Current Osteoporosis Reports最新文献_第9页

In Vivo Assessment of Bone Quality Without X-rays. 无需 X 射线的体内骨骼质量评估

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-02-01 Epub Date: 2024-01-16 DOI: 10.1007/s11914-023-00856-w

Rachel K Surowiec, Mark D Does, Jeffry S Nyman

{"title":"In Vivo Assessment of Bone Quality Without X-rays.","authors":"Rachel K Surowiec, Mark D Does, Jeffry S Nyman","doi":"10.1007/s11914-023-00856-w","DOIUrl":"10.1007/s11914-023-00856-w","url":null,"abstract":"Purpose of review: This review summarizes recent advances in the assessment of bone quality using non-X-ray techniques.Recent findings: Quantitative ultrasound (QUS) provides multiple measurements of bone characteristics based on the propagation of sound through bone, the attenuation of that sound, and different processing techniques. QUS parameters and model predictions based on backscattered signals can discriminate non-fracture from fracture cases with accuracy comparable to standard bone mineral density (BMD). With advances in magnetic resonance imaging (MRI), bound water and pore water, or a porosity index, can be quantified in several long bones in vivo. Since such imaging-derived measurements correlate with the fracture resistance of bone, they potentially provide new BMD-independent predictors of fracture risk. While numerous measurements of mineral, organic matrix, and bound water by Raman spectroscopy correlate with the strength and toughness of cortical bone, the clinical assessment of person's bone quality using spatially offset Raman spectroscopy (SORS) requires advanced spectral processing techniques that minimize contaminating signals from fat, skin, and blood. Limiting exposure of patients to ionizing radiation, QUS, MRI, and SORS has the potential to improve the assessment of fracture risk and track changes of new therapies that target bone matrix and micro-structure.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"56-68"},"PeriodicalIF":4.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11050740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Life Management of Osteogenesis Imperfecta. 成骨不全的早期生命管理。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-09-26 DOI: 10.1007/s11914-023-00823-5

Paul Arundel, Stephanie A Borg

{"title":"Early Life Management of Osteogenesis Imperfecta.","authors":"Paul Arundel, Stephanie A Borg","doi":"10.1007/s11914-023-00823-5","DOIUrl":"10.1007/s11914-023-00823-5","url":null,"abstract":"Purpose of review: This review aims to provide a review of the multidisciplinary management of infants with osteogenesis imperfecta (OI) during the first year of life, focusing on those with severe disease. The authors draw on published literature and direct experience of working in a large paediatric centre specialising in the management of rare bone disease.Recent findings: Whilst understanding of the pathophysiology of OI has grown over the past decade, the evidence base for management of infants remains limited. There has been a greater recognition of certain subjects of concern including pain management, cervical spine deformity, and neurocognitive development. Both international consensus guidelines on rehabilitation and disease-specific growth charts have been welcomed by clinical teams. The early involvement of multidisciplinary specialist care is critical in ensuring optimal care for the infant with severe OI. A long-term perspective which focuses on the axial, craniofacial, and peripheral skeleton as well as on development more generally provides a framework which can guide the management of infants with severe OI.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"779-786"},"PeriodicalIF":4.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Origin and Fate of Chondrocytes: Cell Plasticity in Physiological Setting. 软骨细胞的起源和命运：生理环境中的细胞可塑性。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-10-14 DOI: 10.1007/s11914-023-00827-1

Andrei S Chagin, Tsz Long Chu

{"title":"The Origin and Fate of Chondrocytes: Cell Plasticity in Physiological Setting.","authors":"Andrei S Chagin, Tsz Long Chu","doi":"10.1007/s11914-023-00827-1","DOIUrl":"10.1007/s11914-023-00827-1","url":null,"abstract":"Purpose of review: Here, we discuss the origin of chondrocytes, their destiny, and their plasticity in relationship to bone growth, articulation, and formation of the trabeculae. We also consider these processes from a biological, clinical, and evolutionary perspective.Recent findings: Chondrocytes, which provide the template for the formation of most bones, are responsible for skeletal growth and articulation during postnatal life. In recent years our understanding of the fate of these cells has changed dramatically. Current evidence indicates a paradoxical situation during skeletogenesis, with some cells of mesenchymal condensation differentiating directly into osteoblasts, whereas others of the same kind give rise to highly similar osteoblasts via a complex process of differentiation involving several chondrocyte intermediates. The situation becomes even more paradoxical during postnatal growth when stem cells in the growth plate produce differentiated, functional progenies, which thereafter presumably dedifferentiate into another type of stem cell. Such a remarkable transition from one cell type to another under postnatal physiological conditions provides a fascinating example of cellular plasticity that may have valuable clinical implications.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"815-824"},"PeriodicalIF":4.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41216811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease. 微穿孔：衰老和疾病中的骨细胞腔隙矿化。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-11-02 DOI: 10.1007/s11914-023-00832-4

