Endocrinologia Y Nutricion最新文献

{"title":"Impaired awareness of hypoglycaemia in subjects with type 1 diabetes. Results of an online survey in a diabetes web site","authors":"Ignacio Conget ,&nbsp;Dalia Ávila ,&nbsp;Marga Giménez ,&nbsp;Carmen Quiros ,&nbsp;Vanesa Salaverria ,&nbsp;Belen Dueñas","doi":"10.1016/j.endoen.2016.02.008","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.02.008","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the frequency of impaired awareness of hypoglycaemia (IAH) using a specific questionnaire (Spanish version) in a free access diabetes-related web site.</p></div><div><h3>Methods</h3><p>Data from a free access Spanish version of the Clarke test previously uploaded to the website of the <em>Fundación para la Diabetes</em> (March 2014–January 2015) were assessed. In addition to the eight questions in Clarke's questionnaire, information on type of diabetes, age, and disease duration was obtained. The Clarke test divided participants into three categories: normal awareness, uncertain and IAH.</p></div><div><h3>Results</h3><p>Of the 418 participants with type 1 diabetes, 51.2% were aged 36–55 years. In 34.7%, diabetes had been diagnosed &gt;15 years before, while disease duration was &lt;2 years in 11%. According to Clarke categories, 23.4% had IAH, 15.3% uncertain awareness, and 61.3% normal awareness. The longer the duration of diabetes, the higher the Clarke test score. According to the Clarke test, 14.1% of participants had experienced at least one episode of severe hypoglycaemia in the previous year, and half of these (7.4%) had suffered severe hypoglycaemia two or more times. All but one of the participants with two or more episodes of severe hypoglycaemia had IAH.</p></div><div><h3>Conclusions</h3><p>Our study shows that the rate of IAH using an online survey is similar (25%) to that previously reported in other geographical areas, increases with diabetes duration, and identifies subjects prone to severe hypoglycaemia.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 3","pages":"Pages 121-125"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.02.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72055792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health care of pregnant women with diabetes in Spain: Approach using a questionnaire","authors":"José Antonio Rubio ,&nbsp;Marta Ontañón ,&nbsp;Verónica Perea ,&nbsp;Ana Megia ,&nbsp;on behalf of the Spanish Group of Diabetes and Pregnant","doi":"10.1016/j.endoen.2015.11.017","DOIUrl":"https://doi.org/10.1016/j.endoen.2015.11.017","url":null,"abstract":"<div><h3>Objective</h3><p>To ascertain how health care for pregnant women with gestational diabetes (GD) and pregestational diabetes (PGD) is organized, and to estimate the number of Pregnancy and Diabetes Units (PDUs) in Spain in 2013.</p></div><div><h3>Material and methods</h3><p>The Spanish Group of Diabetes and Pregnancy (GEDE) developed and agreed on a questionnaire based on the recommendations of the group. The questionnaire was sent to members of the Spanish Society of Diabetes and the Spanish Society of Endocrinology and Nutrition.</p></div><div><h3>Results</h3><p>Eighty-seven questionnaires were received from 81 hospitals, 4 outpatient specialty centers, and 2 primary healthcare centers, which accounted for 51% of the Spanish population and for 39% of births in 2013. GD was mainly diagnosed based on GEDE recommendations (98%), and less than 50% of women were reevaluated after delivery in primary care. Fourteen (26%) of the 53 centers identified as PDUs corresponded to a minimal model. Continuous subcutaneous insulin infusion (CSII) therapy was not available in 30% of centers, and 13% of hospitals had no preconceptional clinics. No nurse support was available in 20% of centers.</p></div><div><h3>Conclusions</h3><p>Care of women with PGD has a fair coverage with PDU, but significant deficits still exist, for instance, in preconception clinic and CSII. However, organization of care for women with GD appears to be adequate. There are aspects in need of improvement such as integration of diabetes educators and coordination with primary care for postpartum reclassification.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 3","pages":"Pages 113-120"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2015.11.017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72055783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid changes and their relationship with vitamin D levels in children under 18 years with type 1 diabetes","authors":"Gabriela D.R. Zambrana-Calví ,&nbsp;Enrique Palomo-Atance ,&nbsp;Marie E. Gourdet ,&nbsp;Alberto León-Martín ,&nbsp;María José Ballester-Herrera ,&nbsp;Patricio Giralt-Muiña","doi":"10.1016/j.endoen.2015.10.013","DOIUrl":"https://doi.org/10.1016/j.endoen.2015.10.013","url":null,"abstract":"<div><h3>Objective</h3><p><span>To analyze lipid changes and their relationship with 25-hydroxy vitamin D3 (25-OH-D) levels in patients under 18 years old with </span>type 1 diabetes mellitus (T1DM).