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Jaapa-Journal of the American Academy of Physician Assistants最新文献

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The evaluation of leukocytosis. 白细胞增多的评价。
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000298
Clay W Walker, Thomas Hartman, Manuel Pompa
{"title":"The evaluation of leukocytosis.","authors":"Clay W Walker, Thomas Hartman, Manuel Pompa","doi":"10.1097/01.JAA.0000000000000298","DOIUrl":"10.1097/01.JAA.0000000000000298","url":null,"abstract":"<p><strong>Abstract: </strong>Leukocytosis, defined as an elevated white blood cell count, is a frequently encountered laboratory finding with a broad differential diagnosis ranging from transient reactive processes to life-threatening hematologic malignancies. Distinct patterns of elevation can provide valuable diagnostic clues that narrow the differential diagnosis and guide next steps. This article outlines a systematic approach to evaluating leukocytosis, emphasizing integration of clinical history, physical examination, and laboratory data. The discussion highlights both nonmalignant and malignant causes, including acute and chronic leukemias, lymphomas, and myeloproliferative disorders, and offers guidance on when to pursue advanced diagnostics. Finally, a practical evaluation algorithm is included to support clinical decision-making. By recognizing key clinical features, laboratory patterns, and risk factors associated with malignancy, clinicians can appropriately triage patients for specialist referral and ensure timely intervention.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":" ","pages":"26-32"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physician associates: A modern evolution, 1965-2035. 医师协会：现代演变，1965-2035。
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000297
Jennifer M Kolb
{"title":"Physician associates: A modern evolution, 1965-2035.","authors":"Jennifer M Kolb","doi":"10.1097/01.JAA.0000000000000297","DOIUrl":"10.1097/01.JAA.0000000000000297","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":" ","pages":"14-15"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What PAs should know regarding the Surgeon General's advisory on social media use in children and adolescents. 关于卫生局局长关于儿童和青少年使用社交媒体的建议，私人助理应该知道什么？
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000278
Crystal Powell, Tarah Trokey, Katelyn Maben
{"title":"What PAs should know regarding the Surgeon General's advisory on social media use in children and adolescents.","authors":"Crystal Powell, Tarah Trokey, Katelyn Maben","doi":"10.1097/01.JAA.0000000000000278","DOIUrl":"10.1097/01.JAA.0000000000000278","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":" ","pages":"16-17"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Removing barriers to tecovirimat treatment for individuals infected with mpox via a novel care delivery model. 通过一种新的护理交付模式消除对感染m痘的个体进行替克韦司治疗的障碍。
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000289
Michael Eamonn McCarthy, Joseph Glowacki, Rostislav Livinsky, Daniel Taupin, Dagan Coppock
{"title":"Removing barriers to tecovirimat treatment for individuals infected with mpox via a novel care delivery model.","authors":"Michael Eamonn McCarthy, Joseph Glowacki, Rostislav Livinsky, Daniel Taupin, Dagan Coppock","doi":"10.1097/01.JAA.0000000000000289","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000289","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzed the care delivery of a new clinic model designed to provide access to an investigational new drug (IND) during the 2022 mpox outbreak at a single academic quaternary care center.</p><p><strong>Methods: </strong>A dedicated tecovirimat referral clinic was created and staffed by a physician associate (PA) trained in IND protocol. The PA assessed patients via telemedicine, managed IND paperwork, prescribed tecovirimat and arranged for its home delivery, and monitored drug tolerance.</p><p><strong>Results: </strong>Of 35 patients referred to the clinic, 17 received tecovirimat. Mean time from clinic referral to first mpox provider visit was 1.03 days (SD = 1.90) and from first mpox provider visit to tecovirimat receipt was 0.22 days (SD = 0.43). Time before referral was notably longer, with a mean of 9.37 days (SD = 4.81) between symptom onset and referral.</p><p><strong>Conclusions: </strong>This clinic provided timely, efficient, specialized care for patients with suspected infection despite the practical barriers of IND protocol.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 1","pages":"e5-e8"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aprocitentan, an endothelin receptor antagonist for resistant hypertension. 抗高血压的内皮素受体拮抗剂阿普昔坦。
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000294
Emily Weidman-Evans, Lindsay Ferrington