Petar Milovanovic, Björn Busse

{"title":"Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease.","authors":"Petar Milovanovic, Björn Busse","doi":"10.1007/s11914-023-00832-4","DOIUrl":"10.1007/s11914-023-00832-4","url":null,"abstract":"Purpose of review: As the importance of osteocytes for bone mineral homeostasis is increasingly recognized, there is growing interest in osteocyte cell death as a relevant indicator in various physiological and pathological conditions. Micropetrosis is an established term used to describe osteocyte lacunae that are filled with minerals following osteocyte death. While the early reports of micropetrosis were purely descriptive, there is now an increasing body of literature showing quantitative data on micropetrosis in various conditions such as aging, osteoporosis, immobilization, and diabetes, and in osteoporosis treatment (denosumab and bisphosphonates). This review summarizes quantitative findings on micropetrosis, with a particular emphasis on the recent advances in the field.Recent findings: There is growing evidence that micropetrosis is more common in older, osteoporotic, and immobilized individuals, as well as in individuals with type 1 or type 2 diabetes. Denosumab and bisphosphonates seem to affect lacunar mineralization differently, where specifically bisphosphonates have been shown to prolong osteocyte viability and reduce micropetrosis. Despite continuous proceedings in the field of osteocyte-lacunar-network characteristics, more studies are necessary to further clarify the mechanisms of lacunar mineralization, the inter-site variability of micropetrosis accumulation, the relevance of micropetrosis in various diseases and conditions, and whether micropetrosis could be an indicator of bone fragility or a target for treatment.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"750-757"},"PeriodicalIF":4.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts. 二甲双胍对骨细胞、成骨细胞和破骨细胞的差异作用。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-10-05 DOI: 10.1007/s11914-023-00828-0

Teun J de Vries, Antonella S Kleemann, Jianfeng Jin, Ton Schoenmaker

{"title":"The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts.","authors":"Teun J de Vries, Antonella S Kleemann, Jianfeng Jin, Ton Schoenmaker","doi":"10.1007/s11914-023-00828-0","DOIUrl":"10.1007/s11914-023-00828-0","url":null,"abstract":"Purpose of review: Metformin is an anti-glycemic agent, which is widely prescribed to diabetes patients. Although its alleged role on bone strength has been reported for some time, this review focuses primarily on the recent mechanistical insights of metformin on osteocytes, osteoblasts, and osteoclasts.Recent findings: Overall, metformin contributed to steering anabolic activity in osteocytes. It caused lower expression in osteocytes of the negative regulators of bone formation sclerostin and DKK1. Likewise, the osteoclastogenesis function of osteoblasts was also skewed towards lower RANKL and higher OPG expressions. Osteoblast lineage cells generally responded to metformin by activating bone formation parameters, such as alkaline phosphatase activity, higher expression of anabolic members of the Wnt pathway, transcription factor Runx2, bone matrix protein proteins, and subsequent mineralization. Metformin affected osteoclast formation and activity in a negative way, reducing the number of multinucleated cells in association with lower expression of typical osteoclast markers and with inhibited resorption. A common denominator studied in all three cell types is its beneficial effect on activating phosphorylated AMP kinase (AMPK) which is associated with the coordination of energy metabolism. Metformin differentially affects bone cells, shifting the balance to more bone formation. Although metformin is a drug prescribed for diabetic patients, the overall bone anabolic effects on osteocytes and osteoblasts and the anti-catabolic effect on osteoclast suggest that metformin could be seen as a promising drug in the bone field.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"743-749"},"PeriodicalIF":4.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41121067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Insights into Osteoclast Energy Metabolism. 破骨细胞能量代谢的新见解。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-10-10 DOI: 10.1007/s11914-023-00825-3

Maria G Ledesma-Colunga, Vanessa Passin, Franziska Lademann, Lorenz C Hofbauer, Martina Rauner