</p></div><div><h3>Material and methods</h3><p><span><span><span><span>A cross-sectional, descriptive study. Patients under 18 years with T1DM were enrolled by consecutive, nonrandomized sampling. Data collected included sex, age, pubertal stage, time since T1DM onset, weight, height, body mass index (BMI), waist circumference, </span>glycosylated hemoglobin (HbA1c), 25-OH-D, total cholesterol (TC), </span>LDL cholesterol (LDL-C), </span>HDL cholesterol (HDL-C), and triglycerides (TG). Results were stratified by sex, age, and pubertal stage. Data were analyzed using SPSS</span>^®.</p></div><div><h3>Results</h3><p>Ninety patients with a mean age of 11.7<!--> <!-->±<!--> <!-->3.6 years (51.1% males) and mean HbA1c levels of 7.5<!--> <!-->±<!--> <!-->1.3% were enrolled. Of these, 26.6% had 25-OH-D levels &lt;20<!--> <!-->ng/mL and 13.3% 25-OH-D levels ≤15<!--> <!-->ng/mL. No differences were found in 25-OH-D between patients with overweight or obesity and the rest. HDL-C levels &lt;40<!--> <!-->ng/mL were found in 1.1%, 34.4% had LDL-C levels ≥100<!--> <!-->mg/dL, and 2.2% had TG levels ≥150<!--> <!-->mg/dL. Patients with 25-OH-D &lt;20<!--> <!-->ng/mL had higher TG levels than the rest (76.80<!--> <!-->±<!--> <!-->45.62 vs 57.55<!--> <!-->±<!--> <!-->26.08; <em>P</em> <!-->=<!--> <!-->.04) in the multivariate analysis controlled for BMI, waist circumference, and HbA1c. A correlation was found between 25-OH-D and TG levels (−0.230; <em>P</em> <!-->=<!--> <!-->.029).</p></div><div><h3>Conclusions</h3><p>Patients in our population with vitamin D deficiency had higher TG levels. Long-term follow-up should be performed to understand the potential impact of such levels on diabetes-related complications.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 3","pages":"Pages 126-131"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2015.10.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72056408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial adipose tissue thickness in children and adolescents with cardiometabolic risk factors","authors":"Yubriangel Reyes ,&nbsp;Mariela Paoli ,&nbsp;Nolis Camacho ,&nbsp;Yudisay Molina ,&nbsp;Justo Santiago ,&nbsp;Marcos M. Lima-Martínez","doi":"10.1016/j.endoen.2016.02.005","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.02.005","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the relationship of epicardial adipose tissue (EAT) thickness with cardiometabolic risk factors (CRFs) in children and adolescents.</p></div><div><h3>Methods</h3><p>Seventy-seven subjects of both sexes aged 7–18 years were selected. Medical history, clinical parameters, and glucose, insulin, and lipid levels were collected. EAT thickness was measured using transthoracic echocardiography. Study subjects were divided into two groups based on whether they had less than two or two or more CRFs.</p></div><div><h3>Results</h3><p>The group with two or more CRFs had higher EAT thickness, insulin, and HOMA-IR values (<em>p</em> <!-->&lt;<!--> <!-->0.05). EAT thickness showed a statistically significant positive correlation with body mass index (BMI) (<em>r</em> <!-->=<!--> <!-->0.561, <em>p</em> <!-->=<!--> <!-->0.0001), waist circumference (<em>r</em> <!-->=<!--> <!-->0.549, <em>p</em> <!-->=<!--> <!-->0.0001), systolic blood pressure (SBP) (<em>r</em> <!-->=<!--> <!-->0.256, <em>p</em> <!-->=<!--> <!-->0.028), insulin (<em>r</em> <!-->=<!--> <!-->0.408, <em>p</em> <!-->=<!--> <!-->0.0001), and HOMA-IR (<em>r</em> <!-->=<!--> <!-->0.325, <em>p</em> <!-->=<!--> <!-->0.005). However, these correlations were not significant after adjustment for BMI. The cut-off point for EAT thickness as predictor of two or more CRFs was 3.17<!--> <!-->mm. The risk (odds ratio) of having two or more CRFs if EAT thickness was &gt;3.17<!--> <!-->mm was 3.1 (95% CI: 1.174–8.022). BMI was the independent variable that most affected EAT thickness and the presence of two or more CRFs.</p></div><div><h3>Conclusion</h3><p>In this group of children and adolescents, the relationship of EAT thickness with CRFs was found to be dependent on BMI.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 2","pages":"Pages 70-78"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.02.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72059129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcitriol-modulated human antibiotics: New pathophysiological aspects of vitamin D","authors":"Carlos Antonio Amado Diago ,&nbsp;María Teresa García-Unzueta ,&nbsp;María del Carmen Fariñas ,&nbsp;Jose Antonio Amado","doi":"10.1016/j.endoen.2016.02.003","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.02.003","url":null,"abstract":"<div><p><span>Traditionally, calcitriol has been considered a calcium and phosphate regulating hormone, but has recently been shown to play a pivotal role in innate immunity. Many barrier and immune cells have membrane and </span>intracellular receptors<span><span> that recognize different microbial antigens. Activation of these receptors induces synthesis of 1α-hydroxylase<span>, which acts on 25 hydroxyvitamin D to generate intracellular calcitriol. Calcitriol activates its receptor and enhances the synthesis of important human antibiotics like cathelicidin<span> and β2-defensin while inhibiting hepcidin. These pluripotent peptides have an important role in innate immunity, and their regulation is abnormal in </span></span></span>hypovitaminosis D.