Complementary Therapies in Clinical Practice最新文献

{"title":"Corrigendum to “Network meta-analysis of different traditional Chinese medicine therapies as adjuvant treatments for Alzheimer's disease” [Compl. Ther. Clin. Pract. 64 (2026) 102075]","authors":"Zongbao Li, Xiuhua Bai, Jiping Li, Wenyi Geng, Xin Xing, Jianqing Liang, Jintian Li, Juan Li","doi":"10.1016/j.ctcp.2026.102078","DOIUrl":"10.1016/j.ctcp.2026.102078","url":null,"abstract":"","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"64 ","pages":"Article 102078"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coping strategies mediate the effects of stress on psychological distress in patients with end-stage renal disease: A structural equation modeling approach","authors":"Chun-I Chen,&nbsp;Shih-Yuan Hung,&nbsp;Liu-Chun Lu,&nbsp;Chiung-Yu Huang","doi":"10.1016/j.ctcp.2026.102079","DOIUrl":"10.1016/j.ctcp.2026.102079","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Patients with end-stage renal disease (ESRD) undergoing dialysis often experience substantial psychological and physiological stress, particularly during the coronavirus disease 2019 (COVID-19) pandemic. Coping strategies may influence how patients manage stress and related health outcomes. This study investigated the associations among coping strategies, perceived stress, anxiety, depressive symptoms, sleep quality, and quality of life (QoL) in ESRD patients, with a focus on the mediating role of coping strategies.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional study was conducted with 110 dialysis patients from two centers in southern Taiwan. Participants aged ≥20 years completed questionnaires assessing perceived stress, coping strategies, mental health, sleep quality, and QoL. Individuals with psychiatric conditions or a history of major depressive disorder were excluded. Structural equation modeling was used to examine direct and indirect relationships among perceived stress, coping strategies, and psychological outcomes.</div></div><div><h3>Results</h3><div>Among participants, 73.6% reported poor sleep quality, 45.5% had depressive symptoms, and 92% experienced anxiety. Poor sleep quality was associated with higher levels of anxiety and depressive symptoms. Active coping strategies were associated with better physical quality of life (PQoL), mental quality of life (MQoL), and lower depressive symptoms. In the structural equation model, coping strategies showed significant indirect effects in pathways linking perceived stress with sleep disturbances, psychological distress, PQoL and MQoL.</div></div><div><h3>Conclusion</h3><div>Perceived stress and poor sleep quality were associated with greater psychological distress and poorer QoL. Coping strategies mediated specific associations among perceived stress, sleep disturbance, psychological distress, and physical and mental quality of life.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"64 ","pages":"Article 102079"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148770181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of percussive massage on quadriceps fatigue, soreness, knee torque and jump height in active adults: a randomized crossover trial","authors":"Raphael Oliveira Caetano,&nbsp;Bruno Soares Alves,&nbsp;Fernanda de Oliveira Lauria,&nbsp;Isabela Vergara Marques,&nbsp;Ana Carolina Nicolau Gomes,&nbsp;Túlio Medina Dutra de Oliveira,&nbsp;Diogo Simões Fonseca,&nbsp;Diogo Carvalho Felício","doi":"10.1016/j.ctcp.2026.102080","DOIUrl":"10.1016/j.ctcp.2026.102080","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Percussive massage has gained popularity as a recovery strategy, but its effectiveness remains unclear. This study investigated its effects on muscle fatigue and pain intensity, isometric knee extensor torque, and vertical jump height in physically active adults.</div></div><div><h3>Materials and methods</h3><div>A randomized, assessor-blinded, two-condition, two-period crossover clinical trial was conducted in physically active adults. Participants completed a knee-extensor fatigue protocol consisting of four sets performed to concentric failure at their previously determined 10-repetition maximum load. Following the protocol, participants received either percussive massage or passive recovery according to their randomized intervention sequence. Outcomes included muscle fatigue intensity, quadriceps muscle pain intensity during squats, isometric knee extensor torque, and vertical jump height. Intervention effects were analyzed using generalized estimating equations.