{"title":"Novel Insights into Osteoclast Energy Metabolism.","authors":"Maria G Ledesma-Colunga, Vanessa Passin, Franziska Lademann, Lorenz C Hofbauer, Martina Rauner","doi":"10.1007/s11914-023-00825-3","DOIUrl":"10.1007/s11914-023-00825-3","url":null,"abstract":"Purpose of review: Osteoclasts are crucial for the dynamic remodeling of bone as they resorb old and damaged bone, making space for new bone. Metabolic reprogramming in these cells not only supports phenotypic changes, but also provides the necessary energy for their highly energy-consuming activity, bone resorption. In this review, we highlight recent developments in our understanding of the metabolic adaptations that influence osteoclast behavior and the overall remodeling of bone tissue.Recent findings: Osteoclasts undergo metabolic reprogramming to meet the energy demands during their transition from precursor cells to fully mature bone-resorbing osteoclasts. Recent research has made considerable progress in pinpointing crucial metabolic adaptations and checkpoint proteins in this process. Notably, glucose metabolism, mitochondrial biogenesis, and oxidative respiration were identified as essential pathways involved in osteoclast differentiation, cytoskeletal organization, and resorptive activity. Furthermore, the interaction between these pathways and amino acid and lipid metabolism adds to the complexity of the process. These interconnected processes can function as diverse fuel sources or have independent regulatory effects, significantly influencing osteoclast function. Energy metabolism in osteoclasts involves various substrates and pathways to meet the energetic requirements of osteoclasts throughout their maturation stages. This understanding of osteoclast biology may provide valuable insights for modulating osteoclast activity during the pathogenesis of bone-related disorders and may pave the way for the development of innovative therapeutic strategies.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"660-669"},"PeriodicalIF":4.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41216810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial/Ethnic Differences in Bone Mineral Density for Osteoporosis. 骨质疏松症患者骨密度的种族差异。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-11-29 DOI: 10.1007/s11914-023-00838-y

Qing Wu, Jingyuan Dai

{"title":"Racial/Ethnic Differences in Bone Mineral Density for Osteoporosis.","authors":"Qing Wu, Jingyuan Dai","doi":"10.1007/s11914-023-00838-y","DOIUrl":"10.1007/s11914-023-00838-y","url":null,"abstract":"Purpose of review: We primarily aim to review differences in bone mineral density (BMD) for osteoporosis among different racial/ethnic groups and to highlight the magnitude of racial/ethnic differences in obesity and diabetes. We also explore the factors contributing to the BMD differences among various subgroups. In addition, we investigate the existing disparities in research, educational initiatives, screening practices, and treatment options for osteoporosis and discuss these findings' clinical and public health implications.Recent findings: Racial/ethnic differences in BMD for osteoporosis exist in the USA and other countries. There are disparities regarding osteoporosis screening and treatment. Understanding the factors contributing to these differences can help develop targeted interventions and policies to reduce their impact. Clinicians should consider the racial/ethnic differences in BMD when making treatment decisions and providing preventive care. Future research could contribute to developing effective strategies for preventing osteoporosis among different racial/ethnic groups. This review offered a comprehensive examination of differences in BMD across various racial and ethnic groups, elucidating the influence of genetic, lifestyle, and cultural factors on these differences. This review also highlighted the disparities in osteoporosis screening, treatment options, research on medical effectiveness, and educational outreach tailored to each subgroup. Recognizing the importance of addressing these inequalities, we present this review to advocate for targeted interventions to reduce disparities in osteoporosis and improve bone health for all populations.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"670-684"},"PeriodicalIF":4.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory Processes Affecting Bone Health and Repair. 影响骨骼健康和修复的炎症过程。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-09-28 DOI: 10.1007/s11914-023-00824-4

Haydee M Torres, Katherine M Arnold, Manuela Oviedo, Jennifer J Westendorf, Samantha R Weaver