<span> The literature on their secretion mechanisms, levels in different organic fluids, mechanism of action, and relationship with vitamin D is reviewed here.</span></span></p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 2","pages":"Pages 87-94"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72059130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two decades of growth hormone treatment in adulthood","authors":"Jordi Mesa ,&nbsp;Carlos del Pozo","doi":"10.1016/j.endoen.2016.02.001","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.02.001","url":null,"abstract":"","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 2","pages":"Pages 55-57"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72057927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in clinical and biological characteristics and prevalence of chronic complications related to aging in patients with type 2 diabetes","authors":"María Luisa Basanta-Alario ,&nbsp;Jordi Ferri ,&nbsp;Miguel Civera ,&nbsp;Sergio Martínez-Hervás ,&nbsp;Juan Francisco Ascaso ,&nbsp;José Tomás Real","doi":"10.1016/j.endoen.2015.10.011","DOIUrl":"https://doi.org/10.1016/j.endoen.2015.10.011","url":null,"abstract":"<div><p>Type 2 diabetes mellitus (T2DM) is a chronic, highly prevalent disease that increases with age. Because of this, and due to its chronic complications, T2DM causes high human, social, and financial costs. In addition, the elderly population with T2DM has a marked clinical heterogeneity. Therefore, our main objective was to analyze the relationship of age with the clinical and biological manifestations of the disease and the prevalence of chronic complications in patients with T2DM.</p></div><div><h3>Material and methods</h3><p>A cross-sectional study of a large population with T2DM (n<!--> <!-->=<!--> <!-->405) randomly selected from a Diabetes Unit and 2 health care centers (60%). The clinical, anthropometric, and biochemical variables of the subjects were collected using standard methods to assess the effect of age on the clinical and biochemical phenotype of patients with T2DM.</p></div><div><h3>Results</h3><p>We have noted that patients with T2DM &gt;70 years old have a clinical and biochemical phenotype different from younger subjects (&lt;60 years) including longer times since diabetes onset, higher diastolic blood pressure levels, and lower body mass index (BMI) values. As regards to biological variables, these patients have lower triglyceride levels, impaired kidney function, and lower HbA1c values. Prevalence of metabolic syndrome is lower in patients with T2DM &gt;70 years of age. Age was inversely related to parameters associated to metabolic syndrome (BMI, waist circumference, blood pressure, and triglyceride levels).</p></div><div><h3>Conclusions</h3><p>We have defined the clinical and biochemical profile of patients with T2DM &gt;70 years attending health care centers. In addition, the prevalence of stroke, kidney disease, and distal symmetrical polyneuropathy is higher in patients with T2DM &gt;70 years as compared to younger patients (&lt;60 years).</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 2","pages":"Pages 79-86"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2015.10.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72059131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothyroidism and protein-losing enteropathy: A case report","authors":"Irene Berges-Raso,&nbsp;Ismael Capel,&nbsp;Assumpta Caixàs,&nbsp;Roser Trallero,&nbsp;Mercedes Rigla","doi":"10.1016/j.endoen.2015.11.016","DOIUrl":"https://doi.org/10.1016/j.endoen.2015.11.016","url":null,"abstract":"","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 2","pages":"Pages 95-96"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2015.11.016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72059135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary hyperchylomicronemia syndrome treated with ciprofibrate in childhood","authors":"Marcos M. Lima-Martínez ,&nbsp;Martha Piñango ,&nbsp;Miguel Lima-Ostos","doi":"10.1016/j.endoen.2015.10.012","DOIUrl":"https://doi.org/10.1016/j.endoen.2015.10.012","url":null,"abstract":"","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 2","pages":"Pages 98-99"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2015.10.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72059132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of glycosylated hemoglobin during hospitalization as an opportunity to assess and optimize glycemic control in our patients: An unresolved matter","authors":"Alberto de los Santos Moreno ,&nbsp;Elvira Ruiz Blasco ,&nbsp;Beatriz López Alonso ,&nbsp;José Antonio Girón-González","doi":"10.1016/j.endoen.2015.09.005","DOIUrl":"https://doi.org/10.1016/j.endoen.2015.09.005","url":null,"abstract":"","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 2","pages":"Pages 101-102"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2015.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72019271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}