Seminars in Thoracic and Cardiovascular Surgery最新文献_第6页

Partial Heart Transplant Update: Where Are We In 2025? 部分心脏移植更新：2025年我们在哪里？

IF 2.6 3区医学

Seminars in Thoracic and Cardiovascular Surgery Pub Date : 2025-06-01 DOI: 10.1053/j.semtcvs.2025.03.002

Seth E.M. Wolf MD , Berk Aykut MD , Cathlyn K. Medina BA , John A. Kucera MD , Hiba Z. Ghandour MD , Joseph W. Turek MD, PhD, MBA , Douglas M. Overbey MD, MPH

{"title":"Partial Heart Transplant Update: Where Are We In 2025?","authors":"Seth E.M. Wolf MD , Berk Aykut MD , Cathlyn K. Medina BA , John A. Kucera MD , Hiba Z. Ghandour MD , Joseph W. Turek MD, PhD, MBA , Douglas M. Overbey MD, MPH","doi":"10.1053/j.semtcvs.2025.03.002","DOIUrl":"10.1053/j.semtcvs.2025.03.002","url":null,"abstract":"<div><div>Partial heart transplantation (PHT) creates a new and innovative approach to allow for patient and disease tailored intervention with the ability to treat a larger patient base. It offers the growth capacity of a heart transplantation without the need for high dose immunosuppression. The importance of a valve replacement with the potential of growth is imperative in the pediatric population as these patients will otherwise outgrow their new valves requiring repeat and high-risk interventions. Adaptive valve growth has been observed prior to PHT, in the case of orthotopic heart transplantation and Ross pulmonary autografts. The first human PHT was performed in April of 2022 at Duke. The recipient was a 17-day old infant with truncus arteriosus and severe truncal valve regurgitation. The operation was a success and the transplanted PHT conduit showed appropriate adaptive valve growth. Due to the low immunogenicity and recipient endothelialization of the transplanted PHT graft, the immunosuppressive requirements for PHT patients are low. One of the benefits of PHT is that it utilizes hearts which would otherwise not be suitable for orthotopic heart transplantation. Furthermore, the prospect of domino and split root PHT increases the potential of ethical and efficient organ stewardship. Currently PHT is regulated by the Food and Drug Administration, a ruling which was released in early 2024 as human cells, tissues, or cellular or tissue-based products (HCT/Ps). This means it does not compete with hearts suitable for orthotopic heart transplantation which are regulated as organs under the Organ Procurement and Transplantation Network (OPTN).</div></div>","PeriodicalId":48592,"journal":{"name":"Seminars in Thoracic and Cardiovascular Surgery","volume":"37 2","pages":"Pages 174-179"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Type B Management; Implications of Initial Treatment Strategy: The NIH Type B Trial 急性B型血管理；初始治疗策略的含义：NIH B型试验。

IF 2.6 3区医学

Seminars in Thoracic and Cardiovascular Surgery Pub Date : 2025-06-01 DOI: 10.1053/j.semtcvs.2024.11.013

Alexander P. Nissen MD, Bradley G. Leshnower MD

引用次数: 0

Malperfusion, Malperfusion Syndrome, and Mesenteric Ischemia in Aortic Dissection 主动脉夹层的灌注不良、灌注不良综合征和肠系膜缺血。

IF 2.6 3区医学

Seminars in Thoracic and Cardiovascular Surgery Pub Date : 2025-06-01 DOI: 10.1053/j.semtcvs.2024.11.005

Gardner Yost MD, MS, Bo Yang MD PhD

引用次数: 0

Experience Working With 3rd Party: Lung Bioengineering 有与第三方合作的经验：肺生物工程。

IF 2.6 3区医学

Seminars in Thoracic and Cardiovascular Surgery Pub Date : 2025-06-01 DOI: 10.1053/j.semtcvs.2025.03.010

Caitlin T. Demarest MD, PhD

引用次数: 0

When to Opt for Univentricular versus Biventricular Repair in Complex Congenitally Corrected Transposition of the Great Arteries 复杂先天性大动脉转位何时选择单心室修复还是双心室修复。

IF 2.6 3区医学

Seminars in Thoracic and Cardiovascular Surgery Pub Date : 2025-06-01 DOI: 10.1053/j.semtcvs.2025.03.012

Morgan K. Moroi MD , Alice V. Vinogradsky MD , Amee Shah MD , Kanwal Farooqi MD , Oliver Barry MD , Emile Bacha MD , David M. Kalfa MD PhD

引用次数: 0

Contemporary Review of the Current Status of Cardiothoracic Trainees and Early Career Surgeons 心胸外科培训生和早期职业外科医生现状的当代回顾。

IF 2.5 3区医学

Seminars in Thoracic and Cardiovascular Surgery Pub Date : 2025-05-30 DOI: 10.1053/j.semtcvs.2025.03.014