{"title":"Aprocitentan, an endothelin receptor antagonist for resistant hypertension.","authors":"Emily Weidman-Evans, Lindsay Ferrington","doi":"10.1097/01.JAA.0000000000000294","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000294","url":null,"abstract":"<p><strong>Abstract: </strong>Resistant hypertension (RH) is defined as blood pressure (BP) that remains uncontrolled with use of three or more antihypertensive medications or BP that is controlled with use of four antihypertensive medications. Aprocitentan is a newly approved drug for RH, offering a mechanism unique from currently available antihypertensive drugs. It serves to block endothelin-A and endothelin-B to reduce vasoconstriction. The drug, which is taken once daily, has been shown to yield sustainable reductions in BP across various settings, and it may be especially beneficial for those with chronic kidney disease. Risks with use include fluid retention, anemia, mild hepatic enzyme elevations, and-though less common than with other endothelin antagonists-hepatotoxicity. Aprocitentan is contraindicated in pregnancy, as it includes a boxed warning for embryo-fetal toxicity. Although this new drug expands available options for RH, it requires careful patient selection and monitoring. Finally, cost and insurance coverage may limit access.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 1","pages":"18-20"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening and management of metabolic dysfunction-associated steatotic liver disease (MASLD). 代谢功能障碍相关脂肪变性肝病（MASLD）的筛查和管理
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000296
Anne Geary
{"title":"Screening and management of metabolic dysfunction-associated steatotic liver disease (MASLD).","authors":"Anne Geary","doi":"10.1097/01.JAA.0000000000000296","DOIUrl":"10.1097/01.JAA.0000000000000296","url":null,"abstract":"<p><strong>Abstract: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is an increasingly prevalent condition that poses significant public health challenges. Affecting nearly 30% of the global population, MASLD is intricately linked to metabolic syndrome, insulin resistance, and cardiovascular disease. Primary care providers, including physician associates (PAs), play a critical role in early detection and management. This article provides an updated overview of MASLD for primary care PAs, focusing on disease pathophysiology, risk stratification, and screening recommendations. The use of noninvasive testing (eg, FIB-4, liver stiffness measurement) for diagnosis and monitoring is emphasized, and lifestyle interventions are underscored as first-line therapy. Importantly, the article highlights the recent FDA approval of resmetirom-the first pharmacologic treatment for noncirrhotic metabolic-associated steatohepatitis (MASH) with moderate to advanced fibrosis-and outlines the AASLD guideline supporting its use without the need for liver biopsy. By equipping primary care physician associates with current knowledge and practical tools, this article aims to improve early identification, guide appropriate referral, and enhance outcomes for patients at risk for MASLD progression. It also provides guidance around use of resmetirom in primary care, reviewing the drug's indications, dosing, drug-drug interactions, and safety monitoring. Finally, it highlights semaglutide as an emerging treatment option for noncirrhotic MASH.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":" ","pages":"21-25"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tea, towels, and time. 茶，毛巾，还有时间。
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000290
Laura A Katers
{"title":"Tea, towels, and time.","authors":"Laura A Katers","doi":"10.1097/01.JAA.0000000000000290","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000290","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 1","pages":"50"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ingestion of sulfuric (battery) acid. 摄入硫酸（电池）酸。
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000272
Matthew Letizia, Mae De La Calzada-Jeanlouie, Maeve Maloney, Medea Y Valdez
{"title":"Ingestion of sulfuric (battery) acid.","authors":"Matthew Letizia, Mae De La Calzada-Jeanlouie, Maeve Maloney, Medea Y Valdez","doi":"10.1097/01.JAA.0000000000000272","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000272","url":null,"abstract":"<p><strong>Abstract: </strong>The intentional ingestion of caustic acidic or alkaline substances in adults is most commonly related to prior psychological history and suicidal ideation. Caustic ingestions are a medical emergency and are usually more life-threatening in adults than accidental ingestions in children. The degree of injury is determined by the physical state of the substance, its concentration, the amount ingested, and the duration of exposure to gastric mucosa. This case report describes the evaluation and management of a 36-year-old man with an intentional ingestion of sulfuric (battery) acid.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 1","pages":"34-37"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is causing this patient's severe cramping and heavy bleeding after IUD insertion? 是什么原因导致该患者在植入宫内节育器后出现严重痉挛和大出血？
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000295
Alannah Zheng, Brittany Strelow
{"title":"What is causing this patient's severe cramping and heavy bleeding after IUD insertion?","authors":"Alannah Zheng, Brittany Strelow","doi":"10.1097/01.JAA.0000000000000295","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000295","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 1","pages":"47-49"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19. 新型冠状病毒肺炎。
IF 0.8 4区 医学
Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2026-01-01 Epub Date: 2025-12-23 DOI: 10.1097/01.JAA.0000000000000293
Dylan Jue, Jamie Adler
{"title":"COVID-19.","authors":"Dylan Jue, Jamie Adler","doi":"10.1097/01.JAA.0000000000000293","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000293","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 1","pages":"45-46"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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