Bone mineral density in anorexia nervosa: Only weight and menses recovery?

Ignacio Jáuregui-Lobera , Patricia Bolaños-Ríos , Juan Sabaté
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Abstract

Introduction

The study objectives were to analyze the presence of reduced bone mass in a sample of patients with anorexia nervosa (AN) and amenorrhea, to assess Bone Mineral Density (BMD) recovery after having a normal weight is reached and regular menses are resumed, and to predict BMD after a treatment period considering different variables (baseline BMD, baseline and final body mass index (BMI), treatment duration).

Material & Methods

35 patients with AN (mean age 20.57 ± 5.77) were studied at treatment start (T0) and after they had recovered their normal weight and regular menses (T1) in order to measure their BMD using quantitative computed tomography (QCT) of the lumbar spine (L2–L4).

Results

At T0, 2.86% of patients had normal BMD, while a reduced bone mass consistent with osteopenia or with osteoporosis was found in 22.86% and 74.28% of patients respectively. At T1, the percentages were 20%, 20%, and 60% respectively. No significant differences were seen in L2–L3 and mean BMD (L2–L4). A significant difference was however found for L4 (p < 0.05). A positive relationship was seen between final body mass index (BMI) and final BMD in patients with T0–T1 > 11 months, but not when the time period was ≤11 months.

Conclusions

This follow-up study of changes not only in BMD but also in BMI and recovery of menses has clinical relevance from the viewpoint of the day-by-day treatment process. Use of QCT makes the study more relevant because this is a more advanced technique that allows for differentiating trabecular and cortical bone.

神经性厌食症的骨密度:只有体重和月经恢复?
引言本研究的目的是分析神经性厌食症(AN)和闭经患者样本中骨量减少的情况,评估达到正常体重和恢复月经后的骨密度(BMD)恢复情况,并考虑不同的变量(基线BMD、基线和最终体重指数(BMI),治疗持续时间);方法对35例AN患者(平均年龄20.57±5.77)在治疗开始时(T0)和恢复正常体重和月经后(T1)进行研究,用腰椎(L2–L4)定量计算机断层扫描(QCT)测量其骨密度,而与骨质减少或骨质疏松症一致的骨量减少分别在22.86%和74.28%的患者中发现。在T1,百分比分别为20%、20%和60%。L2–L3和平均BMD(L2–L4)无显著差异。然而,L4有显著差异(p<;0.05)。T0–T1>;患者的最终体重指数(BMI)和最终BMD之间呈正相关;11个月,但当时间段≤11个月时没有。结论从日常治疗过程的角度来看,对BMD、BMI和月经恢复变化的随访研究具有临床意义。QCT的使用使该研究更具相关性,因为这是一种更先进的技术,可以区分骨小梁和皮质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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