Felipe Casanueva , Felipe de la Cruz Vigo , Albert Goday , Juan Carlos Ruiz de Adana , Susana Monereo , Ramón Vilallonga , Purificación Martínez de Icaya , Raquel Sánchez-Santos , José Manuel García Almeida , Ismael Díez del Val
{"title":"Statement on the current treatment of severe obesity in Spain","authors":"Felipe Casanueva , Felipe de la Cruz Vigo , Albert Goday , Juan Carlos Ruiz de Adana , Susana Monereo , Ramón Vilallonga , Purificación Martínez de Icaya , Raquel Sánchez-Santos , José Manuel García Almeida , Ismael Díez del Val","doi":"10.1016/j.endoen.2016.08.011","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.08.011","url":null,"abstract":"","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 10","pages":"Pages 573-574"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.08.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72056040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is diabetes mellitus correctly registered and classified in primary care? A population-based study in Catalonia, Spain","authors":"Manel Mata-Cases , Dídac Mauricio , Jordi Real , Bonaventura Bolíbar , Josep Franch-Nadal","doi":"10.1016/j.endoen.2016.10.005","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.10.005","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the prevalence of miscoding, misclassification, misdiagnosis and under-registration of diabetes mellitus (DM) in primary health care in Catalonia (Spain), and to explore use of automated algorithms to identify them.</p></div><div><h3>Methods</h3><p>In this cross-sectional, retrospective study using an anonymized electronic general practice database, data were collected from patients or users with a diabetes-related code or from patients with no DM or prediabetes code but treated with antidiabetic drugs (unregistered DM). Decision algorithms were designed to classify the true diagnosis of type 1 DM (T1DM), type 2 DM (T2DM), and undetermined DM (UDM), and to classify unregistered DM patients treated with antidiabetic drugs.</p></div><div><h3>Results</h3><p>Data were collected from a total of 376,278 subjects with a DM ICD-10 code, and from 8707 patients with no DM or prediabetes code but treated with antidiabetic drugs. After application of the algorithms, 13.9% of patients with T1DM were identified as misclassified, and were probably T2DM; 80.9% of patients with UDM were reclassified as T2DM, and 19.1% of them were misdiagnosed as DM when they probably had prediabetes. The overall prevalence of miscoding (multiple codes or UDM) was 2.2%. Finally, 55.2% of subjects with unregistered DM were classified as prediabetes, 35.7% as T2DM, 8.5% as UDM treated with insulin, and 0.6% as T1DM.</p></div><div><h3>Conclusions</h3><p>The prevalence of inappropriate codification or classification and under-registration of DM is relevant in primary care. Implementation of algorithms could automatically flag cases that need review and would substantially decrease the risk of inappropriate registration or coding.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 440-448"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72027622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An update on probiotics, prebiotics and symbiotics in clinical nutrition","authors":"Gabriel Olveira , Inmaculada González-Molero","doi":"10.1016/j.endoen.2016.10.011","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.10.011","url":null,"abstract":"<div><p>The concept of prebiotics, probiotics, and symbiotics and their use in different situations of daily clinical practice related to clinical nutrition is reviewed, as well as their role in the treatment/prevention of diarrhea (acute, induced by antibiotics, secondary to radiotherapy), inflammatory bowel disease (ulcerative colitis and pouchitis), in colonic health (constipation, irritable bowel), in liver disease (steatosis and minimum encephalopathy), and in intensive care, surgical, and liver transplantation. While their effectiveness for preventing antibiotic-induced diarrhea and pouchitis in ulcerative colitis appears to be shown, additional studies are needed to establish recommendations in most clinical settings. The risk of infection associated to use of probiotics is relatively low; however, there are selected groups of patients in whom they should be used with caution (as jejunum infusion).</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 482-494"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.10.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72027625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernando Guerrero Pérez , Arturo Lisbona Gil , Mercedes Robledo , Pedro Iglesias , Carles Villabona Artero
{"title":"Pituitary adenoma associated with pheochromocytoma/paraganglioma: A new form of multiple endocrine neoplasia","authors":"Fernando Guerrero Pérez , Arturo Lisbona Gil , Mercedes Robledo , Pedro Iglesias , Carles Villabona Artero","doi":"10.1016/j.endoen.2016.10.012","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.10.012","url":null,"abstract":"","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 506-508"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.10.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72038275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The specific immunotherapy of autoimmune diseases through the nanomedicine","authors":"Joan Verdaguer","doi":"10.1016/j.endoen.2016.10.007","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.10.007","url":null,"abstract":"","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 437-439"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.10.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72027611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena González-Sánchez-Migallón , Benito Flores-Pastor , Carmen Victoria Pérez-Guarinos , Joana Miguel-Perelló , Asunción Chaves-Benito , Fátima Illán-Gómez , Andrés Carrillo-Alcaraz , José Luis Aguayo-Albasini
