise.</div></div><div><h3>Methods</h3><div>Patients with MNP were randomly assigned to either the cervical manipulation plus neck retraction exercise group (CM + NRE) or the neck retraction exercise group (NRE). Both groups completed their respective regimens over an 8-week period. Primary outcomes include visual analogue scale (VAS) and cervical range of motion (CROM). Secondary outcomes include neck disability index (NDI), neck muscle strength, and cervical sagittal alignment (relative rotation angles [RRA]; absolute rotation angles [C_2-7ARA]; cervical sagittal vertical axis [c_2-7SVA]). The statistical analysis applied intention-to-treat (ITT) and per-protocol (PP) analyses.</div></div><div><h3>Results</h3><div>In the ITT analysis, the CM + NRE group demonstrated more pronounced changes in VAS and CROM after the first treatment (VAS: d = 1.83, P = 0.001; CROM: d = 1.92, P = 0.001), at 4 weeks (VAS: d = 0.98, P = 0.001; CROM: d = 1.05, P = 0.001), 8 weeks (VAS: d = 1.05, P = 0.001; CROM: d = 0.93, P = 0.001), and at a 4-week follow-up (VAS: d = 1.16, P = 0.001; CROM: d = 0.91, P = 0.001). In the assessments of NDI, RRA, and C_2-7ARA, the CM + NRE group showed significantly greater changes compared to the NRE group (p &lt; 0.05). These results were consistent with the PP analysis.</div></div><div><h3>Conclusion</h3><div>Cervical manipulation enhances the effectiveness of neck retraction exercise, which promotes rapid recovery from neck pain and stiffness and further facilitates the correction of cervical sagittal alignment in patients with MNP.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101969"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing barriers to meditation in patients with substance use disorder","authors":"Tiffany Champagne-Langabeer ,&nbsp;A. Sarah Cohen ,&nbsp;Audrey Lopez ,&nbsp;Christine Bakos-Block ,&nbsp;Alisha Campbell ,&nbsp;Bhanumathi Gopal ,&nbsp;Marylou Cardenas-Turanzas ,&nbsp;Ashmita Poudel ,&nbsp;Chelsea Ratcliff ,&nbsp;Aila Malik ,&nbsp;Radha Korupolu","doi":"10.1016/j.ctcp.2025.101957","DOIUrl":"10.1016/j.ctcp.2025.101957","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Individuals living with substance use disorder (SUD) often face unique challenges that can hinder their engagement in beneficial practices like meditation, which has been shown to support recovery and well-being. This study aimed to explore the perceived barriers to meditation with SUD, identify key obstacles, and inform future interventions that promote the adoption of a personal practice.</div></div><div><h3>Materials and methods</h3><div>We conducted a cross-sectional analytic study with a convenience sample of participants attending a treatment center for SUD. Data collected included demographics, SUD history, health challenges, meditation knowledge, and previous meditation practice. Barriers to meditation were evaluated using the Determinants of Meditation Practice Inventory (DMPI) and its revised version, DMPI-R. Overall frequencies, proportions, and measures of central tendency were calculated. Participants currently practicing meditation were compared to those not meditating by using Fisher's exact test, Student's t-test, and Wilcoxon rank-sum test.</div></div><div><h3>Results</h3><div>One hundred sixteen individuals completed the survey. Survey respondents were an average of 45 years (standard deviation, SD, 11.46), majority female (67.0 %), and White (90.3 %). Only 28.7 % of respondents were informed of meditation by their healthcare provider, yet 81.7 % were interested in learning about meditation. Among survey respondents, “prayer is my form of meditation,” followed by “I can't stop my thoughts,” were most agreed upon.</div></div><div><h3>Conclusion</h3><div>Individuals living with SUD are interested in education on meditation techniques; however, additional research is needed to understand the determinants of meditation practice and discern the barriers that could help facilitate the adoption and long-term practice of this method.