{"title":"Bridging the BRCA1/2 variant previvor gap in health care.","authors":"Stacie Gopal","doi":"10.1097/01.JAA.0000000000000423","DOIUrl":"10.1097/01.JAA.0000000000000423","url":null,"abstract":"<p><strong>Abstract: </strong>Previvors, defined as those who learn that they carry a germline pathogenic or likely pathogenic (P/LP) variant that increases their risk of cancer in the absence of a cancer diagnosis, are a unique yet growing patient population. Identification of a genetic predisposition to cancer and implementation of subsequent risk-reduction strategies are increasingly common aspects of clinical practice, and the era of direct-to-consumer genetic testing expands the relevance of these issues. Comprehensive care for these patients requires a multidisciplinary approach that addresses both immediate risk-management decisions and lifelong follow-up. Essential components of care include counseling on risk-reduction options, the safety and benefits of estrogen-only hormone replacement therapy, lifestyle modification strategies, and targeted nutrition guidance. Although the term previvor encompasses individuals with a variety of hereditary cancer predisposition syndromes, this article focuses on previvors with P/LP variants in BRCA1 or BRCA2 and aims to raise awareness of the far-reaching impact of this diagnosis on female previvors.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 10","pages":"37-43"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrzej Kozikowski, Mirela Bruza-Augatis, Tamara Ritsema, Cody Sasek, Yanlin Jiang, Andrew Dallas, Joshua Goodman
{"title":"Factors associated with PAs' choice of the traditional PANRE over the PANRE-LA.","authors":"Andrzej Kozikowski, Mirela Bruza-Augatis, Tamara Ritsema, Cody Sasek, Yanlin Jiang, Andrew Dallas, Joshua Goodman","doi":"10.1097/01.JAA.0000000000000411","DOIUrl":"10.1097/01.JAA.0000000000000411","url":null,"abstract":"<p><strong>Objective: </strong>To identify the factors associated with physician associates' (PAs') selection of the Physician Assistant National Recertifying Examination (PANRE) versus the Physician Assistant National Recertifying Examination-Longitudinal Assessment (PANRE-LA) for maintenance of board certification.</p><p><strong>Methods: </strong>We utilized data from 80,553 PAs due for recertification between 2024 and 2027 to examine associations between selecting the traditional PANRE versus the PANRE-LA and PA demographics, practice characteristics, prior traditional PANRE experience, most recent examination performance, and first-attempt Physician Assistant National Certifying Examination (PANCE) scores.</p><p><strong>Results: </strong>Overall, 77.6% of PAs chose the PANRE-LA. Selection of the traditional PANRE was most strongly associated with older age, previous experience with the traditional PANRE, male gender, and African American/Black race. Performance on the PANCE and the most recent traditional PANRE had a negligible association with PAs' choice of assessment type.</p><p><strong>Conclusion: </strong>Understanding the factors associated with examination choice is crucial for addressing PAs' current and future credentialing needs.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 10","pages":"e17-e27"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clotting factor disorders: Hypocoagulable states.","authors":"Leslie C Veit","doi":"10.1097/01.JAA.0000000000000416","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000416","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 10","pages":"47-48"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrian S Banning, Patrick Heagey, Mirela Bruza-Augatis, Kasey Puckett, Frances Arabia, Andrzej Kozikowski
{"title":"Analysis of factors related to PA salaries in Pennsylvania.","authors":"Adrian S Banning, Patrick Heagey, Mirela Bruza-Augatis, Kasey Puckett, Frances Arabia, Andrzej Kozikowski","doi":"10.1097/01.JAA.0000000000000399","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000399","url":null,"abstract":"<p><strong>Objective: </strong>This study examined factors contributing to the income disparity among physician associates (PAs) in Pennsylvania.</p><p><strong>Methods: </strong>Utilizing a 2022 national data set, we compared the annual income of PAs in Pennsylvania with PAs in all other US states, as well as with PAs practicing within a 25-mile radius of Pittsburgh and Philadelphia. We also examined the relationship between the number of PA programs in each state and the corresponding average PA income.</p><p><strong>Results: </strong>Compared with PAs in other states, PAs in Pennsylvania reported lower mean earnings ($109,549 vs $121,586; P < .001). PAs in other zip codes of Pennsylvania earn a slightly higher mean income ($109,826) than PAs within 25 miles of Pittsburgh ($101,066), but less than those within 25 miles of Philadelphia ($116,848). We found no correlation between mean state income and the number of PA programs.</p><p><strong>Conclusion: </strong>The significant salary disparities within Pennsylvania and between Pennsylvania and other states warrant a closer examination of underlying factors such as market norms, cost of living, demand for health care services, and other possible contributing factors.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 9","pages":"e1-e9"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metabolic dysfunction-associated steatotic liver disease (MASLD).","authors":"Laura Solano","doi":"10.1097/01.JAA.0000000000000410","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000410","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 9","pages":"47-48"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clay W Walker, Daniel Champigny, Thomas Hartman, Brittney Hulsey, Cambrei Hoffart