</div></div><div><h3>Results</h3><div>Fifty participants completed the study. Mean differences (MDs) and 95% confidence intervals (CIs) showed significantly lower muscle fatigue intensity (MD 2.58; 95% CI 2.19–2.96) and muscle pain intensity (MD 2.22; 95% CI 1.77–2.67), and significantly higher isometric knee extensor torque (MD 17.2 Nm/kg; 95% CI 11.1–23.4) and vertical jump height (MD 0.86 cm; 95% CI 0.36–1.35) with percussive massage compared with passive recovery.</div></div><div><h3>Conclusion</h3><div>A 5-min percussive massage applied to the quadriceps was more effective than passive recovery in reducing perceived muscle fatigue and soreness, with modest but statistically significant improvements in knee extensor torque and vertical jump height following a fatigue-inducing protocol.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"64 ","pages":"Article 102080"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily ginger supplementation improves plasma cholesterol efflux capacity and reduces oxidative stress in healthy adults: A randomized, double-blind, placebo-controlled crossover trial","authors":"Fahime Ansarifard,&nbsp;Javad Nasrollahzadeh","doi":"10.1016/j.ctcp.2026.102074","DOIUrl":"10.1016/j.ctcp.2026.102074","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Ginger may influence lipoprotein metabolism and macrophage reverse cholesterol transport. This study evaluated the effects of ginger supplementation on ex vivo plasma cholesterol efflux capacity (CEC).</div></div><div><h3>Materials and methods</h3><div>In a randomized, double-blind, placebo-controlled crossover trial, thirty-five healthy participants received either a placebo followed by dried ginger powder capsules (1500 mg/day) or the reverse sequence. Each intervention lasted six weeks, separated by a four-week washout period. Apo B-depleted plasma was assessed for CEC. Plasma paraoxonase arylesterase activity, malondialdehyde (MDA), lipid profiles, body weight, and blood pressure were also measured.</div></div><div><h3>Results</h3><div>Ginger supplementation significantly increased the CEC of apoB-depleted plasma, demonstrating a significant treatment-by-period interaction (p = 0.001). Plasma MDA levels decreased following incubation with an oxidizing agent (copper) during the ginger period compared to placebo (treatment × period, p = 0.029). No significant effects were observed on paraoxonase arylesterase activity, lipid and lipoprotein levels, body weight, or blood pressure. When both intervention periods were combined, reductions in plasma CEC were negatively correlated with reductions in plasma MDA (Spearman r = −0.267; p = 0.027).</div></div><div><h3>Conclusion</h3><div>Short-term supplementation with dried ginger powder enhanced ex vivo plasma CEC. In addition, ginger supplementation improved the antioxidant response following an oxidant challenge. These findings suggest that ginger may promote reverse cholesterol transport and enhance resistance to oxidative stress, two mechanisms that are critically involved in the prevention of atherosclerotic cardiovascular disease.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"64 ","pages":"Article 102074"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and safety of different acupuncture therapies for insomnia in breast cancer patients: A systematic review and Bayesian network meta-analysis","authors":"Zhongli Wang ,&nbsp;Haoyu Yang ,&nbsp;Zhihui Zhou ,&nbsp;Xiaowu Liu ,&nbsp;Jianbang Su ,&nbsp;Hao Jiang ,&nbsp;Jiahui Lin ,&nbsp;Hongge Zuo ,&nbsp;Gaofeng Liu ,&nbsp;Yuan Yuan ,&nbsp;Ying Bai ,&nbsp;Yiqi Li ,&nbsp;Tao Wang ,&nbsp;Zhenhua Xu","doi":"10.1016/j.ctcp.2026.102059","DOIUrl":"10.1016/j.ctcp.2026.102059","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Insomnia is a prevalent symptom among breast cancer patients. This study aimed to compare and rank the efficacy and safety of various acupuncture and related therapies for improving sleep quality in this population.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, and Chinese Science and Technology Periodical Database (VIP) from inception to January 25, 2025. Effect sizes were calculated as relative risks (RRs) for dichotomous outcomes and mean differences (MDs) for continuous outcomes, with 95% credible intervals (CrIs). The study quality was assessed using the RoB 2 tool, and confidence in evidence was evaluated with Confidence in Network Meta-Analysis (CINeMA).