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101957"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143291262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between trait mindfulness and physical activity among emerging adults: The mediating roles of exercise-related cognitive errors and trait self-control","authors":"Ding Yuan ,&nbsp;Jin Kuang ,&nbsp;Jinming Li ,&nbsp;Rebecca Y.M. Cheung ,&nbsp;Fabian Herold ,&nbsp;Markus Gerber ,&nbsp;Alyx Taylor ,&nbsp;Arthur F. Kramer ,&nbsp;Jiahui Wang ,&nbsp;Albert S. Yeung ,&nbsp;Liye Zou","doi":"10.1016/j.ctcp.2025.101953","DOIUrl":"10.1016/j.ctcp.2025.101953","url":null,"abstract":"<div><h3>Objective</h3><div>Exercise-related cognitive errors (ECEs) is a significant factor that can negatively influence physical activity (PA) engagement among emerging adults, whereas mindfulness interventions may be beneficial for promoting PA. Against this background, we investigated the potential association between trait mindfulness and PA levels among emerging adults and determined whether trait self-control and ECEs serve as mediators.</div></div><div><h3>Method</h3><div>328 Chinese participants (61.3 % female, mean age = 20.65, SD = 2.21) completed a series of questionnaires, including demographics, the Five Dimension Mindfulness Questionnaire short form (FFMQ-SF), the Exercise Cognitive Bias Questionnaire (E-CEQ), the Brief Self Control Scale (BSCS), and the short form of the International Physical Activity Questionnaire (IPAQ-SF). A structural equation model was used to investigate the potential relationships between trait mindfulness and PA levels, considering trait self-control and ECEs as mediators.</div></div><div><h3>Results</h3><div>Trait self-control (Indirect 1; B = 0.09, 95%CI: 0.04, 0.16) and ECEs (Indirect 3; B = 0.02, 95%CI: 0.00, 0.04) mediates the relationship between trait mindfulness and PA levels, respectively, when considered as independent mediators. In addition, also in a dual-mediation model ECEs and trait self-control (Indirect 2; B = 0.02, 95%CI [0.00, 0.06]) mediate the relationship between trait mindfulness and PA.</div></div><div><h3>Conclusions</h3><div>This study provides evidence that trait self-control and ECEs are mediators of the relationship between trait mindfulness and PA levels, providing a new direction for further research aiming to reduce ECEs and improve PA levels among emerging adults.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101953"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigona honey effect on wound pH and healing in diabetes-related foot ulcers: A case series","authors":"Sukarni Sukarni ,&nbsp;Muhammad Aminuddin ,&nbsp;Mao Kunimitsu ,&nbsp;Kanae Mukai ,&nbsp;Mayumi Okuwa ,&nbsp;Haryanto Haryanto ,&nbsp;Suriadi Jais ,&nbsp;Makoto Oe","doi":"10.1016/j.ctcp.2025.101975","DOIUrl":"10.1016/j.ctcp.2025.101975","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes-related foot ulcers (DFUs) often become chronic due to prolonged inflammation and alkaline wound pH. Trigona honey is a potential therapy due to its low pH and antimicrobial properties. This case series explores pH dynamics and the effect of Trigona honey therapy on healing of DFUs and offers insights into optimizing treatment strategies to improve healing outcomes.</div></div><div><h3>Patient presentation</h3><div>Four patients with DFUs were treated with Trigona honey and followed until healing or 8 weeks. Wound bed pH was measured and wound characteristics were assessed with the DMIST tool at each follow-up visit. In two patients who healed, the inflammatory phase lasted 11 and 6 days, and the wound bed was acidic during most of the proliferative phase. In two patients who did not heal within 8 weeks, the inflammatory phase lasted 27 and 25 days, and the wound bed was alkaline for most of the proliferative phase.</div></div><div><h3>Conclusion</h3><div>Ulcers that did not heal had a longer inflammatory phase and wound bed pH was more alkaline than in ulcers that healed. Although Trigona honey might not directly affect the pH of the wound bed, treatment should be modified if alkaline granulation tissue is observed.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101975"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}