Texas Heart Institute Journal最新文献

{"title":"Targeting Cell Senescence to Improve Cardiac Regeneration.","authors":"Georgina M Ellison-Hughes","doi":"10.14503/THIJ-23-8262","DOIUrl":"10.14503/THIJ-23-8262","url":null,"abstract":"phenotype (","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a Commercial Physical Activity Monitor in Longitudinal Tracking of Patients With Pulmonary Hypertension: A Pilot Study.","authors":"Eliana Rosenzweig, Gerson Antonio Valencia Villeda, Sarah Crook, Fatima Koli, Erika B Rosenzweig, Usha S Krishnan","doi":"10.14503/THIJ-22-7866","DOIUrl":"10.14503/THIJ-22-7866","url":null,"abstract":"<p><strong>Background: </strong>Patients with pulmonary arterial hypertension have quality-of-life limitations, decreased exercise capacity, and poor prognosis if the condition is left untreated. Standard exercise testing is routinely performed to evaluate patients with pulmonary arterial hypertension but may be limited in its ability to monitor activity levels in daily living.</p><p><strong>Objective: </strong>To evaluate the validity of the commercial Fitbit Charge HR as a tool to assess real-time exercise capacity as compared with standard exercise testing.</p><p><strong>Methods: </strong>Ambulatory pediatric and adult patients were enrolled and given a Fitbit with instructions to continuously wear the device during waking hours. Patients underwent a 6-minute walk test, cardiopulmonary exercise test, and a 36-Item Short Form Health Survey on the day of enrollment and follow-up. Twenty-seven ambulatory patients with pulmonary arterial hypertension were enrolled, and 21 had sufficient data for analyses (median age, 25 years [range, 13-59 years]; 14 female participants).</p><p><strong>Results: </strong>Daily steps measured by the Fitbit had a positive correlation with 6-minute walk distance (r = 0.72, P = .03) and an inverse trend with World Health Organization functional class. On the 36-Item Short Form Health Survey, 77% of patients reported improvement in vitality (P = .055). At follow-up, there was a strong correlation between number of steps recorded by Fitbit and role limitations because of physical problems (r = 0.88, P = .02) and weaker correlations with other quality-of-life markers.</p><p><strong>Conclusion: </strong>The findings of this pilot study suggest activity monitors may have potential as a simple and novel method of assessing longitudinal exercise capacity and activity levels in patients with pulmonary hypertension. Further study in larger cohorts of patients is warranted to determine which accelerometer measures correlate best with outcomes.</p>","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippo Pathway Knockdown Gene Therapy in the Heart.","authors":"Todd R Heallen, James F Martin","doi":"10.14503/THIJ-23-8272","DOIUrl":"10.14503/THIJ-23-8272","url":null,"abstract":"","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Biomarkers for Cardiovascular Disease.","authors":"Stephanie J Kim, Fernanda C P Mesquita, Camila Hochman-Mendez","doi":"10.14503/THIJ-23-8178","DOIUrl":"10.14503/THIJ-23-8178","url":null,"abstract":"<p><p>Cardiovascular disease is the leading cause of death and disability worldwide. Early detection and treatment of cardiovascular disease are crucial for patient survival and long-term health. Despite advances in cardiovascular disease biomarkers, the prevalence of cardiovascular disease continues to increase worldwide as the global population ages. To address this problem, novel biomarkers that are more sensitive and specific to cardiovascular diseases must be developed and incorporated into clinical practice. Exosomes are promising biomarkers for cardiovascular disease. These small vesicles are produced and released into body fluids by all cells and carry specific information that can be correlated with disease progression. This article reviews the advantages and limitations of existing biomarkers for cardiovascular disease, such as cardiac troponin and cytokines, and discusses recent evidence suggesting the promise of exosomes as cardiovascular disease biomarkers.</p>","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Care Echocardiography-A Driven Approach to Undifferentiated Shock.","authors":"Pedro Salinas, Jacqueline Sohn, José L Díaz-Gómez","doi":"10.14503/THIJ-22-8075","DOIUrl":"10.14503/THIJ-22-8075","url":null,"abstract":"<p><p>The clinical approach to undifferentiated shock in critically ill patients should be revised to use modern, point-of-care tools that are readily available. With the increasing availability of 2-dimensional ultrasonography and advanced Doppler capabilities, a quick, simplified, and integrated stepwise approach to shock using critical care echocardiography is proposed. Evidence supports the feasibility and usefulness of critical care echo-cardiography in enhancing diagnostic accuracy for shock, but there is a lack of systematic application of the technology in patients with undifferentiated shock. The proposed approach begins with the use of noninvasive ultrasonography with pulsed-wave Doppler capability to determine the flow state by measuring the velocity time integral of the left ventricular outflow tract. This narrative review explores the use left ventricular outflow tract velocity time integral, velocity time integral variation, limited visceral organ Doppler, and lung ultrasonography as a systematic approach for patients with undifferentiated shock.</p>","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Iliac Artery Dissection Described on Duplex Ultrasonography.","authors":"Shannon M McDonnell, Pegge M Halandras, Robert S Dieter","doi":"10.14503/THIJ-23-8224","DOIUrl":"10.14503/THIJ-23-8224","url":null,"abstract":"","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyploidy in Cardiomyocytes: Machine Learning for Single Cell Analyses.","authors":"Jeremy Scott Mitchell, Mark Alan Sussman","doi":"10.14503/THIJ-23-8246","DOIUrl":"10.14503/THIJ-23-8246","url":null,"abstract":"powers population-based studies of polyploidy, paving the way for advanced explorations of ploidy dynamics in myocardial biology. This methodology will be used to reevaluate ploidy response to myocardial injury, repair, and regeneration.","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Paolo Angelini (1941-2023)-A Pioneer and World-Leading Expert in Coronary Artery Anomalies. A Tribute From the International Coronary Artery Anomalies Collaborative (ICAAC).","authors":"Christoph Gräni,&nbsp;Carlos M Mery,&nbsp;Silvana Molossi","doi":"10.14503/THIJ-23-8311","DOIUrl":"10.14503/THIJ-23-8311","url":null,"abstract":"","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41216708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated Intravenous Administration of Mesenchymal Stromal Cells Produces Cumulative Beneficial Effects in Chronic Ischemic Cardiomyopathy.","authors":"Xian-Liang Tang, Roberto Bolli","doi":"10.14503/THIJ-23-8244","DOIUrl":"10.14503/THIJ-23-8244","url":null,"abstract":"","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Delivery of Embryonic Cells and Products.","authors":"Philippe Menasché","doi":"10.14503/THIJ-23-8263","DOIUrl":"10.14503/THIJ-23-8263","url":null,"abstract":"","PeriodicalId":48680,"journal":{"name":"Texas Heart Institute Journal","volume":"50 5","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41216709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}