</div></div><div><h3>Results</h3><div>Eighteen randomized controlled trials involving 1399 participants were included. Compared to control, auricular acupressure (AP), mindfulness-based stress reduction (MBSR), MBSR plus acupressure, acupressure alone, intradermal needle (IN), and AP combined with wrist-ankle acupuncture (WAA) all significantly improved Pittsburgh Sleep Quality Index (PSQI) scores. The MD ranged from −5.04 (95% CrI: −8.07 to −1.95) for MBSR plus acupressure to −2.34 (95% CrI: −4.34 to −0.35) for IN. Based on the surface under the cumulative ranking curve (SUCRA), MBSR plus acupressure was the most effective intervention. Regarding safety, only IN (RR: 11.23, 95% CrI: 1.95 to 80.48) significantly increased the incidence of adverse reactions compared to control.</div></div><div><h3>Conclusion</h3><div>MBSR plus acupressure, acupressure alone, AP combined with WAA, AP alone, and MBSR alone effectively improved sleep quality in breast cancer patients and were relatively safe.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"63 ","pages":"Article 102059"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148000887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of traditional Chinese exercises in low back pain: a systematic review and network meta-analysis","authors":"Guangyu Xu ,&nbsp;Mingxu Zhang ,&nbsp;Zhixiang Hao ,&nbsp;Yongna Chen ,&nbsp;Shaohong Yu ,&nbsp;Qian Zhang ,&nbsp;Qing Xue ,&nbsp;Yi Ren ,&nbsp;Jinxia Pei ,&nbsp;Zhengang Qiu","doi":"10.1016/j.ctcp.2026.102058","DOIUrl":"10.1016/j.ctcp.2026.102058","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Low back pain (LBP) is becoming increasingly common and has a significant negative impact on the physical and mental health of patients. A certain number of studies have been conducted on traditional Chinese exercises (TCEs) to treat LBP. However, the optimal treatment remains uncertain. The aim of this study was to systematically review the literature and perform a network meta-analysis (NMA) to compare the efficacy of different TCE and combination therapies for clinical practice.</div></div><div><h3>Methods</h3><div>We systematically searched 8 databases from inception to February 2025 for randomised controlled trials (RCTs) of TCE for LBP. The risk of bias was evaluated using the RoB 2.0 tool, and the overall quality of evidence was assessed using the GRADE approach. NMA was conducted using Bayesian theory-based R 4.5.1 and STATA 16.0 software, focusing on pain and dysfunction. In addition, we critically reviewed the methodological limitations and potential bias of the included studies.</div></div><div><h3>Results</h3><div>This NMA included 38 eligible studies involving 2944 patients and 10 interventions: four standalone TCEs, four TCE combined with conventional treatment (CT), CT alone, and no intervention. Key findings indicated that: (a) wuqinxi was most effective for pain reduction [Visual Analogue Scale (VAS)]; (b) yijinjing + CT, taiji + CT, and yijinjing alone showed superior improvement in dysfunction [Oswestry Disability Index (ODI)/Japanese Orthopaedic Association (JOA)/Roland-Morris Disability Questionnaire (RMDQ)]; (c) yijinjing optimized lumbar flexion and extension range of motion (ROM), while baduanjin + CT enhanced lateral flexion ROM; and (d) taiji + CT achieved the highest total effective rate.</div></div><div><h3>Conclusion</h3><div>TCEs and their combinations with CT may effectively improve pain, dysfunction, joint movement and overall efficacy in LBP. Wuqinxi, yijinjing + CT, taiji + CT, baduanjin + CT and yijinjing appear to be the most beneficial interventions. However, this study has limitations including notable heterogeneity and potential publication bias across some included studies. High-quality RCTs with standardized protocols and long-term follow-up are needed to validate these results and address clinical uncertainty.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"63 ","pages":"Article 102058"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148000886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of complementary interventions on pain and disability in patients with chronic non-cancer pain: A network meta-analysis","authors":"Yuxing Zhang ,&nbsp;Yusheng Zhao ,&nbsp;Yupei Cheng ,&nbsp;Longxiao Liu ,&nbsp;Zihe Wang ,&nbsp;Bangqi Wu","doi":"10.1016/j.ctcp.2026.102060","DOIUrl":"10.1016/j.ctcp.2026.102060","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Chronic non-cancer pain (CNCP) imposes a substantial burden on individuals and healthcare systems worldwide. Limitations and risks of long-term pharmacological treatment have increased interest in complementary therapies; however, the lack of direct comparisons limits evidence-based decision-making. Therefore, this study aimed to compare complementary therapies for pain and disability using a network meta-analysis.