Justin A. Robinson MD , Anish Katta BA , Rashed Mahboubi MD , Ruchika Kamojjala BA , Rimsha Hussaini BS , Shivni Patel BA , John P. Costello MD , Tara Karamlou MD, MSc

{"title":"Contemporary Review of the Current Status of Cardiothoracic Trainees and Early Career Surgeons","authors":"Justin A. Robinson MD , Anish Katta BA , Rashed Mahboubi MD , Ruchika Kamojjala BA , Rimsha Hussaini BS , Shivni Patel BA , John P. Costello MD , Tara Karamlou MD, MSc","doi":"10.1053/j.semtcvs.2025.03.014","DOIUrl":"10.1053/j.semtcvs.2025.03.014","url":null,"abstract":"<div><div>There have been profound shifts in the landscape of cardiothoracic surgery (CTS) training and practice in recent decades, influenced by evolving demographics, changing career aspirations among trainees, and emerging challenges in workforce diversity. This commentary synthesizes current literature and data to (1) explore changes in training paradigms, career trajectories, and the broader professional environment and (2) provide a comprehensive exploration of the factors shaping CTS training and early career experiences. Key themes include the impact of demographic trends, efforts to enhance diversity, adjustments in training programs—such as the extension of congenital heart surgery training to 2 years and the development of integrated CTS pathways—and initiatives to increase and sustain interest among aspiring cardiothoracic surgeon-scientists. By contextualizing these issues, this commentary provides insights into complexities and opportunities defining contemporary CTS practice.</div></div>","PeriodicalId":48592,"journal":{"name":"Seminars in Thoracic and Cardiovascular Surgery","volume":"37 3","pages":"Pages 315-328"},"PeriodicalIF":2.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Recurrence Following Sublobar Resection for Clinical T1N0M0 Non-Small Cell Lung Cancer. 临床T1N0M0非小细胞肺癌肺叶下切除术后复发的预测因素。

IF 2.6 3区医学

Seminars in Thoracic and Cardiovascular Surgery Pub Date : 2025-05-20 DOI: 10.1053/j.semtcvs.2025.05.002

Lauren Drake, Benny Weksler

{"title":"Predictors of Recurrence Following Sublobar Resection for Clinical T1N0M0 Non-Small Cell Lung Cancer.","authors":"Lauren Drake, Benny Weksler","doi":"10.1053/j.semtcvs.2025.05.002","DOIUrl":"10.1053/j.semtcvs.2025.05.002","url":null,"abstract":"<p><p>Recurrence is a significant concern after sublobar resection for clinical T1N0M0 lung cancer. Identifying modifiable risk factors is essential for improving oncologic outcomes. This review examines recurrence risk factors following sublobar resection, focusing on disease stage, tumor characteristics, and surgeon-related factors. Data from randomized trials and retrospective studies were analyzed to assess the impact of tumor biology, stage, surgical margins, and lymph node dissection on recurrence. Recurrence is influenced by tumor stage, biology, and surgical technique. While tumor characteristics and stage are non-modifiable, inadequate surgical margins and incomplete nodal dissection significantly increase recurrence risk. A margin of ≥1 cm or equal to the tumor diameter is associated with lower recurrence rates. Systematic nodal dissection enhances staging accuracy and informs adjuvant therapy. Although sublobar resection is non-inferior to lobectomy in select cases, inadequate margins and suboptimal nodal assessment elevate recurrence risk. Surgical margins and lymph node dissection are the most critical modifiable risk factors for recurrence. To optimize long-term survival, adequate margins and systematic nodal evaluation should be prioritized. Further research is needed to assess the role of completion lobectomy or adjuvant therapy, particularly in patients with multiple high-risk features.</p>","PeriodicalId":48592,"journal":{"name":"Seminars in Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary: The Composite Allocation Score (CAS) Lung Allocation System − The Good, the Bad, and the Ugly 评论：CAS的肺分配系统——好、坏、丑。

IF 2.5 3区医学

Seminars in Thoracic and Cardiovascular Surgery Pub Date : 2025-05-20 DOI: 10.1053/j.semtcvs.2025.05.001

Faiza M. Khan MD, Ramiro Fernandez MD

引用次数: 0

Myocardial Bridge in Children: Do We Care About It? 儿童心肌桥：我们关心它吗？

IF 2.6 3区医学

Seminars in Thoracic and Cardiovascular Surgery Pub Date : 2025-05-20 DOI: 10.1053/j.semtcvs.2025.04.007

Arvind Kumar Bishnoi, Michael Ma

引用次数: 0

The Role of Surgery for Local Consolidative Therapy in the Management of Oligometastatic Disease. 手术在少转移性疾病的局部巩固治疗中的作用。