{"title":"Inflammatory Processes Affecting Bone Health and Repair.","authors":"Haydee M Torres, Katherine M Arnold, Manuela Oviedo, Jennifer J Westendorf, Samantha R Weaver","doi":"10.1007/s11914-023-00824-4","DOIUrl":"10.1007/s11914-023-00824-4","url":null,"abstract":"Purpose of review: The purpose of this article is to review the current understanding of inflammatory processes on bone, including direct impacts of inflammatory factors on bone cells, the effect of senescence on inflamed bone, and the critical role of inflammation in bone pain and healing.Recent findings: Advances in osteoimmunology have provided new perspectives on inflammatory bone loss in recent years. Characterization of so-called inflammatory osteoclasts has revealed insights into physiological and pathological bone loss. The identification of inflammation-associated senescent markers in bone cells indicates that therapies that reduce senescent cell burden may reverse bone loss caused by inflammatory processes. Finally, novel studies have refined the role of inflammation in bone healing, including cross talk between nerves and bone cells. Except for the initial stages of fracture healing, inflammation has predominately negative effects on bone and increases fracture risk. Eliminating senescent cells, priming the osteo-immune axis in bone cells, and alleviating pro-inflammatory cytokine burden may ameliorate the negative effects of inflammation on bone.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"842-853"},"PeriodicalIF":4.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical Imaging. 使用高级医学成像表征与骨骼脆弱性相关的骨表型。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-10-26 DOI: 10.1007/s11914-023-00830-6

Danielle E Whittier, Melissa S A M Bevers, Piet P M M Geusens, Joop P van den Bergh, Leigh Gabel

{"title":"Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical Imaging.","authors":"Danielle E Whittier, Melissa S A M Bevers, Piet P M M Geusens, Joop P van den Bergh, Leigh Gabel","doi":"10.1007/s11914-023-00830-6","DOIUrl":"10.1007/s11914-023-00830-6","url":null,"abstract":"Purpose of review: Summarize the recent literature that investigates how advanced medical imaging has contributed to our understanding of skeletal phenotypes and fracture risk across the lifespan.Recent findings: Characterization of bone phenotypes on the macro-scale using advanced imaging has shown that while wide bones are generally stronger than narrow bones, they may be more susceptible to age-related declines in bone strength. On the micro-scale, HR-pQCT has been used to identify bone microarchitecture phenotypes that improve stratification of fracture risk based on phenotype-specific risk factors. Adolescence is a key phase for bone development, with distinct sex-specific growth patterns and significant within-sex bone property variability. However, longitudinal studies are needed to evaluate how early skeletal growth impacts adult bone phenotypes and fracture risk. Metabolic and rare bone diseases amplify fracture risk, but the interplay between bone phenotypes and disease remains unclear. Although bone phenotyping is a promising approach to improve fracture risk assessment, the clinical availability of advanced imaging is still limited. Consequently, alternative strategies for assessing and managing fracture risk include vertebral fracture assessment from clinically available medical imaging modalities/techniques or from fracture risk assessment tools based on clinical risk factors. Bone fragility is not solely determined by its density but by a combination of bone geometry, distribution of bone mass, microarchitecture, and the intrinsic material properties of bone tissue. As such, different individuals can exhibit distinct bone phenotypes, which may predispose them to be more vulnerable or resilient to certain perturbations that influence bone strength.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"685-697"},"PeriodicalIF":4.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54231790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Material Properties in Bone Diseases Affecting Children. 儿童骨病的骨材料特性。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-10-28 DOI: 10.1007/s11914-023-00822-6

Adalbert Raimann, Barbara M Misof, Peter Fratzl, Nadja Fratzl-Zelman

{"title":"Bone Material Properties in Bone Diseases Affecting Children.","authors":"Adalbert Raimann, Barbara M Misof, Peter Fratzl, Nadja Fratzl-Zelman","doi":"10.1007/s11914-023-00822-6","DOIUrl":"10.1007/s11914-023-00822-6","url":null,"abstract":"Purpose of review: Metabolic and genetic bone disorders affect not only bone mass but often also the bone material, including degree of mineralization, matrix organization, and lacunar porosity. The quality of juvenile bone is moreover highly influenced by skeletal growth. This review aims to provide a compact summary of the present knowledge on the complex interplay between bone modeling and remodeling during skeletal growth and to alert the reader to the complexity of bone tissue characteristics in children with bone disorders.Recent findings: We describe cellular events together with the characteristics of the different tissues and organic matrix organization (cartilage, woven and lamellar bone) occurring during linear growth. Subsequently, we present typical alterations thereof in disorders leading to over-mineralized bone matrix compared to those associated with low or normal mineral content based on bone biopsy studies. Growth spurts or growth retardation might amplify or mask disease-related alterations in bone material, which makes the interpretation of bone tissue findings in children complex and challenging.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":" ","pages":"787-805"},"PeriodicalIF":4.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0