</div></div><div><h3>Methods</h3><div>A network meta-analysis of randomized controlled trials was reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Network Meta-Analyses (PRISMA-NMA) guidelines. Four databases were searched from inception to December 2024, with an update in May 2025. Two reviewers independently performed study selection, data extraction, and risk-of-bias assessment. A Bayesian random-effects network meta-analysis was performed. Treatment rankings were evaluated using the surface under the cumulative ranking curve (SUCRA), and inconsistency and publication bias were assessed.</div></div><div><h3>Results</h3><div>Thirty-three randomized controlled trials involving 6196 participants were included. Dry needling ranked highest for pain and disability, but the evidence quality was very low because of substantial heterogeneity. Cognitive behavioral therapy and acupuncture showed moderate-quality evidence and consistent improvements in both outcomes versus wait control. Safety reporting was inconsistent, and reported adverse events were mostly mild and transient.</div></div><div><h3>Conclusion</h3><div>Cognitive behavioral therapy and acupuncture appear to be reliable options for improving pain and disability in chronic non-cancer pain, supported by moderate-quality evidence. Dry needling may provide short-term benefits but should be interpreted cautiously because of low certainty.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"63 ","pages":"Article 102060"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148000883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acupoint catgut embedding therapy on polycystic ovary syndrome: a systematic review and meta-analysis","authors":"Shiyi Xie ,&nbsp;Ye Huang ,&nbsp;Ziyan Wang ,&nbsp;Da Lei ,&nbsp;Yubing Xia ,&nbsp;Huajie Huang ,&nbsp;Fangying Hu ,&nbsp;Qiaoying Yao","doi":"10.1016/j.ctcp.2026.102056","DOIUrl":"10.1016/j.ctcp.2026.102056","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with limited optimal therapies. Acupoint catgut embedding (ACE) is widely used for PCOS, but evidence remains fragmented. This systematic review and meta-analysis aimed to: (1) evaluate the efficacy and safety of ACE in terms of overall efficacy rate, pregnancy rates, and insulin resistance (IR); (2) explore whether treatment effects vary by diagnostic criteria; and (3) assess evidence certainty using the Grading of Recommendations, Assessment, Development and Evaluation framework to inform standardized protocols.</div></div><div><h3>Methods</h3><div>Randomized controlled trials (RCTs) evaluating the efficacy and safety of ACE for PCOS were systematically retrieved from eight databases until September 1, 2024. Two investigators independently conducted study screening, data extraction, and risk-of-bias assessment. Meta-analyses were performed via Review Manager 5.4 and Stata 15.0.</div></div><div><h3>Results</h3><div>Included were 77 RCTs on 5945 patients. ACE significantly improved overall treatment effectiveness (risk ratio [RR] = 1.24, 95% confidence interval [CI]: 1.20 to 1.28, P &lt; 0.00001), increased pregnancy rates (RR = 1.65, 95% CI: 1.49 to 1.82, P &lt; 0.00001), and reduced insulin resistance (mean difference [MD] = −0.38, 95% CI: −0.53 to −0.23, P &lt; 0.00001). Adverse events (AEs) with ACE were mainly mild (e.g., bruising, transient pain), with significantly lower incidence than pharmacotherapy (RR = 0.57, 95% CI: 0.36 to 0.91, P = 0.02).</div></div><div><h3>Conclusion</h3><div>ACE may improve symptoms, pregnancy outcomes, and insulin sensitivity in PCOS patients with only mild adverse events. However, these findings should be interpreted with caution, given study limitations. Further RCTs are warranted to establish standardized protocols and identify optimal patient subgroups to verify the efficacy of ACE.