{"title":"Hair loss: A systematic approach to evaluation, diagnosis, and management.","authors":"Clay W Walker, Daniel Champigny, Thomas Hartman, Brittney Hulsey, Cambrei Hoffart","doi":"10.1097/01.JAA.0000000000000405","DOIUrl":"10.1097/01.JAA.0000000000000405","url":null,"abstract":"<p><strong>Abstract: </strong>Hair loss (alopecia) is a common presentation in both primary care and dermatology. It often signals underlying inflammation or abnormalities in hair cycling or hair shaft structure, requiring a thorough and systematic evaluation. Clinical guidelines emphasize pattern recognition, trigger identification, and targeted interventions. This article equips physician associates (PAs) with an evidence-based approach to assessing patient history, conducting physical examinations, selecting appropriate diagnostics, and implementing treatment strategies for alopecia. History and scalp inspection guide diagnosis, with the differential including such conditions as telogen effluvium (diffuse), alopecia areata (focal), and androgenetic alopecia (patterned). Recommended laboratory tests include thyroid-stimulating hormone, complete blood cell count, and iron studies, while scalp biopsy is used to confirm scarring. Treatments address causes, with avoidance of triggers central to effluvium, intralesional steroids or baricitinib for alopecia areata, minoxidil-based therapy for androgenetic alopecia, and antifungals for tinea capitis. By integrating trichoscopy, selective testing, and etiology-specific care, PAs can enhance diagnostic accuracy and optimize outcomes for patients with hair loss.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 9","pages":"27-34"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A calling.","authors":"Cameron Young Sweeney","doi":"10.1097/01.JAA.0000000000000403","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000403","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 9","pages":"50"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sixty years of learning.","authors":"David J Bunnell","doi":"10.1097/01.JAA.0000000000000407","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000407","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 9","pages":"18"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Precision oncology in breast cancer: Biomarker-driven treatment strategies and the expanding role of APPs.","authors":"Whitney Tobin","doi":"10.1097/01.JAA.0000000000000408","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000408","url":null,"abstract":"<p><strong>Abstract: </strong>Recent advances in breast cancer management have transformed treatment across molecular subtypes and expanded the role of precision oncology. Hormone receptor-positive (HR-positive), human epidermal growth factor receptor 2-positive (HER2-positive), HER2-low, and triple-negative breast cancer (TNBC) each demonstrate distinct biologic behavior requiring tailored therapeutic strategies. In HR-positive disease, cyclin-dependent kinase 4/6 (CDK4/6) inhibitors and next-generation selective estrogen receptor degraders have improved survival, while HER2-directed antibody-drug conjugates (ADCs) have expanded treatment options beyond traditional HER2-positive disease. HER2-low disease has recently emerged as a therapeutically actionable HER2-expression category, addressing a previously limited treatment space. In TNBC, immunotherapy and ADCs have broadened therapeutic options for historically difficult-to-treat disease. Advances in genomic profiling, including next-generation sequencing and circulating tumor DNA testing, allow clinicians to identify biomarkers to guide targeted therapy selection. As treatment complexity increases, APPs play an essential role in implementing precision oncology through patient education, toxicity management, genomic counseling, and clinical trial coordination. This review summarizes current treatment strategies across breast cancer subtypes, highlights emerging therapies, and emphasizes the expanding APP role.</p>","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 9","pages":"35-43"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What is causing this patient's dome-shaped papule?","authors":"Lanah Almatroud, Amor Khachemoune","doi":"10.1097/01.JAA.0000000000000401","DOIUrl":"https://doi.org/10.1097/01.JAA.0000000000000401","url":null,"abstract":"","PeriodicalId":48728,"journal":{"name":"Jaapa-Journal of the American Academy of Physician Assistants","volume":"39 9","pages":"44-46"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}