{"title":"Incidental versus non-incidental thyroid carcinoma: Clinical presentation, surgical management and prognosis","authors":"Elena González-Sánchez-Migallón , Benito Flores-Pastor , Carmen Victoria Pérez-Guarinos , Joana Miguel-Perelló , Asunción Chaves-Benito , Fátima Illán-Gómez , Andrés Carrillo-Alcaraz , José Luis Aguayo-Albasini","doi":"10.1016/j.endoen.2016.10.008","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.10.008","url":null,"abstract":"<div><h3>Background and objective</h3><p>Thyroid cancer may be clinically evident as a tumor mass in the neck or as a histopathological incidental finding after thyroid surgery for an apparent benign condition. Our objective was to assess the differences in clinical signs, surgical management, and course between incidental and clinically diagnosed thyroid tumors.</p></div><div><h3>Methods</h3><p>A retrospective study was conducted on patients operated on for benign or malignant thyroid disease from January 2000 to March 2014. Among the 1415 patients who underwent any thyroid surgery, 264 neoplasms were found, of which 170 were incidental. A comparison was made of incidental versus non-incidental carcinomas. Among incidental carcinomas, cases whose indication for surgery was Graves’ disease were compared to those with multinodular goiter.</p></div><div><h3>Results</h3><p>Incidental carcinomas were in earlier stages and required less aggressive surgery. There were no differences in surgical complications between incidental and clinical tumors, but mortality and relapses were markedly higher in non-incidental cancers (4.4% vs 0% and 13.2% vs 4.8% respectively). Carcinomas developing on Graves’ disease showed no differences from all other incidental tumors in terms of complications, mortality, or relapse after surgery.</p></div><div><h3>Conclusions</h3><p>Early stage thyroid cancer has better survival and prognosis after surgical treatment.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 475-481"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.10.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72027624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonsoles Botella Martínez , Nerea Varo Cenarruzabeitia , Javier Escalada San Martin , Amparo Calleja Canelas
{"title":"The diabetic paradox: Bone mineral density and fracture in type 2 diabetes","authors":"Sonsoles Botella Martínez , Nerea Varo Cenarruzabeitia , Javier Escalada San Martin , Amparo Calleja Canelas","doi":"10.1016/j.endoen.2016.10.010","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.10.010","url":null,"abstract":"<div><p>Type 2 diabetes mellitus prevalence and morbidity are increasing. Osteoporotic fractures are among the ‘non-classical’ complications of diabetes and been overlooked for a long time, maybe because of their complex diagnostic and therapeutic approach. The usual tools for preventing fragility fractures (such as the fracture risk assessment tool and bone densitometry) underestimate risk of fractures in type 2 diabetic patients. New techniques, such as trabecular bone score or bone turnover markers, could be useful, but greater scientific evidence is required to recommend their use in clinical practice. The special characteristics of their pathophysiology result in decreased bone remodeling with normal or even increased bone mineral density, but with low quality. These changes lead to the occurrence of osteoporotic fractures without evidence of densitometric changes, which could be called ‘the diabetic paradox’.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 495-501"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.10.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72038278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Miguel Gomes , Sofia Martins , Olinda Marques , Nicole da Silva , Ana Antunes
{"title":"Severe systemic type 1 pseudohypoaldosteronism: 5 years of evolution","authors":"Maria Miguel Gomes , Sofia Martins , Olinda Marques , Nicole da Silva , Ana Antunes","doi":"10.1016/j.endoen.2016.10.006","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.10.006","url":null,"abstract":"","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 502-505"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.10.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72038279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ignacio Jáuregui-Lobera , Patricia Bolaños-Ríos , Juan Sabaté
{"title":"Bone mineral density in anorexia nervosa: Only weight and menses recovery?","authors":"Ignacio Jáuregui-Lobera , Patricia Bolaños-Ríos , Juan Sabaté","doi":"10.1016/j.endoen.2016.10.003","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.10.003","url":null,"abstract":"<div><h3>Introduction</h3><p>The study objectives were to analyze the presence of reduced bone mass in a sample of patients with anorexia nervosa (AN) and amenorrhea, to assess Bone Mineral Density (BMD) recovery after having a normal weight is reached and regular menses are resumed, and to predict BMD after a treatment period considering different variables (baseline BMD, baseline and final body mass index (BMI), treatment duration).</p></div><div><h3>Material & Methods</h3><p>35 patients with AN (mean age 20.57<!--> <!-->±<!--> <!-->5.77) were studied at treatment start (T<sub>0</sub>) and after they had recovered their normal weight and regular menses (T<sub>1</sub>) in order to measure their BMD using quantitative computed tomography (QCT) of the lumbar spine (L2–L4).</p></div><div><h3>Results</h3><p>At T<sub>0</sub>, 2.86% of patients had normal BMD, while a reduced bone mass consistent with osteopenia or with osteoporosis was found in 22.86% and 74.28% of patients respectively. At T<sub>1</sub>, the percentages were 20%, 20%, and 60% respectively. No significant differences were seen in L2–L3 and mean BMD (L2–L4). A significant difference was however found for L4 (<em>p</em> <!--><<!--> <!-->0.05). A positive relationship was seen between final body mass index (BMI) and final BMD in patients with T<sub>0</sub>–T<sub>1</sub> <!-->><!--> <!-->11 months, but not when the time period was ≤11 months.</p></div><div><h3>Conclusions</h3><p>This follow-up study of changes not only in BMD but also in BMI and recovery of menses has clinical relevance from the viewpoint of the day-by-day treatment process. Use of QCT makes the study more relevant because this is a more advanced technique that allows for differentiating trabecular and cortical bone.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 458-465"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72038277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}