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"63 ","pages":"Article 102056"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of traditional vs. emerging rehabilitation exercises in enhancing daily living activities and lower extremity function among stroke survivors: A network meta-analysis","authors":"Zhenhui Zhao,&nbsp;Chao Ma,&nbsp;Xianliang Wang","doi":"10.1016/j.ctcp.2026.102061","DOIUrl":"10.1016/j.ctcp.2026.102061","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Post-stroke lower limb motor dysfunction significantly impairs activities of daily living (ADL). The present study provides a comparative analysis of various exercise interventions to determine their relative effectiveness in improving lower extremity function and ADL post-stroke.</div></div><div><h3>Methods</h3><div>We systematically searched six databases for randomized controlled trials published from database inception through December 2024. After quality assessment, a network meta-analysis was conducted to evaluate comparative efficacy, with intervention hierarchies ranked using the surface under the cumulative ranking curve (SUCRA).</div></div><div><h3>Results</h3><div>A total of 12,326 studies were identified, among which 54 randomized controlled trials involving 2104 stroke survivors met inclusion criteria. The key findings revealed distinct optimal interventions for each functional domain. Motor imagery therapy was identified as the most effective approach for lower limb function (SUCRA = 92.5%). For ADL, aquatic exercise showed the highest probability of being the most beneficial intervention (SUCRA = 70.9%). Finally, mirror therapy demonstrated superior efficacy for both balance (SUCRA = 92.8%) and walking endurance (SUCRA = 92.1%).</div></div><div><h3>Conclusion</h3><div>Multiple exercise interventions demonstrate clinically meaningful benefits for post-stroke lower limb function and ADL performance. Motor imagery therapy may represent the optimal exercise modality for improving lower limb function, while aquatic exercise appears to be the most promising intervention for enhancing ADL. Mirror therapy demonstrated superior efficacy in improving both balance and gait function. These findings provide evidence-based guidance for personalized neurorehabilitation protocols.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"63 ","pages":"Article 102061"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148000884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese patent medicine in the treatment of Parkinson's disease: A systematic review and network meta-analysis","authors":"Xiongying Huang ,&nbsp;Qilai Cheng ,&nbsp;Yuan Xie ,&nbsp;Yufen Jiang ,&nbsp;Yi Yu ,&nbsp;Yingchen Li","doi":"10.1016/j.ctcp.2025.102042","DOIUrl":"10.1016/j.ctcp.2025.102042","url":null,"abstract":"<div><h3>Background and purpose</h3><div>The growing prevalence of Parkinson's disease (PD) drives the need for better therapies. Chinese patent medicines (CPMs) can complement conventional western medicine (CWM) in treating PD, but their variety complicates clinical choices. This study systematically ranks CPMs combined with CWM to guide treatment decisions.</div></div><div><h3>Methods</h3><div>We systematically searched for randomized controlled trials (RCTs) of CPM for the treatment of PD in China National Knowledge Infrastructure (CNKI), Wanfang Database, China Weipu Science and Technology Journal Database (VIP), Chinese Biomedical Literature Database (CBM), PubMed, Embase, Web of Science, and Cochrane Library from the establishment of the database to January 2nd, 2025. R 4.4.2 and Stata 14.0 software were used for data analysis<strong>.</strong></div></div><div><h3>Results</h3><div>We analyzed 35 RCTs comprising 3281 patients and 11 CPMs. Among the CPMs evaluated, Bushen Huoxue capsules (BSHX) showed higher total effective rates, while Tianma Gouteng granules (TMGT) led in reducing Unified Parkinson's Disease Rating Scale (UPDRS) total scores and improving Mini-Mental State Examination (MMSE) performance. Zishen Pingchan granules (ZSPC) were most effective in improving the Parkinson's Disease Sleep Scale (PDSS) score. Qishen Huanwu capsules (QSHW) excelled in reducing cystatin C (Cys-C) and homocysteine (Hcy). Xifeng Dingchan pills (XFDC) maximized superoxide dismutase (SOD) activity, and Tiandan Tongluo capsules (TDTL) lowered malondialdehyde (MDA) levels.</div></div><div><h3>Conclusion</h3><div>This study demonstrated the efficacy of combining CPMs with CWM for PD, identifying QSHW and TMGT as the optimal CPMs. QSHW markedly reduced Hcy and Cys-C levels, and TMGT improved MMSE and UPDRS scores. However, their personalized application necessitates validation in large-scale RCTs.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"62 ","pages":"Article 102042"},"PeriodicalIF":3.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}